The Ligandable Human Proteome


Histone deacetylase 4

Histone deacetylase domain

IndexLigand NameStructurePDB codeligand desolvation
1tfgStructure of HDAC4 catalytic domain (a double cysteine-to-alanine mutant) bound to a trifluoromethylketone inhbitor2vqq95.03
2tfgStructure of HDAC4 catalytic domain with a gain-of-function muation bound to a trifluoromethylketone inhbitor2vqo93.86
3otfPotent, selective and CNS-penetrant tetrasubstituted cyclopropane class IIa histone deacetylase (HDAC) inhibitors5a2s78.77
4ebeDevelopment and characterization of a CNS-penetrant benzhydryl hydroxamic acid class IIa histone deacetylase inhibitor6fyz78.58
5keeDesign, synthesis, and biological evaluation of potent and selective Class IIa HDAC inhibitors as a potential therapy for Huntington's disease4cby76.3
6tfgStructure of HDAC4 catalytic domain bound to a trifluoromethylketone inhbitor2vqj55.14
7ha3Structure of HDAC4 catalytic domain bound to a hydroxamic acid inhbitor2vqm50.05