| Index | Ligand Name | Structure | PDB code | ligand desolvation |
| 1 | 2lk | Crystal structure of the bromodomain of human CREBBP in complex with an isoxazolyl-benzimidazole ligand | 4nr4 | 87.77 |
| 2 | 6xb | Crystal structure of the bromodomain of human CREBBP bound to pyrazolopiperidine scaffold | 5ktu | 85.88 |
| 3 | e3t | Crystal structure of CREBBP bromodomain complexd with PA10 | 6frf | 83.74 |
| 4 | ay2 | Crystal structure of CREBBP bromodomain complexd with DR46 | 6fqt | 82.4 |
| 5 | 99e | Crystal structure of the human bromodomain of CREBBP bound to the inhibitor XDM-CBP | 5nu3 | 82.34 |
| 6 | 69a | Crystal structure of the bromodomain of human CREBBP bound to the benzodiazepinone G02778174 | 5i86 | 78.99 |
| 7 | ul4 | Crystal structure of the bromodomain of human CREBBP in complex with UL04 | 4tqn | 77.53 |
| 8 | 77x | Structure of bromodomain of CREBBP with a pyrazolo[4,3-c]pyridin fragment | 5tb6 | 76.37 |
| 9 | 2o3 | Crystal Structure of the Bromodomain of human CREBBP in complex with a dihydroquinoxalinone ligand | 4nyw | 74.99 |
| 10 | 69b | Crystal structure of the bromodomain of human CREBBP bound to the benzodiazepinone G02857790 | 5i89 | 74.71 |
| 11 | 68y | Crystal structure of the bromodomain of human CREBBP bound to the benzodiazepinone G02773986 | 5i83 | 74.6 |
| 12 | xdm | Crystal structure of the bromodomain of human CREBBP bound to the inhibitor XDM1 | 5lpj | 74.3 |
| 13 | 96n | Crystal structure of the human bromodomain of CREBBP bound to the inhibitor XDM4 | 5nrw | 73.86 |
| 14 | 9ug | CREBBP Bromodomain in complex with Cpd17 (N,2,7-trimethyl-2,3-dihydro-4H-benzo[b][1,4]oxazine-4-carboxamide) | 5w0q | 73.75 |
| 15 | 71x | Crystal structure of the bromodomain of human CREBBP bound to the inhibitor XDM3c | 5lpl | 73.34 |
| 16 | 5qr | Crystal structure of the bromodomain of human CREBBP in complex with UN32 | 5ep7 | 68.9 |
| 17 | 2o4 | Crystal Structure of the Bromodomain of human CREBBP in complex with a dihydroquinoxalinone ligand | 4nyx | 68.83 |
| 18 | 6xh | CREBBP bromodomain in complex with Cpd59 ((S)-1-(3-((2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)phenyl)amino)-1-(tetrahydrofuran-3-yl)-6,7-dihydro-1H-pyrazolo[4,3-c]pyridin-5(4H)-yl)ethanone) | 5ktx | 67.96 |
| 19 | 53w | Selective pharmacological inhibition of the CREB binding protein bromodomain regulates inflammatory cytokines in macrophages and RGS4 in neurons | 5cgp | 67.7 |
| 20 | 5xs | Crystal structure of the bromodomain of human CREBBP in complex with UO37D | 5h85 | 67.44 |
| 21 | 3ot | BROMO domain of CREB binding protein | 4whu | 66.13 |
| 22 | 9u7 | CREBBP Bromodomain in complex with Cpd3 ((S)-1-(3-(6-(1-methyl-1H-pyrazol-4-yl)-3,4-dihydroquinolin-1(2H)-yl)-1-(tetrahydrofuran-3-yl)-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridin-5-yl)ethan-1-one) | 5w0f | 66.09 |
| 23 | e0d | Crystal Structure Analysis of the CBP | 5xxh | 65.54 |
| 24 | 6xg | CREBBP bromodomain in complex with Cpd 44 (3-((5-acetyl-1-(cyclopropylmethyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl)amino)-N-isopropylbenzamide) | 5ktw | 65.24 |
| 25 | 2lo | Crystal structure of the bromodomain of human CREBBP in complex with an isoxazolyl-benzimidazole ligand | 4nr7 | 64.65 |
| 26 | bkj | CREBBP bromodomain in complex with Cpd 30 (1-(3-(3-(1-methyl-1H-pyrazol-4-yl)isoquinolin-8-yl)-1-(tetrahydro-2H-pyran-4-yl)-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridin-5-yl)ethan-1-one) | 6alb | 63.82 |
| 27 | 9u4 | CREBBP bromodomain in complex with Cpd19 (3-(7-(difluoromethyl)-6-(1-methyl-1H-pyrazol-4-yl)-3,4-dihydroquinolin-1(2H)-yl)-N-methyl-1-(tetrahydro-2H-pyran-4-yl)-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-5-carboxamide) | 5w0e | 63.66 |
| 28 | 9ua | CREBBP Bromodomain in complex with Cpd8 (1-(3-(7-(difluoromethyl)-6-(1-methyl-1H-pyrazol-4-yl)-3,4-dihydroquinolin-1(2H)-yl)-1-(tetrahydrofuran-3-yl)-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridin-5-yl)ethan-1-one) | 5w0i | 63.43 |
| 29 | 9ud | CREBBP Bromodomain in complex with Cpd10 (1-(3-(7-(difluoromethyl)-6-(1-methyl-1H-pyrazol-4-yl)-3,4-dihydroquinolin-1(2H)-yl)-1-(tetrahydro-2H-pyran-4-yl)-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridin-5-yl)ethan-1-one) | 5w0l | 63 |
| 30 | 2ll | Crystal structure of the bromodomain of human CREBBP in complex with an isoxazolyl-benzimidazole ligand | 4nr5 | 62.65 |
| 31 | 2ll | A multiconformer ligand model of an isoxazolyl-benzimidazole ligand bound to the bromodomain of human CREBBP | 6dmk | 60.96 |
| 32 | 6f9 | Crystal structure of the bromodomain of human CREBBP in complex with a benzoxazepine compound | 5j0d | 59.34 |
| 33 | 2ln | Crystal structure of the bromodomain of human CREBBP in complex with an oxazepin ligand | 4nr6 | 58.09 |
| 34 | 5qn | Crystal structure of the bromodomain of human CREBBP in complex with UP39 | 5eng | 57.49 |