The Ligandable Human Proteome

Aldo-keto reductase family 1 member B1

Index	Ligand Name	Structure	PDB code	ligand desolvation
1	tol	Human Aldose Reductase complexed with four tolrestat molecules at 1.5 A resolution.	2fzb	99.89
2	fid	Complex of Aldose Reductase with NADP+ and simaltaneously bound competetive inhibitors Fidarestat and IDD594. Concentration of Fidarestat in soaking solution is less than concentration of IDD594.	2pfh	96.13
3	fid	Complex of Aldose Reductase with NADP+ and simaltaneously bound competetive inhibitors Fidarestat and IDD594. Concentration of Fidarestat in soaking solution is equal to concentration of IDD594.	2pf8	96.12
4	lit	Human aldose reductase complexed with nitrofuryl-oxadiazol inhibitor at 1.55 A	2ikh	95.83
5	fid	Complex of Aldose Reductase with NADP+ and simaltaneously bound competetive inhibitors Fidarestat and IDD594. Concentration of Fidarestat in soaking solution exceeds concentration of IDD594.	2pev	94.84
6	ldt	Complex of Aldose Reductase with NADP+ and simaltaneously bound competetive inhibitors Fidarestat and IDD594. Concentration of Fidarestat in soaking solution exceeds concentration of IDD594.	2pev	94.7
7	2x9	Complex of Aldose Reductase with inhibitor IDD 1219	4gca	94.63
8	ldt	Complex of Aldose Reductase with NADP+ and simaltaneously bound competetive inhibitors Fidarestat and IDD594. Concentration of Fidarestat in soaking solution is less than concentration of IDD594.	2pfh	94.2
9	ldt	Complex of Aldose Reductase with NADP+ and simaltaneously bound competetive inhibitors Fidarestat and IDD594. Concentration of Fidarestat in soaking solution is equal to concentration of IDD594.	2pf8	93.85
10	id5	Crystal structure of human aldose reductase complexed with NADP and IDD552	1t41	93.84
11	ldt	Human Aldose Reductase structure	2r24	93.38
12	zst	Human Aldose Reductase mutant T113A complexed with Zopolrestat	3mb9	93.11
13	zst	Human Aldose Reductase mutant T113S complexed with Zopolrestat	3len	93
14	bfi	Crystal structure of human Aldose Reductase complexed with NADP and Minalrestat	1pwl	92.94
15	zst	Human Aldose Reductase mutant T113V in complex with Zopolrestat	3m0i	92.83
16	3na	Human aldose reductase in complex with NADP+ and the inhibitor lidorestat at 1.04 angstrom	1z3n	92.74
17	zst	Human aldose reductase mutant V47I complexed with zopolrestat	2pd5	92.69
18	id5	Crystal structure of human aldose reductase complexed with NADP and IDD552 at ph 5	1t40	92.56
19	37v	Human Aldose Reductase complexed with a ligand with an IDD structure (2-[2-(1,3-benzothiazol-2-ylmethylcarbamoyl)-5-fluoro-phenoxy]acetic acid) at 1.05 A	4qr6	92.53
20	zst	Human Aldose reductase complexed with inhibitor zopolrestat at 1.48 A(1 day soaking).	2fz8	92.42
21	zst	Human aldose reductase mutant F121P complexed with zopolrestat.	2pdb	92.39
22	zst	Crystal structure of human Aldose Reductase complexed with zopolrestat after 3 days soaking (3days_soaked_1)	2dux	92.35
23	4o9	Crystal structure of human AR complexed with NADP+ and {5-chloro-2-[(2,6-difluoro-4-iodobenzyl)carbamoyl]phenoxy}acetic acid	4lbr	92.33
24	zst	Human Aldose Reductase complexed with inhibitor zopolrestat after three days soaking (3days_soaked_3)	2hv5	92.3
25	zst	Human Aldose Reductase complexed with inhibitor zopolrestat after six days soaking.	2fz9	92.26
26	zst	Human Aldose Reductase-zopolrestat complex obtained by cocrystallisation (10days_cocryst)	2hvo	92.17
27	zst	Human Aldose Reductase complexed with zopolrestat after 6 days soaking(6days_soaked_2)	2dv0	92.15
28	m15	Crystal structure of human AR complexed with NADP+ and {5-chloro-2-[(2-fluoro-4-iodobenzyl)carbamoyl]phenoxy}acetic acid	4lb3	92.14
29	4o8	Crystal structure of human AR complexed with NADP+ and {2-[(4-bromo-2,6-difluorobenzyl)carbamoyl]-5-chlorophenoxy}acetic acid	4lbs	92.13
30	zst	Human aldose reductase double mutant S302R-C303D complexed with zopolrestat.	2pdx	92.12
31	zst	Human Aldose Reductase-zopolrestat complex obtained by cocrystallisation after one day (1day_cocryst)	2hvn	92.11
32	zst	Human aldose reductase mutant S302R complexed with zopolrestat.	2pdm	92.1
33	1wx	Crystal structure of human AR complexed with NADP+ and {2-[(4-bromo-2,3,5,6-tetrafluorobenzyl)carbamoyl]-5-chlorophenoxy}acetic acid	4lb4	92.06
34	30l	Human Aldose Reductase complexed with a ligand with an IDD structure ({5-fluoro-2-[(3-nitrobenzyl)carbamoyl]phenoxy}acetic acid) at 0.98 A	4qbx	91.91
35	zst	Human Aldose Reductase complexed with inhibitor zopolrestat after 3 days soaking (3days_soaked_2)	2duz	91.83
36	ldt	Human aldose reductase mutant T113S complexed with IDD594	3ld5	91.82
37	3t4	Human aldose reductase in complex with a nitrile-containing IDD inhibitor	3t42	91.76
38	ldt	Human Aldose Reductase mutant T113A complexed with IDD 594	3lql	91.73
39	ldt	Human aldose reductase mutant T113V complexed with IDD594	3lz5	91.72
40	w8x	Crystal structure of human AR complexed with NADP+ and {2-[(4-bromobenzyl)carbamoyl]-5-chlorophenoxy}acetic acid	4lau	91.72
41	1ww	Crystal structure of human AR complexed with NADP+ and {5-chloro-2-[(4-iodobenzyl)carbamoyl]phenoxy}acetic acid	4laz	91.66
42	q74	Human aldose reductase complexed with IDD 740 inhibitor	3g5e	91.59
43	393	Human aldose reductase mutant S302R complexed with IDD 393.	2pdp	91.58
44	ldt	Perdeuterated alr2 in complex with idd594	2qxw	91.58
45	ldt	Human aldose reductase mutant T113C complexed with IDD594	3lbo	91.56
46	ldt	Human aldose reductase in complex with NADP+ and the inhibitor IDD594. Investigation of global effects of radiation damage on protein structure. Forth stage of radiation damage.	3ghu	91.49
47	393	Human aldose reductase mutant T113V complexed with IDD393	3m64	91.46
48	393	Human aldose reductase complexed with nitro-substituted IDD-type inhibitor	2ikj	91.37
49	ldt	Human aldose reductase in complex with NADP+ and the inhibitor IDD594. Investigation of global effects of radiation damage on protein structure. Third stage of radiation damage.	3ght	91.36
50	ldt	Human aldose reductase in complex with NADP+ and the inhibitor IDD594 at temperature of 15K	2i16	91.36
51	393	Human Aldose Reductase mutant T113V in complex with IDD393 crystallized in spacegroup P1	3mc5	91.35
52	393	Human aldose reductase mutant F121P complexed with IDD393.	2pdc	91.34
53	ldt	Human aldose reductase in complex with NADP+ and the inhibitor IDD594. Investigation of global effects of radiation damage on protein structure. First stage of radiation damage	3ghr	91.32
54	i98	Crystal structure of human AR complexed with NADP+ and AK198	4qxi	91.3
55	393	Human aldose reductase mutant C303D complexed with IDD393.	2pdu	91.27
56	393	The crystallographic structure of Aldose Reductase IDD393 complex confirms Leu300 as a specificity determinant	2pzn	91.27
57	ldt	Human aldose reductase in complex with NADP+ and the inhibitor IDD594. Investigation of global effects of radiation damage on protein structure. Second stage of radiation damage.	3ghs	91.24
58	ldt	Human Aldose Reductase in complex with NADP+ and the inhibitor IDD594 at 0.66 Angstrom	1us0	91.23
59	ldt	Human aldose reductase in complex with NADP+ and the inhibitor IDD594 at temperature of 60K	2i17	91.16
60	388	Human aldose reductase complexed with halogenated IDD-type inhibitor	2iki	91.14
61	388	Human Aldose Reductase mutant T113V complexed with IDD388	3m4h	91.12
62	2yz	Human Aldose Reductase complexed with a ligand with an IDD structure ([2-(benzylcarbamoyl)-5-fluorophenoxy]acetic acid) at 1.19 A	4q7b	91.1
63	zes	CRYSTAL STRUCTURE OF HUMAN ALDOSE REDUCTASE COMPLEXED WITH THE INHIBITOR ZENARESTAT.	1iei	90.58
64	zst	Human aldose reductase mutant L300A complexed with zopolrestat at 1.55 A.	2pdi	90.53
65	zst	Human aldose reductase mutant L300P complexed with zopolrestat.	2pdf	90.47
66	tol	Human aldose reductase complexed with tolrestat at 1.08 A resolution.	2fzd	89.92
67	tol	Human aldose reductase mutant L301M complexed with tolrestat.	2pdl	89.63
68	393	Human aldose reductase mutant L300A complexed with IDD393.	2pdj	89.17
69	fir	Crystal structure of Aldose Reductase complexed with 2R4S (Stereoisomer of Fidarestat, 2S4S)	1x97	86.67
70	doy	Novel Benzothiazepine Inhibitor in Complex with human Aldose Reductase	3p2v	86.52
71	3uh	Human Aldose Reductase complexed with a ligand with an IDD structure at 1.20 A (1)	4rpq	85.98
72	fid	Aldose Reductase Mutant Leu 300 Pro complexed with Fidarestat	2agt	85.97
73	fid	Human aldose reductase mutant V47I complexed with fidarestat.	2pd9	85.39
74	fid	FIDARESTAT BOUND TO HUMAN ALDOSE REDUCTASE	1ef3	85.38
75	fid	Human aldose reductase double mutant S302R-C303D complexed with fidarestat.	2pdy	85.32
76	fid	Human aldose reductase mutant C303D complexed with fidarestat.	2pdw	85.31
77	fid	Crystal structure of human Aldose Reductase complexed with NADP and Fidarestat	1pwm	85.11
78	2wq	Human Aldose Reductase complexed with a ligand with an IDD structure (2-[5-fluoro-2-(prop-2-ynylcarbamoyl)phenoxy]acetic acid) at 1.12 A	4puw	84.99
79	2wr	Human Aldose Reductase complexed with a ligand with an IDD structure (2-(2-carbamoyl-5-fluoro-phenoxy)acetic acid) at 1.14 A	4puu	84.17
80	nti	Aldose reductase complexed with a nitro compound	3v35	82.15
81	suz	Aldose reductase in complex with NSAID-type inhibitor at 1.0 A resolution	3u2c	81.92
82	lpa	Crystal Structure of Aldose Reductase complexed with Lipoic Acid	2iqd	81.03
83	itb	Human Aldose Reductase complexed with novel naphtho[1,2-d]isothiazole acetic acid derivative (2)	2nvd	79.98
84	av5	Crystal structure of human AKR1B1 complexed with NADP+ and compound 37	5ou0	79.47
85	ita	Human Aldose Reductase complexed with novel naphtho[1,2-d]isothiazole acetic acid derivative (3)	2nvc	78.94
86	aw8	Crystal structure of human AKR1B1 complexed with NADP+ and compound 39	5ouj	75.79
87	sfi	Crystal Structure of Human Aldose Reductase complexed with Sulindac Sulfide	3rx4	75.33
88	avt	Crystal structure of human AKR1B1 complexed with NADP+ and compound 41	5ouk	75.01
89	slo	Crystal Structure of Human Aldose Reductase Complexed with Sulindac Sulfone	3rx2	73.61
90	suz	Crystal Structure of Human Aldose Reductase Complexed with Sulindac	3rx3	73.48
91	4g7	Human Aldose Reductase complexed with a ligand with an IDD structure (2) at 1.07 A.	4ys1	68.52
92	tlt	Crystal Structure of Human Aldose Reductase Complexed with Tolmetin	3s3g	67.09
93	wy1	Human Aldose Reductase in Complex with NADP+ and WY14643 in Space Group P212121	5ha7	63.91
94	i84	HUMAN ALDOSE REDUCTASE COMPLEXED WITH IDD384 INHIBITOR	1el3	62.74