The Ligandable Human Proteome

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Egl nine homolog 1

Oxoglutarate/iron-dependent dioxygenase

IndexLigand NameStructurePDB codeligand desolvation
11qaCrystal Structure of Hypoxia-Inducible Factor Prolyl Hydroxylase (PHD2) with (S)-{2-[2-(5-Cyano-3-hydroxy-pyridin-2-yl)-thiazol-4-yl]-acetylamino}-phenyl-acetic acid4kbz90.35
2fntHIF prolyl hydroxylase 2 (PHD2/ EGLN1) in complex with Fe(II) and N-[(1-chloro-4-hydroxyisoquinolin-3-yl)carbonyl]alanine4bqy89.16
3un9S-nitrosylated PHD2 (NO exposed) in complex with Fe(II) and UN92y3488.92
4un9Crystal structure of HIF prolyl hydroxylase EGLN-1 in complex with a biologically active inhibitor2hbu88.44
5un9HIF prolyl hydroxylase 2 (PHD2/EGLN1) K293K/G294E variant in complex with Mn(II) and N-[(1-chloro-4-hydroxyisoquinolin-3-yl)carbonyl]glycine (IOX3/FG2216)5lbf88.42
6un9PHD2:Fe:UN9:partial HIF1-alpha substrate complex3hqu88.39
7un9Crystal structure of HIF prolyl hydroxylase EGLN-1 in complex with a biologically active inhibitor2hbt88.32
8un9HIF prolyl hydroxylase 2 (PHD2/EGLN1) I280V/R281L/I292V variant in complex with Mn(II) and N-[(1-chloro-4-hydroxyisoquinolin-3-yl)carbonyl]glycine (IOX3/FG2216)5lbc88.31
9un9HIF prolyl hydroxylase 2 (PHD2/ EGLN1) in complex with Mn(II) and N-[(1-chloro-4-hydroxyisoquinolin-3-yl)carbonyl]glycine (IOX3/UN9)4bqx88.18
10ku1Hypoxia-Inducible Factor (HIF) Prolyl Hydroxylase 2 (PHD2) in Complex with the Carboxamide Analog JNJ430581716nmq87.98
11un9S-nitrosylated PHD2 (GSNO soaked) in complex with Zn(II) and UN92y3387.88
12un9HIF prolyl hydroxylase 2 (PHD2/EGLN1) G294E variant in complex with Mn(II) and N-[(1-chloro-4-hydroxyisoquinolin-3-yl)carbonyl]glycine (IOX3/FG2216)5lbe87.6
13un9HIF prolyl hydroxylase 2 (PHD2/EGLN1) R396T variant in complex with Mn(II) and N-[(1-chloro-4-hydroxyisoquinolin-3-yl)carbonyl]glycine (IOX3/UN9)5lbb87.42
14un9HIF prolyl hydroxylase 2 (PHD2/EGLN1) R371H variant in complex with Mn(II) and N-[(1-chloro-4-hydroxyisoquinolin-3-yl)carbonyl]glycine (IOX3/UN9)5lb687.37
15un9HIF prolyl hydroxylase 2 (PHD2/EGLN1) P317R variant in complex with Mn(II) and N-[(1-chloro-4-hydroxyisoquinolin-3-yl)carbonyl]glycine (IOX3/UN9)5lat87.33
16un9HIF prolyl hydroxylase 2 (PHD2/ EGLN1) D315E VARIANT in complex with Mn(II) and N-[(1-chloro-4-hydroxyisoquinolin-3-yl)carbonyl]glycine (IOX3/UN9)4uwd86.06
17qnmHIF prolyl hydroxylase 2 (PHD2/ EGLN1) in complex with Mn(II) and 2-(4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxamido)acetic acid4bqw85.96
184hgCellular Oxygen Sensing: Crystal Structure of Hypoxia-Inducible Factor Prolyl Hydroxylase (PHD2)2g1m83.77
1942zPHD2-R717 with 407874223oui83.4
204hgCellular Oxygen Sensing: Crystal Structure of Hypoxia-Inducible Factor Prolyl Hydroxylase (PHD2)2g1982.67
21a1zHIF prolyl hydroxylase 2 (PHD2/ EGLN1) in complex with Vadadustat5ox676.76
224jrStructure of Prolyl Hydroxylase Domain-containing Protein (PHD) with Inhibitors4jzr71.66