The Ligandable Human Proteome

Proto-oncogene tyrosine-protein kinase Src

Index	Ligand Name	Structure	PDB code	ligand desolvation
1	pd3	Crystal structure of c-Src in complex with pyrazolopyrimidine 3	3el7	91.13
2	vsp	Crystal Structure of T338C c-Src covalently bound to vinylsulfonamide-pyrazolopyrimidine 9	3svv	91.03
3	6g3	Src kinase in complex with a sulfonamide inhibitor	5j5s	90.82
4	pp2	Structural basis for the chemical rescue of Src kinase activity	3geq	89.24
5	pd5	Crystal structure of the L317I mutant of the C-src tyrosine kinase domain complexed with pyrazolopyrimidine 5	3qlf	89.2
6	pd5	Crystal structure of c-Src in complex with pyrazolopyrimidine 5	3el8	88.57
7	bk5	c-SRC kinase domain in complex with BKI RM-1-89	3uqf	88
8	vgg	Structure of 3MB-PP1 bound to analog-sensitive Src kinase	4lgg	86.72
9	0jn	Crystal structure of 1NM-PP1 bound to analog-sensitive Src kinase	4lgh	86.35
10	ks1	Targeted polypharmacology: crystal structure of the c-Src kinase domain in complex with PP121, a multitargeted kinase inhibitor	3en4	85.49
11	72f	c-Src V281C bound to N-[3-({6-[(1E)-2-cyano-3-(methylamino)-3-oxoprop-1-en-1-yl]-7-(2-methoxyethyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl}ethynyl)-4-methylphenyl]-3-(trifluoromethyl)benzamide inhibitor	5sys	85.12
12	sti	Crystal Structure of chicken c-Src kinase domain in complex with the cancer drug imatinib.	2oiq	84.98
13	i76	c-SRC kinase domain in complex with RM-1-176	4dgg	84.57
14	73a	c-Src kinase domain in complex with Rao-IV-151	5t0p	84.17
15	abj	Targeted polypharmacology: crystal structure of the c-Src kinase domain in complex with S1, a multitargeted kinase inhibitor	3en7	84.12
16	sti	crystal structure of the L317I mutant of the chicken c-Src tyrosine kinase domain complexed with imatinib	3oez	83.85
17	sr2	Crystal structure of drug resistant SRC kinase domain with irreversible inhibitor	2qq7	82.56
18	rbs	Crystal structure of Src kinase domain in complex with covalent inhibitor	2hwo	81.01
19	4a9	Type II Dasatinib Analog Crystallized with c-Src Kinase	4ybj	81.01
20	ks4	Targeted polypharmacology: crystal structure of the c-Src kinase domain in complex with PP494, a multitargeted kinase inhibitor	3en5	80.05
21	hvy	DGY-06-116, a novel and selective covalent inhibitor of SRC kinase	6e6e	79.36
22	ihh	c-Src kinase domain in complex with small molecule inhibitor	3f6x	78.85
23	4b7	C-Helix-Out Dasatinib Analog Crystallized with c-Src Kinase	4ybk	78.2
24	djk	Drug resistant cSrc kinase domain in complex with covalent inhibitor PD168393	3lok	78.01
25	11v	Kinase domain of cSrc in complex with a substituted pyrazolopyrimidine	4o2p	77.59
26	p01	Crystal structure of Src kinase domain in complex with Purvalanol A	1yom	77.52
27	s03	Crystal structure of Src kinase domain in complex with CGP77675	1yol	77.23
28	71d	c-Src V281C kinase domain in complex with Rao-IV-151	5swh	75.2
29	o44	Crystal structure of c-SRC in complex with a covalent lysine probe	5k9i	74.98
30	b5a	c-SRC kinase domain in complex with bumpless BKI analog UW1243	3uqg	74.86
31	6h3	SRC kinase bound to covalent inhibitor	6ate	73.15
32	1n1	Crystal structure of the L317I mutant of the C-src tyrosine kinase domain complexed with dasatinib	3qlg	72.29
33	db8	human Src kinase bound to kinase inhibitor bosutinib	4mxo	70.85
34	h8h	Src kinase in complex with a quinazoline inhibitor	2h8h	70.69
35	1n1	Kinase domain of cSrc in complex with Dasatinib	3g5d	70.13
36	db8	Src M314L T338M double mutant bound to kinase inhibitor bosutinib	4mxz	69.69
37	db8	Src M314L T338M double mutant bound to kinase inhibitor bosutinib	4mxy	69.69
38	db8	Human Src A403T mutant bound to kinase inhibitor bosutinib	4mxx	69.07
39	djk	Crystal structure of Src kinase domain in complex with covalent inhibitor PD168393	2hwp	67.66
40	s56	c-Src V281C kinase domain in complex with Rao-IV-156	5teh	66.57
41	56g	Kinase domain of cSrc in complex with RL235	5d11	66.36
42	gut	Kinase domain of cSrc in complex with compound 29B	6hvf	62.05
43	mpz	Structure of unphosphorylated c-Src in complex with an inhibitor	1y57	61.1
44	563	Kinase domain of cSrc in complex with RL236	5d10	60.29
45	g97	Kinase domain of cSrc in complex with RL40	5d12	58.54