The Ligandable Human Proteome

Dihydroorotate dehydrogenase

Index	Ligand Name	Structure	PDB code	ligand desolvation
1	w7a	Structure of Human dihydroorotate dehydrogenase in complex with mii-4-097	3w7r	99.84
2	vgn	Complex of human dihydroorotate dehydrogenase with the inhibitor 221290	2wv8	99.83
3	238	The structures of apo- and inhibitor bound human dihydroorotate dehydrogenase reveal conformational flexibility within the inhibitor binding site	2prh	99.75
4	bre	HUMAN DIHYDROOROTATE DEHYDROGENASE COMPLEXED WITH BREQUINAR ANALOG	1d3g	99.74
5	r2c	The structures of apo- and inhibitor bound human dihydroorotate dehydrogenase reveal conformational flexibility within the inhibitor binding site	2prl	99.37
6	f51	Human dihydroorotate dehydrogenase bound to napthyridine inhibitor 46	6cjg	98.39
7	duh	Targeting myeloid differentiation using potent human dihydroorotate dehydrogenase (hDHODH) inhibitors based on 2-hydroxypyrazolo[1,5-a]pyridine scaffold	6fmd	98.22
8	sdv	HUMAN DIHYDROOROTATE DEHYDROGENASE IN COMPLEX WITH NOVEL INHIBITOR	6et4	97.65
9	jje	Crystal structure of human DHODH in complex with BAY 2402234	6qu7	97.31
10	kfz	Structure of Human Dihydroorotate Dehydrogenase with a Bound Inhibitor	3zwt	96.68
11	f54	Human dihydroorotate dehydrogenase bound to 4-quinoline carboxylic acid inhibitor 43	6cjf	96.67
12	9au	Crystal structure of human DHODH in complex with ferulenol	6idj	96.63
13	9bo	Structure of human dihydroorotate dehydrogenase in complex with 277-11-OAc	5zf8	96.46
14	avq	Structure of Human Dihydroorotate Dehydrogenase with a Bound Inhibitor	3zws	96.37
15	chw	Structure of human dihydroorotate dehydrogenase in complex with 277-9-OH	5zf7	96.29
16	b5o	Crystal structure of human DHODH in complex with inhibitor 1289	6j3b	96.19
17	jtu	Crystal structure of human dihydroorotate dehydrogenase (DHODH) with brequinar analogue	4jtu	96.14
18	6x1	Crystal structure of human dihydroorotate dehydrogenase (DHODH) with amino-benzoic acid inhibitor 641 at 2.05A resolution	3kvk	96.05
19	03u	Dihydroorotate Dehydrogenase (DHODH) crystal structure in complex with small molecule inhibitor	3u2o	95.82
20	ilb	Dual Binding Mode of a Novel Series of DHODH inhibitors	2fpt	95.81
21	ilc	Dual binding mode of a novel series of DHODH inhibitors	2fpv	95.45
22	9bx	Structure of human dihydroorotate dehydrogenase in complex with ascofuranone (open-form)	5zfb	95.43
23	b5x	Crystal structure of human DHODH in complex with inhibitor 1291	6j3c	95.43
24	3ry	Crystal structure of human dihydroorotate dehydrogenase (DHODH) with DH03A347	4rka	95.33
25	7z5	Crystal structure of human dihydroorotate dehydrogenase (DHODH) with amino-benzoic acid inhibitor 715 at 1.85A resolution	3kvl	95.21
26	hyt	Crystal structure of potent human Dihydroorotate Dehydrogenase inhibitors based on hydroxylated azole scaffolds	5mut	95.15
27	1ea	High resolution crystal structure of human dihydroorotate dehydrogenase bound with 4-quinoline carboxylic acid analog	4igh	95.1
28	ilh	dual binding modes of a novel series of DHODH inhibitors	2fqi	95.07
29	3rv	Crystal structure of human dihydroorotate dehydrogenase (DHODH) with DH03A356	4rk8	94.98
30	u91	Crystal structure of potent human Dihydroorotate Dehydrogenase inhibitors based on hydroxylated azole scaffolds	5mvd	94.95
31	9bu	Structure of human dihydroorotate dehydrogenase in complex with 287-12-OCOiPr	5zfa	94.95
32	951	Crystal structure of human dihydroorotate dehydrogenase (DHODH) with amino-benzoic acid inhibitor 951 at 2.00A resolution	3kvm	94.87
33	y9b	Crystal structure of potent human Dihydroorotate Dehydrogenase inhibitors based on hydroxylated azole scaffolds	5mvc	94.76
34	3ft	Dual binding mode of a novel series of DHODH inhibitors	2bxv	94.49
35	3x2	Crystal structure of human dihydroorotate dehydrogenase (DHODH) with DH03A312	4ls1	94.48
36	1x5	Crystal Structure of Human Dihydroorotate Dehydrogenase (DHODH) with Amino-Benzoic Acid Inhibitor 105 at 1.94A Resolution	3kvj	94.34
37	cih	Human dihydroorotate dehydrogenase in complex with a leflunomide derivative inhibitor 2	3fj6	93.87
38	ilf	Dual binding mode of a novel series of DHODH inhibitors	2fpy	93.76
39	mlj	Crystal structure of human dihydroorotate dehydrogenase with ML390	5k9c	93.26
40	4r5	Crystal structure of Human Dihydroorotate Dehydrogenase (DHODH) with DH03A338	4zmg	92.89
41	m0b	Human DHODH bound to inhibitor IPP/CNRS-A017	6syp	78.65
42	3v1	Crystal structure of human dihydroorotate dehydrogenase (DHODH) with DH03A367	4rr4	78.35