The Ligandable Human Proteome

Renin

Index	Ligand Name	Structure	PDB code	ligand desolvation
1	74z	Structure-based design of a new series of N-piperidin-3-ylpyrimidine-5-carboxamides as renin inhibitors	5sy3	97.95
2	22x	Optimization of Orally Bioavailable Alkyl Amine Renin Inhibitors	3km4	95.81
3	7ek	Optimization of 3,5-Disubstitued Piperidine: Discovery of Non-Peptide mimetics as an Orally Active Renin Inhibitor	5tmg	95.09
4	6vu	Discovery of TAK-272: A Novel, Potent and Orally Active Renin In-hibitor	5kot	94.95
5	0lu	Crystal structure of renin in complex with PKF909-724 (compound 3)	4gj8	92.91
6	0m2	Crystal structure of renin in complex with GP055321 (compound 4)	4gj9	92.62
7	74u	Structure-based design of a new series of N-piperidin-3-ylpyrimidine-5-carboxamides as renin inhibitors	5sxn	91.89
8	s53	Structure-Based Optimization of Potent 4- and 6-Azaindole-3-Carboxamides as Renin Inhibitors	3sfc	91.78
9	0lt	Crystal structure of renin in complex with NVP-BCA079 (compound 12a)	4gj7	91.48
10	l1b	Ketopiperazine-Based Renin Inhibitors: Optimization of the ""C"" Ring	2g21	91.44
11	74v	Structure-based design of a new series of N-piperidin-3-ylpyrimidine-5-carboxamides as renin inhibitors	5sy2	91.42
12	6vs	Discovery of TAK-272: A Novel, Potent and Orally Active Renin In-hibitor	5kos	90.72
13	2ig	Ketopiperazine-Based Renin Inhibitors: Optimization of the ""C"" Ring	2g1o	90.56
14	6vr	Discovery of TAK-272: A Novel, Potent and Orally Active Renin In-hibitor	5koq	90.29
15	5ig	Ketopiperazine-Based Renin Inhibitors: Optimization of the ""C"" Ring	2g1y	90.29
16	ssr	Crystal Structure Analysis of Renin-indole-piperazin inhibitor complexes	3oot	90.11
17	rx6	Clinically Useful Alkyl Amine Renin Inhibitors	3q5h	89.96
18	6ig	Ketopiperazine-Based Renin Inhibitors: Optimization of the ""C"" Ring	2g22	89.86
19	c40	Crystal Structure of Renin with Inhibitor 7	2v13	89.76
20	3zj	RENIN IN COMPLEXED WITH N-({(3S,4S)-4-[(benzylsulfonyl)amino]pyrrolidin-3-yl}methyl)-4-methoxy-3-(3-methoxypropoxy)-N-(propan-2-yl)benzamide INHIBITOR	4ryg	89.76
21	s52	Crystal Structure Analysis of Renin-indole-piperazin inhibitor complexes	3oqk	89.67
22	3ig	Ketopiperazine-Based Renin Inhibitors: Optimization of the C Ring	2g1r	89.41
23	1ig	Ketopiperazine-based renin inhibitors: Optimization of the ""C"" ring	2g1n	89.33
24	3zk	RENIN IN COMPLEXED WITH 4-methoxy-3-(3-methoxypropoxy)-N-{[(3S,4S)-4-{[(4-methylphenyl)sulfonyl]amino}pyrrolidin-3-yl]methyl}-N-(propan-2-yl)benzamide INHIBITOR	4ryc	89.18
25	rx5	Clinically Useful Alkyl Amine Renin Inhibitors	3q4b	89.13
26	74y	Structure-based design of a new series of N-piperidin-3-ylpyrimidine-5-carboxamides as renin inhibitors	5sz9	89.13
27	72x	Crystal structure of human renin complexed with a novel inhibitor	3gw5	89.09
28	c41	Crystal Structure of Renin with Inhibitor 10 (Aliskiren)	2v0z	88.9
29	s51	Crystal Structure Analysis of Renin-indole-piperazine inhibitor complexes	3oqf	88.84
30	03d	HIGH RESOLUTION CRYSTAL STRUCTURES OF RECOMBINANT HUMAN RENIN IN COMPLEX WITH POLYHYDROXYMONOAMIDE INHIBITORS	1hrn	88.83
31	70x	Renin in complex with (S)-1-(3-(benzylcarbamoyl)benzyl)-4-isopropyl-4-methyl-6-oxotetrahydropyrimidin-2(1H)-iminium	4xx3	88.62
32	rx0	Alkyl Amine Renin Inhibitors: Filling S1 from S3	3q3t	88.52
33	4lg	Ketopiperazine-Based Renin Inhibitors: Optimization of the ""C"" Ring	2g27	88.33
34	rpf	crystal structure of renin-pf00257567 complex	2bkt	88.12
35	bfx	New Classes of Potent and Bioavailable Human Renin Inhibitors	3k1w	88.06
36	43t	Renin in complex with (S)-1-(3-fluoro-5-(((S)-1-phenylethyl)carbamoyl)benzyl)-4-isopropyl-4-methyl-6-oxotetrahydropyrimidin-2(1H)-iminium	4s1g	88.02
37	7ej	Optimization of 3,5-Disubstitued Piperidine: Discovery of Non-Peptide mimetics as an Orally Active Renin Inhibitor	5tmk	87.96
38	3zn	RENIN IN COMPLEXED WITH (3S,4S)-4-({[4-methoxy-3-(3-methoxypropoxy)benzoyl](propan-2-yl)amino}methyl)pyrrolidin-3-yl benzylcarbamate INHIBITOR	4rz1	87.71
39	c47	Crystal Structure of Renin with Inhibitor 3	2v16	86.81
40	70y	Renin in complex with (4S)-4-isopropyl-4-methyl-6-oxo-1-(3-(2-oxo-4-phenylpyrrolidin-1-yl)benzyl)tetrahydropyrimidin-2(1H)-iminium	4xx4	86.75
41	2y9	Structure-based design of 4-hydroxy-3,5-substituted piperidines as direct renin inhibitors	4q1n	86.73
42	9g7	Crystal Structure of Human Renin in Complex with a biphenylpipderidinylcarbinol	5vpm	86.38
43	0n0	Crystal structure of renin in complex with NVP-BGQ311 (compound 12)	4gjd	86.26
44	vyf	Human renin in complex with inhibitor 9	3vyf	85.89
45	liy	Crystal Structure of Human Renin Complexed with Inhibitors	2iku	85.83
46	r32	Human renin in complex with compound 18	3vsx	85.46
47	0m3	Crystal structure of renin in complex with NVP-AYL747 (compound 5)	4gja	85.24
48	0iu	CRYSTALLOGRAPHIC STUDIES ON THE BINDING MODES OF P2-P3 BUTANEDIAMIDE RENIN INHIBITORS	1bil	85.2
49	0mj	Crystal structure of renin in complex with NVP-BCH965 (compound 9)	4gjc	85.02
50	0me	Crystal structure of renin in complex with NVP-BBV031 (compound 6)	4gjb	84.54
51	0qb	CRYSTALLOGRAPHIC STUDIES ON THE BINDING MODES OF P2-P3 BUTANEDIAMIDE RENIN INHIBITORS	1bim	83.54
52	4ig	Ketopiperazine-Based Renin Inhibitors: Optimization of the C Ring	2g1s	83.43
53	ua4	Human renin/PF02342674 complex	2i4q	83.09
54	hhe	Human renin in complex with compound 5	3vuc	83.07
55	vyd	Human renin in complex with inhibitor 6	3vyd	82.27
56	2xf	Crystal structure of renin in complex with compound4	4pyv	82.02
57	vye	Human renin in complex with inhibitor 7	3vye	81.85
58	90d	Crystal Structure of Human Renin in Complex with a biphenylpipderidinylcarbinol	5v8v	80
59	7ig	Ketopiperazine-Based Renin Inhibitors: Optimization of the ""C"" Ring	2g24	78
60	7ig	Crystal Structure of Human Renin Complexed with Inhibitor	2iko	77.77