ProxyBind

A Compendium of Binding Sites for Proximity-Induced Pharmacology

 
Search
 
Search Results: 1007 records

Protein family Gene name [PDB chain] Uniprot ID [PDB chain] Domain Interpro domain ID Interpro domain name PDB ID Pocket residues Ligandability confidence (1 = best) PDB [ligand] PDB [peptide] Ligand/fragment/peptide in homologous protein/domain (PDB[ligand]) Pocket details Pocket group colour Reactive cysteine residues Distance to catalytic residues Pocket volume Pocket area Pocket hydrophobicity Pocket buriedness Pocket DLID
Acetyltransferases CREBBP[a] Q92793[a] Bromo domain IPR018359[a] Bromodomain, conserved site[a] 5TB6 a/1109,1110,1111,1112,1113,1114,
1115,1116,1119,1120,1122,1125,
1133,1134,1160,1163,1164,1167,
1168,1174
1

2D82[ttr],2L84[j28],2L85[l85],

5BT3[2lo],5LPK[xdm],5LPM[71y],
red 0 371.6 343.7 0.6616 0.835 0.4611
Acetyltransferases EP300[b] Q09472[b] Bromo domain IPR018359[b] Bromodomain, conserved site[b] 6GYT b/1073,1074,1075,1076,1077,1078,
1079,1080,1083,1084,1086,1089,
1096,1097,1098,1124,1127,1128,
1131,1132,1138
1

5BT3[2lo],5LPK[xdm],5LPM[71y],

2D82[ttr],2L84[j28],2L85[l85],
red 0 402.9 363.8 0.6468 0.8338 0.4826
Acetyltransferases KAT2B[a] Q92831[a] Bromo domain IPR018359[a] Bromodomain, conserved site[a] 6J3O a/746,747,748,749,750,751,752,
753,756,757,760,767,768,769,795,
798,799,802,803,809
1

1WUG[np1],1WUM[np2],1ZS5[mib],

2D82[ttr],2L84[j28],2L85[l85],
red a/C799(reactive:0.635) 0 376.9 330.8 0.6237 0.86 0.4837
Acetyltransferases KAT2A[a] Q92830[a] Bromo domain IPR018359[a] Bromodomain, conserved site[a] 6J3P a/751,752,753,754,755,756,757,
758,761,762,765,773,774,800,803,
804,807,808,814
1

5MLJ[9st],6J3P[b8o]

2D82[ttr],2L84[j28],2L85[l85],
red a/C804(0.33) 0 359.3 311 0.6534 0.8809 0.5981
Acetyltransferases TAF1L Q8IZX4 Bromo domain IPR001487,
IPR018359
3

2D82[ttr],2L84[j28],2L85[l85],
0 0 0 0 0 0
Acetyltransferases TAF1 P21675 Bromo domain IPR001487,
IPR018359
3

2D82[ttr],2L84[j28],2L85[l85],
0 0 0 0 0 0
Acetyltransferases BRD4 O60885 Bromo domain IPR001487,
IPR018359
3

2D82[ttr],2L84[j28],2L85[l85],
0 0 0 0 0 0
Methyltransferases KMT2A Q03164 Bromo domain IPR001487 3

2D82[ttr],2L84[j28],2L85[l85],
0 0 0 0 0 0
Methyltransferases ASH1L Q9NR48 Bromo domain IPR001487 3

2D82[ttr],2L84[j28],2L85[l85],
0 0 0 0 0 0
Acetyltransferases CREBBP[a] Q92793[a] Bromo domain IPR018359[a] Bromodomain, conserved site[a] 5I8B a/1082,1083,1084,1085,1086,1087,
1145,1147,1148,1149,1150,1151,
1198,1286,1287,1288,1289
4 blue 0 182.3 208.9 0.5435 0.7772 -0.5611
Deubiquitinases USP7[a] Q93009[a] C-terminal domain IPR029346[a] Ubiquitin carboxyl-terminal hydrolase, C-terminal[a] 2YLM a/898,899,900,901,902,903,904,
931,932,933,934,935,940,942,971,
973,974,975,976,977,978,979,
1006,1007,1008,1009,1010,1023,
1026,1027,1029
4 blue 0 541 492.2 0.602 0.7972 0.4538
Deubiquitinases USP7[a] Q93009[a] C-terminal domain 2YLM a/801,840,841,842,843,844,845,
849,850,851,852,857,863,864,866,
867,868,869,872
4 blue 0 343.8 439.2 0.5227 0.7058 -0.4207
Deubiquitinases USP7[a] Q93009[a] C-terminal domain 2YLM a/841,842,843,844,845,846,847,
848,849,868,872,873,875,876,877
4 blue 0 245.9 215.5 0.5971 0.8705 0.1496
Deubiquitinases USP7[a] Q93009[a] C-terminal domain 4WPI a/819,820,823,834,835,837,838,
854,855,881
4 blue 0 198.7 206.6 0.5556 0.7534 -0.5635
Deubiquitinases DNMT1[a],USP7[c] P26358[a],
Q93009[c]
C-terminal domain IPR029346[c] Ubiquitin carboxyl-terminal hydrolase, C-terminal[c] 4YOC a/1445,1449; c/946,947,948,949,
950,951,952,988,989,990,991,999,
1000,1001,1002,1008,1043,1044,
1045,1046,1063,1070,1071,1072,
1073,1074,1075,1076
4 blue 41.830002 552.1 571.5 0.5109 0.7299 -0.002934
Deubiquitinases USP7[a] Q93009[a] C-terminal domain 4Z96 a/571,572,573,576,615,663,664,
665,666,667,669,674,675,676,677,
701,702,703,704,705,706,723
4 blue a/C576(reactive:0.755),
a/C702(0.405)
0 468.1 452.6 0.5259 0.6979 -0.217
Deubiquitinases USP7[a] Q93009[a] C-terminal domain IPR029346[a] Ubiquitin carboxyl-terminal hydrolase, C-terminal[a] 4Z96 a/892,893,894,895,896,897,907,
962,963,964,965,966,968,969,970
4 blue a/C896(0.23) 0 307.3 260.2 0.5648 0.8021 -0.02873
Deubiquitinases USP7[a] Q93009[a] C-terminal domain IPR029346[a] Ubiquitin carboxyl-terminal hydrolase, C-terminal[a] 4Z96 a/897,905,944,945,946,947,948,
967,969,971,1004,1005,1006
4 blue 0 213 201.5 0.5877 0.7781 -0.3422
Deubiquitinases USP7[a] Q93009[a] C-terminal domain IPR029346[a] Ubiquitin carboxyl-terminal hydrolase, C-terminal[a] 5C56 a/948,949,950,951,952,982,984,
987,988,989,990,991,993,999,
1000,1008,1043,1044,1045,1061,
1070,1071,1072,1073,1074,1075,
1076
4 blue 0 559.4 538.2 0.5147 0.7257 -0.001535
Deubiquitinases USP7[a] Q93009[a] C-terminal domain 5C56 a/573,574,575,576,577,578,579,
580,581,582,583,584,585,586,588,
589,590,625,627,628,631,632,633,
634,740,790,791
4 blue a/C576(reactive:0.62) 0 439.9 486.6 0.5053 0.6938 -0.3258
Deubiquitinases USP7[a] Q93009[a] C-terminal domain IPR029346[a] Ubiquitin carboxyl-terminal hydrolase, C-terminal[a] 5C56 a/919,922,923,926,937,938,939,
940,941,952,953,954,955,975,979,
980,989
4 blue 0 193.9 243.5 0.4603 0.7523 -0.8019
Deubiquitinases USP7[a],USP7[b] Q93009[a],
Q93009[b]
C-terminal domain 5GG4 a/842,843,844,845,846,847,848,
849,867,868,869,871,872,873,875,
876,877; b/862
4 blue 0 232.5 236.4 0.4722 0.6937 -0.8721
Deubiquitinases USP7[a] Q93009[a] C-terminal domain 5J7T a/602,603,606,617,618,619,620,
621,622,624,638,639,640,675,676,
677,678,679,680
4 blue 40.700001 416.8 391.6 0.5029 0.7777 -0.04042
Deubiquitinases USP25[a] Q9UHP3[a] C-terminal domain 6H4K a/880,898,901,902,905,906,965,
968,1019,1020,1021,1022,1023,
1024,1025,1026
4 blue a/C902(reactive:0.815) 0 246 225.4 0.5556 0.7053 -0.5952
Deubiquitinases USP7 Q93009 C-terminal domain IPR029346 4 0 0 0 0 0 0
Deubiquitinases USP15 Q9Y4E8 C-terminal domain IPR029346 4 0 0 0 0 0 0
Deubiquitinases USP11 P51784 C-terminal domain IPR029346 4 0 0 0 0 0 0
Protein Kinases PRKCD[a] Q05655[a] C1 domain IPR002219[a] Protein kinase C-like, phorbol ester[a] 2YUU a/165,166,167,168,177,178,179,
180,181,182,183,184,185,186,197,
198,199
1

1PTR[prb]
blue 0 399.9 342.1 0.5895 0.8142 0.2694
Protein Kinases ROCK2 O75116 C1 domain IPR002219 3

1PTR[prb]
0 0 0 0 0 0
Protein Kinases ROCK1 Q13464 C1 domain IPR002219 3

1PTR[prb]
0 0 0 0 0 0
Protein Kinases PRKD3 O94806 C1 domain IPR002219 3

1PTR[prb]
0 0 0 0 0 0
Protein Kinases PRKD2 Q9BZL6 C1 domain IPR002219 3

1PTR[prb]
0 0 0 0 0 0
Protein Kinases PRKD1 Q15139 C1 domain IPR002219 3

1PTR[prb]
0 0 0 0 0 0
Protein Kinases PRKCZ Q05513 C1 domain IPR002219 3

1PTR[prb]
0 0 0 0 0 0
Protein Kinases PRKCQ Q04759 C1 domain IPR002219 3

1PTR[prb]
0 0 0 0 0 0
Protein Kinases PRKCI P41743 C1 domain IPR002219 3

1PTR[prb]
0 0 0 0 0 0
Protein Kinases PRKCH P24723 C1 domain IPR002219 3

1PTR[prb]
0 0 0 0 0 0
Protein Kinases PRKCG P05129 C1 domain IPR002219 3

1PTR[prb]
0 0 0 0 0 0
Protein Kinases PRKCE Q02156 C1 domain IPR002219 3

1PTR[prb]
0 0 0 0 0 0
Protein Kinases PRKCB P05771 C1 domain IPR002219 3

1PTR[prb]
0 0 0 0 0 0
Protein Kinases PRKCA P17252 C1 domain IPR002219 3

1PTR[prb]
0 0 0 0 0 0
Protein Kinases KSR2 Q6VAB6 C1 domain IPR002219 3

1PTR[prb]
0 0 0 0 0 0
Protein Kinases KSR1 Q8IVT5 C1 domain IPR002219 3

1PTR[prb]
0 0 0 0 0 0
Protein Kinases CIT O14578 C1 domain IPR002219 3

1PTR[prb]
0 0 0 0 0 0
Protein Kinases CDC42BPG Q6DT37 C1 domain IPR002219 3

1PTR[prb]
0 0 0 0 0 0
Protein Kinases CDC42BPB Q9Y5S2 C1 domain IPR002219 3

1PTR[prb]
0 0 0 0 0 0
Protein Kinases CDC42BPA Q5VT25 C1 domain IPR002219 3

1PTR[prb]
0 0 0 0 0 0
Protein Kinases BRAF P15056 C1 domain IPR002219 3

1PTR[prb]
0 0 0 0 0 0
Protein Kinases ARAF P10398 C1 domain IPR002219 3

1PTR[prb]
0 0 0 0 0 0
Protein Phosphatases TNS2 Q63HR2 C1 domain IPR002219 3

1PTR[prb]
0 0 0 0 0 0
Protein Kinases KRAS[b],RAF1[d] P01116[b],
P04049[d]
C1 domain IPR002219[d] Protein kinase C-like, phorbol ester[d] 6PTW b/1,2,47,48,49,50; d/148,149,
150,151,152,153,158,171
4 blue 0 201.6 250.5 0.514 0.707 -0.8302
Protein Kinases PRKCA[a] P17252[a] C2 domain IPR000008[a] C2 domain[a] 4DNL a/186,187,188,193,247,248,249,
250,251,254
2

1DSY[psf]
blue 0 139.2 153.2 0.443 0.711 -1.249
Protein Kinases PRKCG P05129 C2 domain IPR000008 3

1DSY[psf]
0 0 0 0 0 0
Protein Kinases PRKCE Q02156 C2 domain IPR000008 3

1DSY[psf]
0 0 0 0 0 0
Protein Kinases PRKCB P05771 C2 domain IPR000008 3

1DSY[psf]
0 0 0 0 0 0
Protein Kinases PKN2 Q16513 C2 domain IPR000008 3

1DSY[psf]
0 0 0 0 0 0
Protein Kinases PRKCH[a] P24723[a] C2 domain IPR000008[a] C2 domain[a] 2FK9 a/25,27,28,31,32,90,91,92,93,94,
95,96,97
4 blue 0 189.8 238.1 0.5301 0.6704 -0.9821
Protein Kinases PRKCH[a] P24723[a] C2 domain IPR000008[a] C2 domain[a] 2FK9 a/32,33,36,38,42,59,61,62,88,89,
90,91
4 blue 0 160.8 179.3 0.5016 0.7231 -0.9614
Protein Kinases PRKCA[a] P17252[a] C2 domain IPR000008[a] C2 domain[a] 4DNL a/200,202,203,204,205,207,208,
209,210,228,229,230,231,232,235,
238
4 blue 0 213.8 224 0.5363 0.77 -0.4879
Protein Kinases ABL1[a] P00519[a] Catalytic domain IPR020635[a] Tyrosine-protein kinase, catalytic domain[a] 6NPU a/332,337,340,341,344,429,430,
432,433,434,435,440,441,443,456,
458,459,460,461,462,463,464,465,
468,493
1

3PYY[3yy],6NPE[kwd],6NPU[kwv],

6Q4D[hht5],6Q4K[hhw],6NBS[kj4]
Pocket PK3 green a/C464(0.195) 15.36 340.9 382.4 0.5619 0.7165 -0.2962
Protein Kinases MAPK14[a] Q16539[a] Catalytic domain IPR000719[a] Protein kinase domain[a] 3UVP a/191,192,195,197,198,199,200,
201,229,232,236,242,246,249,250,
251,255,258,259,262,291,292,293,
294,296
1

1IAN[d132],2YIS[i46],2YIW[i46]

6QA1[hvk7]
Pocket PK4 orange 16.76 456.4 464.8 0.5789 0.6851 -0.1659
Protein Phosphatases PPP2R1A[a],PPP2R5A[b],PPP2CA[c] P30153[a],
Q15172[b],
P67775[c]
Catalytic domain 6NTS a/61,63,99,100,101,102,103,140,
141; b/234,236,237,238,239,240,
241,273,274,275,277,278,281,282,
283,316,317; c/307,308
1

6NTS[l2j]
Pocket PPI1 blue 19.82 433.8 421.9 0.623 0.8492 0.5436
Protein Kinases CDK2[a],CDKN1B[c] P24941[a],
P46527[c]
Catalytic domain IPR000719[a] Protein kinase domain[a] 1JSU a/17,18,19,32,33,34,35,36,
77; c/67,78,81,88,89,90,91,92
2

6Q4D[hht2],6Q4D[hht3],6Q4D[hht

6C9F[r34]
Pocket PK2 black 12.77 279.7 259.8 0.5064 0.7676 -0.3668
Protein Kinases PRKAA1[a],PRKAB1[b] Q13131[a],
Q9Y478[b]
Catalytic domain 6C9F a/22,29,30,31,32,39,40,42,57,59,
99,101; b/81,83,106,107,108,109,
111,112,113
2

6C9F[r34]

6Q4D[hht2],6Q4D[hht3],6Q4D[hht
Pocket PKI1,Pocket PK2 black 16.879999 378.9 348.3 0.6457 0.7803 0.2234
Protein Kinases CDK2[c] P24941[c] Catalytic domain IPR000719[c] Protein kinase domain[c] 4CFX c/97,98,99,100,101,102,104,105,
193,196,197,198,199,253,254,255,
256,285
2

6Q4D[hht5],6Q4K[hhw]

3PYY[3yy],6NPE[kwd],6NPU[kwv],
Pocket PK3 green 19.85 218 252.3 0.5139 0.6895 -0.8413
Protein Kinases MAPK1[a] P28482[a] Catalytic domain IPR000719[a] Protein kinase domain[a] 4FV6 a/120,121,122,123,126,221,222,
223,225,226,227,229,243,278,279,
280,281,282,283
2

6NBS[kj4],6QA1[hvk],6QAH[hvb2]

3PYY[3yy],6NPE[kwd],6NPU[kwv],
Pocket PK3 green 17.049999 263.5 296.7 0.5271 0.7075 -0.6007
Protein Kinases MAPK1[a] P28482[a] Catalytic domain 6DMG a/138,141,142,174,176,179,180,
197,200,201,202,206,207,208,211,
251,254,255,296,297,298,299,301,
303,304,305,324
2

6QA1[hvk7]

1IAN[d132],2YIS[i46],2YIW[i46]
Pocket PK4 orange a/C254(reactive:0.87) 12.05 372.3 438.9 0.6253 0.7903 0.2037
Protein Phosphatases PTPN1[a] P18031[a] Catalytic domain IPR000242[a] PTP type protein phosphatase[a] 2F70 a/43,60,61,62,63,94,97,100,101,
137,138,139,140,162,164
2

5QDG[aws],5QDJ[jfp3],5QFN[jov2
Pocket PP4 purple 19.440001 175.9 198.3 0.4959 0.7486 -0.8078
Protein Phosphatases PTPN1[a] P18031[a] Catalytic domain IPR000242[a] PTP type protein phosphatase[a] 1L8G a/73,74,75,78,79,80,203,204,205,
206,208,209,210,211,233,237
2

5QE4[jh4],5QE7[jhd],5QED[7mu3]

6H8R[fwb],5QG5[0r0],5QFO[8h8],
Pocket PP3 red 10.84 250.1 259.6 0.533 0.793 -0.289
Protein Phosphatases PTPN5[a] P54829[a] Catalytic domain IPR000242[a] PTP type protein phosphatase[a] 2BV5 a/365,366,367,368,369,390,391,
478,479,482,483,486,487,488,489,
490,491,492,510,514
2

6H8R[fwb]

5QE4[jh4],5QE7[jhd],5QED[7mu3]
Pocket PP3 red a/C489(reactive:0.82) 13.59 255.5 309.5 0.463 0.6675 -0.9264
Protein Phosphatases PTPN1[a] P18031[a] Catalytic domain IPR000242[a] PTP type protein phosphatase[a] 2CM8 a/74,76,77,234,235,237,238,240,
243,244,245,248,249,252
2

5QG5[0r0],5QFO[8h8],5QFJ[joj],

5QE4[jh4],5QE7[jhd],5QED[7mu3]
Pocket PP3 red 13.33 175.8 208.1 0.5774 0.7609 -0.5749
Protein Kinases MAP2K1[a],MAP2K1[a1] Q02750[a],
Q02750[a1]
Catalytic domain 3EQG a/65,66,68,69,70,83,85,88,96,
98; a1/65,66,68,69,70,83,85,88,
96,98
3

6Q4D[hht2],6Q4D[hht3],6Q4D[hht
Pocket PK2 black 19.139999 335 346.4 0.5582 0.7379 -0.2327
Protein Kinases MAP2K1[a],MAP2K1[a1] Q02750[a],
Q02750[a1]
Catalytic domain 3OS3 a/235,236,311,314,315,
318; a1/65,68,69,70,83,85,96,98,
100,135,136,138
3

6Q4D[hht2],6Q4D[hht3],6Q4D[hht
Pocket PK2 black 14.67 220.9 263.3 0.5321 0.7511 -0.548
Protein Kinases PRKCQ[a],PRKCQ[b] Q04759[a],
Q04759[b]
Catalytic domain IPR000719[a] Protein kinase domain[a] 4RA5 a/388,389,390,391,392,393,410,
411,412,415,668,675,676; b/515,
517,645,648,649,652
3

6Q4D[hht2],6Q4D[hht3],6Q4D[hht
Pocket PK2 black 10.58 253.9 286 0.5778 0.8396 0.007235
Protein Kinases MAP4K4[a],MAP4K4[b] O95819[a],
O95819[b]
Catalytic domain IPR000719[a],
IPR000719[b]
Protein kinase domain[a],Protein kinase domain[b] 4U43 a/57,91,92,93,94,97,98,
100; b/30,31,32,33,34,35,38,39,
40
3

6Q4D[hht2],6Q4D[hht3],6Q4D[hht
Pocket PK2 black 10.8 213.6 218.5 0.5236 0.8416 -0.2352
Protein Kinases MAPK1[a] P28482[a] Catalytic domain IPR003527[a] Mitogen-activated protein (MAP) kinase, conserved site[a] 6GDQ a/18,20,21,22,23,24,25,88,89,90,
91,92,93,97,98,99,100,102,354,
355,356
3

6Q4D[hht2],6Q4D[hht3],6Q4D[hht
Pocket PK2 black 23.01 258.7 282.7 0.5129 0.7594 -0.4417
Protein Kinases ACVR1[a] Q04771[a] Catalytic domain 6SRH a/205,206,207,208,227,232,266,
267,269,271,278,280,282
3

6Q4D[hht2],6Q4D[hht3],6Q4D[hht
Pocket PK2 black 22.120001 219.1 222.2 0.6509 0.7681 -0.2172
Protein Kinases FGFR2[a],FGFR2[b] P21802[a],
P21802[b]
Catalytic domain IPR020635[a],
IPR020635[b]
Tyrosine-protein kinase, catalytic domain[a],Tyrosine-protein kinase, catalytic domain[b] 2PSQ a/494,518,519,520,521,559,
561; b/668,705,706,707,708,709,
710
3

6Q4D[hht2],6Q4D[hht3],6Q4D[hht
Pocket PK2 black 9.819 163.9 165.1 0.4886 0.7419 -0.9032
Protein Kinases JAK3[a] P52333[a] Catalytic domain IPR001245[a] Serine-threonine[a] 4RIO a/890,891,892,893,894,895,896,
897,898,899
3

6Q4D[hht2],6Q4D[hht3],6Q4D[hht
Pocket PK2 black 20.57 174.6 181.8 0.519 0.754 -0.7396
Protein Kinases GSK3B[a],GSK3B[a1] P49841[a],
P49841[a1]
Catalytic domain IPR000719[a],
IPR000719[a1]
Protein kinase domain[a],Protein kinase domain[a1] 1O9U a/252,254,255,256,257,258,268,
272,299,304,306; a1/143,144,146,
147,148,150,151,152,153,250,252,
253
3

3PYY[3yy],6NPE[kwd],6NPU[kwv],
Pocket PK3 green 16.59 292 323 0.5528 0.8382 0.0485
Protein Kinases GSK3B[a],GSK3B[a1] P49841[a],
P49841[a1]
Catalytic domain IPR008271[a],
IPR008271[a1]
Serine[a],Serine[a1] 1UV5 a/140,184,185,219,220,221,222,
249,255,259,260; a1/140,184,185,
219,220,221,222,249,255,259,260
3

3PYY[3yy],6NPE[kwd],6NPU[kwv],
Pocket PK3 green 7.383 225.8 279.5 0.4889 0.7333 -0.6997
Protein Kinases DAPK1[a] P53355[a] Catalytic domain IPR000719[a] Protein kinase domain[a] 1WVW a/208,214,215,216,217,218,219,
228,233,234,235,237,240,241
3

3PYY[3yy],6NPE[kwd],6NPU[kwv],
Pocket PK3 green 10.95 164.8 181.1 0.5166 0.7674 -0.7351
Protein Kinases MAPK1[a] P28482[a] Catalytic domain IPR000719[a] Protein kinase domain[a] 1WZY a/227,228,229,230,231,236,239,
240,243,275,294
3

3PYY[3yy],6NPE[kwd],6NPU[kwv],
Pocket PK3 green 13.82 186.1 182.7 0.7129 0.7806 -0.1473
Protein Kinases DAPK2[a],DAPK2[b] Q9UIK4[a],
Q9UIK4[b]
Catalytic domain 2A2A a/59,60,61; b/218,219,223,224,
225,226,227,228,238,243,244,245,
247,250,306,309,310,312,313
3

3PYY[3yy],6NPE[kwd],6NPU[kwv],
Pocket PK3 green 8.296 302.6 324.9 0.5765 0.7895 -0.06327
Protein Kinases GRK6[a] P43250[a] Catalytic domain IPR000719[a] Protein kinase domain[a] 2ACX a/376,380,382,383,384,385,386,
387,392,400,404,405,406,407,408,
409,412
3

3PYY[3yy],6NPE[kwd],6NPU[kwv],
Pocket PK3 green 15.78 214.5 237.2 0.5269 0.6519 -0.9721
Protein Kinases MAPK14[b] Q16539[b] Catalytic domain IPR000719[b] Protein kinase domain[b] 2ONL b/117,118,119,120,121,122,123,
124,127,215,216,217,218,219,274,
275,276,277,278
3

3PYY[3yy],6NPE[kwd],6NPU[kwv],
Pocket PK3 green b/C119(reactive:0.68) 18.809999 320.9 347 0.5423 0.728 -0.3396
Protein Kinases MAPK14[a] Q16539[a] Catalytic domain IPR000719[a] Protein kinase domain[a] 2ONL a/214,218,220,221,222,223,224,
234,235,237,238,268,273,274
3

3PYY[3yy],6NPE[kwd],6NPU[kwv],
Pocket PK3 green 21.27 222.9 217.9 0.5961 0.7117 -0.551
Protein Kinases GSK3B[a] P49841[a] Catalytic domain IPR008271[a] Serine[a] 2OW3 a/140,143,144,146,147,150,151,
152,153,184,249,250,251,252,253,
254,255
3

3PYY[3yy],6NPE[kwd],6NPU[kwv],
Pocket PK3 green 11.74 279.5 306.3 0.6948 0.8062 0.2123
Protein Kinases SGK1[a],SGK1[a2] O00141[a],
O00141[a2]
Catalytic domain IPR000719[a],
IPR000719[a2]
Protein kinase domain[a],Protein kinase domain[a2] 2R5T a/288,292,294,295,296,297,298,
299,300,301,304,312,313,314,315,
317,318,319; a2/288,292,294,295,
296,297,298,299,300,301,304,312,
313,314,315,317,318,319
3

3PYY[3yy],6NPE[kwd],6NPU[kwv],
Pocket PK3 green 12.1 478.8 537.7 0.5177 0.8086 0.2174
Protein Kinases VRK1[a] Q99986[a] Catalytic domain IPR008271[a] Serine[a] 2RSV a/139,140,142,143,147,179,180,
227,253,254,258,262,263,264,265
3

3PYY[3yy],6NPE[kwd],6NPU[kwv],
Pocket PK3 green 8.054 257.3 235.4 0.5892 0.8203 -0.03267
Protein Kinases ROCK1[a] Q13464[a] Catalytic domain IPR000719[a] Protein kinase domain[a] 2V55 a/165,168,169,170,171,172,270,
271,272,273,274,302,304,305,306
3

3PYY[3yy],6NPE[kwd],6NPU[kwv],
Pocket PK3 green 11.74 192.8 210.4 0.5515 0.7873 -0.4615
Protein Kinases CAMK2G[a] Q13555[a] Catalytic domain 2V7O a/140,177,179,180,206,210,211,
212,215,290,293,294,297,298,301
3

3PYY[3yy],6NPE[kwd],6NPU[kwv],
Pocket PK3 green a/C290(reactive:0.805) 7.047 297.3 280.4 0.6386 0.7068 -0.2611
Protein Kinases OXSR1[d] O95747[d] Catalytic domain IPR000719[d] Protein kinase domain[d] 2VWI d/108,113,114,116,222,223,224,
225,226,228,229,249,250,251,252,
253,256,257
3

3PYY[3yy],6NPE[kwd],6NPU[kwv],
Pocket PK3 green 10.65 259.2 244.5 0.6581 0.8349 0.1866
Protein Kinases CAMK4[a] Q16566[a] Catalytic domain 2W4O a/232,238,239,240,241,242,243,
244,253,259,260,262,265,316,323
3

3PYY[3yy],6NPE[kwd],6NPU[kwv],
Pocket PK3 green 18.290001 213.9 235.6 0.5774 0.7408 -0.5093
Protein Kinases CDK4[b] P11802[b] Catalytic domain IPR000719[b] Protein kinase domain[b] 2W9Z b/103,104,106,107,108,109,110,
111,112,113,116,117,120,207,208,
209,210
3

3PYY[3yy],6NPE[kwd],6NPU[kwv],
Pocket PK3 green 16.9 299.8 287.8 0.6602 0.8096 0.1988
Protein Kinases CAMK2D[a] Q13557[a] Catalytic domain IPR008271[a] Serine[a] 2WEL a/99,102,103,106,139,177,178,
179,180,202,206,209,210,211,212,
215
3

3PYY[3yy],6NPE[kwd],6NPU[kwv],
Pocket PK3 green 7.481 232.5 257.4 0.6115 0.6993 -0.5336
Protein Kinases CHEK2[a] O96017[a] Catalytic domain IPR000719[a] Protein kinase domain[a] 2WTI a/316,318,422,423,424,425,427,
428,430,431,432,434,439,444,445,
446,448,451
3

3PYY[3yy],6NPE[kwd],6NPU[kwv],
Pocket PK3 green 12.94 303.8 333.9 0.5235 0.7517 -0.3294
Protein Kinases SRPK2[a] P78362[a] Catalytic domain IPR000719[a] Protein kinase domain[a] 2X7G a/174,177,182,575,576,580,581,
582,583,584,585,587,601,604,605,
637,639,644,648,649
3

3PYY[3yy],6NPE[kwd],6NPU[kwv],
Pocket PK3 green 11.77 348.6 357.4 0.6002 0.7784 0.05118
Protein Kinases NEK2[a] P51955[a] Catalytic domain IPR000719[a] Protein kinase domain[a] 2XK7 a/101,102,105,106,107,207,211,
212,213,234,235,236,237,238
3

3PYY[3yy],6NPE[kwd],6NPU[kwv],
Pocket PK3 green 14.43 214.6 263.9 0.4902 0.7408 -0.7048
Protein Kinases DAPK1[a] P53355[a] Catalytic domain IPR000719[a] Protein kinase domain[a] 2YAK a/102,105,106,109,110,111,112,
113,116,209,210,211,212,213,239,
240,241,242,243,244
3

3PYY[3yy],6NPE[kwd],6NPU[kwv],
Pocket PK3 green 8.742 350.2 340.4 0.5483 0.7629 -0.1244
Protein Kinases RPS6KB1[b] P23443[b] Catalytic domain IPR000719[b] Protein kinase domain[b] 3A60 b/185,188,190,191,192,285,286,
287,288,289,315,316,317
3

3PYY[3yy],6NPE[kwd],6NPU[kwv],
Pocket PK3 green 11.89 188.9 196.7 0.5251 0.7308 -0.7592
Protein Kinases TTK[a] P33981[a] Catalytic domain IPR000719[a] Protein kinase domain[a] 3GFW a/613,614,616,617,618,619,621,
624,726,727,728,729,730,759,760,
761,764
3

3PYY[3yy],6NPE[kwd],6NPU[kwv],
Pocket PK3 green 15.62 291.9 285.8 0.586 0.809 0.008542
Protein Kinases GRK6[a] P43250[a] Catalytic domain IPR000719[a] Protein kinase domain[a] 3NYO a/274,278,280,281,282,283,284,
285,287,379,411
3

3PYY[3yy],6NPE[kwd],6NPU[kwv],
Pocket PK3 green 19.219999 182.9 212.6 0.4842 0.7158 -0.935
Protein Kinases RAF1[a] P04049[a] Catalytic domain IPR001245[a] Serine-threonine[a] 3OMV a/433,437,438,439,440,441,442,
445,541,544,574,576
3

3PYY[3yy],6NPE[kwd],6NPU[kwv],
Pocket PK3 green 18.5 181.4 181.1 0.6015 0.8424 -0.1758
Protein Kinases GRK2[a] P25098[a] Catalytic domain IPR000719[a] Protein kinase domain[a] 3V5W a/382,386,388,390,391,393,405,
409,410,411,412,413,414
3

3PYY[3yy],6NPE[kwd],6NPU[kwv],
Pocket PK3 green 16.68 214.2 199.7 0.5503 0.7542 -0.5168
Protein Kinases MAPK8[a] P45983[a] Catalytic domain IPR000719[a] Protein kinase domain[a] 3VUG a/118,119,120,121,122,123,128,
218,219,220,221,278,279,280,281
3

3PYY[3yy],6NPE[kwd],6NPU[kwv],
Pocket PK3 green 17.43 231.7 217.2 0.6176 0.8311 -0.003184
Protein Kinases CSNK2A1[a] P68400[a] Catalytic domain IPR000719[a] Protein kinase domain[a] 3WIL a/227,229,232,233,234,244,247,
248,279,283,284,286
3

3PYY[3yy],6NPE[kwd],6NPU[kwv],
Pocket PK3 green 17.1 157 186.1 0.5828 0.7035 -0.872
Protein Kinases ACVR2A[a] P27037[a] Catalytic domain IPR000719[a] Protein kinase domain[a] 4ASX a/395,399,400,408,409,410,411,
412,413,414,415,416,417,418,439,
440,442,445
3

3PYY[3yy],6NPE[kwd],6NPU[kwv],
Pocket PK3 green 15.65 171.3 188.4 0.608 0.7544 -0.5498
Protein Kinases PAK4[a] O96013[a] Catalytic domain IPR000719[a] Protein kinase domain[a] 4FIH a/506,510,512,513,514,515,516,
517,530,531,532,533,534,535,536
3

3PYY[3yy],6NPE[kwd],6NPU[kwv],
Pocket PK3 green 14.81 236.6 250.8 0.514 0.7523 -0.5334
Protein Kinases EIF2AK3[a] Q9NZJ5[a] Catalytic domain IPR000719[a] Protein kinase domain[a] 4G31 a/897,900,901,904,909,1016,1020,
1021,1022,1023,1024,1027
3

3PYY[3yy],6NPE[kwd],6NPU[kwv],
Pocket PK3 green a/C904(reactive:0.64) 12.68 164 166.4 0.6146 0.8924 -0.02367
Protein Kinases MAP3K14[a] Q99558[a] Catalytic domain IPR000719[a] Protein kinase domain[a] 4G3D a/596,599,600,611,612,613,614,
615,616,617
3

3PYY[3yy],6NPE[kwd],6NPU[kwv],
Pocket PK3 green 16.700001 182.1 164.9 0.7796 0.8656 0.3224
Protein Kinases PRPF4B[b] Q13523[b] Catalytic domain IPR000719[b] Protein kinase domain[b] 4IAN b/775,778,779,782,783,784,785,
786,881,885,886,887
3

3PYY[3yy],6NPE[kwd],6NPU[kwv],
Pocket PK3 green 12.17 160.4 163.6 0.4933 0.7291 -0.9588
Protein Kinases TBK1[a] Q9UHD2[a] Catalytic domain 4IM0 a/101,102,103,104,105,106,107,
108,268,420,423,424,426,427,553,
556
3

3PYY[3yy],6NPE[kwd],6NPU[kwv],
Pocket PK3 green a/C423(reactive:0.735),
a/C426(reactive:0.76)
16.799999 202 207.1 0.6406 0.7983 -0.1815
Protein Kinases TTN[a] Q8WZ42[a] Catalytic domain 4JNW a/214,215,242,243,245,246,247,
289,290,291,292,293,294,295
3

3PYY[3yy],6NPE[kwd],6NPU[kwv],
Pocket PK3 green 0 184.6 176.7 0.5647 0.7314 -0.6836
Protein Kinases RIPK1[a] Q13546[a] Catalytic domain IPR001245[a] Serine-threonine[a] 4NEU a/219,225,227,228,229,230,231,
236,237,240,241,245,246,247,248,
251
3

3PYY[3yy],6NPE[kwd],6NPU[kwv],
Pocket PK3 green a/C240(reactive:0.785) 11.51 183.4 200.3 0.5618 0.7781 -0.5112
Protein Kinases GSK3B[a],GSK3B[a1] P49841[a],
P49841[a1]
Catalytic domain IPR000719[a1] Protein kinase domain[a1] 4NM5 a/144,147,148,150; a1/143,146,
147,150,151,152,153,249,250,251,
252,253,254,255,256,257,258,268,
272,299,304,306
3

3PYY[3yy],6NPE[kwd],6NPU[kwv],
Pocket PK3 green 16.08 276.8 334.3 0.5095 0.7345 -0.498
Protein Kinases GAK[b] O14976[b] Catalytic domain IPR008271[b] Serine[b] 4O38 b/131,134,135,137,138,141,142,
143,176,255,256,259
3

3PYY[3yy],6NPE[kwd],6NPU[kwv],
Pocket PK3 green 7.218 187 206.8 0.6417 0.7848 -0.2892
Protein Kinases PAK1[a] Q13153[a] Catalytic domain IPR000719[a] Protein kinase domain[a] 4P90 a/459,461,462,463,464,465,466,
482,483,485
3

3PYY[3yy],6NPE[kwd],6NPU[kwv],
Pocket PK3 green 10.48 170.3 172.6 0.4919 0.8172 -0.5708
Protein Kinases STK24[a] Q9Y6E0[a] Catalytic domain IPR000719[a] Protein kinase domain[a] 4QMX a/222,226,228,229,230,231,232,
233,246,247,248,249,250,251,252
3

3PYY[3yy],6NPE[kwd],6NPU[kwv],
Pocket PK3 green 10.03 229.2 255.6 0.4812 0.7024 -0.8278
Protein Kinases MAPK3[a] P27361[a] Catalytic domain IPR000719[a] Protein kinase domain[a] 4QTB a/137,138,139,140,143,236,239,
240,242,243,244,260,295,296,297,
298,299,300
3

3PYY[3yy],6NPE[kwd],6NPU[kwv],
Pocket PK3 green 16.83 225.3 261.1 0.5614 0.8246 -0.1771
Protein Kinases MAPKAPK2[a],MAPK14[b] P49137[a],
Q16539[b]
Catalytic domain IPR000719[b] Protein kinase domain[b] 4TYH a/230,231,232,233,235; b/117,
120,121,122,123,124,127,215,216,
217,218,219,274,275,276,277,278
3

3PYY[3yy],6NPE[kwd],6NPU[kwv],
Pocket PK3 green 10.49 261.7 279 0.6308 0.8622 0.239
Protein Kinases CDK12[c] Q9NYV4[c] Catalytic domain IPR000719[c] Protein kinase domain[c] 4UN0 c/824,829,830,831,832,833,836,
929,930,931,932
3

3PYY[3yy],6NPE[kwd],6NPU[kwv],
Pocket PK3 green 18.120001 158.6 172.4 0.6023 0.75 -0.6371
Protein Kinases MAPK10[a] P53779[a] Catalytic domain IPR000719[a] Protein kinase domain[a] 4W4V a/160,161,162,163,166,256,257,
259,316,317,318,319
3

3PYY[3yy],6NPE[kwd],6NPU[kwv],
Pocket PK3 green 20.83 166.7 179.8 0.6046 0.7769 -0.489
Protein Kinases BMP2K[a] Q9NSY1[a] Catalytic domain IPR000719[a] Protein kinase domain[a] 4W9W a/145,146,147,148,149,150,260,
261,262,281,283,284,285,286
3

3PYY[3yy],6NPE[kwd],6NPU[kwv],
Pocket PK3 green a/C260(0.14) 18.610001 198.1 197.7 0.5687 0.7705 -0.4687
Protein Kinases TNNI3K[a] Q59H18[a] Catalytic domain IPR001245[a] Serine-threonine[a] 4YFI a/551,552,555,556,557,558,563,
658,659,660,661,662,663,666
3

3PYY[3yy],6NPE[kwd],6NPU[kwv],
Pocket PK3 green 16.16 210.6 224.2 0.5531 0.7617 -0.4935
Protein Kinases DAPK3[a] O43293[a] Catalytic domain IPR000719[a] Protein kinase domain[a] 5A6O a/102,105,106,108,109,110,111,
112,113,116,209,210,211,212,213,
239,240,242,243,244
3

3PYY[3yy],6NPE[kwd],6NPU[kwv],
Pocket PK3 green 8.614 304.4 332.6 0.5119 0.7156 -0.4967
Protein Kinases PRKACA[a],PKIA[b] P17612[a],
P61925[b]
Catalytic domain IPR000719[a] Protein kinase domain[a] 5BX7 a/230,236,237,238,239,240,250,
253,255,256,257,258,259; b/7
3

3PYY[3yy],6NPE[kwd],6NPU[kwv],
Pocket PK3 green 12.47 217.2 216.8 0.5288 0.7932 -0.4018
Protein Kinases PAK1[a] Q13153[a] Catalytic domain IPR000719[a] Protein kinase domain[a] 5DEY a/356,357,358,359,360,361,362,
363,366,456,457,458,459,460,484,
485,486,489,490,494
3

3PYY[3yy],6NPE[kwd],6NPU[kwv],
Pocket PK3 green 11.75 288.8 320.7 0.5365 0.7564 -0.319
Protein Kinases MARK2[a] Q7KZI7[a] Catalytic domain IPR008271[a] Serine[a] 5EAK a/137,138,141,142,178,181,215,
239,242,243,246,247,248
3

3PYY[3yy],6NPE[kwd],6NPU[kwv],
Pocket PK3 green 8.71 160.7 184.6 0.6086 0.7857 -0.4726
Protein Kinases CDK13[a] Q14004[a] Catalytic domain IPR000719[a] Protein kinase domain[a] 5EFQ a/802,805,807,808,809,810,811,
814,906,907,908,909,910
3

3PYY[3yy],6NPE[kwd],6NPU[kwv],
Pocket PK3 green 16.440001 200.9 197.8 0.5466 0.7653 -0.5287
Protein Kinases PBK[a],PBK[b] Q96KB5[a],
Q96KB5[b]
Catalytic domain IPR008271[a],
IPR041989[b]
Serine[a],TOPK, catalytic domain[b] 5J0A a/122,124,125,127,128,170,171,
212,239,243,244,245; b/57,58,63,
66,67,69,72,75
3

3PYY[3yy],6NPE[kwd],6NPU[kwv],
Pocket PK3 green 8.915 222.8 228.5 0.5963 0.8864 0.1376
Protein Kinases KSR2[b] Q6VAB6[b] Catalytic domain IPR001245[b] Serine-threonine[b] 5KKR b/758,759,760,763,864,865,868,
869,893,894,895,896,897,898,899,
903,904,907
3

3PYY[3yy],6NPE[kwd],6NPU[kwv],
Pocket PK3 green 15.1 285.1 291.3 0.6972 0.8237 0.3015
Protein Kinases MASTL[a] Q96GX5[a] Catalytic domain IPR000719[a] Protein kinase domain[a] 5LOH a/678,679,680,681,769,772,773,
775,796,798,802,803,804,805
3

3PYY[3yy],6NPE[kwd],6NPU[kwv],
Pocket PK3 green 14.11 209.7 227.6 0.5597 0.7164 -0.6602
Protein Kinases TTK[a] P33981[a] Catalytic domain IPR000719[a] Protein kinase domain[a] 5NAD a/725,729,731,732,733,734,735,
736,737,752,754,755,757
3

3PYY[3yy],6NPE[kwd],6NPU[kwv],
Pocket PK3 green 16.77 178.8 169.5 0.534 0.716 -0.8377
Protein Kinases LIMK1[l] P53667[l] Catalytic domain 5NXC l/544,545,567,568,569,570,571,
572,573,574,575,576,577,578,579,
580,581,611,625,628,629
3

3PYY[3yy],6NPE[kwd],6NPU[kwv],
Pocket PK3 green l/C571(reactive:0.74),
l/C575(0.485)
21.879999 334.1 387 0.5314 0.7152 -0.3851
Protein Kinases AURKA[a] O14965[a] Catalytic domain IPR000719[a] Protein kinase domain[a] 5ODT a/320,324,326,327,328,329,330,
340,345,346,347,348,349
3

3PYY[3yy],6NPE[kwd],6NPU[kwv],
Pocket PK3 green 10.21 166.8 175.6 0.5438 0.7797 -0.616
Protein Kinases AURKA[a] O14965[a] Catalytic domain IPR000719[a] Protein kinase domain[a] 5ODT a/225,227,228,229,230,232,323,
351,352,353
3

3PYY[3yy],6NPE[kwd],6NPU[kwv],
Pocket PK3 green 15.39 160.8 199 0.5952 0.7031 -0.8278
Protein Kinases VRK1[b] Q99986[b] Catalytic domain IPR000719[b] Protein kinase domain[b] 6AC9 b/148,149,150,151,255,256,258,
259,260,262,263,287,288,289,290,
291,293,294,295,296,297
3

3PYY[3yy],6NPE[kwd],6NPU[kwv],
Pocket PK3 green b/C289(0.36) 17.530001 332.5 391.8 0.4846 0.6728 -0.6621
Protein Kinases STK3[a] Q13188[a] Catalytic domain IPR000719[a] Protein kinase domain[a] 6AO5 a/212,216,218,219,220,221,222,
223,236,237,238,239,240,241,242
3

3PYY[3yy],6NPE[kwd],6NPU[kwv],
Pocket PK3 green 9.821 186.7 218.3 0.4801 0.7065 -0.9659
Protein Kinases SRPK1[a] Q96SB4[a] Catalytic domain IPR000719[a] Protein kinase domain[a] 6FAD a/542,548,549,550,551,552,568,
571,572,604,606,611,615,616
3

3PYY[3yy],6NPE[kwd],6NPU[kwv],
Pocket PK3 green 16.110001 271.4 236.2 0.6604 0.7948 0.06771
Protein Kinases ULK3[u] Q6PHR2[u] Catalytic domain IPR000719[u] Protein kinase domain[u] 6FDY u/204,212,213,224,227,229,230,
231,232,253
3

3PYY[3yy],6NPE[kwd],6NPU[kwv],
Pocket PK3 green 17.67 178.5 172.2 0.5603 0.7778 -0.5359
Protein Kinases CLK1[a] P49759[a] Catalytic domain IPR000719[a] Protein kinase domain[a] 6FT9 a/251,252,255,258,259,260,261,
262,264,265,313,314,315,316,373,
441,447
3

3PYY[3yy],6NPE[kwd],6NPU[kwv],
Pocket PK3 green 17.879999 261 268.5 0.6223 0.8352 0.1115
Protein Kinases CLK2[a] P49760[a] Catalytic domain IPR000719[a] Protein kinase domain[a] 6FYK a/253,254,257,260,261,262,263,
264,266,267,306,308,311,315,316,
317,318,375,443,449
3

3PYY[3yy],6NPE[kwd],6NPU[kwv],
Pocket PK3 green 17.530001 268.4 284.2 0.5721 0.7555 -0.2957
Protein Kinases CLK3[a] P49761[a] Catalytic domain IPR000719[a] Protein kinase domain[a] 6FYR a/513,517,519,520,521,522,523,
533,537,571,575,576,577,581,582
3

3PYY[3yy],6NPE[kwd],6NPU[kwv],
Pocket PK3 green a/C576(reactive:0.765) 16.1 208.3 219.6 0.4987 0.7436 -0.6963
Protein Kinases STK10[b] O94804[b] Catalytic domain IPR000719[b] Protein kinase domain[b] 6I2Y b/228,232,234,235,236,237,238,
255,256,257,258
3

3PYY[3yy],6NPE[kwd],6NPU[kwv],
Pocket PK3 green 10.59 164.8 168.6 0.525 0.7 -0.9812
Protein Kinases ROCK2[a] O75116[a] Catalytic domain IPR000719[a] Protein kinase domain[a] 6P5M a/178,181,182,183,184,185,186,
187,188,286,287,288,289,290,319,
320,321
3

3PYY[3yy],6NPE[kwd],6NPU[kwv],
Pocket PK3 green 8.029 269.3 290.7 0.4643 0.7199 -0.6783
Protein Kinases DAPK2[a] Q9UIK4[a] Catalytic domain 6PAW a/112,113,116,219,223,224,225,
305,306,307,308,309,310,313
3

3PYY[3yy],6NPE[kwd],6NPU[kwv],
Pocket PK3 green 7.756 236.3 224.3 0.5317 0.7598 -0.4648
Protein Kinases PRPF4B[a] Q13523[a] Catalytic domain IPR000719[a] Protein kinase domain[a] 6PJJ a/777,781,782,785,786,787,788,
789,790,791,794,795,827,828,880,
883,884,886,958,959,960,961,962,
963,965,969
3

3PYY[3yy],6NPE[kwd],6NPU[kwv],
Pocket PK3 green a/C962(reactive:0.73) 17.73 445.1 457.4 0.4794 0.6904 -0.389
Protein Kinases BRAF[b] P15056[b] Catalytic domain IPR001245[b] Serine-threonine[b] 6Q0K b/541,542,545,546,547,548,549,
550,553,648,649,650,651,652,653,
682,684,685
3

3PYY[3yy],6NPE[kwd],6NPU[kwv],
Pocket PK3 green b/C685(reactive:0.81) 18.02 296.8 281 0.5897 0.8095 0.03123
Protein Kinases STK17B[a] O94768[a] Catalytic domain IPR000719[a] Protein kinase domain[a] 6QF4 a/127,130,131,132,135,228,229,
231,261,262,263,266,292
3

3PYY[3yy],6NPE[kwd],6NPU[kwv],
Pocket PK3 green 15.22 163.7 165.1 0.6181 0.816 -0.3181
Protein Kinases MAPK12[a] P53778[a] Catalytic domain IPR000719[a] Protein kinase domain[a] 6UNA a/120,121,122,123,124,125,126,
127,130,216,218,219,220,222,279,
280,281,284,310
3

3PYY[3yy],6NPE[kwd],6NPU[kwv],
Pocket PK3 green 16.65 219 278.6 0.5355 0.7698 -0.4729
Protein Kinases PAK4[a] O96013[a] Catalytic domain IPR000719[a] Protein kinase domain[a] 6WLX a/407,408,409,410,411,412,413,
414,417,507,508,509,510,511,537,
540,541
3

3PYY[3yy],6NPE[kwd],6NPU[kwv],
Pocket PK3 green 16.59 245.7 240.2 0.5733 0.8209 -0.1005
Protein Kinases CLK3[a] P49761[a] Catalytic domain IPR000719[a] Protein kinase domain[a] 6Z55 a/398,402,403,404,405,406,447,
449,452,456,457,458,516,584,585,
590
3

3PYY[3yy],6NPE[kwd],6NPU[kwv],
Pocket PK3 green 20.84 196 231.2 0.5012 0.7488 -0.7152
Protein Kinases FGFR1[a],FGFR1[b] P11362[a],
P11362[b]
Catalytic domain IPR001245[a],
IPR001245[b]
Serine-threonine[a],Serine-threonine[b] 1FGK a/691,700,701,702,704,717,719,
720,721,722,723; b/691,695,700,
701,702,717,719,720,721,722,723
3

3PYY[3yy],6NPE[kwd],6NPU[kwv],
Pocket PK3 green 11.3 330.8 265.1 0.7725 0.9324 1.011
Protein Kinases TEK[a] Q02763[a] Catalytic domain 1FVR a/1029,1032,1033,1034,1037,1038,
1039,1040,1042,1055,1057,1058,
1059,1060,1061,1062,1063,1064,
1101,1102,1103,1104,1106,1108,
1110,1111,1112,1113,1114,1115
3

3PYY[3yy],6NPE[kwd],6NPU[kwv],
Pocket PK3 green a/C1040(reactive:0.795),
a/C1063(0.05)
11.67 508.4 539.5 0.5418 0.7584 0.1187
Protein Kinases INSR[b] P06213[b] Catalytic domain IPR001245[b] Serine-threonine[b] 1RQQ b/1130,1131,1136,1227,1229,1230,
1231,1232,1234,1236,1237,1238,
1240,1248,1254,1255,1256,1258,
1259,1260,1261,1262
3

3PYY[3yy],6NPE[kwd],6NPU[kwv],
Pocket PK3 green b/C1261(0.035) 11.67 288.1 338.2 0.4845 0.6656 -0.7965
Protein Kinases SRC[a] P12931[a] Catalytic domain IPR001245[a] Serine-threonine[a] 1Y57 a/456,460,463,464,465,466,467,
469,482,484,485,486,487,488
3

3PYY[3yy],6NPE[kwd],6NPU[kwv],
Pocket PK3 green a/C486(reactive:0.835) 14.38 160.9 184 0.579 0.7584 -0.6465
Protein Kinases EPHA3[a] P29320[a] Catalytic domain 2QOC a/712,715,716,718,719,720,723,
815,818,819,820,821,822,826,844,
845,846,847,848,849,850,892,893,
894,895,897
3

3PYY[3yy],6NPE[kwd],6NPU[kwv],
Pocket PK3 green a/C849(0.035) 10.39 374.8 409.3 0.4708 0.6829 -0.5652
Protein Kinases EPHA5[a] P54756[a] Catalytic domain IPR001245[a] Serine-threonine[a] 2R2P a/769,770,772,773,774,777,869,
872,873,874,876,880,898,899,900,
901,902
3

3PYY[3yy],6NPE[kwd],6NPU[kwv],
Pocket PK3 green 13.88 233.5 254 0.492 0.7265 -0.6946
Protein Kinases ABL2[a] P42684[a] Catalytic domain IPR020635[a] Tyrosine-protein kinase, catalytic domain[a] 2XYN a/378,383,386,387,390,475,478,
479,480,481,507,508,509,510,511,
514,518,539
3

3PYY[3yy],6NPE[kwd],6NPU[kwv],
Pocket PK3 green a/C510(0.115) 14.79 211.9 232.2 0.7087 0.8216 0.1004
Protein Kinases CSK[a],SRC(chick)[b] P41240[a],
P00523[b]
Catalytic domain IPR020635[a] Tyrosine-protein kinase, catalytic domain[a] 3D7T a/279,283,377,381,382,383,384,
388,389,406,407,408,409; b/513,
514,516,517
3

3PYY[3yy],6NPE[kwd],6NPU[kwv],
Pocket PK3 green 16.969999 235.9 247.5 0.5346 0.8164 -0.2362
Protein Kinases MET[a] P08581[a] Catalytic domain 3DKC a/1170,1172,1278,1279,1280,1281,
1282,1352,1353,1354,1355,1356,
1357
3

3PYY[3yy],6NPE[kwd],6NPU[kwv],
Pocket PK3 green 10.12 251.3 216.6 0.6707 0.8817 0.3769
Protein Kinases EPHA7[a] Q15375[a] Catalytic domain IPR001245[a] Serine-threonine[a] 3DKO a/724,727,728,730,731,732,735,
827,830,831,832,833,834,838,856,
858,859,860,861
3

3PYY[3yy],6NPE[kwd],6NPU[kwv],
Pocket PK3 green a/C861(0.065) 10.84 213.2 282.9 0.4853 0.7039 -0.8662
Protein Kinases EPHB2[a] P29323[a] Catalytic domain IPR001245[a] Serine-threonine[a] 3ZFM a/712,715,716,718,719,720,723,
820,821,822,824,848,849,850,851
3

3PYY[3yy],6NPE[kwd],6NPU[kwv],
Pocket PK3 green a/C851(0.11) 11.05 220.2 259.5 0.5326 0.7337 -0.6176
Protein Kinases NTRK2[a] Q16620[a] Catalytic domain IPR001245[a] Serine-threonine[a] 4AT5 a/630,633,634,635,636,744,747,
748,749,751,755,756,773,774,775,
776,777
3

3PYY[3yy],6NPE[kwd],6NPU[kwv],
Pocket PK3 green 10.67 197.9 236.4 0.4572 0.7696 -0.726
Protein Kinases EPHB4[a] P54760[a] Catalytic domain IPR001245[a] Serine-threonine[a] 4AW5 a/706,709,710,712,713,714,717,
811,814,815,816,817,818,822,840,
841,842,843,844,845
3

3PYY[3yy],6NPE[kwd],6NPU[kwv],
Pocket PK3 green a/C845(0.13) 10.91 251.4 299.8 0.5412 0.6957 -0.6498
Protein Kinases ALK[a] Q9UM73[a] Catalytic domain 4FNX a/1320,1324,1325,1327,1330,1331,
1333,1341,1347,1348,1349,1350,
1351,1352,1398,1399,1400
3

3PYY[3yy],6NPE[kwd],6NPU[kwv],
Pocket PK3 green 13.25 304.7 315.5 0.5928 0.7631 -0.1254
Protein Kinases NTRK1[a] P04629[a] Catalytic domain IPR001245[a] Serine-threonine[a] 4GT5 a/602,605,606,607,608,718,721,
722,723,724,725,728,729,730,731,
746,747,748,749,750,751
3

3PYY[3yy],6NPE[kwd],6NPU[kwv],
Pocket PK3 green 9.982 331.3 358.5 0.5285 0.6686 -0.5817
Protein Kinases SRC[a] P12931[a] Catalytic domain IPR001245[a] Serine-threonine[a] 4K11 a/358,359,360,361,362,363,366,
458,459,460,461,463,488,489,490,
491
3

3PYY[3yy],6NPE[kwd],6NPU[kwv],
Pocket PK3 green a/C490(0.1) 18.93 170.4 179.9 0.4543 0.7539 -0.9048
Protein Kinases CSF1R[a],CSF1R[a1] P07333[a],
P07333[a1]
Catalytic domain IPR020635[a],
IPR020635[a1]
Tyrosine-protein kinase, catalytic domain[a],Tyrosine-protein kinase, catalytic domain[a1] 4R7H a/676,679,680,683,850,851,852,
853,854,857,858,880; a1/676,679,
680,683,850,851,852,853,854,857,
858,880
3

3PYY[3yy],6NPE[kwd],6NPU[kwv],
Pocket PK3 green 7.642 385 329.7 0.7631 0.9123 1.022
Protein Kinases ERBB3[a],EGFR[b] P21860[a],
P00533[b]
Catalytic domain IPR001245[a] Serine-threonine[a] 4RIW a/902,909,910,911,912,913,914,
915,923,928,929,930,931,932,
941; b/703,704,705,706,707,708,
711,731,733,734,736
3

3PYY[3yy],6NPE[kwd],6NPU[kwv],
Pocket PK3 green 16.24 256.6 320.4 0.4693 0.6807 -0.857
Protein Kinases IGF1R[a] P08069[a] Catalytic domain IPR001245[a] Serine-threonine[a] 5FXS a/1095,1106,1107,1108,1109,1112,
1203,1205,1206,1207,1208,1210,
1213,1214,1216,1224,1230,1231,
1232,1233,1234,1235,1236,1237,
1238
3

3PYY[3yy],6NPE[kwd],6NPU[kwv],
Pocket PK3 green a/C1237(0.21) 11.83 404.1 425.5 0.5158 0.7503 -0.1417
Protein Kinases BTK[b],BTK[c],BTK[d] Q06187[b],
Q06187[c],
Q06187[d]
Catalytic domain IPR001245[c],
IPR001245[d]
Serine-threonine[c],Serine-threonine[d] 5J87 b/434; c/487,489,492,493,494,
495,591,592,593,594,595,620,
621; d/598,599,600,601,605,608,
609,612,614,615,617
3

3PYY[3yy],6NPE[kwd],6NPU[kwv],
Pocket PK3 green 17.219999 517.3 474.1 0.5089 0.7028 -0.1622
Protein Kinases EPHA2[a] P29317[a] Catalytic domain 5NKI a/705,708,709,711,713,716,808,
811,812,813,814,815,816,818,819,
820,821,825,828,829,834,835,836,
837,838,839,840,841,887,888,889,
890
3

3PYY[3yy],6NPE[kwd],6NPU[kwv],
Pocket PK3 green 8.71 491.5 628.5 0.4916 0.6711 -0.3643
Protein Kinases FGFR4[a] P22455[a] Catalytic domain IPR001245[a] Serine-threonine[a] 5NUD a/680,684,687,690,691,693,698,
701,702,706,707,708,709,710,711,
712
3

3PYY[3yy],6NPE[kwd],6NPU[kwv],
Pocket PK3 green 12.48 172.6 213.9 0.5718 0.6697 -0.9603
Protein Kinases BTK[a] Q06187[a] Catalytic domain IPR001245[a] Serine-threonine[a] 5P9L a/588,591,592,593,595,598,599,
600,601,609,615,616,617,618,619,
620,621
3

3PYY[3yy],6NPE[kwd],6NPU[kwv],
Pocket PK3 green 16.530001 326.7 306.8 0.6507 0.7603 0.04681
Protein Kinases MERTK[a] Q12866[a] Catalytic domain IPR001245[a] Serine-threonine[a] 5TD2 a/687,697,700,791,794,795,796,
798,802,820,821,822,823,824,825,
829
3

3PYY[3yy],6NPE[kwd],6NPU[kwv],
Pocket PK3 green a/C825(reactive:0.735) 14.02 243.2 263.3 0.4848 0.7197 -0.7077
Protein Kinases MERTK[a],MERTK[b] Q12866[a],
Q12866[b]
Catalytic domain IPR001245[a],
IPR001245[b]
Serine-threonine[a],Serine-threonine[b] 5U6C a/687,694,794,795,796,798,822,
823,824; b/686,687,694,794,795,
796,822,823,824
3

3PYY[3yy],6NPE[kwd],6NPU[kwv],
Pocket PK3 green 13.85 331.3 280 0.5645 0.8156 0.07915
Protein Kinases KDR[a] P35968[a] Catalytic domain IPR020635[a] Tyrosine-protein kinase, catalytic domain[a] 6GQQ a/1096,1100,1103,1106,1107,1109,
1115,1118,1119,1123,1124,1125,
1126,1127,1128,1129,1130
3

3PYY[3yy],6NPE[kwd],6NPU[kwv],
Pocket PK3 green 13.23 263.9 297.9 0.6601 0.8315 0.1909
Protein Kinases BMX[a] P51813[a] Catalytic domain IPR001245[a] Serine-threonine[a] 6I99 a/603,612,613,614,616,624,629,
630,631,632
3

3PYY[3yy],6NPE[kwd],6NPU[kwv],
Pocket PK3 green 15.49 171.6 172.5 0.6623 0.7987 -0.2511
Protein Kinases JAK1[a] P23458[a] Catalytic domain IPR001245[a] Serine-threonine[a] 6SM8 a/972,976,977,980,1075,1076,
1077,1079,1082,1117,1118,1119,
1120,1121
3

3PYY[3yy],6NPE[kwd],6NPU[kwv],
Pocket PK3 green a/C1120(0.26) 19.02 184.5 197.1 0.5424 0.7573 -0.6326
Protein Kinases GSK3B[a1],AXIN1[b1] P49841[a1],
O15169[b1]
Catalytic domain IPR000719[a1] Protein kinase domain[a1] 1O9U a1/215,216,220,223,227,228,229,
230,231,232,233,262,285,286,287,
288; b1/384,385,388
3

1IAN[d132],2YIS[i46],2YIW[i46]
Pocket PK4 orange 10.08 214.5 268.1 0.5062 0.7159 -0.7669
Protein Kinases GSK3B[a],GSK3B[a1] P49841[a],
P49841[a1]
Catalytic domain IPR000719[a],
IPR000719[a1]
Protein kinase domain[a],Protein kinase domain[a1] 1UV5 a/214,215,216,229,230,231,232,
233,285,286,287,288,289; a1/214,
215,216,229,230,231,232,233,285,
286,287,288,289
3

1IAN[d132],2YIS[i46],2YIW[i46]
Pocket PK4 orange 13.11 310.6 339.1 0.5068 0.8549 0.0558
Protein Kinases CDK2[a],CCNE1[b] P24941[a],
P24864[b]
Catalytic domain IPR000719[a] Protein kinase domain[a] 1W98 a/119,156,172,177,178,179,180,
181,182,183,186,227,228,229,232,
233,234,270,271,272,274,275,276,
277; b/109,110,264,266,267
3

1IAN[d132],2YIS[i46],2YIW[i46]
Pocket PK4 orange a/C177(reactive:0.755) 11.61 342.9 370.2 0.5739 0.8117 0.1109
Protein Kinases DAPK1[a] P53355[a] Catalytic domain IPR000719[a] Protein kinase domain[a] 1WVY a/138,166,167,168,169,170,171,
172,173,174,177,194,195
3

1IAN[d132],2YIS[i46],2YIW[i46]
Pocket PK4 orange 9.057 207.1 216.3 0.4934 0.7737 -0.5941
Protein Kinases 72(SHV21)[a],CDK6[b] Q01043[a],
Q00534[b]
Catalytic domain IPR000719[b] Protein kinase domain[b] 1XO2 a/12,13,14,15,16,17; b/170,188,
189,194,195,196,197,199,241,242,
243,244,245,283,284,285,286,288,
289,290
3

1IAN[d132],2YIS[i46],2YIW[i46]
Pocket PK4 orange 12.6 238.9 302.6 0.4827 0.7308 -0.6818
Protein Kinases STK16[a] O75716[a] Catalytic domain IPR000719[a] Protein kinase domain[a] 2BUJ a/201,202,204,205,206,207,210,
211,212,250,275,276,277,278
3

1IAN[d132],2YIS[i46],2YIW[i46]
Pocket PK4 orange a/C210(reactive:0.765) 14.96 189.4 194.2 0.5772 0.7418 -0.5954
Protein Kinases CHEK1[a] O14757[a] Catalytic domain IPR000719[a] Protein kinase domain[a] 2E9N a/176,177,179,180,181,183,184,
185,211,212,213,218,222,248,249,
250
3

1IAN[d132],2YIS[i46],2YIW[i46]
Pocket PK4 orange 10.93 177.8 221.1 0.5253 0.6957 -0.9415
Protein Kinases CDK2[a] P24941[a] Catalytic domain IPR000719[a] Protein kinase domain[a] 2UUE a/157,158,159,160,161,162,169,
173,174,176,177,178,208,235
3

1IAN[d132],2YIS[i46],2YIW[i46]
Pocket PK4 orange a/C177(reactive:0.625) 10.76 186.7 196 0.4542 0.7444 -0.8749
Protein Kinases CDK4[b] P11802[b] Catalytic domain IPR000719[b] Protein kinase domain[b] 2W99 b/178,181,182,183,184,185,186,
187,219,220,222,223,226,243,244,
245,246
3

1IAN[d132],2YIS[i46],2YIW[i46]
Pocket PK4 orange 9.23 208.4 225 0.728 0.9181 0.5119
Protein Kinases MAPK3[a] P27361[a] Catalytic domain IPR000719[a] Protein kinase domain[a] 2ZOQ a/196,197,213,214,217,218,219,
221,223,224,225,228,268,269,270,
271,272,313,314,315,316,318,319,
320
3

1IAN[d132],2YIS[i46],2YIW[i46]
Pocket PK4 orange a/C271(reactive:0.79) 11.42 255.1 309.5 0.5188 0.7263 -0.5693
Protein Kinases DAPK3[a],DAPK3[a1] O43293[a],
O43293[a1]
Catalytic domain IPR000719[a1] Protein kinase domain[a1] 3BQR a/186,187,190,191,192,
194; a1/187,190,191,192,193,194,
195,197,258,259,260,261
3

1IAN[d132],2YIS[i46],2YIW[i46]
Pocket PK4 orange 12.45 250.6 300.4 0.4598 0.6877 -0.8683
Protein Kinases OXSR1[a],OXSR1[d] O95747[a],
O95747[d]
Catalytic domain IPR000719[a],
IPR000719[d]
Protein kinase domain[a],Protein kinase domain[d] 3DAK a/195,196,199,202,240,241,274,
275,276; d/195,196,199,202,240,
274,275,276,277
3

1IAN[d132],2YIS[i46],2YIW[i46]
Pocket PK4 orange 14.93 309 266.3 0.5924 0.7834 -0.03569
Protein Kinases MAP3K9[a] P80192[a] Catalytic domain IPR001245[a] Serine-threonine[a] 3DTC a/314,318,322,333,337,349,361,
362,364,366,367,368,386,388
3

1IAN[d132],2YIS[i46],2YIW[i46]
Pocket PK4 orange 10.13 184 204.1 0.633 0.8283 -0.1496
Protein Kinases AKT1[a] P31749[a] Catalytic domain IPR000719[a] Protein kinase domain[a] 3OCB a/302,303,305,318,319,322,324,
325,326,327,328,329,362,386,387,
388,389,394,395
3

1IAN[d132],2YIS[i46],2YIW[i46]
Pocket PK4 orange 13.3 233.9 269.3 0.5185 0.732 -0.6115
Protein Kinases PRKCH[a],PRKCH[a1] P24723[a],
P24723[a1]
Catalytic domain IPR034665[a],
IPR034665[a1]
Novel protein kinase C eta, catalytic domain[a],Novel protein kinase C eta, catalytic domain[a1] 3TXO a/523,524,527,567,568,591,592,
593,594; a1/523,524,527,567,568,
591,592,593,594
3

1IAN[d132],2YIS[i46],2YIW[i46]
Pocket PK4 orange 13.91 275.8 266.9 0.5672 0.8188 -0.03768
Protein Kinases DYRK2[a] Q92630[a] Catalytic domain IPR000719[a] Protein kinase domain[a] 4AZF a/380,381,382,392,393,394,396,
397,398,399,427,448,449,450,451
3

1IAN[d132],2YIS[i46],2YIW[i46]
Pocket PK4 orange 11.12 265.1 272.7 0.6054 0.8006 -0.05139
Protein Kinases STK10[a],STK10[b] O94804[a],
O94804[b]
Catalytic domain IPR000719[a],
IPR000719[b]
Protein kinase domain[a],Protein kinase domain[b] 4EQU a/201,202,205,206,209,243,244,
246,247,250,251,277,278,279,
280; b/201,202,204,205,206,208,
209,214,250,277,278,279,280
3

1IAN[d132],2YIS[i46],2YIW[i46]
Pocket PK4 orange 10.91 447.6 511.5 0.4929 0.6526 -0.5035
Protein Kinases CDK9[a] P50750[a] Catalytic domain IPR000719[a] Protein kinase domain[a] 4IMY a/174,175,176,177,178,179,180,
181,182,183,184,185,198,201,202,
203,204,205,206,207,208,209,210,
253,254,255,256,258,259,260,261,
299,300,301
3

1IAN[d132],2YIS[i46],2YIW[i46]
Pocket PK4 orange 12.19 414.3 506.3 0.4938 0.6881 -0.4184
Protein Kinases RPS6KA1[a],MAPK1[b] Q15418[a],
P28482[b]
Catalytic domain 4NIF a/591,595,598,614,629,630,632,
656,657,658,659,660,663,
705; b/13,14,15,16
3

1IAN[d132],2YIS[i46],2YIW[i46]
Pocket PK4 orange a/C595(reactive:0.78) 7.515 215.7 217.8 0.4763 0.7335 -0.7613
Protein Kinases RPS6KA1[a],MAPK1[b] Q15418[a],
P28482[b]
Catalytic domain IPR000719[a] Protein kinase domain[a] 4NIF a/587,590,591,593,594,597,660,
661,663,664,665; b/15,16,17
3

1IAN[d132],2YIS[i46],2YIW[i46]
Pocket PK4 orange 12.16 170.9 185.8 0.5952 0.7476 -0.6076
Protein Kinases MAP4K4[a],MAP4K4[b] O95819[a],
O95819[b]
Catalytic domain IPR000719[a],
IPR000719[b]
Protein kinase domain[a],Protein kinase domain[b] 4OBQ a/197,198,200,201,202,203,204,
205,242,243,246,247,272,273,
274; b/200,201,202,203,239,242,
243,246,247
3

1IAN[d132],2YIS[i46],2YIW[i46]
Pocket PK4 orange a/C202(reactive:0.81),
b/C202(reactive:0.77)
9.2 396.8 401.9 0.6841 0.8262 0.5258
Protein Kinases BUB1[a] O43683[a] Catalytic domain IPR000719[a] Protein kinase domain[a] 4QPM a/974,975,977,978,980,981,985,
1006,1007,1008,1011,1012,1013,
1036,1037,1038,1039,1040,1041
3

1IAN[d132],2YIS[i46],2YIW[i46]
Pocket PK4 orange a/C1013(reactive:0.805),
a/C1041(reactive:0.84)
14.94 200.9 248.4 0.491 0.7315 -0.7884
Protein Kinases SRPK1[a] Q96SB4[a] Catalytic domain IPR000719[a] Protein kinase domain[a] 4WUA a/507,510,511,512,518,522,523,
525,526,527,528,562,585,586,590
3

1IAN[d132],2YIS[i46],2YIW[i46]
Pocket PK4 orange 9.628 220.1 239.9 0.615 0.7735 -0.2739
Protein Kinases MAPK7[a] Q13164[a] Catalytic domain IPR000719[a] Protein kinase domain[a] 4ZSG a/220,221,225,228,233,234,235,
266,267,291,294
3

1IAN[d132],2YIS[i46],2YIW[i46]
Pocket PK4 orange 9.225 170.3 207.4 0.5431 0.7116 -0.8702
Protein Kinases MAPK7[a] Q13164[a] Catalytic domain IPR008271[a] Serine[a] 4ZSJ a/179,181,205,206,207,208,209,
213,215,216,217,219,222,232,235,
237,238,239,240,243
3

1IAN[d132],2YIS[i46],2YIW[i46]
Pocket PK4 orange a/C208(reactive:0.7) 8.116 288 313.6 0.6143 0.8099 0.06634
Protein Kinases DYRK1A[d] Q13627[d] Catalytic domain IPR000719[d] Protein kinase domain[d] 5AIK d/331,336,337,338,339,383,384,
387,463,464,465
3

1IAN[d132],2YIS[i46],2YIW[i46]
Pocket PK4 orange 13.95 160 170.2 0.6187 0.7676 -0.5244
Protein Kinases MAP3K12[a] Q12852[a] Catalytic domain IPR001245[a] Serine-threonine[a] 5CEN a/235,258,259,260,262,267,270,
271,274,277,281,282,284,285,286,
287,319
3

1IAN[d132],2YIS[i46],2YIW[i46]
Pocket PK4 orange 7.387 234.4 245.5 0.5957 0.7671 -0.2964
Protein Kinases GSK3B[a] P49841[a] Catalytic domain IPR000719[a] Protein kinase domain[a] 5F94 a/226,231,232,233,234,235,282,
283,284,285,286,325,326
3

1IAN[d132],2YIS[i46],2YIW[i46]
Pocket PK4 orange 14.05 162.3 180 0.4846 0.7231 -0.9937
Protein Kinases GSK3B[a] P49841[a] Catalytic domain IPR000719[a] Protein kinase domain[a] 5KPL a/176,207,208,209,210,211,212,
213,232,233,234,235,236
3

1IAN[d132],2YIS[i46],2YIW[i46]
Pocket PK4 orange 12.01 226 223 0.5383 0.7185 -0.6453
Protein Kinases LIMK1[l],CFL1[c] P53667[l],
P23528[c]
Catalytic domain IPR001245[l] Serine-threonine[l] 5L6W l/509,520,521,522,523,557,
559; c/103,105,107,114,118,121,
122,136,138
3

1IAN[d132],2YIS[i46],2YIW[i46]
Pocket PK4 orange 13.41 226.3 238.2 0.581 0.8333 -0.09487
Protein Kinases STK10[a],STK10[a1] O94804[a],
O94804[a1]
Catalytic domain IPR008271[a1] Serine[a1] 5OWR a/202,203,206,207,210; a1/152,
153,154,156,179,182,183,185,186,
206,207,209,210,211,215,218
3

1IAN[d132],2YIS[i46],2YIW[i46]
Pocket PK4 orange 7.016 403.6 409 0.6129 0.824 0.3679
Protein Kinases MAP3K5[a] Q99683[a] Catalytic domain IPR000719[a] Protein kinase domain[a] 5V19 a/848,851,852,865,894,895,898,
899,900,919,921
3

1IAN[d132],2YIS[i46],2YIW[i46]
Pocket PK4 orange 12.51 183.1 189.4 0.709 0.8015 -0.0864
Protein Kinases CSNK2A2[x] P19784[x] Catalytic domain IPR000719[x] Protein kinase domain[x] 5YF9 x/188,191,192,203,204,205,206,
207,208,209,239,240,264,265,266,
267,270
3

1IAN[d132],2YIS[i46],2YIW[i46]
Pocket PK4 orange 13.36 208 272 0.4532 0.7081 -0.9408
Protein Kinases DYRK2[b] Q92630[b] Catalytic domain IPR000719[b] Protein kinase domain[b] 5ZTN b/375,376,391,392,395,397,398,
399,400,402,441,445,448,449,518,
519,520
3

1IAN[d132],2YIS[i46],2YIW[i46]
Pocket PK4 orange 12.81 235.7 245.6 0.6884 0.7837 -0.01638
Protein Kinases CAMKK2[a] Q96RR4[a] Catalytic domain IPR000719[a] Protein kinase domain[a] 6BRC a/345,346,347,357,358,359,360,
361,362,363,364,366,396,399,400,
403
3

1IAN[d132],2YIS[i46],2YIW[i46]
Pocket PK4 orange 13.15 179.8 213 0.4597 0.7429 -0.8964
Protein Kinases AURKA[a],AURKA[b] O14965[a],
O14965[b]
Catalytic domain IPR000719[a],
IPR000719[b]
Protein kinase domain[a],Protein kinase domain[b] 6C83 a/301,302,303,304,334,335,
338; b/180,183,184,187,188,250,
251,252
3

1IAN[d132],2YIS[i46],2YIW[i46]
Pocket PK4 orange 9.191 233.6 244.2 0.7034 0.8517 0.2789
Protein Kinases VRK1[a] Q99986[a] Catalytic domain IPR000719[a] Protein kinase domain[a] 6DD4 a/215,216,217,219,220,221,222,
232,235,236,237,238
3

1IAN[d132],2YIS[i46],2YIW[i46]
Pocket PK4 orange a/C220(reactive:0.85) 7.228 173.9 159.6 0.6082 0.8954 0.01687
Protein Kinases STK10[a],STK10[b] O94804[a],
O94804[b]
Catalytic domain IPR008271[a],
IPR008271[b]
Serine[a],Serine[b] 6EIM a/154,156,181,184,185,188,189,
190,191,192,193,202,203,206,207,
210,214,215,217,218; b/154,156,
184,185,188,189,190,191,192,193,
202,203,206,207,210,214,215,218
3

1IAN[d132],2YIS[i46],2YIW[i46]
Pocket PK4 orange 8.09 599.4 652.4 0.5988 0.84 0.691
Protein Kinases STK10[a],STK10[b] O94804[a],
O94804[b]
Catalytic domain IPR000719[a] Protein kinase domain[a] 6EIM a/204,205,208,209,214,277,278,
279,280; b/201,202,205,246,247,
250
3

1IAN[d132],2YIS[i46],2YIW[i46]
Pocket PK4 orange 10.09 217.7 250.7 0.5218 0.6617 -0.9341
Protein Kinases CSNK1G3[a] Q9Y6M4[a] Catalytic domain IPR000719[a] Protein kinase domain[a] 6GRO a/205,206,207,208,209,221,222,
223,257,258,261,262
3

1IAN[d132],2YIS[i46],2YIW[i46]
Pocket PK4 orange 8.701 189.6 232.3 0.4929 0.7005 -0.949
Protein Kinases CSNK1D[a] P48730[a] Catalytic domain IPR000719[a] Protein kinase domain[a] 6GZM a/170,171,172,173,184,185,186,
187,221,222,225,226,229,230,233
3

1IAN[d132],2YIS[i46],2YIW[i46]
Pocket PK4 orange 11.03 229 245 0.4797 0.6971 -0.8528
Protein Kinases DYRK2[a] Q92630[a] Catalytic domain IPR000719[a] Protein kinase domain[a] 6HDP a/426,428,429,431,432,435,454,
455,462,463,464,480,481,482,483,
488
3

1IAN[d132],2YIS[i46],2YIW[i46]
Pocket PK4 orange 19.23 188.2 195.6 0.6232 0.772 -0.3771
Protein Kinases CSNK2A1[a] P68400[a] Catalytic domain 6L22 a/4,6,187,190,191,198,202,203,
204,205,206,207,208,238,239,263,
264,265,266,269
3

1IAN[d132],2YIS[i46],2YIW[i46]
Pocket PK4 orange 9.749 317 350.7 0.5778 0.8023 0.02444
Protein Kinases MAP4K1[a],MAP4K1[b] Q92918[a],
Q92918[b]
Catalytic domain IPR000719[a],
IPR000719[b]
Protein kinase domain[a],Protein kinase domain[b] 6NG0 a/182,185,186,189,190,191,192,
193,227,228,229,230,232,257,258,
259,260; b/181,182,185,186,189,
191,192,193,259,260
3

1IAN[d132],2YIS[i46],2YIW[i46]
Pocket PK4 orange 13.27 376.1 424.4 0.492 0.6297 -0.7244
Protein Kinases TBK1[a] Q9UHD2[a] Catalytic domain IPR000719[a] Protein kinase domain[a] 6O8B a/181,182,183,186,187,193,194,
196,235,239,287,288,289
3

1IAN[d132],2YIS[i46],2YIW[i46]
Pocket PK4 orange 12.71 161.5 181.5 0.5634 0.7387 -0.7569
Protein Kinases CDK4[b] P11802[b] Catalytic domain IPR000719[b] Protein kinase domain[b] 6P8E b/184,189,190,191,192,194,235,
236,237,238,239,240,242,245,246,
278,279,280,281
3

1IAN[d132],2YIS[i46],2YIW[i46]
Pocket PK4 orange 12.5 248.4 322.5 0.4799 0.6874 -0.8306
Protein Kinases BRAF[a] P15056[a] Catalytic domain IPR008271[a] Serine[a] 6Q0J a/573,575,599,600,601,602,604,
605,608,609,610,611,627,629,630,
631,632,633,634
3

1IAN[d132],2YIS[i46],2YIW[i46]
Pocket PK4 orange 10.45 307.7 335.4 0.4925 0.7222 -0.5066
Protein Kinases DAPK1[a] P53355[a] Catalytic domain IPR000719[a] Protein kinase domain[a] 6QMO a/171,172,186,187,190,192,193,
194,195,197,258,259,260,261
3

1IAN[d132],2YIS[i46],2YIW[i46]
Pocket PK4 orange 11.73 168.1 189.5 0.5704 0.7551 -0.6467
Protein Kinases CLK3[a],CLK3[b] P49761[a],
P49761[b]
Catalytic domain IPR000719[a],
IPR000719[b]
Protein kinase domain[a],Protein kinase domain[b] 6RCT a/420,423,424,492,497,498,499,
500,501,502,505,544,545,547,548,
604,605,606,610,611,612; b/487,
523,524,525,565,566,567,568,570,
571
3

1IAN[d132],2YIS[i46],2YIW[i46]
Pocket PK4 orange 11.53 555.6 568 0.649 0.7981 0.5838
Protein Kinases SRC[a] P12931[a] Catalytic domain IPR008266[a] Tyrosine-protein kinase, active site[a] 1Y57 a/386,412,413,414,415,416,417,
418,419,440,441,442,443
3

1IAN[d132],2YIS[i46],2YIW[i46]
Pocket PK4 orange 9.951 199.8 193.5 0.6111 0.8787 0.06009
Protein Kinases FYN[x] P06241[x] Catalytic domain IPR020635[x] Tyrosine-protein kinase, catalytic domain[x] 2DQ7 x/422,424,425,426,427,428,430,
437,438,439,440,441,443
3

1IAN[d132],2YIS[i46],2YIW[i46]
Pocket PK4 orange 8.311 176.7 173.4 0.6341 0.8245 -0.1916
Protein Kinases SRC[a] P12931[a] Catalytic domain IPR001245[a] Serine-threonine[a] 2SRC a/421,422,423,424,425,427,429,
437,438,471,472,475
3

1IAN[d132],2YIS[i46],2YIW[i46]
Pocket PK4 orange 9.699 192.7 203.9 0.5628 0.7542 -0.5664
Protein Kinases LCK[a] P06239[a] Catalytic domain IPR001245[a] Serine-threonine[a] 3ACJ a/395,396,397,398,400,401,402,
404,411,412,413,414,415
3

1IAN[d132],2YIS[i46],2YIW[i46]
Pocket PK4 orange 9.809 209.1 204.2 0.5141 0.7768 -0.5276
Protein Kinases INSR[a] P06213[a] Catalytic domain IPR001245[a] Serine-threonine[a] 3BU6 a/1192,1193,1194,1195,1196,1197,
1198,1200,1203,1207,1208,1209,
1210,1211,1213,1242,1243,1246
3

1IAN[d132],2YIS[i46],2YIW[i46]
Pocket PK4 orange 7.818 218.5 252.5 0.5055 0.6843 -0.8793
Protein Kinases FES[a] P07332[a] Catalytic domain IPR001245[a] Serine-threonine[a] 3CD3 a/724,725,726,727,728,729,732,
733,744,748,761,769,770,773,774
3

1IAN[d132],2YIS[i46],2YIW[i46]
Pocket PK4 orange 9.019 177.3 183.7 0.779 0.9075 0.4667
Protein Kinases MET[a] P08581[a] Catalytic domain IPR001245[a] Serine-threonine[a] 4KNB a/1236,1237,1238,1239,1245,1247,
1250,1254,1255,1256,1258,1289,
1290,1292,1293
3

1IAN[d132],2YIS[i46],2YIW[i46]
Pocket PK4 orange 9.906 187.4 214.1 0.6153 0.794 -0.3112
Protein Kinases MET[a],MET[b] P08581[a],
P08581[b]
Catalytic domain IPR001245[a] Serine-threonine[a] 5DG5 a/1252,1253,1256,1257,1259,1261,
1322,1323,1324,1325,
1326; b/1055,1063,1066,1067,
1069,1070,1071,1072,1073,1074,
1075,1097,1098,1099,1100,1143,
1144,1146,1147,1148,1149,1150
3

1IAN[d132],2YIS[i46],2YIW[i46]
Pocket PK4 orange b/C1146(reactive:0.765) 13.39 511.4 512.8 0.5 0.7184 -0.1298
Protein Kinases IGF1R[a] P08069[a] Catalytic domain IPR001245[a] Serine-threonine[a] 5FXS a/1166,1168,1169,1170,1171,1172,
1174,1176,1179,1183,1184,1185,
1186,1187,1222
3

1IAN[d132],2YIS[i46],2YIW[i46]
Pocket PK4 orange 9.775 176.4 166.9 0.6632 0.7594 -0.3831
Protein Kinases EPHA2[a] P29317[a] Catalytic domain IPR001245[a] Serine-threonine[a] 5NKB a/781,782,783,784,785,786,789,
790,801,805,818,824,826,827,828,
830,831,856
3

1IAN[d132],2YIS[i46],2YIW[i46]
Pocket PK4 orange 7.334 195 227.8 0.644 0.8037 -0.1785
Protein Kinases FGFR3[a],FGFR3[b] P22607[a],
P22607[b]
Catalytic domain IPR020635[a],
IPR020635[b]
Tyrosine-protein kinase, catalytic domain[a],Tyrosine-protein kinase, catalytic domain[b] 6PNX a/664,667,701,702,704,705,
708; b/571,572,589,591,594,685,
688,689,690,695,696,698,711,713,
714,715,716,717,718
3

1IAN[d132],2YIS[i46],2YIW[i46]
Pocket PK4 orange 13.65 437.2 452.1 0.5156 0.6862 -0.337
Protein Kinases CDK2[a],CCNA2[b] P24941[a],
P20248[b]
Catalytic domain IPR000719[a] Protein kinase domain[a] 1H24 a/37,38,39,43,44,71,72,73,
74; b/255,289,290,292,293,294,
295,296,297
3

3ORZ[2a2]
Pocket PK5 yellow 22.059999 284 325.3 0.5094 0.7007 -0.6123
Protein Kinases TGFBR1[c],TGFBR1[e] P36897[c],
P36897[e]
Catalytic domain 1IAS c/172; e/195,198,199,242,243,
246,247,250,265,266,267
3

3ORZ[2a2]
Pocket PK5 yellow 16.84 211.8 205.6 0.6119 0.7776 -0.2933
Protein Kinases CDK2[a],CCNA2[b],CDKN1B[c] P24941[a],
P20248[b],
P46527[c]
Catalytic domain IPR000719[a] Protein kinase domain[a] 1JSU a/37,38,39,43,44,71,72,73,
74; b/292,293,295,296; c/46,49,
50,51,52,53,65
3

3ORZ[2a2]
Pocket PK5 yellow c/C49(reactive:0.725) 21.59 342.6 310.7 0.7361 0.888 0.7787
Protein Kinases DMPK[a] Q09013[a] Catalytic domain IPR000719[a] Protein kinase domain[a] 2VD5 a/27,30,31,34,62,65,66,67,104,
138,139,140,141,397,400,401,404,
407
3

3ORZ[2a2]
Pocket PK5 yellow a/C407(reactive:0.78) 19.280001 332.8 275.8 0.6843 0.9267 0.7921
Protein Kinases CDK2[c],CCNA2[d] P24941[c],
P20248[d]
Catalytic domain IPR000719[c] Protein kinase domain[c] 2X1N c/37,38,39,43,44,73,74; d/289,
292,293,295,296,297
3

3ORZ[2a2]
Pocket PK5 yellow 21.67 286.5 254.3 0.6151 0.7833 -0.04028
Protein Kinases GRK2[a] P25098[a] Catalytic domain IPR000719[a] Protein kinase domain[a] 3CIK a/181,182,183,184,185,186,187,
224,259,260,261,262,263,264,503,
510,511,512,514,637,638,641
3

3ORZ[2a2]
Pocket PK5 yellow 22.85 402.4 419.4 0.5336 0.7384 -0.1518
Protein Kinases ROCK1[b] Q13464[b] Catalytic domain IPR000719[b] Protein kinase domain[b] 3D9V b/32,35,36,39,66,67,70,71,72,73,
109,143,144,145,146,391,394,395,
398
3

3ORZ[2a2]
Pocket PK5 yellow 18.530001 266 253 0.7637 0.9269 0.808
Protein Kinases MAP2K1[a1] Q02750[a1] Catalytic domain 3EQC a1/57,58,60,61,62,63,112,116,
119,130,131,132,133
3

3ORZ[2a2]
Pocket PK5 yellow 17.280001 159.8 173.1 0.5069 0.7578 -0.8177
Protein Kinases GRK6[a] P43250[a] Catalytic domain IPR000719[a] Protein kinase domain[a] 3NYN a/177,178,180,181,182,252,253,
254,503,504,505,506,508
3

3ORZ[2a2]
Pocket PK5 yellow 23.870001 168.7 203 0.4635 0.7331 -0.9733
Protein Kinases ACVR1[a],ACVR1[b] Q04771[a],
Q04771[b]
Catalytic domain 3Q4U a/204,206,269,270,271,272,273,
276,277,278; b/203,204,205,206,
207,208,227,232,266,267,269,270,
271,282
3

3ORZ[2a2]
Pocket PK5 yellow 21.75 232.3 283.8 0.5758 0.798 -0.2267
Protein Kinases CDC42BPB[b] Q9Y5S2[b] Catalytic domain IPR000719[b] Protein kinase domain[b] 3QFV b/32,35,36,39,66,67,70,71,72,73,
74,109,143,144,145,146,395,398,
399,402
3

3ORZ[2a2]
Pocket PK5 yellow b/C36(reactive:0.875) 19.389999 364.6 323.3 0.6049 0.8484 0.3706
Protein Kinases TTBK1[a] Q5TCY1[a] Catalytic domain IPR000719[a] Protein kinase domain[a] 4BTJ a/65,72,74,75,78,79,96,97,98,
103,104,105
3

3ORZ[2a2]
Pocket PK5 yellow a/C96(reactive:0.745) 14.83 170.2 173.7 0.6225 0.7222 -0.6484
Protein Kinases ACVR1[a],ACVR1[a1] Q04771[a],
Q04771[a1]
Catalytic domain IPR001245[a],
IPR001245[a1]
Serine-threonine[a],Serine-threonine[a1] 4DYM a/245,249,253,265,268,269,
270; a1/245,249,253,265,267,268,
269,270
3

3ORZ[2a2]
Pocket PK5 yellow 18.200001 181.6 166.3 0.6519 0.8657 0.03145
Protein Kinases CAB39[a],STK25[b] Q9Y376[a],
O00506[b]
Catalytic domain IPR000719[b] Protein kinase domain[b] 4NZW a/92,95,96,137,138,139,140,141,
142,177,179,180; b/70,71,72,73,
74,80,81,82,83,84,85
3

3ORZ[2a2]
Pocket PK5 yellow b/C73(reactive:0.73) 7.211 347.6 327.4 0.5567 0.8019 0.04307
Protein Kinases GAK[a],GAK[b] O14976[a],
O14976[b]
Catalytic domain IPR000719[a],
IPR000719[b]
Protein kinase domain[a],Protein kinase domain[b] 4O38 a/73,74,75,76,79,106,108,109,
110,117; b/230,231,232,233,235,
236,237,238,239,243,299,300,301
3

3ORZ[2a2]
Pocket PK5 yellow 14.81 382.7 371.2 0.5851 0.8006 0.1736
Protein Kinases ROCK2[a] O75116[a] Catalytic domain IPR000719[a] Protein kinase domain[a] 4WOT a/48,51,52,55,83,86,87,88,125,
159,160,161,162,407,410,414,416
3

3ORZ[2a2]
Pocket PK5 yellow 18.690001 247.8 228 0.707 0.9007 0.5237
Protein Kinases ROCK2[a],ROCK2[c] O75116[a],
O75116[c]
Catalytic domain IPR000719[c] Protein kinase domain[c] 4WOT a/74,75; c/37,38,39,40,42,44,45,
138,141,411,412,414,415
3

3ORZ[2a2]
Pocket PK5 yellow 15.23 160.2 167.5 0.4619 0.8212 -0.6679
Protein Kinases MAPK14[a] Q16539[a] Catalytic domain IPR003527[a] Mitogen-activated protein (MAP) kinase, conserved site[a] 5ETC a/3,4,5,6,8,21,23,88,89,90,91,
92,93,94,342,345,346,348,350
3

3ORZ[2a2]
Pocket PK5 yellow 18.77 292.4 239.5 0.5713 0.7687 -0.1825
Protein Kinases CDK8[a],CCNC[b] P49336[a],
P24863[b]
Catalytic domain 5HBE a/9,12,13,14,70,71,72,73,74,80,
81,82,83,84,85,86; b/7,8,9,12,
13,144,147,148
3

3ORZ[2a2]
Pocket PK5 yellow b/C148(reactive:0.62) 17.43 450 437.4 0.5228 0.7852 0.09074
Protein Kinases CDK8[a],CCNC[b] P49336[a],
P24863[b]
Catalytic domain 5HNB a/13,14,70,71,73,74,80,81,82,83,
84,85,86,88; b/9,12,13,144,147,
148
3

3ORZ[2a2]
Pocket PK5 yellow b/C148(reactive:0.62) 17.120001 393.9 389 0.5502 0.826 0.2154
Protein Kinases KSR2[b],KSR2[b1] Q6VAB6[b],
Q6VAB6[b1]
Catalytic domain IPR008271[b1] Serine[b1] 5KKR b/656,657,658,659,660,661,662,
663,664; b1/687,688,719,720,722,
723,724,740,741,742,743,793,795,
798,800
3

3ORZ[2a2]
Pocket PK5 yellow b1/C742(reactive:0.72) 14.24 502.9 423.9 0.6182 0.7804 0.3707
Protein Kinases CSNK2A1[b],CSNK2A1[a] P68400[b],
P68400[a]
Catalytic domain IPR000719[a] Protein kinase domain[a] 5OUM b/30,31,32,33,34,35,72,75,78,79,
102,103,104,107,108,109; a/86,
87,88,89,90,91,92,93,94,96,114,
146,150,172
3

3ORZ[2a2]
Pocket PK5 yellow 15.09 484.5 424.2 0.6524 0.853 0.7067
Protein Kinases ROCK1[a] Q13464[a] Catalytic domain IPR000719[a] Protein kinase domain[a] 6E9W a/21,22,23,24,26,28,29,122,125,
126,130,396,397,398,399,402
3

3ORZ[2a2]
Pocket PK5 yellow a/C29(reactive:0.665) 15.95 163.5 157.5 0.5128 0.9377 -0.07833
Protein Kinases STK10[b] O94804[b] Catalytic domain IPR042743[b] Serine[b] 6I2Y b/25,26,27,82,85,86,88,89,90,93,
94,95,96,97,98,99,100
3

3ORZ[2a2]
Pocket PK5 yellow b/C88(reactive:0.805) 8.428 191.3 224.3 0.5415 0.7642 -0.5808
Protein Kinases ROCK2[a] O75116[a] Catalytic domain IPR000719[a] Protein kinase domain[a] 6P5M a/37,38,39,40,41,42,45,46,49,
138,141,142,146,411,412
3

3ORZ[2a2]
Pocket PK5 yellow 15.12 200.9 222.2 0.4763 0.7431 -0.7758
Protein Kinases MET[a] P08581[a] Catalytic domain 2G15 a/1053,1054,1055,1057,1058,1114,
1115,1116,1118,1121,1124,1125,
1147,1148,1149,1150,1151,1153
3

3ORZ[2a2]
Pocket PK5 yellow 17.030001 270.4 249.3 0.5693 0.7602 -0.2778
Protein Kinases EGFR[a],EGFR[a1] P00533[a],
P00533[a1]
Catalytic domain IPR001245[a],
IPR001245[a1]
Serine-threonine[a],Serine-threonine[a1] 2GS6 a/701,703,704,705,706,707,708,
711,731,733,1016,1018; a1/931,
932,933,934,935,936,937,939,940,
944
3

3ORZ[2a2]
Pocket PK5 yellow a1/C939(0.035) 17.51 297.7 347.1 0.4619 0.6507 -0.8825
Protein Kinases ZAP70[a] P43403[a] Catalytic domain 2OZO a/322,323,324,325,326,327,328,
329,331,332,333,336,357,358,359,
360,361,362,402
3

3ORZ[2a2]
Pocket PK5 yellow 21.6 474.3 395.1 0.552 0.8155 0.3155
Protein Kinases FGFR2[a],FGFR2[c] P21802[a],
P21802[c]
Catalytic domain 2PVY a/676,710,711,713,714,
717; c/464,465,466,467,468,528,
555,556,557,558
3

3ORZ[2a2]
Pocket PK5 yellow 16.66 241.7 236.7 0.5325 0.756 -0.461
Protein Kinases LCK[a] P06239[a] Catalytic domain 3ACK a/233,234,235,236,237,239,240,
241,242,307,308,309
3

3ORZ[2a2]
Pocket PK5 yellow 25.360001 263.5 278.8 0.6147 0.7397 -0.275
Protein Kinases MET[a] P08581[a] Catalytic domain 3DKG a/1055,1056,1058,1063,1066,1067,
1070,1071,1072,1073,1125,1146,
1147,1148
3

3ORZ[2a2]
Pocket PK5 yellow a/C1146(reactive:0.8) 19.57 193.1 213.1 0.5944 0.7167 -0.6411
Protein Kinases PTK2[a],PTK2[b] Q05397[a],
Q05397[b]
Catalytic domain IPR020635[b] Tyrosine-protein kinase, catalytic domain[b] 3PXK a/480,481,482,528,529,
532; b/459,460,462,465,466,491,
492,493
3

3ORZ[2a2]
Pocket PK5 yellow 17.67 178.3 195.9 0.458 0.7884 -0.7271
Protein Kinases SRC[a] P12931[a] Catalytic domain 1KSW a/118,119,120,121,256,257,259,
260,261,262,263,317,318,319,320,
321,327,328,329
3

3ORZ[2a2]
Pocket PK5 yellow 13.91 263.7 255.8 0.5563 0.8378 -0.02018
Protein Kinases PRKAA2[a],PRKAB1[b] P54646[a],
Q9Y478[b]
Catalytic domain IPR000719[a] Protein kinase domain[a] 5ISO a/48,49,50,53,86,87,88; b/81,82,
83,84,85,86,125,127,136,137,138,
139,153,154,156,159,168,169
3

3ORZ[2a2]
Pocket PK5, Pocket PKI2 yellow 22.49 394 417.7 0.4899 0.7561 -0.1968
Protein Phosphatases PTPN14[a] Q15678[a] Catalytic domain IPR000242[a] PTP type protein phosphatase[a] 2BZL a/953,955,991,995,998,999,1036,
1037,1038,1060
3

5QDG[aws],5QDJ[jfp3],5QFN[jov2
Pocket PP4 purple 17.73 171.1 177.4 0.6552 0.7288 -0.545
Protein Phosphatases PTPRB[a],PTPRB[a1] P23467[a],
P23467[a1]
Catalytic domain IPR000242[a] PTP type protein phosphatase[a] 2H03 a/1725,1726,1728,1729,1730,1779,
1780,1781,1782; a1/1824,1829,
1851,1852,1853,1854
3

5QDG[aws],5QDJ[jfp3],5QFN[jov2
Pocket PP4 purple 13.34 179.4 201.8 0.4615 0.7379 -0.9134
Protein Phosphatases PTPN7[a] P35236[a] Catalytic domain IPR000242[a] PTP type protein phosphatase[a] 3O4S a/116,117,118,119,121,122,138,
139,140,141,142,143,145,146,147,
148,149,178,181
3

5QDG[aws],5QDJ[jfp3],5QFN[jov2
Pocket PP4 purple 16.440001 280.7 304.3 0.613 0.8192 0.08122
Protein Phosphatases PTPN11[a] Q06124[a] Catalytic domain IPR000242[a] PTP type protein phosphatase[a] 3O5X a/272,275,276,292,293,294,295,
296,297,299,300,301,302,336,339,
340,343,346,347,381,382,383,405
3

5QDG[aws],5QDJ[jfp3],5QFN[jov2
Pocket PP4 purple 16.1 366.6 404.8 0.5265 0.7425 -0.2202
Protein Phosphatases PTPN9[a] P43378[a] Catalytic domain IPR000242[a] PTP type protein phosphatase[a] 4GE6 a/346,347,348,349,352,354,384,
385,388,391,392,426,427,428,429,
451,453,454
3

5QDG[aws],5QDJ[jfp3],5QFN[jov2
Pocket PP4 purple 17.879999 302.6 293.7 0.6185 0.8231 0.1648
Protein Phosphatases PTPN6[a] P29350[a] Catalytic domain IPR000387[a] Tyrosine specific protein phosphatases domain[a] 1GWZ a/308,309,310,311,312,313,314,
315,316,317,318,319,320,434,437,
438,440,441,443,444,446,447,448,
449,467,470,471,472,474,475,476,
515
3

5QE4[jh4],5QE7[jhd],5QED[7mu3]
Pocket PP3 red 15.46 477.3 581.4 0.4528 0.71 -0.3208
Protein Phosphatases PTPRM[a] P28827[a] Catalytic domain IPR000242[a] PTP type protein phosphatase[a] 1RPM a/959,960,961,962,963,964,965,
1110,1111,1114,1122,1125,1126,
1129,1130
3

5QE4[jh4],5QE7[jhd],5QED[7mu3]
Pocket PP3 red a/C1126(0.27) 14.35 177.2 202.1 0.6078 0.7112 -0.6959
Protein Phosphatases PTPN14[a] Q15678[a] Catalytic domain IPR000242[a] PTP type protein phosphatase[a] 2BZL a/969,975,976,977,978,1097,1100,
1101,1104,1107,1108,1109,1110,
1111,1112,1113,1114,1115,1116,
1117,1139
3

5QE4[jh4],5QE7[jhd],5QED[7mu3]
Pocket PP3 red 14.05 418.7 416.5 0.4898 0.7507 -0.1732
Protein Phosphatases PTPN1[a],PTPN1[a1] P18031[a],
P18031[a1]
Catalytic domain IPR000242[a],
IPR000242[a1]
PTP type protein phosphatase[a],PTP type protein phosphatase[a1] 2CM3 a/73,74,75,78,79,80,204,205,206,
208,209,210,211; a1/73,74,75,78,
79,80,204,205,206,208,209,210,
211
3

5QE4[jh4],5QE7[jhd],5QED[7mu3]
Pocket PP3 red 11.55 454.6 407.6 0.524 0.8437 0.3317
Protein Phosphatases PTPRO[a],PTPRO[b] Q16827[a],
Q16827[b]
Catalytic domain IPR000242[b] PTP type protein phosphatase[b] 2G59 a/952,953,976; b/997,1002,1003,
1004,1005,1006,1028,1029,1032,
1122,1125,1126,1128,1129,1130,
1131,1132
3

5QE4[jh4],5QE7[jhd],5QED[7mu3]
Pocket PP3 red 14.4 266 289.7 0.4689 0.644 -0.9761
Protein Phosphatases PTPRO[a] Q16827[a] Catalytic domain IPR000242[a] PTP type protein phosphatase[a] 2GJT a/997,1002,1003,1005,1006,1028,
1030,1031,1032,1122,1125,1126,
1128,1129,1130,1131,1132
3

5QE4[jh4],5QE7[jhd],5QED[7mu3]
Pocket PP3 red 13.85 231.4 256.2 0.5188 0.7428 -0.5762
Protein Phosphatases PTPRB[a] P23467[a] Catalytic domain IPR000242[a] PTP type protein phosphatase[a] 2I4H a/1765,1766,1767,1768,1769,1770,
1771,1793,1794,1796,1797,1888,
1891,1892,1894,1895,1896,1897,
1898,1899,1900,1919,1922,1923,
1926,1927
3

5QE4[jh4],5QE7[jhd],5QED[7mu3]
Pocket PP3 red 14.96 369.9 440.6 0.4558 0.6974 -0.5519
Protein Phosphatases PTPN22[a] Q9Y2R2[a] Catalytic domain IPR000242[a] PTP type protein phosphatase[a] 2QCT a/92,93,94,95,96,97,98,99,213,
216,217,218,219,220,221,222,223,
245
3

5QE4[jh4],5QE7[jhd],5QED[7mu3]
Pocket PP3 red 14.45 318 259.6 0.6133 0.8456 0.2778
Protein Phosphatases PTPN7[a] P35236[a] Catalytic domain 3O4U a/75,76,77,78,156,157,158,159,
160,306,310,314,318,321,322,324,
325,326
3

5QE4[jh4],5QE7[jhd],5QED[7mu3]
Pocket PP3 red a/C324(0.25) 16.15 203 222 0.5522 0.7976 -0.3811
Protein Phosphatases PTPN6[a],PTPN6[a1] P29350[a],
P29350[a1]
Catalytic domain IPR000242[a] PTP type protein phosphatase[a] 3PS5 a/308,309,310,312,313,314,315,
316,317,318,320; a1/82,95,97
3

5QE4[jh4],5QE7[jhd],5QED[7mu3]
Pocket PP3 red 19.190001 199.2 182.7 0.5245 0.7599 -0.6066
Protein Phosphatases PTPN3[a] P26045[a] Catalytic domain IPR000242[a] PTP type protein phosphatase[a] 4QUM a/703,704,705,706,707,857,861,
866,867,868,869,872,873,876
3

5QE4[jh4],5QE7[jhd],5QED[7mu3]
Pocket PP3 red 18.01 199.1 189.9 0.6329 0.7175 -0.5277
Protein Phosphatases PTPN11[a] Q06124[a] Catalytic domain IPR000242[a] PTP type protein phosphatase[a] 4RDD a/312,313,314,315,316,317,318,
320,322,323,324,325,327,443,447,
474,475,477,478,480,481,482,486,
487,488,489,492,493,495,496
3

5QE4[jh4],5QE7[jhd],5QED[7mu3]
Pocket PP3 red a/C318(reactive:0.7),
a/C486(reactive:0.685)
15.49 550 553.3 0.5386 0.7393 0.09417
Protein Phosphatases PTPN12[b] Q05209[b] Catalytic domain IPR000242[b] PTP type protein phosphatase[b] 5J8R b/98,99,100,101,102,124,125,214,
217,218,221,222,223,224,225,226,
249,252,253
3

5QE4[jh4],5QE7[jhd],5QED[7mu3]
Pocket PP3 red 17.440001 340.9 403.2 0.4833 0.6925 -0.5691
Protein Phosphatases PTPN12[c] Q05209[c] Catalytic domain IPR000242[c] PTP type protein phosphatase[c] 5J8R c/94,95,96,97,98,99,100,103,243,
246,250,257,259,260,261,264,265,
268,269,272
3

5QE4[jh4],5QE7[jhd],5QED[7mu3]
Pocket PP3 red 13.44 317.9 333.5 0.6155 0.763 -0.04271
Protein Phosphatases PTPRE[a] P23469[a] Catalytic domain IPR000387[a] Tyrosine specific protein phosphatases domain[a] 6D4F a/489,490,491,492,495,496,608,
611,612,614,615,618,619,622,623,
626,640,644,647,648,651,689
3

5QE4[jh4],5QE7[jhd],5QED[7mu3]
Pocket PP3 red 12.72 353.8 355.1 0.6969 0.8448 0.5432
Acetyltransferases KAT8[a1],MSL1(mouse)[b1] Q9H7Z6[a1],
Q6PDM1[b1]
Catalytic domain IPR002717[a1] Histone acetyltransferase domain, MYST-type[a1] 2Y0M a1/213,215,225,226,229,230,231,
232,236,255,256,257,258,
259; b1/495,496,497,498,499,500
4 blue 16.09 341.1 363.8 0.5551 0.7324 -0.2481
Acetyltransferases KAT8[a] Q9H7Z6[a] Catalytic domain 3QAH a/238,250,284,286,304,305,306,
307,308,311,312,313,340,343,345,
346,347,445,446,448
4 blue 7.213 206.3 249.3 0.5 0.7349 -0.7349
Acetyltransferases KAT8[a] Q9H7Z6[a] Catalytic domain IPR002717[a] Histone acetyltransferase domain, MYST-type[a] 6OIN a/373,376,377,378,379,380,415,
416,417,419,422
4 blue a/C416(reactive:0.76) 25.450001 159.9 158.2 0.6057 0.8262 -0.3232
Deacetylases HDAC4[g] P56524[g] Catalytic domain 5ZOO g/912,913,917,1018,1021,1022,
1025,1030,1031,1032,1033,1034,
1035,1036,1037,1040,1045,1048,
1049,1052
4 blue g/C1030(reactive:0.595),
g/C1048(reactive:0.74)
24.09 321.7 319 0.56 0.7591 -0.1752
Deacetylases HDAC1[c] Q13547[c] Catalytic domain 6Z2J c/169,191,192,194,221,222,248,
251,252,253,370,373,374,375
4 blue 21.139999 219.9 206.9 0.6105 0.8052 -0.1597
Deacetylases HDAC4[a] P56524[a] Catalytic domain 2VQJ a/661,662,705,722,723,724,725,
726,727,728,730,745,756,762,764,
765,766,768,769,770,772,773,814
4 red 12.84 407.7 403 0.6077 0.7354 0.01449
Deacetylases HDAC8[a] Q9BY41[a] Catalytic domain 5THT a/27,30,31,32,33,101,102,103,
105,106,107,108,111,152,154
4 red a/C102(0.01) 8.221 172 181 0.6971 0.8606 0.07369
Deacetylases HDAC4[g] P56524[g] Catalytic domain 5ZOO g/665,666,667,669,670,671,672,
675,676,677,678,679,759,760,761,
798,799,812
4 red g/C667(reactive:0.77),
g/C669(reactive:0.75)
7.21 163.3 209.2 0.6301 0.874 -0.06418
Deacetylases HDAC1[c],MIDEAS[d] Q13547[c],
Q6PJG2[d]
Catalytic domain 6Z2J c/18,21,22,23,24,25,26,81,101,
102,103,104,105; d/850,851,852,
853,863,864,865,868
4 red 17.4 438.4 379.1 0.6274 0.7804 0.2901
Deacetylases HDAC4[a] P56524[a] Catalytic domain 4CBY a/936,937,938,949,950,951,954,
955,977,979,980,983,986,987,990,
991,995,996,997,998
4 yellow 19.01 235.1 277 0.5756 0.7878 -0.2585
Deacetylases HDAC1[c] Q13547[c] Catalytic domain 6Z2J c/279,282,283,286,314,317,318,
321,322,323,324,325,326,344
4 yellow 23.93 172.5 214.1 0.5328 0.7231 -0.839
Demethylases KDM4C[a] Q9H3R0[a] Catalytic domain 4XDO a/195,215,216,218,219,275,301,
304,305,306,342,343,345
4 blue 7.033 165.4 182.8 0.6262 0.7723 -0.4644
Demethylases KDM4A[c],KDM4A[d] O75164[c],
O75164[d]
Catalytic domain 5LY1 c/77,78,79,80,82,119,122,123,
125,126,127,246,248,249,
252; d/77,78,79,80,82,118,119,
122,123,125,126,127,209,246,247,
248,249,259
4 blue 12.29 401.5 503.9 0.4602 0.6125 -0.8156
Demethylases KDM4A[a] O75164[a] Catalytic domain 5LY1 a/294,295,297,298,299,324,325,
328,339,340,341,342,345,346,347,
348,350,351,354
4 blue 12.93 228.1 258 0.488 0.6915 -0.8591
Demethylases KDM4A[c] O75164[c] Catalytic domain 5LY1 c/48,49,50,51,53,54,55,59,199,
201,264,265,266
4 blue 11.73 162.7 171.8 0.5211 0.7516 -0.7963
Demethylases KDM4A[c],KDM4A[d] O75164[c],
O75164[d]
Catalytic domain 5LY2 c/76,77,78,81,82,83,85,226,227,
230,237,240,242,243; d/72,105,
106,127,128,129
4 blue 8.038 303.5 296.9 0.5606 0.829 0.05877
Deubiquitinases USP4[c],USP4[d],USP4[f] Q13107[c],
Q13107[d],
Q13107[f]
Catalytic domain IPR001394[d],
IPR001394[f]
Peptidase C19, ubiquitin carboxyl-terminal hydrolase[d],Peptidase C19, ubiquitin carboxyl-terminal hydrolase[f] 2Y6E c/877; d/354,357,358,361,370,
371,372,373,374,375; f/350,353,
354,357,374,378,381
4 Pocket DU3 black 12.7 226.4 234.4 0.5571 0.7916 -0.3133
Deubiquitinases USP4[b],USP4[c] Q13107[b],
Q13107[c]
Catalytic domain IPR001394[c] Peptidase C19, ubiquitin carboxyl-terminal hydrolase[c] 2Y6E b/350,353,354,357,374,
378; c/357,358,361,371,372,373,
374,375
4 Pocket DU3 black 12.7 179.6 193.2 0.4872 0.7023 -0.9946
Deubiquitinases USP4[a],USP4[b],USP4[c] Q13107[a],
Q13107[b],
Q13107[c]
Catalytic domain IPR001394[b] Peptidase C19, ubiquitin carboxyl-terminal hydrolase[b] 2Y6E a/877; b/354,357,358,361,370,
371,372,373,374,375; c/348,350,
374,378,381
4 Pocket DU3 black 11.87 169.6 191.6 0.4693 0.7558 -0.8667
Deubiquitinases USP7[a] Q93009[a] Catalytic domain IPR001394[a] Peptidase C19, ubiquitin carboxyl-terminal hydrolase[a] 5J7T a/217,259,262,263,265,266,270,
272,273,274,275,276,277,278,279,
544,547,548,551
4 Pocket DU3 black 7.305 337.1 278.4 0.6438 0.871 0.4905
Deubiquitinases USP25[a1] Q9UHP3[a1] Catalytic domain 6H4J a1/224,227,228,231,237,239,240,
241,242,243,244,245,688,691,692
4 Pocket DU3 black 12.6 248.1 268.7 0.5234 0.6681 -0.8087
Deubiquitinases USP28[b] Q96RU2[b] Catalytic domain 6HEJ b/217,220,221,224,228,230,232,
233,234,235,237,238,680,684
4 Pocket DU3 black 12.29 208.8 222.1 0.627 0.8312 -0.05852
Deubiquitinases MINDY1[a],RPS27A(bovin)[d] Q8N5J2[a],
P62992[d]
Catalytic domain 5JQS a/240,258,265,266,269,270,284,
287,288,291,293; d/6,7,8,68,69
4 blue 9.41 237.1 282.9 0.6022 0.7196 -0.4602
Deubiquitinases MINDY1[a] Q8N5J2[a] Catalytic domain IPR033979[a] MINDY deubiquitinase domain[a] 5JQS a/218,219,220,222,226,229,230,
233,234,235,236
4 blue a/C226(reactive:0.745) 11.46 192.6 197.2 0.5774 0.7564 -0.5249
Deubiquitinases MINDY1[a] Q8N5J2[a] Catalytic domain 5JQS a/118,124,125,126,127,150,152,
153,154,155,156
4 blue 17.459999 177.1 197.6 0.6203 0.7696 -0.4377
Deubiquitinases UCHL5[a] Q9Y5K5[a] Catalytic domain IPR033837[a] Ubiquitinyl hydrolase-L5[a] 4UF5 a/14,15,16,19,20,23,31,32,33,34,
36,226,228,274,275,277,278,279,
281,282
4 blue 15.25 301.1 304.5 0.6983 0.8277 0.3602
Deubiquitinases UCHL5[a],NFRKB[b] Q9Y5K5[a],
Q6P4R8[b]
Catalytic domain IPR033837[a] Ubiquitinyl hydrolase-L5[a] 4WLP a/14,15,16,19,20,23,31,32,33,34,
35,36,37,42,45,46,226,228,274,
277,278,280,281,284,288; b/97
4 blue 15.16 501.6 490.2 0.6364 0.8333 0.6185
Deubiquitinases UCHL5[a1],NFRKB[b1] Q9Y5K5[a1],
Q6P4R8[b1]
Catalytic domain IPR001578[a1] Peptidase C12, ubiquitin carboxyl-terminal hydrolase[a1] 4WLP a1/37,38,39,201,205,208,209,211,
212,215,216,217,218,288,289,290,
291,292,293,296; b1/97,98,99,
100,101,103,106,107,110
4 blue 12.11 403.8 442.5 0.5064 0.6821 -0.4327
Deubiquitinases USP7[a] Q93009[a] Catalytic domain IPR001394[a] Peptidase C19, ubiquitin carboxyl-terminal hydrolase[a] 1NBF a/224,256,283,285,294,295,298,
299,302,303,306
4 blue 8.19 177.6 187.1 0.6836 0.7284 -0.4541
Deubiquitinases USP7[a] Q93009[a] Catalytic domain IPR001394[a] Peptidase C19, ubiquitin carboxyl-terminal hydrolase[a] 1NBF a/211,213,470,471,472,474,475,
476,477,478,487,488,489,490
4 blue a/C478(reactive:0.805),
a/C488(reactive:0.61)
11.08 164.2 194.6 0.4625 0.7565 -0.9033
Deubiquitinases USP8[a],UBC[b] P40818[a],
P0CG48[b]
Catalytic domain IPR001394[a] Peptidase C19, ubiquitin carboxyl-terminal hydrolase[a] 3N3K a/932,934,935,936,941,942,943,
945,947,983,984,985,986,987,994,
996; b/11,13,15,16,29,32,33,34
4 blue a/C936(reactive:0.665),
a/C985(reactive:0.555)
29.4 321.7 352 0.4845 0.7475 -0.3923
Deubiquitinases USP8[a],UBC[b] P40818[a],
P0CG48[b]
Catalytic domain IPR001394[a] Peptidase C19, ubiquitin carboxyl-terminal hydrolase[a] 3N3K a/868,870,871,953,1010,1012,
1013,1014,1015; b/70,71,72,73,
74
4 blue 12.37 164.8 165.2 0.505 0.7625 -0.7806
Deubiquitinases USP7[a],USP7[a1],USP7[a2],USP7[a3] Q93009[a],
Q93009[a1],
Q93009[a2],
Q93009[a3]
Catalytic domain IPR001394[a1],
IPR001394[a2]
Peptidase C19, ubiquitin carboxyl-terminal hydrolase[a1],Peptidase C19, ubiquitin carboxyl-terminal hydrolase[a2] 5JTJ a/502,503,504,505; a1/354,355,
356,357,358,410,419,420,421,422,
423,424,425,500,509; a2/354,355,
356,357,358,410,419,420,421,422,
423,424,425,500,509; a3/502,503,
504,505
4 blue 13.95 563.6 574.4 0.5581 0.8017 0.4024
Deubiquitinases USP12[a],WDR48[b] O75317[a],
Q8TAF3[b]
Catalytic domain IPR001394[a] Peptidase C19, ubiquitin carboxyl-terminal hydrolase[a] 5K1C a/188,189,191,235,236,237,
238; b/30,31,32,50,77,252,253,
256,272,273,274,275,296,298,317,
318,319,320,359,360,361,362,380,
381,424,425,427
4 blue 50.66 475.3 484.3 0.4735 0.7547 -0.1006
Deubiquitinases USP12[a],WDR48[b] O75317[a],
Q8TAF3[b]
Catalytic domain IPR001394[a] Peptidase C19, ubiquitin carboxyl-terminal hydrolase[a] 5K1C a/183,184,185,192,222,243,244,
245,247; b/188,190,211,212
4 blue 36.23 197.9 209.7 0.5352 0.8016 -0.4227
Deubiquitinases USP7[a],USP7[b] Q93009[a],
Q93009[b]
Catalytic domain IPR001394[a],
IPR001394[b]
Peptidase C19, ubiquitin carboxyl-terminal hydrolase[a],Peptidase C19, ubiquitin carboxyl-terminal hydrolase[b] 5VSB a/430,432,434,439,440,442,443,
445,447; b/249,250,251,254,255,
256,257,281,282,283,284,285,302,
306,309,310,312
4 blue 12.15 450.9 467.6 0.538 0.7878 0.137
Deubiquitinases USP15[a] Q9Y4E8[a] Catalytic domain IPR001394[a] Peptidase C19, ubiquitin carboxyl-terminal hydrolase[a] 6GHA a/324,325,326,327,328,329,397,
398,400
4 blue 27.129999 182.7 187.5 0.5394 0.8106 -0.4368
Deubiquitinases USP25[a],USP25[a1] Q9UHP3[a],
Q9UHP3[a1]
Catalytic domain IPR001394[a],
IPR001394[a1]
Peptidase C19, ubiquitin carboxyl-terminal hydrolase[a],Peptidase C19, ubiquitin carboxyl-terminal hydrolase[a1] 6H4J a/431,434,435,438,439,440,441,
445; a1/457,460,461,462,530,531,
532,533,534,535,536
4 blue 34.860001 304.7 322.1 0.4617 0.6991 -0.6746
Deubiquitinases ATG4A[a],ATG4A[b] Q8WYN0[a],
Q8WYN0[b]
Catalytic domain 2P82 a/122,123,125,130,133,134,136,
137,142,158,161; b/156,159,160,
162,163,166,167,168,169,185,188,
189,221
4 blue a/C125(reactive:0.785) 16.67 372.5 409.6 0.5376 0.7551 -0.1334
Deubiquitinases ATG4B[a] Q9Y4P1[a] Catalytic domain 2Z0D a/10,11,12,13,14,16,40,43,44,47,
48,98,99,100,302,303,304
4 blue 10.28 404.5 361 0.6551 0.7872 0.3203
Deubiquitinases ATG4B[a] Q9Y4P1[a] Catalytic domain 2Z0E a/336,337,339,340,342,345,346,
347,348,349,350,351
4 blue 23.33 185.2 214.3 0.649 0.7681 -0.3455
Deubiquitinases ATG4B[a] Q9Y4P1[a] Catalytic domain 2Z0E a/89,93,94,250,251,252,253,322,
323,324,328
4 blue a/C89(reactive:0.68),
a/C323(reactive:0.64)
17.08 162.2 164 0.5827 0.8028 -0.4571
Deubiquitinases ATG4B[a],MAP1LC3B[b] Q9Y4P1[a],
Q9GZQ8[b]
Catalytic domain 2ZZP a/229,232,233,260,314,315,
316; b/38,40,41,42,43,114,115,
116,117,118
4 blue 10.35 205.2 205 0.4986 0.7637 -0.6288
Deubiquitinases TNFAIP3[b] P21580[b] Catalytic domain 3ZJD b/48,49,51,52,53,54,55,56,264,
265,333,334,335,336,337,340,342,
343,346
4 blue b/C54(reactive:0.74) 17.5 225.2 276.7 0.5257 0.7331 -0.6192
Deubiquitinases TNFAIP3[b] P21580[b] Catalytic domain 3ZJD b/31,32,33,34,35,36,37,38,128,
129,132,133
4 blue 18.389999 170.6 162 0.6246 0.7684 -0.4604
Deubiquitinases TNFAIP3[b] P21580[b] Catalytic domain 3ZJG b/35,36,37,129,133,134,135,136,
137,138,237,238,239
4 blue 20.24 157.2 188.4 0.5535 0.7049 -0.9323
Deubiquitinases TNFAIP3[a] P21580[a] Catalytic domain 5LRX a/209,210,211,212,213,226,227,
228,229,230,231,277,279,284,285,
286,287
4 blue 10.2 231.7 207.9 0.5247 0.8036 -0.3225
Deubiquitinases TNFAIP3[a] P21580[a] Catalytic domain 5LRX a/144,145,148,286,287,288,289,
290,291,292,293,296,299
4 blue 19.190001 194.6 193.3 0.5244 0.8463 -0.2837
Deubiquitinases OTULIN[a] Q96BN8[a] Catalytic domain 3ZNV a/138,141,142,143,144,145,146,
147,148,199,299,300,324,326,327,
328
4 blue 14.93 279.3 269.3 0.6425 0.8078 0.09959
Deubiquitinases OTULIN[a],UBC[b] Q96BN8[a],
P0CG48[b]
Catalytic domain 3ZNZ a/254,255,256,259,292,296,320,
321,322; b/6,7,8,9,10
4 blue 17.620001 198.4 194.3 0.6302 0.818 -0.1407
Deubiquitinases OTULIN[a] Q96BN8[a] Catalytic domain 6I9C a/148,151,153,154,157,235,238,
239,242,296,297,299
4 blue 16.74 164.4 163.1 0.558 0.7681 -0.64
Deubiquitinases OTULIN[a],SNX27[c] Q96BN8[a],
Q96L92[c]
Catalytic domain 6SAK a/85,116,117,137,140,141,207,
208,209,212,329,330,331,343,344,
345,346; c/60,61,62,63,64
4 blue 12.82 323.1 354.8 0.4591 0.7107 -0.5917
Deubiquitinases OTULIN[a],SNX27[c] Q96BN8[a],
Q96L92[c]
Catalytic domain 6SAK a/87,88,89,92,93,97,107,110,111,
114,118,119; c/58,59,60,68,77,
78,80,97,98,100
4 blue a/C92(reactive:0.715) 13.67 248.1 281.9 0.5743 0.798 -0.1813
Deubiquitinases OTULIN[a] Q96BN8[a] Catalytic domain 6SAK a/169,171,172,173,174,175,177,
178,179,180,181,183,184,187
4 blue 12.08 173.6 202.1 0.5301 0.7795 -0.6184
Deubiquitinases ZUP1[a] Q96AP4[a] Catalytic domain 6EI1 a/275,279,283,300,303,304,307,
308,312,313,314,315,316,317,352,
353,363,389,390
4 blue a/C389(reactive:0.79) 10.05 266.3 248.4 0.5684 0.8789 0.1763
Deubiquitinases ZUP1[a] Q96AP4[a] Catalytic domain 6EI1 a/325,328,329,332,333,523,524,
525,526,527,528
4 blue 15.05 171 170 0.5519 0.8231 -0.4082
Deubiquitinases ZUP1[a],UBB[c] Q96AP4[a],
P0CG47[c]
Catalytic domain 6FGE a/427,442,444,547,549,572,573,
574,576; c/39,40,42,72,73
4 blue a/C427(reactive:0.63) 10.4 174.1 171.1 0.6156 0.9023 0.06204
Deubiquitinases ZUP1[a] Q96AP4[a] Catalytic domain 6FGE a/430,441,442,565,568,569,571,
572,573,574,575
4 blue 15.15 170.5 162.1 0.5644 0.8153 -0.4127
Deubiquitinases SENP2[a] Q9HC62[a] Catalytic domain IPR003653[a] Ulp1 protease family, C-terminal catalytic domain[a] 1TH0 a/468,483,485,487,488,492,534,
536,537,538,539,540,541,559,562,
563,564,565,566,567,568
4 blue 8.032 232 286.7 0.4859 0.7143 -0.7614
Deubiquitinases SENP1[a] Q9P0U3[a] Catalytic domain IPR003653[a] Ulp1 protease family, C-terminal catalytic domain[a] 2G4D a/457,458,460,461,462,463,599,
602,624,625,627,628,631,632,635
4 blue 7.154 213.1 251.2 0.5619 0.7058 -0.6851
Deubiquitinases SENP7[a] Q9BQF6[a] Catalytic domain IPR003653[a] Ulp1 protease family, C-terminal catalytic domain[a] 3EAY a/826,830,833,834,837,838,841,
959,963,964
4 blue 24.299999 167 195.7 0.5202 0.7212 -0.8991
Deubiquitinases USP14[a] P54578[a] Catalytic domain IPR001394[a] Peptidase C19, ubiquitin carboxyl-terminal hydrolase[a] 2AYN a/318,319,320,360,362,363,366,
408,410,413,414
4 Pocket DU1 cyan 29.32 165.9 176.1 0.5631 0.7934 -0.5224
Deubiquitinases USP7[c] Q93009[c] Catalytic domain 5FWI c/321,322,325,326,327,396,397,
398,399,400,437,439,440,441,444,
520,523
4 Pocket DU1 cyan 26.23 253.1 268.4 0.5467 0.7189 -0.5412
Deubiquitinases USP7[a] Q93009[a] Catalytic domain 5J7T a/321,322,325,326,327,396,397,
398,399,400,437,438,439,440,441,
444,446,520,523
4 Pocket DU1 cyan 26.219999 365.2 346.8 0.5466 0.7585 -0.1145
Deubiquitinases USP15[a] Q9Y4E8[a] Catalytic domain IPR001394[a] Peptidase C19, ubiquitin carboxyl-terminal hydrolase[a] 6GH9 a/416,419,420,423,435,436,439,
440,441,825,826,827,828,829,865,
867,869,870,871,872,873
4 Pocket DU1 cyan 24.91 249.6 298.1 0.5275 0.7074 -0.6401
Deubiquitinases USP28[a],UBA52[c] Q96RU2[a],
P62987[c]
Catalytic domain 6H4H a/268,289,290,293,294,295,309,
310,311,312,358,359,360,361,398,
400,582,584,649,651,652; c/45,
46,48,59,60,61,62,63,64,65
4 Pocket DU1 cyan 22.49 446.3 535.6 0.4744 0.6776 -0.449
Deubiquitinases USP28[a] Q96RU2[a] Catalytic domain IPR001394[a] Peptidase C19, ubiquitin carboxyl-terminal hydrolase[a] 6H4I a/154,156,157,160,161,162,163,
231,232,619,620,621,622,623
4 Pocket DU4 darkblue 11.94 198.6 208.6 0.5254 0.6938 -0.8669
Deubiquitinases USP25[a1] Q9UHP3[a1] Catalytic domain IPR001394[a1] Peptidase C19, ubiquitin carboxyl-terminal hydrolase[a1] 6H4J a1/159,160,162,163,164,167,168,
169,170,238,626,627,628,629
4 Pocket DU4 darkblue 11.72 186 193.8 0.5967 0.7991 -0.339
Deubiquitinases USP14[b] P54578[b] Catalytic domain IPR001394[b] Peptidase C19, ubiquitin carboxyl-terminal hydrolase[b] 2AYN b/291,294,295,314,315,316,356,
357,358,359,361,364
4 Pocket DU5 green b/C359(0.24) 28.959999 170.8 178.5 0.6384 0.7964 -0.3175
Deubiquitinases USP46[b] P62068[b] Catalytic domain IPR001394[b] Peptidase C19, ubiquitin carboxyl-terminal hydrolase[b] 5CVN b/209,212,213,216,217,243,244,
247,280,281,282,283,285
4 Pocket DU5 green 24.93 256.1 220.6 0.6448 0.7872 -0.04048
Deubiquitinases USP12[a] O75317[a] Catalytic domain IPR001394[a] Peptidase C19, ubiquitin carboxyl-terminal hydrolase[a] 5L8W a/213,216,217,220,221,245,247,
248,251,281,283,284,285,286,287,
288,289,299
4 Pocket DU5 green 24.559999 344 313.3 0.5683 0.7707 -0.06117
Deubiquitinases USP25[a] Q9UHP3[a] Catalytic domain IPR001394[a] Peptidase C19, ubiquitin carboxyl-terminal hydrolase[a] 5O71 a/331,332,334,335,338,339,396,
398,399,400,403,419,423,574,577,
578,580,581,582,586,587
4 Pocket DU5 green 20.74 333.7 344.9 0.4748 0.7216 -0.4895
Deubiquitinases USP28[b] Q96RU2[b] Catalytic domain IPR001394[b] Peptidase C19, ubiquitin carboxyl-terminal hydrolase[b] 6HEJ b/325,327,328,331,389,391,392,
393,396,412,416,570,571,572,573,
574,575,579,580
4 Pocket DU5 green b/C575(reactive:0.74) 25.27 342.2 344.4 0.4598 0.723 -0.4995
Deubiquitinases USP7[a] Q93009[a] Catalytic domain IPR001394[a] Peptidase C19, ubiquitin carboxyl-terminal hydrolase[a] 2F1Z a/208,212,213,214,230,233,234,
236,239,267,268,269,471,472,480,
485,524,525,528,529,530,531,533
4 Pocket DU6 orange 7.932 331.1 372.1 0.524 0.7264 -0.3647
Deubiquitinases USP25[a] Q9UHP3[a] Catalytic domain IPR018200[a] Ubiquitin specific protease, conserved site[a] 6H4J a/397,398,592,593,594,613,615,
618,619,620,632,633,655,656,657,
659,660,663
4 Pocket DU6 orange 16.17 204 261.4 0.53 0.7468 -0.6282
Deubiquitinases USP28[a] Q96RU2[a] Catalytic domain IPR001394[a] Peptidase C19, ubiquitin carboxyl-terminal hydrolase[a] 6HEK a/156,159,161,162,178,181,182,
183,184,187,225,226,585,586,587,
605,606,607,608,609,610,616,648,
665,666,667,669
4 Pocket DU6 orange 11.52 508.2 437.1 0.5487 0.8465 0.4809
Deubiquitinases USP14[a] P54578[a] Catalytic domain IPR001394[a] Peptidase C19, ubiquitin carboxyl-terminal hydrolase[a] 6IIM a/104,121,124,125,127,130,323,
419,421,440,441,442,443,448,450,
481,482,483,484
4 Pocket DU6 orange 11.05 315.7 322.9 0.5026 0.6972 -0.5634
Deubiquitinases UCHL1[a] P09936[a] Catalytic domain IPR001578[a] Peptidase C12, ubiquitin carboxyl-terminal hydrolase[a] 3KW5 a/71,72,73,75,76,77,78,79,80,81,
100,101,102,103,104,105,118,119,
122,124,125,126,129,166,167,168,
169,170,181,182,190
4 Pocket DU7 red 7.727 489 525.3 0.4674 0.702 -0.3014
Deubiquitinases UCHL5[a] Q9Y5K5[a] Catalytic domain IPR033837[a] Ubiquitinyl hydrolase-L5[a] 3RIS a/40,43,44,47,48,49,50,74,75,76,
77,78,79,98,99,100,101,102,115,
119,120,121,122,123,126,170,171,
172,193,194,195,196,197,198
4 Pocket DU7 red a/C100(reactive:0.89) 8.659 479.5 539.6 0.526 0.8183 0.2755
Deubiquitinases ATG4B[a] Q9Y4P1[a] Catalytic domain 2D1I a/150,153,167,168,169,170,171,
173,174,175,178,355,357,360,361,
362
4 red a/C361(reactive:0.64) 20.15 171.4 183.9 0.4777 0.7158 -0.9979
Deubiquitinases ATG4A[a],ATG4A[b] Q8WYN0[a],
Q8WYN0[b]
Catalytic domain 2P82 a/137,138,139,153,156,157,170,
171,172,173,174,176,178,181,185,
355,356; b/137,138,139,153,156,
157,170,171,172,173,174,176,178,
181,185,355,356
4 red 17.49 515.5 496.7 0.4908 0.7307 -0.09633
Deubiquitinases ATG4B[a],MAP1LC3B(rat)[b] Q9Y4P1[a],
Q62625[b]
Catalytic domain 2Z0E a/150,153,167,168,169,170,171,
173,175,178; b/61,64,65,75,76,
91
4 red 19.110001 226.9 258.1 0.5274 0.7237 -0.6467
Deubiquitinases ATG4B[a],MAP1LC3B[b] Q9Y4P1[a],
Q9GZQ8[b]
Catalytic domain 2ZZP a/134,135,137,144,145,146,147,
150; b/43,44,73,74,76,77,78,115,
116,117,118
4 red 10.1 326.4 287.9 0.5798 0.8587 0.2727
Deubiquitinases USP14[c] P54578[c] Catalytic domain IPR001394[c] Peptidase C19, ubiquitin carboxyl-terminal hydrolase[c] 2AYN c/128,131,132,133,135,136,137,
214,215,216,217,218,242
4 Pocket DU2 yellow 22.389999 281.7 253.7 0.608 0.7339 -0.2638
Deubiquitinases USP7[a] Q93009[a] Catalytic domain IPR001394[a] Peptidase C19, ubiquitin carboxyl-terminal hydrolase[a] 5J7T a/243,244,245,246,247,248,261,
314,537,539,540,543
4 Pocket DU2 yellow 24.01 181.1 174.6 0.6639 0.8246 -0.1054
Deubiquitinases USP7[a],USP7[b] Q93009[a],
Q93009[b]
Catalytic domain IPR001394[a],
IPR001394[b]
Peptidase C19, ubiquitin carboxyl-terminal hydrolase[a],Peptidase C19, ubiquitin carboxyl-terminal hydrolase[b] 6F5H a/237,241,243,244,245,246,247,
248,261,313,314,315,316,317,318,
319,322,537,539,540,543; b/244,
245,246,265,269,313,314,315,533,
534,536,537,538,539,541
4 Pocket DU2 yellow a/C315(reactive:0.605),
b/C315(reactive:0.67)
23.030001 637.5 622.5 0.5534 0.7635 0.332
Deubiquitinases USP28[a] Q96RU2[a] Catalytic domain IPR001394[a] Peptidase C19, ubiquitin carboxyl-terminal hydrolase[a] 6H4H a/187,188,191,192,193,194,195,
196,197,199,200,216,219,220,226,
669,672,673,674,676,677
4 Pocket DU2 yellow 20.91 381.3 388 0.5736 0.7894 0.1004
Glycosidases MAN1B1[a] Q9UKM7[a] Catalytic domain 5KIJ a/608,609,612,673,674,675,676,
680,681,682
4 blue 14.88 180.6 215.8 0.5677 0.763 -0.5685
Glycosidases OGA[a],OGA[b],OGA[c],OGA[d] O60502[a],
O60502[b],
O60502[c],
O60502[d]
Catalytic domain 5UHK a/70,71,72,73,74,77,288,289,316,
317,318; b/638,639,640,641,642,
643; c/70,71,72,73,74,77,288,
289,316,317,318; d/638,639,640,
641,642,643,646
4 blue a/C316(reactive:0.675),
c/C316(reactive:0.68)
14.63 637.9 601.2 0.5464 0.8485 0.6516
Glycosidases OGA[a],OGA[b] O60502[a],
O60502[b]
Catalytic domain 6HKI a/288,289,290,291,292,564,565,
566,567,568,569,570,571,642,643,
646,647,650,682,683; b/288,289,
642,643,681,682,683,684,685,686,
687,688,690,691
4 blue 17.809999 615 546.3 0.6905 0.9489 1.347
Glycosidases OGA[a],OGA[b] O60502[a],
O60502[b]
Catalytic domain 6HKI a/579,583,586,682,690,691,693,
694,695,696,698,699,701,
702; b/677,679,680,688,691,692,
693,694,695,701
4 blue 22.540001 469.5 384.6 0.6155 0.8944 0.7631
Glycosidases OGA[a],OGA[b] O60502[a],
O60502[b]
Catalytic domain 6HKI a/638,639,640,641,642,643; b/70,
71,72,73,74,77,289,316,317,318
4 blue b/C316(reactive:0.675) 13.54 271.4 267.3 0.5339 0.7818 -0.2708
Glycosidases OGA[a] O60502[a] Catalytic domain 6HKI a/91,123,126,127,130,131,132,
133,165,166,167,168
4 blue a/C166(0.03) 22.959999 169.2 174.7 0.5252 0.7584 -0.7314
Glycosidases OGA[a],OGA[g] O60502[a],
O60502[g]
Catalytic domain 6PM9 a/105,106,108,109,142; g/626,
629,630,631,634,645,648
4 blue g/C631(reactive:0.755) 13.32 177.6 190.2 0.4805 0.7327 -0.8983
Glycosyltransferases ST8SIA3[a] O43173[a] Catalytic domain 5BO7 a/185,188,190,191,192,193,194,
195,198,203,204,205,206,208,214,
218,219,234,237,238,239,240,241,
242,274
4 blue 10.44 496.7 492.1 0.5199 0.7648 0.0767
Glycosyltransferases ST8SIA3[a] O43173[a] Catalytic domain 5BO7 a/118,146,147,148,149,150,151,
153,264,267,268,269,270,271,273,
274,275
4 blue 23.75 211.5 232.9 0.4891 0.6884 -0.9242
Glycosyltransferases B3GAT3[a],B3GAT3[b] O94766[a],
O94766[b]
Catalytic domain 1KWS a/90,94,97,98,101,123,124,127,
128; b/200,201,202
4 blue 12.02 159.7 174 0.5246 0.7426 -0.8375
Glycosyltransferases B3GAT1[a] Q9P2W7[a] Catalytic domain 1V84 a/182,183,184,185,186,187,188,
189,190,209,210,211,212,261,262,
263,266
4 blue 18.049999 172.8 216 0.5343 0.7563 -0.7033
Glycosyltransferases B3GAT2[a],B3GAT2[b] Q9NPZ5[a],
Q9NPZ5[b]
Catalytic domain 2D0J a/191,192,193,295,297,299; b/95,
99,102,103,106,128,129,131,132,
133,134
4 blue 11.47 343.5 295.7 0.5746 0.8566 0.2902
Glycosyltransferases POFUT2[a],POFUT2[b] Q9Y2G5[a],
Q9Y2G5[b]
Catalytic domain 4AP5 a/88,89,91,92,98,99,100,101,177,
178,181,183; b/89,91,92,98
4 blue 10.65 157.1 194.6 0.5944 0.7625 -0.6127
Glycosyltransferases POFUT2[a] Q9Y2G5[a] Catalytic domain 4AP6 a/225,228,234,305,384,385,386,
387,390,391,392,394,395,408,410,
416,419,420,421,422,423,425
4 blue 10.35 337.6 358.1 0.6115 0.7682 0.01301
Methyltransferases SETD7[a] Q8WTS6[a] Catalytic domain 4J7I a/118,130,131,132,133,134,140,
141,142,143,144,156,179,180,181,
182
4 blue 19.950001 213.1 232.7 0.4557 0.7069 -0.9214
Methyltransferases PRMT3[a1] O60678[a1] Catalytic domain 4HSG a1/232,235,236,237,238,406,476,
477,478,479,481
4 blue 8.62 184.3 185.7 0.5273 0.7258 -0.7922
Methyltransferases CARM1[a],CARM1[b] Q86X55[a],
Q86X55[b]
Catalytic domain 5DXJ a/144,145,148,333,336,337,445,
470,471; b/147,148,151,152,154,
155,157,158,217,221
4 blue 8.131 316.3 364.8 0.4821 0.7252 -0.4983
Methyltransferases PRMT3[a] O60678[a] Catalytic domain 4QQN a/486,487,488,489,491,519,520,
521,522,524,525,526,528
4 yellow 18.540001 199.2 180.5 0.6339 0.9419 0.3588
Methyltransferases PRMT8[a1],PRMT8[b1] Q9NR22[a1],
Q9NR22[b1]
Catalytic domain 4X41 a1/252,255,256,341,342,343,344,
346,387,389,390,391; b1/346,347,
348,349,350,351,352,353,378,379,
380,381,382,383,385
4 yellow b1/C383(reactive:0.74) 17.65 428.7 432.1 0.6278 0.8867 0.6933
Protein Kinases CDK5[a],CDK5R1[d] Q00535[a],
Q15078[d]
Catalytic domain IPR000719[a] Protein kinase domain[a] 1UNL a/125,147,149,155,156,157,158,
159,160,161,177; d/191,192,193,
194,195,197,200,234,237,238,239,
240,241,243
4 Pocket PKI4 blue a/C157(reactive:0.71) 7.282 395.8 383.2 0.5051 0.8712 0.2947
Protein Kinases PDK3[a1] Q15120[a1] Catalytic domain 1Y8N a1/170,171,174,175,178,179,180,
181,183,184,185,186,237,238,239
4 blue 7.268 227.4 250.5 0.4896 0.6794 -0.9054
Protein Kinases CDK6[a],CDKN2C[b] Q00534[a],
P42773[b]
Catalytic domain IPR000719[a] Protein kinase domain[a] 1G3N a/38,39,80,99,100,101,102,154,
155; b/47,76,79,80,82,115
4 blue 18.18 238.5 225.9 0.5475 0.7438 -0.4851
Protein Kinases PDPK1[a],PDPK1[a1] O15530[a],
O15530[a1]
Catalytic domain 1H1W a/138,139,140,141,191,194,195,
198,199,337,347,348,349,350,351,
352; a1/74,75,77,81,101,102,103,
104,105
4 blue 13.61 328.1 341.2 0.4767 0.7692 -0.3102
Protein Kinases GSK3B[a] P49841[a] Catalytic domain 1I09 a/44,45,46,101,104,105,106,109,
110,111,112,113,114
4 blue 12.55 189.6 218.6 0.5144 0.7664 -0.6402
Protein Kinases TGFBR1[b],TGFBR1[c] P36897[b],
P36897[c]
Catalytic domain 1IAS b/182,183,186,187; c/184,185,
186,187,188,189,190,191,192,193,
194,195,198,249,250,251,252,253,
254,255,262,319,320,321,322,323,
324,325,326,327,357,359,360
4 blue 16.17 600.5 631.3 0.5318 0.7498 0.1847
Protein Kinases TGFBR1[d] P36897[d] Catalytic domain 1IAS d/184,185,190,191,192,193,195,
198,249,250,253,254,255,262,315,
320,324,325,326
4 blue 16.48 291.7 323.1 0.6139 0.8052 0.05655
Protein Kinases TGFBR1[b] P36897[b] Catalytic domain IPR003605[b] GS domain[b] 1IAS b/177,178,181,227,228,229,281,
282,283,284,285,341,342,343
4 blue 18.23 175 197 0.4719 0.716 -0.9946
Protein Kinases CDK2[a],CCNA2[b] P24941[a],
P20248[b]
Catalytic domain IPR000719[a] Protein kinase domain[a] 1OL1 a/157,158,159,160,161,162,169,
173,174,176,177,178,208,
235; b/270
4 blue a/C177(reactive:0.595) 10.76 197.1 210.3 0.527 0.773 -0.5574
Protein Kinases MAPK1[a] P28482[a] Catalytic domain 1PME a/75,76,78,79,80,81,83,84,85,86,
87,105,106,164,353,354
4 blue 14.8 186.3 218.4 0.4515 0.7577 -0.8307
Protein Kinases BRAF[a],BRAF[b] P15056[a],
P15056[b]
Catalytic domain IPR001245[a],
IPR001245[b]
Serine-threonine[a],Serine-threonine[b] 1UWH a/511,515,530,585,586,588,589,
591; b/511,515,530,585,586,588,
589,591
4 blue 17.879999 211.8 201.9 0.6294 0.8978 0.2203
Protein Kinases MAPK14[a] Q16539[a] Catalytic domain IPR003527[a] Mitogen-activated protein (MAP) kinase, conserved site[a] 1WBN a/48,49,81,82,107,108,109,110,
111,129,132,133,136,157,158,159,
163,164,165,311,313,316
4 blue 9.296 281.5 325.2 0.4629 0.696 -0.7429
Protein Kinases MAPK6[a],MAPK6[b] Q16659[a],
Q16659[b]
Catalytic domain IPR000719[b] Protein kinase domain[b] 2I6L a/112,113,117,118,121,
162; b/190,191,192,193,194,195,
196,234,235
4 blue 7.849 199.2 176.7 0.5897 0.8846 0.03306
Protein Kinases SLK[a],SLK[a1] Q9H2G2[a],
Q9H2G2[a1]
Catalytic domain IPR000719[a1] Protein kinase domain[a1] 2JFL a/; a1/184,187,188,190,197,201,
202,204,206,208,209
4 blue a1/C204(reactive:0.73) 8.525 167.5 171.6 0.6346 0.8904 0.0291
Protein Kinases MAPK8[a] P45983[a] Catalytic domain IPR008271[a] Serine[a] 2NO3 a/64,65,68,69,72,150,172,174,
177,178,179,181,182,183,186,202,
343,344,346
4 blue 7.254 257.7 257.8 0.4878 0.8794 -0.0289
Protein Kinases PLK1[a],PLK1[a1] P53350[a],
P53350[a1]
Catalytic domain IPR000719[a],
IPR000719[a1]
Protein kinase domain[a],Protein kinase domain[a1] 2OWB a/209,210,211,213,214,215,218,
222,223,225,228,257,260,
261; a1/209,210,211,213,214,215,
218,222,223,225,228,257,260,261
4 blue 7.73 497.3 436.8 0.7291 0.9204 1.166
Protein Kinases VRK1[a] Q99986[a] Catalytic domain IPR000719[a] Protein kinase domain[a] 2RSV a/97,100,101,104,105,106,107,
108,112,132,133,156,159,160,163,
186,189,192,194,321,325,335,336,
337
4 blue 13.91 488.4 533 0.4683 0.7154 -0.2472
Protein Kinases VRK1[a] Q99986[a] Catalytic domain 2RSV a/15,16,17,18,19,24,25,26,28,38,
58,59,60,61,62
4 blue 31.93 213.1 239.4 0.5565 0.74 -0.5625
Protein Kinases VRK1[a] Q99986[a] Catalytic domain IPR000719[a] Protein kinase domain[a] 2RSV a/99,103,105,108,162,163,166,
167,170,317,318,321
4 blue 13.37 183.6 191.6 0.7361 0.9076 0.3954
Protein Kinases DMPK[a],DMPK[a1] Q09013[a],
Q09013[a1]
Catalytic domain IPR000719[a1] Protein kinase domain[a1] 2VD5 a/45,46,49,50,53,56,57; a1/17,
18,19,20,21,23,24,107,108,111,
112,114,115,116,117,118,120,124,
125,218,398,399,400,401,402,404,
405
4 blue a1/C115(reactive:0.72) 11.65 628.7 576.5 0.5545 0.7699 0.3496
Protein Kinases STRADA[e],STK11[f] Q7RTN6[e],
Q15831[f]
Catalytic domain IPR039154[f] Serine[f] 2WTK e/218,219,220,222,227,229,230,
231,232,233,234,235,236,237,238,
251; f/71,73,74,75,130,131,185,
186,187
4 blue f/C73(reactive:0.775) 19.33 398.3 447.8 0.4541 0.674 -0.5931
Protein Kinases CAB39[d],STK11[f] Q9Y376[d],
Q15831[f]
Catalytic domain IPR039154[f] Serine[f] 2WTK d/154,194,195,196,197,
198; f/107,108,162,165,166,300,
301,304,305
4 blue 15.73 284.1 279.6 0.499 0.7551 -0.4213
Protein Kinases DAPK1[a],CALM3[b] P53355[a],
P0DP25[b]
Catalytic domain IPR000719[a] Protein kinase domain[a] 2X0G a/21,22,23,24,25,26,45,54,310,
311,314; b/15,16,17,18,19,21,22,
23,24,35,36,39,112,113,114,115
4 blue 8.828 460.3 441.2 0.5625 0.7239 -0.04391
Protein Kinases PDPK1[a],PDPK1[a1] O15530[a],
O15530[a1]
Catalytic domain 2XCK a/139,140,141,191,194,195,198,
199,337,347,348,349,350,
351; a1/100,101,102,103,104,105
4 blue 13.51 314.5 310 0.5191 0.77 -0.2419
Protein Kinases MAPK1[a] P28482[a] Catalytic domain 2Y9Q a/73,76,77,78,79,139,325,326,
327,328,329,330,350,353
4 blue 16.440001 234.6 279.6 0.4714 0.7306 -0.7217
Protein Kinases MAPK14[a] Q16539[a] Catalytic domain 2YIX a/73,75,76,77,78,79,80,81,83,84,
85,86,87,106,107,165,321,323,
324,348,349,351
4 blue 9.181 264.4 331.8 0.4916 0.7332 -0.5775
Protein Kinases MAP2K4[a],MAP2K4[a1] P45985[a],
P45985[a1]
Catalytic domain IPR000719[a],
IPR000719[a1]
Protein kinase domain[a],Protein kinase domain[a1] 3ALO a/110,113,114,115,132,133,134,
173; a1/110,113,114,115,132,133,
134,173
4 blue 9.245 207.8 207.9 0.6046 0.7681 -0.3614
Protein Kinases GRK2[a] P25098[a] Catalytic domain IPR000961[a] AGC-kinase, C-terminal[a] 3CIK a/37,66,67,69,70,74,169,170,172,
173,176,526,527,530,531,534,537,
538
4 blue 38.389999 244.1 286.3 0.4813 0.7299 -0.6729
Protein Kinases OXSR1[a],OXSR1[b] O95747[a],
O95747[b]
Catalytic domain 3DAK a/128,132,135,136,139,283,286,
287,288,291,292; b/128,132,135,
136,139,283,286,287,288,291,292
4 blue 13.98 452.7 441.4 0.5006 0.7596 -0.05598
Protein Kinases CDK2[c],CCNA2(bovin)[d] P24941[c],
P30274[d]
Catalytic domain IPR000719[c] Protein kinase domain[c] 3DDP c/122,151,152,153,155,157,
159; d/222,223,226,227,228,229,
230,234,267,268,307,308,309,312,
313,316,412,415,417,418
4 blue 14.7 390.6 408.5 0.5 0.8038 0.00806
Protein Kinases MAPK9[a] P45984[a] Catalytic domain 3E7O a/81,82,83,133,137,140,141,144,
313,316,317,322,325,329,330,331,
332,334
4 blue a/C137(reactive:0.895) 15.69 320 349.2 0.4542 0.7396 -0.4965
Protein Kinases HASPIN[a] Q8TF76[a] Catalytic domain IPR000719[a] Protein kinase domain[a] 3FMD a/552,553,554,555,631,634,635,
662,665,666,667,676,682,683
4 blue 14.23 187 184.9 0.6503 0.8911 0.1493
Protein Kinases ACVR1[a] Q04771[a] Catalytic domain IPR003605[a] GS domain[a] 3H9R a/180,184,194,230,231,232,258,
259,260,262,263,264,265,266,284,
285,286,287,288,345,346,347,351
4 blue a/C351(reactive:0.7) 13.72 284.5 372.1 0.47 0.6747 -0.8028
Protein Kinases AURKA[a],TPX2[b],AURKA[a1] O14965[a],
Q9ULW0[b],
O14965[a1]
Catalytic domain IPR000719[a1] Protein kinase domain[a1] 3HA6 a/175,179,183; b/6,7,8,9,10,11,
38; a1/287,288,289,299,300,301,
302,303,304,305,306,338
4 blue 9.624 328.2 307.7 0.5876 0.8828 0.3898
Protein Kinases GRK2[a] P25098[a] Catalytic domain IPR000719[a] Protein kinase domain[a] 3KRW a/52,57,59,60,61,62,65,86,87,90,
91,94,178,215,216,217,250,258,
272,273,275,326,332,514,515,516,
518,519,520,523
4 blue 18.17 514.5 613 0.5117 0.6774 -0.26
Protein Kinases GRK2[a] P25098[a] Catalytic domain 3KRX a/249,250,251,252,253,303,306,
307,310,311,448,458,459,462
4 blue a/C251(reactive:0.87) 15.11 198.8 218.3 0.5513 0.7244 -0.6874
Protein Kinases CDK16[a],CDK16[a1] Q00536[a],
Q00536[a1]
Catalytic domain IPR000719[a1] Protein kinase domain[a1] 3MTL a/214,215,216,217; a1/213,216,
217,218,219,223,224,225,226,240
4 blue 14.62 170 160.9 0.58 0.8309 -0.3179
Protein Kinases ROCK1[a] Q13464[a] Catalytic domain 3NDM a/333,334,335,336,338,339,340,
343,344,345
4 blue 19.26 176.3 183.7 0.5972 0.7085 -0.7342
Protein Kinases GRK6[a] P43250[a] Catalytic domain IPR000961[a] AGC-kinase, C-terminal[a] 3NYN a/39,66,69,165,166,168,169,172,
525,526,527
4 blue 40.580002 232.6 231.6 0.6884 0.8229 0.1282
Protein Kinases GRK6[a] P43250[a] Catalytic domain 3NYN a/285,286,289,290,413,414,415,
446,447,448,449,450,451,461,462,
463,464
4 blue 21.6 220 245.7 0.4954 0.6956 -0.8528
Protein Kinases GRK6[a] P43250[a] Catalytic domain IPR000719[a] Protein kinase domain[a] 3NYO a/32,33,34,35,36,37,38,41,172,
175,176,177,179,180,181,182,184,
185,205,206,207,208,251,506,511,
515
4 blue 27.200001 394.9 430.3 0.5359 0.7337 -0.1784
Protein Kinases MAPK10[a] P53779[a] Catalytic domain IPR003527[a] Mitogen-activated protein (MAP) kinase, conserved site[a] 3PTG a/106,109,110,113,376,377,380,
381,382,383,385,390,393
4 blue 14.71 167.9 163 0.811 0.9313 0.5929
Protein Kinases ACVR1[a],ACVR1[b] Q04771[a],
Q04771[b]
Catalytic domain IPR008271[a],
IPR001245[b]
Serine[a],Serine-threonine[b] 3Q4U a/243,246,247,250,335,356,357,
358,359,370,371,372,373,374,
399; b/243,246,247,250,251,358,
359,360,361,362,365,367,368,369,
370,371,372,373
4 blue 7.26 610.3 586.2 0.5967 0.8703 0.8189
Protein Kinases CDK2[a] P24941[a] Catalytic domain IPR000719[a] Protein kinase domain[a] 3QZH a/51,54,55,57,58,117,121,122,
123,147,150,151
4 blue 9.181 163.8 193.8 0.6293 0.7213 -0.6654
Protein Kinases MAPKAPK2[a2] P49137[a2] Catalytic domain 3R30 a2/49,50,51,52,53,55,109,110,
113,119,120,121,122,123
4 blue 12.86 210.2 230.7 0.4787 0.7669 -0.6431
Protein Kinases CASK[a],PPFIA2[b] O14936[a],
O75334[b]
Catalytic domain 3TAC a/112,114,116,117,120,279,285,
286; b/972,973,974,975,976,977,
978,979,980,981,982,987,990,991
4 blue 23.1 276.4 300.5 0.6837 0.9 0.5486
Protein Kinases CASK[a],PPFIA2[b] O14936[a],
O75334[b]
Catalytic domain 3TAC a/123,127,130,134,268,271,272,
277; b/1079,1082,1083,1085
4 blue 18.049999 177.1 225.1 0.4795 0.7251 -0.9329
Protein Kinases CDC42BPB[a],CDC42BPB[b] Q9Y5S2[a],
Q9Y5S2[b]
Catalytic domain IPR000961[b] AGC-kinase, C-terminal[b] 3TKU a/51,54,55,58; b/18,19,22,25,26,
29,121,122,125,126,130,396,397,
398,399,400,401,411
4 blue 13.14 293.7 329.7 0.5612 0.7645 -0.2185
Protein Kinases MAP3K5[a],MAP3K5[b] Q99683[a],
Q99683[b]
Catalytic domain IPR000719[a],
IPR000719[b]
Protein kinase domain[a],Protein kinase domain[b] 3VW6 a/884,885,886,888,889,892,
893; b/900,902,903,904,905,912,
916
4 blue 17.030001 221.5 200.9 0.6268 0.8422 0.02843
Protein Kinases GSK3B[a],GSK3B[b] P49841[a],
P49841[b]
Catalytic domain IPR039192[a],
IPR000719[b]
Glycogen synthase kinase 3, catalytic domain[a],Protein kinase domain[b] 3ZRM a/307,308,309,310,311,312,338,
339,341,342; b/273,274,275,276,
277,280,293,295,296,297,298,299,
300,301,302,318,319,321,322,323
4 blue 19.48 445.9 492.7 0.5046 0.7318 -0.1673
Protein Kinases PLK1[a],PLK1[a1] P53350[a],
P53350[a1]
Catalytic domain IPR000719[a] Protein kinase domain[a] 4A4O a/209,210,211,213,214,215,218,
222,223,225,228,260; a1/225,257,
260,261
4 blue 7.834 213.5 197.7 0.6246 0.9106 0.2655
Protein Kinases GSK3B[b] P49841[b] Catalytic domain 4ACG b/343,345,346,348,349,355,356,
357,358,359,360,361,362,378,381,
382,383,384
4 blue 24.32 273.8 278.6 0.4831 0.7262 -0.5985
Protein Kinases DYRK2[a] Q92630[a] Catalytic domain IPR000719[a] Protein kinase domain[a] 4AZF a/443,446,447,449,450,452,453,
456,457,458,460
4 blue 22.940001 192.9 194.2 0.6057 0.787 -0.3393
Protein Kinases CDK2[a],CCNA2[b] P24941[a],
P20248[b]
Catalytic domain IPR000719[a] Protein kinase domain[a] 4BCK a/50,54,122,150,151,152,153,154,
155,156,157,159; b/186,219,222,
223,226,227,228,229,230,232,234,
267,268,307,308,309,312,313,316,
334,412,415,417,418
4 blue 11.84 633.1 619.5 0.5754 0.8599 0.7566
Protein Kinases RIPK2[a],RIPK2[b] O43353[a],
O43353[b]
Catalytic domain IPR001245[b] Serine-threonine[b] 4C8B a/74,75,76,80,96; b/74,75,76,78,
80,82,96
4 blue 16.4 221.5 194.4 0.6486 0.8671 0.176
Protein Kinases MELK[a] Q14680[a] Catalytic domain IPR000719[a] Protein kinase domain[a] 4D2T a/35,36,37,71,73,87,88,141,142,
143,147,277,278,318,319,321,322,
325,326
4 blue 18.32 374.7 357.7 0.6102 0.8055 0.2343
Protein Kinases MELK[a] Q14680[a] Catalytic domain 4D2T a/67,68,111,114,115,118,145,267,
269,271,272,276
4 blue 16.73 185.5 170.8 0.5147 0.8219 -0.4371
Protein Kinases RPS6KA3[a],RPS6KA3[a1] P51812[a],
P51812[a1]
Catalytic domain IPR000719[a],
IPR000719[a1]
Protein kinase domain[a],Protein kinase domain[a1] 4D9T a/462,465,466,468,469,470,472,
567,569,575; a1/462,465,466,468,
469,470,472,567,569,575
4 blue 12.57 355.1 360.9 0.681 0.8635 0.5834
Protein Kinases ACVR1[a],ACVR1[a1] Q04771[a],
Q04771[a1]
Catalytic domain IPR001245[a] Serine-threonine[a] 4DYM a/252,253,254,255,256,257,258,
264,265,322,323,324,328,329,330,
360,361,362,364,365,367,
369; a1/272,275,276,277
4 blue 14.7 378.7 422.9 0.478 0.735 -0.3358
Protein Kinases BRAF[a],BRAF[b] P15056[a],
P15056[b]
Catalytic domain IPR000719[b] Protein kinase domain[b] 4e+26 a/456,458,475,476,477,478,479,
480,517,530,531,533,585,
586; b/510,511,512,558,559,562,
565,588,589,711,715
4 blue 18.469999 346.7 395.3 0.4588 0.7204 -0.5022
Protein Kinases TBK1[a],TBK1[b] Q9UHD2[a],
Q9UHD2[b]
Catalytic domain IPR000719[a] Protein kinase domain[a] 4EUT a/129,130,163,164,165,166,169,
170,196; b/43,46,47,48
4 blue 12.3 229.8 218.5 0.5966 0.7872 -0.2299
Protein Kinases CSNK1G3[a] Q9Y6M4[a] Catalytic domain IPR000719[a] Protein kinase domain[a] 4G17 a/87,90,91,93,94,95,96,97,98,99,
100,101,102,117,177,180,182
4 blue 14 218.3 239.6 0.5227 0.7464 -0.5963
Protein Kinases MAP3K14[a] Q99558[a] Catalytic domain IPR000719[a] Protein kinase domain[a] 4G3D a/451,493,494,497,498,500,501,
504,645,648,649,651,652,655
4 blue 16.219999 169.2 176.8 0.559 0.7267 -0.7794
Protein Kinases PRPF4B[a] Q13523[a] Catalytic domain IPR000719[a] Protein kinase domain[a] 4IIR a/913,914,919,920,923,924,925,
927
4 blue 24.700001 164.9 160.6 0.599 0.7526 -0.6058
Protein Kinases MAPK1[a],PEA15[g] P28482[a],
Q15121[g]
Catalytic domain IPR003527[a] Mitogen-activated protein (MAP) kinase, conserved site[a] 4IZ5 a/61,62,63,66,181,182,183,186,
337,338; g/26,27,28,29,30,62,65,
66,69
4 blue g/C27(reactive:0.81) 12.58 260.3 253.4 0.509 0.6742 -0.7822
Protein Kinases MAPK1[a] P28482[a] Catalytic domain IPR008271[a] Serine[a] 4IZA a/146,148,172,173,174,175,176,
178,179,180,181,182,183,184,185,
202,203,204,205,330,331,333,334,
335,336
4 blue 8.605 440.7 377.9 0.5949 0.8645 0.5514
Protein Kinases IKBKB[b] O14920[b] Catalytic domain IPR000719[b] Protein kinase domain[b] 4KIK b/186,187,188,189,194,206,210,
220,221,222,223,224,225,226,227,
228,231
4 blue 8.409 401 303.7 0.6679 0.9336 0.9198
Protein Kinases MAPK8[a] P45983[a] Catalytic domain IPR003527[a] Mitogen-activated protein (MAP) kinase, conserved site[a] 4L7F a/68,71,72,147,337,338,339,340,
341,342,343,345,347,352,355
4 blue 11.21 230.7 293.1 0.4836 0.7278 -0.7175
Protein Kinases GRK2[a] P25098[a] Catalytic domain IPR000961[a] AGC-kinase, C-terminal[a] 4MK0 a/31,32,33,34,35,36,37,176,529,
532,533,536,537,540
4 blue 41.18 174.5 182.9 0.6714 0.794 -0.2366
Protein Kinases CSNK2A1[b] P68400[b] Catalytic domain 4NH1 b/24,25,26,27,180,181,183,186,
188
4 blue 12.45 175.7 172.7 0.5977 0.8162 -0.3111
Protein Kinases PRKAA1[a],PRKAA1[b] Q13131[a],
Q13131[b]
Catalytic domain 4RED a/350,351,353,354; b/84,85,136,
139,140,274,283,284,285,286,287,
288,289,290
4 blue 14.81 189.3 242.1 0.5309 0.7471 -0.68
Protein Kinases RPS6KB1[a] P23443[a] Catalytic domain 4RLO a/192,193,194,196,197,317,319,
320,350,351,352,353,354,355,365,
366,368
4 blue a/C196(reactive:0.815) 17.459999 232.5 242.4 0.532 0.7689 -0.4399
Protein Kinases CSNK1D[a] P48730[a] Catalytic domain IPR000719[a] Protein kinase domain[a] 4TN6 a/106,107,110,273,274,277,284,
285,286
4 blue 19.309999 188.3 182.5 0.7453 0.8187 0.08487
Protein Kinases GRK5[a] P34947[a] Catalytic domain IPR000719[a] Protein kinase domain[a] 4TND a/33,34,176,177,179,180,181,182,
184,185,205,206,207,208,251,506,
511,515
4 blue 26.98 299 246.5 0.6543 0.8445 0.3214
Protein Kinases LIMK2[a],LIMK2[b] P53671[a],
P53671[b]
Catalytic domain IPR001245[a],
IPR001245[b]
Serine-threonine[a],Serine-threonine[b] 4TPT a/503,504,505,506,520,521,
523; b/510,511,547,552,553,554,
556
4 blue 10.06 199.1 189.5 0.6761 0.8761 0.1952
Protein Kinases ERN1[a] O75460[a] Catalytic domain 4U6R a/663,666,667,670,768,794,795,
800,801,802,804,805,830,831,832,
833,834,835,838
4 blue a/C794(reactive:0.74) 16.309999 371.1 344.2 0.604 0.7878 0.1431
Protein Kinases ERN1[a] O75460[a] Catalytic domain 4U6R a/798,803,806,807,810,861,864,
865,868,869,871,937,938,939,942,
943,946,947
4 blue 21.58 212.5 295.7 0.4821 0.6942 -0.9139
Protein Kinases PRKACA[a] P17612[a] Catalytic domain IPR000719[a] Protein kinase domain[a] 4WB7 a/0,0,0,0,12,15,16,19,20,23,101,
153,156,157,160,293,294,296,298,
299,301,303,304,307
4 blue 15.86 375.3 421.1 0.5 0.6585 -0.5941
Protein Kinases PRKAA2[a] P54646[a] Catalytic domain 4ZHX a/72,73,74,78,129,132,133,278,
279,280,281,283,284,287,288,289,
290,331,332,335,336
4 blue 17.24 408.2 426.7 0.5274 0.7607 -0.06708
Protein Kinases DYRK1A[a] Q13627[a] Catalytic domain IPR008271[a] Serine[a] 5AIK a/202,205,284,311,312,313,314,
315,316,317,318,319,337,338,339
4 blue a/C312(reactive:0.8) 9.54 293 278.8 0.4896 0.7764 -0.3359
Protein Kinases CDK8[a] P49336[a] Catalytic domain IPR000719[a] Protein kinase domain[a] 5FGK a/37,47,48,99,100,101,102,160,
161,162,163,164,165,350,351,352,
353,354,355
4 blue 19.84 312.5 299.1 0.6046 0.8111 0.1096
Protein Kinases HSP90AB1[a],HSP90AB1[b],CDC37[e],CDK4[k] P08238[a],
P08238[b],
Q16543[e],
P11802[k]
Catalytic domain IPR008271[k] Serine[k] 5FWL a/346,347; b/343,344,345,346,
348,350,372,373,375,436,439,442,
443,445,448; e/24,26; k/41,42,
43,44,46,47,90,91,92,93,94,95,
96,147,155
4 blue 15.49 596.3 571.1 0.5103 0.7812 0.2545
Protein Kinases HSP90AB1[a],CDK4[k] P08238[a],
P11802[k]
Catalytic domain IPR000719[k] Protein kinase domain[k] 5FWM a/568,572,573,574,575,576,619,
622,623,624; k/43,44,45,47,48,
50,51
4 blue 48.029999 260.7 273.4 0.4578 0.7342 -0.6607
Protein Kinases HSP90AB1[a],HSP90AB1[b],CDK4[k] P08238[a],
P08238[b],
P11802[k]
Catalytic domain IPR000719[k] Protein kinase domain[k] 5FWP a/339,340,341,342,343,344,345,
348,431,432,433,434,435; b/609,
611,612,613,616,620; k/91,92,93,
94,96,149,150,151,153,155
4 blue 20.889999 479.1 471.5 0.5156 0.7305 -0.09454
Protein Kinases HASPIN[a] Q8TF76[a] Catalytic domain IPR000719[a] Protein kinase domain[a] 5HTB a/515,516,517,518,519,526,593,
594,595,597,598,599
4 blue 23.209999 179 185.4 0.5874 0.7669 -0.5151
Protein Kinases PBK[a],PBK[b] Q96KB5[a],
Q96KB5[b]
Catalytic domain IPR041989[a],
IPR041989[b]
TOPK, catalytic domain[a],TOPK, catalytic domain[b] 5J0A a/77,78,101,103,114,115,116,
117; b/77,78,101,103,114,115,
116,117
4 blue 16.709999 194.7 188 0.7183 0.8854 0.3112
Protein Kinases KSR2[b] Q6VAB6[b] Catalytic domain 5KKR b/651,652,653,654,696,697,698,
699,700,701,703,704,707,708,730,
732,733
4 blue 17.379999 261.3 260 0.5636 0.7993 -0.1622
Protein Kinases CDK2[a],CCNE1[b] P24941[a],
P24864[b]
Catalytic domain IPR000719[a] Protein kinase domain[a] 5L2W a/50,53,54,57,58,121,122,123,
150,151,152,153,154,155,156,157,
159; b/119,120,122,123,126,162,
163,164,168,202,203,241,242,243,
244,245,247,248,251,252,268,270,
275,358,359
4 blue 12.01 652.1 610.1 0.628 0.8766 0.9638
Protein Kinases PIM1[a] P11309[a] Catalytic domain IPR000719[a] Protein kinase domain[a] 5N5L a/63,97,99,100,101,103,104,105,
121,122,123,124,176,179,183
4 blue 12.53 161.8 181.2 0.5681 0.7291 -0.7825
Protein Kinases GRK2[a] P25098[a] Catalytic domain 5UKL a/36,37,38,537,540,541,543,544,
545,547,549,550,551,552,553,564,
580,591,592,593,594,595,596
4 blue 49.759998 525.5 555 0.4871 0.695 -0.2309
Protein Kinases GRK2[a] P25098[a] Catalytic domain 5UKL a/183,185,617,618,619,633,634,
635,636,637,640
4 blue a/C619(0.19),
a/C634(reactive:0.675)
34.16 219.8 192.7 0.5448 0.8117 -0.2836
Protein Kinases CDK2[a],SPDYA[b] P24941[a],
Q5MJ70[b]
Catalytic domain IPR000719[a] Protein kinase domain[a] 5UQ1 a/38,40,41,43,44,45,46; b/128,
138,141,142,145,153,154,157,161,
164
4 blue 15.25 235.7 229.4 0.5691 0.8028 -0.2123
Protein Kinases DAPK3[a],DAPK3[c] O43293[a],
O43293[c]
Catalytic domain IPR000719[a],
IPR042870[c]
Protein kinase domain[a],DAPK3, catalytic domain[c] 5VJA a/37,39,68,69,70,71,72,73,74,78,
79,80,94; c/8,11,12,13,32,33,34,
39,80,81
4 blue 10.2 341.2 415.1 0.4502 0.7074 -0.5849
Protein Kinases SRPK1[a] Q96SB4[a] Catalytic domain IPR000719[a] Protein kinase domain[a] 5XV7 a/578,581,582,584,585,587,588,
591,592,593,594,595,598
4 blue 23.43 223 231.4 0.5374 0.7029 -0.7184
Protein Kinases VRK1[a] Q99986[a] Catalytic domain IPR000719[a] Protein kinase domain[a] 6AC9 a/78,79,81,82,85,89,173,199,200,
201,202,203,211,216,218,219,220,
221
4 blue a/C220(reactive:0.735) 7.393 387.2 316.3 0.6009 0.7918 0.1834
Protein Kinases PRKAA2[a],PRKAB2[b] P54646[a],
O43741[b]
Catalytic domain 6B2E a/68,69,71,72,73,74,78,79,80,81,
82,125,128,129,132,275,276,277,
278,281,285,287; b/60,63,66,67,
70,71,72,73
4 blue 15.86 571.7 572.6 0.5565 0.797 0.3906
Protein Kinases TAOK3[a] Q9H2K8[a] Catalytic domain 6BDN a/13,14,15,16,76,77,79,80,81,82,
84,85,86,87,88,89,90,102
4 blue a/C90(0.005) 9.057 243.4 295.9 0.4668 0.7296 -0.709
Protein Kinases PRKAA1[a] Q13131[a] Catalytic domain 6C9H a/274,275,280,283,285,288,289,
290,291,292,297,299,300,335,336,
339,340,342,343,346,348,349,352
4 blue 22.540001 370.3 405.1 0.544 0.7553 -0.1227
Protein Kinases MAP4K1[a],MAP4K1[b] Q92918[a],
Q92918[b]
Catalytic domain IPR000719[a],
IPR000719[b]
Protein kinase domain[a],Protein kinase domain[b] 6CQD a/132,134,136,161,162,165,166,
168,169,170,171,173,186,187,188,
189,190,191,192,193,194; b/136,
162,165,166,169,172,173,186,187,
190,192
4 blue 7.587 580.8 603.6 0.4762 0.6916 -0.1954
Protein Kinases EIF2AK2[a],EIF2AK2[a2] P19525[a],
P19525[a2]
Catalytic domain IPR000719[a],
IPR000719[a2]
Protein kinase domain[a],Protein kinase domain[a2] 6D3L a/291,293,312,313,314,315,316,
317,318,320,322,323,367,404,408,
429; a2/291,312,313,314,315,316,
317,318,320,322,323,367,404,408,
429
4 blue 15.11 333.3 386.6 0.6224 0.8597 0.3889
Protein Kinases AURKC[a],INCENP[b] Q9UQB9[a],
Q9NQS7[b]
Catalytic domain IPR000719[a] Protein kinase domain[a] 6GR9 a/67,68,99,100,101,103,105,107,
121,122,123,124,175,176,181,302,
303; b/855,858,859,862,863,865
4 blue 11.54 347.1 301.3 0.5671 0.8081 0.09015
Protein Kinases CDK1[a],CKS2[c] P06493[a],
P33552[c]
Catalytic domain IPR000719[a] Protein kinase domain[a] 6GU4 a/160,161,162,164,170,174,175,
177,178,179,181,209,236; c/60,
62
4 blue 7.655 194.3 189.7 0.5631 0.7838 -0.4432
Protein Kinases DYRK2[a] Q92630[a] Catalytic domain 6HDP a/134,135,136,163,182,183,184,
185,186,187,215,223,242
4 blue 32.060001 160.1 174.9 0.5603 0.7794 -0.6097
Protein Kinases CSNK2A2[a] P19784[a] Catalytic domain 6HMQ a/30,32,33,83,86,87,89,90,91,92,
93,94,95,96,97,98,99,100,101,
115
4 blue 12.95 267.7 309.9 0.5243 0.7378 -0.4758
Protein Kinases BRAF[b],BRAF[a] P15056[b],
P15056[a]
Catalytic domain IPR001245[a] Serine-threonine[a] 6NSQ b/510,511,512,559,562,588,
589; a/476,477,478,479,480,517,
530,531,533,585,586
4 blue 21.58 209.5 193.5 0.5535 0.8324 -0.218
Protein Kinases ROCK2[a] O75116[a] Catalytic domain IPR000719[a] Protein kinase domain[a] 6P5M a/54,55,56,58,59,80,83,126,162,
163,396,397,398,399,400,404,405,
406,407
4 blue 22.299999 208.3 235 0.5884 0.7954 -0.2887
Protein Kinases ROCK2[a] O75116[a] Catalytic domain 6P5P a/346,349,350,354,355,356,357,
359,360,361,363
4 blue 19.76 186.3 211.2 0.5118 0.7631 -0.6724
Protein Kinases CDK4[b] P11802[b] Catalytic domain IPR000719[b] Protein kinase domain[b] 6P8E b/29,30,31,94,95,96,97,98,148,
149,150,155
4 blue 17.76 181.3 176.6 0.5242 0.7097 -0.8748
Protein Kinases PRPF4B[b],PRPF4B[c] Q13523[b],
Q13523[c]
Catalytic domain IPR000719[c] Protein kinase domain[c] 6PJJ b/793,794,797,998,1003,
1004; c/730,733,734,737,738,741,
756,758
4 blue 17.049999 186.2 230.3 0.608 0.8304 -0.1892
Protein Kinases TBK1[a] Q9UHD2[a] Catalytic domain IPR000719[a] Protein kinase domain[a] 6RSU a/223,224,225,226,228,229,230,
232,233,250,253,254
4 blue 14.26 192.1 210 0.5312 0.7778 -0.5478
Protein Kinases TBK1[a] Q9UHD2[a] Catalytic domain 6RSU a/272,273,275,276,323,324,325,
338,341,342
4 blue 24.4 192 168.3 0.8041 0.9206 0.6339
Protein Kinases RIPK2[a],RIPK2[b] O43353[a],
O43353[b]
Catalytic domain IPR001245[a] Serine-threonine[a] 6SZJ a/72,74,75,76,78,80,82,96,134,
137,138,139,161; b/8,9,10,11,12,
13,14,17,37,39,40,71,74,75,76,
78,80,81,82,96
4 blue 15.76 581.3 553.9 0.5763 0.8612 0.7007
Protein Kinases IRAK4[a],IRAK4[b],IRAK4[d] Q9NWZ3[a],
Q9NWZ3[b],
Q9NWZ3[d]
Catalytic domain IPR001245[a],
IPR001245[d]
Serine-threonine[a],Serine-threonine[d] 6UYA a/202,204,208,209,241,242,243,
245,247,263,264,265,266,320,321,
322,324,326; b/185,186,278,
279; d/281,282,284,286,287,290,
322,323,418,419,420
4 blue 16.209999 554.8 529.7 0.4868 0.7611 0.0688
Protein Kinases CDC7[a],DBF4[b] O00311[a],
Q9UBU7[b]
Catalytic domain 6YA7 a/48,55,56,57,58,59,76,77,78,
84; b/341,342,343,344
4 blue 28.129999 214.6 242.3 0.5603 0.734 -0.5722
Protein Kinases IGF1R[a] P08069[a] Catalytic domain 1K3A a/1058,1059,1060,1064,1080,1125,
1150,1275,1276,1277,1278,1279,
1281,1282,1284
4 blue a/C1059(reactive:0.685) 11.56 175.4 223.8 0.516 0.7407 -0.7957
Protein Kinases KDR[a] P35968[a] Catalytic domain 1Y6B a/825,826,827,828,829,830,833,
854,855,856,857,858,859,860,902,
903
4 blue 11.52 234.1 251.8 0.4843 0.6917 -0.8473
Protein Kinases INSR[b],INSR[d] P06213[b],
P06213[d]
Catalytic domain IPR001245[b],
IPR001245[d]
Serine-threonine[b],Serine-threonine[d] 2B4S b/1059,1061,1068,1071,1072,1097,
1098,1099; d/1036,1038,1058,
1059,1060,1061,1068,1071,1072,
1097,1098,1099
4 blue 12.21 252.5 300.6 0.537 0.8395 -0.08966
Protein Kinases HCK[a],HCK[b] P08631[a],
P08631[b]
Catalytic domain IPR001245[b] Serine-threonine[b] 2HCK a/517,519,520; b/152,153,155,
156,157,159,160,161,190,191,194,
195,196,197,315,316,356,357,359,
360,363,392,393,394,511,512,514,
515,516,517,520,521,523
4 blue 19.190001 605.7 632 0.4725 0.7034 -0.1264
Protein Kinases FGFR1[a],PLCG1[b] P11362[a],
P19174[b]
Catalytic domain IPR028174[a],
IPR000980[b]
Fibroblast growth factor receptor 1, catalytic domain[a],SH2 domain[b] 3GQI a/605,609,612,613,751,752,
755; b/594,609,611,612,613,614,
615,622
4 blue 14.14 251.6 221.2 0.5967 0.8907 0.2452
Protein Kinases CSF1R[a] P07333[a] Catalytic domain 3LCD a/566,569,570,571,572,574,575,
635,638,639
4 blue 13.96 159.7 168 0.5256 0.7875 -0.6585
Protein Kinases HCK[a] P08631[a] Catalytic domain IPR001245[a] Serine-threonine[a] 3VS4 a/151,152,153,155,156,157,159,
160,161,191,194,195,196,197,315,
316,356,357,359,360,364,392,393,
394,512,513,515,516,520,521
4 blue 19.709999 601.9 597.5 0.5071 0.7352 0.07274
Protein Kinases SYK[a] P43405[a] Catalytic domain 4FL3 a/350,351,352,359,360,361,362,
422,425,426,427,428,434,435,436
4 blue 16.33 205.7 215.4 0.5588 0.8133 -0.2945
Protein Kinases SYK[a] P43405[a] Catalytic domain 4FL3 a/136,138,343,345,346,348,349,
350,351,353,354,357,392,394,395,
397
4 blue 24.24 181.4 203 0.463 0.7164 -0.9865
Protein Kinases JAK2[a] O60674[a] Catalytic domain 4GMY a/836,837,838,839,840,841,842,
843,844,845,846,847,848,868,870,
914,917,918,919,921,922
4 blue a/C917(0.465) 23.17 382.5 418.6 0.494 0.7039 -0.415
Protein Kinases ZAP70[a] P43403[a] Catalytic domain 4K2R a/131,133,310,312,313,314,315,
316,317,318,320,321,362,364,365,
402,415,416
4 blue 18.940001 247.2 273.8 0.5475 0.7743 -0.3384
Protein Kinases ITK[a] Q08881[a] Catalytic domain IPR020635[a] Tyrosine-protein kinase, catalytic domain[a] 4QD6 a/386,387,422,436,437,438,439,
491,492,495,497
4 blue 17.48 184.7 187.6 0.4984 0.7445 -0.782
Protein Kinases ERBB3[a],EGFR[b] P21860[a],
P00533[b]
Catalytic domain IPR001245[b] Serine-threonine[b] 4RIX a/939,942,943,946,964; b/757,
761,764,765,859,860,861
4 blue 9.108 165.3 180.2 0.5405 0.7103 -0.9037
Protein Kinases ROS1[a],ROS1[a1] P08922[a],
P08922[a1]
Catalytic domain IPR001245[a],
IPR001245[a1]
Serine-threonine[a],Serine-threonine[a1] 4UXL a/2042,2046,2047,2048,2049,2051,
2052,2152,2155,2156,2157,2159,
2163,2181,2182,2183,2184,
2185; a1/2042,2046,2047,2048,
2049,2051,2052,2152,2155,2156,
2157,2159,2163,2181,2182,2183,
2184,2185
4 blue 12.7 584.6 632.5 0.6244 0.7582 0.4085
Protein Kinases ALK[a] Q9UM73[a] Catalytic domain 5IUH a/1094,1095,1098,1099,1170,1173,
1174,1243,1244,1245,1246,1248
4 blue 9.545 167 174.8 0.6107 0.785 -0.4419
Protein Kinases EPHA2[a] P29317[a] Catalytic domain IPR008266[a] Tyrosine-protein kinase, active site[a] 5NKH a/665,666,669,670,733,734,735,
736,738,760,761,762,763,764,765,
766,767,768,770,771,792
4 blue 8.937 302.6 383.4 0.452 0.655 -0.8757
Protein Kinases JAK3[a] P52333[a] Catalytic domain IPR001245[a] Serine-threonine[a] 5W86 a/1035,1036,1038,1039,1040,1041,
1042,1044,1045,1046,1049
4 blue 16.73 198.3 198.4 0.6766 0.8234 -0.01453
Protein Kinases BTK[a],BTK[b] Q06187[a],
Q06187[b]
Catalytic domain IPR001245[a],
IPR001245[b]
Serine-threonine[a],Serine-threonine[b] 5XYZ a/449,452,453,454,455,457,458,
459,460,536,539; b/449,450,452,
453,454,455,457,458,459,460
4 blue 13.89 331.8 330.1 0.5979 0.8703 0.3718
Protein Kinases EPHA2[a] P29317[a] Catalytic domain 6HES a/604,605,606,667,668,670,671,
672,673,675,676,677,678,679,680
4 blue 9.462 178.7 195.6 0.4756 0.7644 -0.7803
Protein Kinases FGFR4[a] P22455[a] Catalytic domain 6JPE a/459,460,461,462,463,466,488,
489,491,494,529,537,538
4 blue 14.53 205.9 228 0.5075 0.6816 -0.9295
Protein Kinases FGFR3[a] P22607[a] Catalytic domain 6LVM a/464,465,466,467,468,471,493,
494,495,496,542,543
4 blue 15.83 229.6 234.5 0.5084 0.6935 -0.7999
Protein Kinases ABL1[a] P00519[a] Catalytic domain 1OPL a/94,95,96,98,99,226,227,228,
229,230,231,232,233,234,235,294,
302,303
4 blue 21.799999 285.2 242.4 0.5285 0.8539 0.03782
Protein Kinases HCK[a] P08631[a] Catalytic domain 1QCF a/92,93,111,112,113,114,131,246,
247,248,249,250,251,252,253,254,
255,284,285,286,287,309,310,312,
313,318,319,320,321,334,335,336,
337,390,391,400
4 blue 13.8 568.7 614.2 0.4963 0.7699 0.1433
Protein Kinases SRC[a] P12931[a] Catalytic domain 2H8H a/120,136,137,138,254,255,256,
321,322,323,325,327
4 blue 15.92 161.4 190.8 0.4913 0.737 -0.9276
Protein Kinases HCK[a] P08631[a] Catalytic domain 3VS3 a/92,93,94,95,96,114,127,251,
252,282,284
4 blue 30.52 242.4 242 0.6848 0.8285 0.1725
Protein Kinases CDK2[a] P24941[a] Catalytic domain IPR000719[a] Protein kinase domain[a] 1F5Q a/218,219,220,221,222,223,226,
242,243,244,245,246,248,264,267,
268,269,270
4 Pocket PK1 purple 17.85 281 288.7 0.542 0.7012 -0.5442
Protein Kinases MAPKAPK2[a3],MAPKAPK2[a5] P49137[a3],
P49137[a5]
Catalytic domain IPR000719[a5] Protein kinase domain[a5] 1NY3 a3/314,315,317,318,321,
322; a5/281,282,283,284,285,303,
306,307,308,309,312
4 Pocket PK1 purple 16.639999 236.2 244.7 0.5222 0.8189 -0.2535
Protein Kinases MAPK10[a] P53779[a] Catalytic domain IPR000719[a] Protein kinase domain[a] 1PMU a/278,279,280,281,282,283,305,
306,307,308,309,340,341,342,343,
346
4 Pocket PK1 purple a/C283(reactive:0.645) 17.16 156.2 176.7 0.521 0.7419 -0.8648
Protein Kinases MKNK2[a] Q9HBH9[a] Catalytic domain IPR000719[a] Protein kinase domain[a] 2AC5 a/279,286,294,295,325,326,327,
328,329,345,346,349,350,351
4 Pocket PK1 purple 15.81 249 212.5 0.7265 0.8646 0.4294
Protein Kinases PAK6[a] Q9NQU5[a] Catalytic domain IPR000719[a] Protein kinase domain[a] 2C30 a/592,618,619,620,621,624,632,
635,636,639,640
4 Pocket PK1 purple 16.99 170.9 182.7 0.5815 0.7538 -0.6139
Protein Kinases PAK5[a] Q9P286[a] Catalytic domain IPR000719[a] Protein kinase domain[a] 2F57 a/634,659,660,661,662,663,666,
674,677,678,681,682
4 Pocket PK1 purple 16.98 156 165.8 0.625 0.8411 -0.2391
Protein Kinases MAPK6[a] Q16659[a] Catalytic domain IPR000719[a] Protein kinase domain[a] 2I6L a/245,246,247,248,249,250,251,
271,273,274,275,276,277,278,279,
294,297,298,299
4 Pocket PK1 purple 20.040001 270.7 310 0.4991 0.6833 -0.7396
Protein Kinases CDK4[a] P11802[a] Catalytic domain IPR000719[a] Protein kinase domain[a] 3G33 a/230,231,232,233,234,237,254,
273,276,277,278,279,282
4 Pocket PK1 purple 17.73 186.6 196.8 0.5821 0.7375 -0.6123
Protein Kinases MAPK14[a] Q16539[a] Catalytic domain IPR000719[a] Protein kinase domain[a] 3HVC a/239,240,241,242,243,245,246,
247,259,260,262,264,265,266,267,
290,291,292,295
4 Pocket PK1 purple 25.450001 243.8 289 0.4732 0.7004 -0.8083
Protein Kinases CDK5[a] Q00535[a] Catalytic domain IPR000719[a] Protein kinase domain[a] 3O0G a/218,219,220,221,222,223,226,
227,244,246,247,248,249,260,261,
264,267,268,269,270,273
4 Pocket PK1 purple a/C269(reactive:0.7) 18.9 332.1 325.5 0.4956 0.7848 -0.1965
Protein Kinases MAPK1[a] P28482[a] Catalytic domain IPR000719[a] Protein kinase domain[a] 3W55 a/200,237,241,246,247,248,249,
252,255,256,257,260,261,263,264,
265,267,268,269,296
4 Pocket PK1 purple 18.559999 247 273.9 0.5918 0.7381 -0.3808
Protein Kinases MAPKAPK2[d1],MAPKAPK2[f1] P49137[d1],
P49137[f1]
Catalytic domain IPR000719[d1],
IPR000719[f1]
Protein kinase domain[d1],Protein kinase domain[f1] 3WI6 d1/281,282,283,284,285,286,303,
306,307,308,309,312; f1/314,315,
317,318,321,322,323
4 Pocket PK1 purple 16.59 332.7 313.4 0.5592 0.7819 -0.06245
Protein Kinases GSK3B[a],GSK3B[b] P49841[a],
P49841[b]
Catalytic domain IPR000719[b] Protein kinase domain[b] 3ZRL a/307,308,309,310,311; b/273,
274,275,276,277,280,293,295,296,
297,298,299,300,301,302,318,321,
322,323
4 Pocket PK1 purple 19.41 336 374.2 0.5114 0.7508 -0.2863
Protein Kinases CSNK2A1[c] P68400[c] Catalytic domain IPR000719[c] Protein kinase domain[c] 4DGL c/248,249,253,256,257,260,278,
279,280,281,282,298,302,305,306,
307,308,311
4 Pocket PK1 purple 18.65 316.5 339 0.5896 0.7886 -0.004127
Protein Kinases MAPK8[a] P45983[a] Catalytic domain IPR000719[a] Protein kinase domain[a] 4HYU a/241,242,243,244,245,246,248,
249,260,261,263,265,266,267,268,
269,270,271,273,302,303,304,305,
308
4 Pocket PK1 purple a/C245(reactive:0.745) 17.41 299.5 376.3 0.4617 0.6854 -0.7413
Protein Kinases MAPK7[a] Q13164[a] Catalytic domain IPR000719[a] Protein kinase domain[a] 4IC7 a/275,277,278,279,280,281,282,
283,286,298,299,300,301,302,303,
304,305,306,307,308,309,325,328,
329,330,331
4 Pocket PK1 purple 18.629999 326.6 378.3 0.4751 0.7255 -0.4891
Protein Kinases IKBKB[a] O14920[a] Catalytic domain IPR000719[a] Protein kinase domain[a] 4KIK a/240,241,272,275,276,278,279,
282,287,288,289,290,291,292,293,
294,302,305,306
4 Pocket PK1 purple 19.030001 324.2 323.2 0.5757 0.757 -0.1421
Protein Kinases RPS6KB1[a] P23443[a] Catalytic domain IPR000719[a] Protein kinase domain[a] 4L45 a/284,292,293,308,309,310,311,
312,313,316,321,324,325,328,329,
330
4 Pocket PK1 purple a/C308(reactive:0.795) 13.1 250.2 228.9 0.7058 0.8305 0.2514
Protein Kinases MAPK13[a] O15264[a] Catalytic domain IPR000719[a] Protein kinase domain[a] 4MYG a/233,236,237,239,240,241,258,
261,263,264,265,266,268
4 Pocket PK1 purple 21.690001 165.8 185.7 0.631 0.7859 -0.3977
Protein Kinases MAPK13[a] O15264[a] Catalytic domain IPR000719[a] Protein kinase domain[a] 4YNO a/239,240,241,242,243,245,246,
264,265,266,267,290,291,292,295
4 Pocket PK1 purple 18.9 164.8 197.9 0.52 0.7014 -0.987
Protein Kinases DYRK1A[a] Q13627[a] Catalytic domain IPR000719[a] Protein kinase domain[a] 4YU2 a/367,371,394,396,398,404,405,
406,407,408,412,413,414,415,416,
417,418
4 Pocket PK1 purple 22.43 290.8 311.3 0.5114 0.6737 -0.6967
Protein Kinases RPS6KA3[a] P51812[a] Catalytic domain IPR000719[a] Protein kinase domain[a] 5D9L a/252,268,282,283,284,285,287,
300,303,304,305,306,309
4 Pocket PK1 purple 13.57 241.9 250.1 0.5433 0.737 -0.5107
Protein Kinases GRK2[a] P25098[a] Catalytic domain IPR000719[a] Protein kinase domain[a] 5UKL a/375,391,406,409,410,411,412,
413,422,425,426,429,430,431,432,
435
4 Pocket PK1 purple 15.37 219.9 249.5 0.5079 0.7653 -0.5498
Protein Kinases CLK2[a] P49760[a] Catalytic domain IPR000719[a] Protein kinase domain[a] 6FYK a/391,394,395,396,397,398,399,
419,421,423,431,432,437,438,439,
457,460,461,462
4 Pocket PK1 purple 18.9 259.3 331.3 0.4983 0.7014 -0.7021
Protein Kinases GSK3B[a] P49841[a] Catalytic domain IPR000719[a] Protein kinase domain[a] 6HK7 a/229,266,267,270,273,274,275,
276,277,278,280,281,289,291,292,
293,294,295,296,297,298,323
4 Pocket PK1 purple 19.59 388.7 410.8 0.5737 0.7192 -0.1616
Protein Kinases SLK[a] Q9H2G2[a] Catalytic domain IPR000719[a] Protein kinase domain[a] 6HVD a/252,253,254,255,258,266,269,
270,271,273,274,275,279,280,281
4 Pocket PK1 purple 14.62 185 258.1 0.5521 0.6996 -0.8361
Protein Kinases CLK1[a] P49759[a] Catalytic domain IPR000719[a] Protein kinase domain[a] 6Q8K a/389,392,393,394,395,396,397,
399,413,416,417,418,419,421,426,
429,430,435,436,437,455,458,459,
460
4 Pocket PK1 purple 18.1 366.4 482.8 0.4742 0.6903 -0.5451
Protein Kinases CSNK2A2[a] P19784[a] Catalytic domain IPR000719[a] Protein kinase domain[a] 6QY9 a/249,250,254,257,258,261,279,
280,281,282,283,296,299,300,303,
306,307,308,309,312
4 Pocket PK1 purple 18.75 363.4 391.9 0.5771 0.7752 0.01705
Protein Kinases FLT3[a],FLT3[a1] P36888[a],
P36888[a1]
Catalytic domain IPR020635[a],
IPR020635[a1]
Tyrosine-protein kinase, catalytic domain[a],Tyrosine-protein kinase, catalytic domain[a1] 4RT7 a/905,906,907,920,923,924,927,
928,929,932,933,934; a1/906,907,
920,923,924,927,928,929,932,933,
934
4 Pocket PK1 purple 19.389999 347.1 348.1 0.5235 0.6707 -0.5503
Protein Kinases INSR[a] P06213[a] Catalytic domain IPR001245[a] Serine-threonine[a] 4XLV a/1254,1255,1256,1257,1266,1269,
1270,1273,1274,1275
4 Pocket PK1 purple 15.49 180.5 195.2 0.7054 0.8371 0.03527
Protein Kinases NTRK1[a] P04629[a] Catalytic domain IPR001245[a] Serine-threonine[a] 5KVT a/692,693,694,711,715,728,740,
743,744,745,746,761,764,765,766
4 Pocket PK1 purple 8.699 189.6 210 0.6624 0.8775 0.1334
Protein Kinases DDR1[a],DDR1[b] Q08345[a],
Q08345[b]
Catalytic domain IPR020635[a] Tyrosine-protein kinase, catalytic domain[a] 6GWR a/865,867,868,869,881,885,
889; b/663,664,666,667,670
4 Pocket PK1 purple 17.41 159.6 195.4 0.5819 0.7167 -0.8102
Protein Kinases TGFBR1[b] P36897[b] Catalytic domain IPR000719[b] Protein kinase domain[b] 1B6C b/314,317,318,394,397,398,401,
479,480,482,483,484,485,486
4 Pocket PK6 red 11.93 181.4 199.4 0.5348 0.8551 -0.2774
Protein Kinases MAPKAPK2[a5],MAPKAPK2[a10] P49137[a5],
P49137[a10]
Catalytic domain IPR000719[a5],
IPR000719[a10]
Protein kinase domain[a5],Protein kinase domain[a10] 1NY3 a5/178,179,181,232,233,236,237,
238,239,241,242,243,246,310,311,
313,314,315,316,317; a10/277,
280,281,308,309,310,312
4 Pocket PK6 red 10.24 405.4 376.9 0.6009 0.8405 0.409
Protein Kinases SLK[a] Q9H2G2[a] Catalytic domain IPR000719[a] Protein kinase domain[a] 2JFL a/147,148,150,208,209,210,211,
214,215,218,282,283,284
4 Pocket PK6 red 11.34 180.5 173.5 0.6146 0.809 -0.2813
Protein Kinases MAPK14[a] Q16539[a] Catalytic domain 2ONL a/139,142,143,201,202,203,206,
283,286,287,290,293,294,295,296,
297,298,299,300,301,302,304,305,
306,319
4 Pocket PK6 red 15.19 360.6 458.9 0.5379 0.6496 -0.573
Protein Kinases CAMK2D[a] Q13557[a] Catalytic domain IPR000719[a] Protein kinase domain[a] 2WEL a/125,128,129,167,169,193,194,
197,244,247,251,257,258,259,260,
261,262,263,264,265,266,268,269,
270
4 Pocket PK6 red 10.16 429.5 507.1 0.5124 0.6809 -0.3779
Protein Kinases MARK2[a] Q7KZI7[a] Catalytic domain IPR000719[a] Protein kinase domain[a] 3IEC a/164,167,168,200,202,229,230,
233,283,286,290,291,292,293,294,
295,296,297
4 Pocket PK6 red 11.88 221 272 0.46 0.692 -0.9441
Protein Kinases RPS6KA1[a] Q15418[a] Catalytic domain IPR000719[a] Protein kinase domain[a] 3RNY a/524,527,528,574,590,591,593,
594,597,660,661,663,664,665,666,
667
4 Pocket PK6 red 11.95 262.4 281.2 0.5602 0.7054 -0.5368
Protein Kinases GRK2[a] P25098[a] Catalytic domain IPR000719[a] Protein kinase domain[a] 3V5W a/306,309,310,312,342,369,370,
371,374,433,438,439,441,442,443,
444,445,448
4 Pocket PK6 red a/C439(0.255) 12.58 233.9 260.7 0.4793 0.7163 -0.7624
Protein Kinases CDKL2[a] Q92772[a] Catalytic domain IPR000719[a] Protein kinase domain[a] 4AAA a/115,118,119,171,176,178,179,
180,181,182,185,222,224,225,272,
273,275,276,277,278,279
4 Pocket PK6 red a/C278(reactive:0.65) 11.85 235.9 292.4 0.5331 0.6926 -0.7274
Protein Kinases PRPF4B[a],PRPF4B[b] Q13523[a],
Q13523[b]
Catalytic domain IPR000719[b] Protein kinase domain[b] 4IAN a/996; b/867,868,869,872,988,
989,991,992,993,994
4 Pocket PK6 red 11.26 165.6 160 0.5868 0.7622 -0.5927
Protein Kinases RPS6KA3[a] P51812[a] Catalytic domain IPR000719[a] Protein kinase domain[a] 4NW5 a/182,185,186,188,219,220,221,
222,223,224,245,246,247,248,251,
307,308,312,313,314,317,318
4 Pocket PK6 red 11.64 279.1 353.6 0.4898 0.6863 -0.7263
Protein Kinases MAPKAPK2[a] P49137[a] Catalytic domain IPR000719[a] Protein kinase domain[a] 4TYH a/214,215,216,217,219,220,221,
236,238,239,241,242,243,246,304,
307,310,311,312,313,314,315,316,
318
4 Pocket PK6 red 11.53 394 405.7 0.4945 0.7186 -0.3338
Protein Kinases ULK1[a] O75385[a] Catalytic domain IPR008271[a] Serine[a] 4WNP a/126,129,130,133,134,135,172,
173,174,176,199,200,201
4 Pocket PK6 red 8.478 187.4 189.6 0.5727 0.766 -0.5182
Protein Kinases PDPK1[a] O15530[a] Catalytic domain IPR000719[a] Protein kinase domain[a] 4XX9 a/194,197,198,237,238,260,261,
262,265,321,322,326,327,328,329,
332,333
4 Pocket PK6 red a/C260(reactive:0.795),
a/C327(0.31)
12.11 188 224.9 0.6049 0.8031 -0.2968
Protein Kinases DYRK1A[a] Q13627[a] Catalytic domain IPR000719[a] Protein kinase domain[a] 5A4Q a/213,219,273,274,275,277,278,
279,339,340,341,343,344,458,464,
465,466,467,468,469,470,471,472
4 Pocket PK6 red 9.195 292.2 399.3 0.4978 0.6896 -0.6612
Protein Kinases BRAF[a],BRAF[b] P15056[a],
P15056[b]
Catalytic domain IPR001245[a],
IPR000719[b]
Serine-threonine[a],Protein kinase domain[b] 5FD2 a/634,635,636,701,702,704,705,
706,709; b/692,695,698,702,703,
704,705,706,709,713
4 Pocket PK6 red 12.76 187.9 222.1 0.6093 0.8008 -0.2964
Protein Kinases BRAF[a],BRAF[b] P15056[a],
P15056[b]
Catalytic domain IPR000719[a] Protein kinase domain[a] 5FD2 a/688,691,692,695,705,709,710,
713,716; b/709,712,715,716,719
4 Pocket PK6 red 18.549999 165.2 181.4 0.5251 0.7022 -0.9707
Protein Kinases GSK3B[a] P49841[a] Catalytic domain 5HLP a/170,173,174,235,236,237,240,
319,325,326,327,328,329,330,331,
332,333,369
4 Pocket PK6 red 10.34 202 228.9 0.6007 0.7674 -0.3935
Protein Kinases PRKCI[a] P41743[a] Catalytic domain IPR000719[a] Protein kinase domain[a] 5LI1 a/367,370,371,372,373,404,405,
406,407,408,409,423,429,430,431,
432,433,436,501,502,506,507,508,
509,510,512,513,514
4 Pocket PK6 red a/C507(0.49) 11.97 406.6 398.5 0.4847 0.7017 -0.3996
Protein Kinases SNRK[a] Q9NRH2[a] Catalytic domain IPR000719[a] Protein kinase domain[a] 5YKS a/131,132,192,194,195,198,254,
255,257,258,259,260,261
4 Pocket PK6 red 11.86 164.7 182.9 0.5223 0.7321 -0.8614
Protein Kinases PRKACA[a] P17612[a] Catalytic domain IPR000719[a] Protein kinase domain[a] 6BYR a/0,0,0,0,0,0,0,0,0,0,0,0,0,282,
287,290,291,294,295,296
4 Pocket PK6 red 21.65 392 390.7 0.5145 0.7115 -0.3202
Protein Kinases PRKAA1[a],PRKAB1[b] Q13131[a],
Q9Y478[b]
Catalytic domain 6C9H a/139,142,143,145,175,202,204,
205,208,258,264,265,266,267,268,
269,270,271,292,293,294,
295; b/209,230,231,232,233,256,
258,259,261
4 Pocket PK6 red 12.77 515.1 492.3 0.5404 0.7803 0.2112
Protein Kinases MKNK2[a] Q9HBH9[a] Catalytic domain IPR000719[a] Protein kinase domain[a] 6CJH a/194,197,198,200,270,271,272,
274,275,278,358,359,360
4 Pocket PK6 red 11.5 220.6 205.6 0.6008 0.7801 -0.2783
Protein Kinases CSNK2A1[a] P68400[a] Catalytic domain IPR000719[a] Protein kinase domain[a] 6FVG a/9,10,11,148,210,211,212,215,
303,306,309,310,311,312,313,314,
315,317
4 Pocket PK6 red 10.79 201 241.7 0.6481 0.8292 -0.04657
Protein Kinases ACVR1[a],ACVR1[b] Q04771[a],
Q04771[b]
Catalytic domain IPR001245[a],
IPR001245[b]
Serine-threonine[a],Serine-threonine[b] 6GIN a/397,401,483,484,485,486,
490; b/361,365,366,367,368,394,
395,396,397
4 Pocket PK6 red b/C395(reactive:0.645) 15.9 281.7 305.6 0.4605 0.7504 -0.5333
Protein Kinases ULK2[a] Q8IYT8[a] Catalytic domain IPR008271[a] Serine[a] 6QAU a/119,122,123,127,128,129,165,
193,194,196,197,261,262
4 Pocket PK6 red 7.269 162.8 173.6 0.7094 0.8344 -0.04238
Protein Kinases STK17B[a] O94768[a] Catalytic domain IPR000719[a] Protein kinase domain[a] 6QF4 a/147,150,151,213,214,215,218,
278,279,281,282,283,284,285
4 Pocket PK6 red 12.12 171 203.7 0.5929 0.7886 -0.451
Protein Kinases EGFR[a],EGFR[a1] P00533[a],
P00533[a1]
Catalytic domain IPR020635[a1] Tyrosine-protein kinase, catalytic domain[a1] 2GS2 a/753,756,757,760; a1/946,949,
952,956,957,958,959,960,963,967
4 Pocket PK6 red 15.41 189.8 200.3 0.5445 0.6968 -0.8454
Protein Kinases HCK[a],HCK[b] P08631[a],
P08631[b]
Catalytic domain IPR001245[a],
IPR001245[b]
Serine-threonine[a],Serine-threonine[b] 2HCK a/492,499,500,501,502,503,505,
506,509; b/492,499,500,501,502,
503,505,506,509
4 Pocket PK6 red 18.1 284.4 279.5 0.5735 0.8735 0.215
Protein Kinases SYK[a] P43405[a] Catalytic domain IPR001245[a] Serine-threonine[a] 4FL2 a/22,42,44,45,46,52,63,64,65,67,
75,76,77,79,80,82,88,92,97,98,
99,599,600,601,603,604,621,624,
625,628,629,631,632
4 Pocket PK6 red 20.77 460.1 483.4 0.5669 0.816 0.3286
Protein Kinases PTK2[a],PTK2[b] Q05397[a],
Q05397[b]
Catalytic domain IPR020635[a],
IPR020635[b]
Tyrosine-protein kinase, catalytic domain[a],Tyrosine-protein kinase, catalytic domain[b] 4GU6 a/532,535,536,538,539,668,670,
673; b/532,535,536,538,539,668,
670,673
4 Pocket PK6 red 14.51 249.8 280.6 0.5515 0.7727 -0.3276
Protein Kinases JAK1[a] P23458[a] Catalytic domain IPR001245[a] Serine-threonine[a] 4IVB a/998,1028,1029,1030,1031,1032,
1033,1059,1060,1061,1064,1136,
1137,1139,1140,1141
4 Pocket PK6 red 12.68 194.8 254.2 0.5352 0.6648 -0.9737
Protein Kinases PTK2[a],PTK2[b] Q05397[a],
Q05397[b]
Catalytic domain IPR020635[a] Tyrosine-protein kinase, catalytic domain[a] 4K8A a/657,660,664,665,666,667,
671; b/477,478,539,540,541,542
4 Pocket PK6 red 11.29 233 244.3 0.476 0.7243 -0.7414
Protein Kinases EPHA2[a],EPHA2[b] P29317[a],
P29317[b]
Catalytic domain IPR008266[a] Tyrosine-protein kinase, active site[a] 4PDO a/728,731,732,734,736,795,796,
797,800,858,859,861,862,863,864,
865; b/617,629,694,696
4 Pocket PK6 red 11.22 253.9 270.7 0.5416 0.7983 -0.2372
Protein Kinases EGFR[b] P00533[b] Catalytic domain IPR001245[b] Serine-threonine[b] 4RIX b/829,830,832,862,863,864,865,
866,867,868,892,893,894,955,956,
960
4 Pocket PK6 red 12.8 232.8 255 0.4551 0.7191 -0.81
Protein Kinases ERBB3[a],EGFR[b] P21860[a],
P00533[b]
Catalytic domain IPR001245[a] Serine-threonine[a] 4RIX a/943,946,953,954,955,956,957,
960,961,964; b/753,754,756,757,
760
4 Pocket PK6 red 14.49 214.5 240.3 0.5046 0.7309 -0.7115
Protein Kinases ERBB3[a],EGFR[b] P21860[a],
P00533[b]
Catalytic domain IPR001245[b] Serine-threonine[b] 4RIY a/939,942,943,946,956,960,961,
964,967,968,975; b/753,754,757,
760,761,764,765,859,860,861,869
4 Pocket PK6 red 8.513 366.8 425.1 0.504 0.649 -0.6394
Protein Kinases ROS1[a] P08922[a] Catalytic domain IPR000719[a] Protein kinase domain[a] 4UXL a/2189,2190,2192,2193,2196,2204,
2205,2206,2210,2214,2217,2218,
2221
4 Pocket PK6 red 18.9 183.2 249.5 0.5525 0.6963 -0.8553
Protein Kinases TYK2[a] P29597[a] Catalytic domain IPR001245[a] Serine-threonine[a] 5F20 a/1012,1015,1016,1018,1048,1050,
1051,1052,1053,1079,1080,1081,
1084,1156,1157,1159,1161,1162,
1163
4 Pocket PK6 red 11.25 230.5 308.9 0.5357 0.6419 -0.9381
Protein Kinases SYK[a],SYK[b] P43405[a],
P43405[b]
Catalytic domain IPR000719[b] Protein kinase domain[b] 5T68 a/371,372,373,374,375,
389; b/600,601,603,604,607,625,
628,629
4 Pocket PK6 red 20.35 209.4 230.5 0.536 0.7171 -0.7123
Protein Kinases SYK[a] P43405[a] Catalytic domain IPR001245[a] Serine-threonine[a] 5TT7 a/486,488,489,490,518,519,520,
521,522,523,524,525,542,548,550,
551,552,613,614
4 Pocket PK6 red 11.36 332.7 373.6 0.5846 0.7614 -0.08536
Protein Kinases FLT3[a] P36888[a] Catalytic domain IPR008266[a] Tyrosine-protein kinase, active site[a] 5X02 a/579,581,583,584,585,586,588,
589,803,806,807,808,866,867,868
4 Pocket PK6 red a/C807(0.01) 10.57 185.4 188 0.6632 0.7878 -0.2346
Protein Kinases JAK3[a],JAK3[b] P52333[a],
P52333[b]
Catalytic domain IPR001245[a] Serine-threonine[a] 6AAK a/938,941,942,944,1006,1007,
1010,1087,1088,1089; b/862,865,
866,869
4 Pocket PK6 red 12.58 170.2 184.8 0.5599 0.6901 -0.9172
Protein Kinases PRKAA1[a],PRKAB2[b] Q13131[a],
O43741[b]
Catalytic domain IPR000719[a] Protein kinase domain[a] 4REW a/204,205,208,264,265,267,268,
269; b/211,214,216,219,233,234,
236,237
4 Pocket PK6, Pocket PKI3 red 13.55 218.7 226 0.554 0.8141 -0.2572
Protein Phosphatases PTPRG[a] P23470[a] Catalytic domain IPR000242[a] PTP type protein phosphatase[a] 2NLK a/1215,1216,1219,1220,1244,1245,
1336,1337,1340,1341,1343,1344,
1345,1346,1347,1365,1369
4 Pocket PP1 black 24.58 280.3 275.8 0.6018 0.8407 0.1394
Protein Phosphatases PTPRS[a] Q13332[a] Catalytic domain IPR000387[a] Tyrosine specific protein phosphatases domain[a] 4BPC a/1743,1744,1745,1746,1749,1750,
1857,1858,1860,1861,1864,1865,
1867,1868,1876,1894,1895,1897,
1898,1901,1939
4 Pocket PP1 black 14.89 354.1 316.6 0.6199 0.7804 0.1156
Protein Phosphatases PTPRA[a] P18433[a] Catalytic domain IPR000242[a] PTP type protein phosphatase[a] 6UZT a/596,597,598,599,600,601,602,
603,624,625,716,717,720,721,725,
726,727,728,746,750
4 Pocket PP1 black 13.88 328.9 322.8 0.5645 0.7712 -0.1011
Protein Phosphatases PPP1CA[a],PPP1R7[c] P62136[a],
Q15435[c]
Catalytic domain IPR004843[a] Calcineurin-like phosphoesterase domain, ApaH type[a] 6OBN a/128,129,149,150,153,154,157,
194; c/260,261,280,282,283,302,
304,305,327,329,330
4 Pocket PPI2 blue 10.07 157.8 171.2 0.4635 0.9103 -0.3247
Protein Phosphatases DUSP6[a] Q16828[a] Catalytic domain IPR020422[a] Dual specificity protein phosphatase domain[a] 1MKP a/298,301,302,305,316,317,320,
332,333,334,336,337,340
4 blue 8.948 202.5 180.3 0.7808 0.888 0.492
Protein Phosphatases DUSP5[a],DUSP5[b],DUSP5[c] Q16690[a],
Q16690[b],
Q16690[c]
Catalytic domain IPR020422[a],
IPR020422[b],
IPR020422[c]
Dual specificity protein phosphatase domain[a],Dual specificity protein phosphatase domain[b],Dual specificity protein phosphatase domain[c] 2G6Z a/184,185,204,206,224,253,254,
255,256,257,258; b/226,244,247,
248,250,251,254,255; c/206,222,
224,251,254,255,256,257
4 blue b/C251(reactive:0.75),
c/C251(reactive:0.725)
15.1 486.1 525.5 0.4661 0.6961 -0.332
Protein Phosphatases DUSP14[b1],DUSP14[b2] O95147[b1],
O95147[b2]
Catalytic domain IPR020422[b1],
IPR016130[b2]
Dual specificity protein phosphatase domain[b1],Protein-tyrosine phosphatase, active site[b2] 2WGP b1/61,77,78,79,81,83,84,
85; b2/80,81,82,116,149,150,151,
152,185
4 blue 7.149 261 225.5 0.7171 0.8672 0.4532
Protein Phosphatases DUSP3[a],DUSP3[a1] P51452[a],
P51452[a1]
Catalytic domain IPR000387[a],
IPR020422[a1]
Tyrosine specific protein phosphatases domain[a],Dual specificity protein phosphatase domain[a1] 3F81 a/10,13,14,15,16,17,18,19,21,23,
151,152,155,156; a1/64,65,66,67,
70,72,73,74,75,76,85,89
4 blue 9.562 354 346.8 0.6618 0.9044 0.699
Protein Phosphatases DUSP3[a],DUSP3[a1] P51452[a],
P51452[a1]
Catalytic domain IPR000387[a] Tyrosine specific protein phosphatases domain[a] 3F81 a/27,28,29,30,31,32,38,50,54,
155,156,157,158,159; a1/89,91,
93,95,96,97
4 blue a/C30(reactive:0.725) 11.33 232.8 250 0.4644 0.7657 -0.6052
Protein Phosphatases DUSP26[a],DUSP26[b] Q9BV47[a],
Q9BV47[b]
Catalytic domain IPR000387[b] Tyrosine specific protein phosphatases domain[b] 4HRF a/64,65,66,67,181,185; b/64,65,
66,67,68,181,185
4 blue 16.18 203.2 216.1 0.6438 0.729 -0.443
Protein Phosphatases DUSP12[a] Q9UNI6[a] Catalytic domain IPR020422[a] Dual specificity protein phosphatase domain[a] 4JNB a/44,45,46,48,49,52,53,54,67,69,
70,71,72,75
4 blue 13.01 180.7 196.6 0.6671 0.7986 -0.2023
Protein Phosphatases DUSP11[a] O75319[a] Catalytic domain IPR020422[a] Dual specificity protein phosphatase domain[a] 4NYH a/124,127,128,132,133,134,135,
154,155,156,157,184,188,193
4 blue 15.5 174 203.6 0.5768 0.7957 -0.4469
Protein Phosphatases PTEN[a] P60484[a] Catalytic domain IPR016130[a] Protein-tyrosine phosphatase, active site[a] 5BUG a/16,17,21,22,23,24,42,43,45,46,
47,48,49,52,126,127,128,159,160
4 blue 7.026 228.7 285.9 0.4833 0.7608 -0.5946
Protein Phosphatases DUSP26[a],DUSP26[b] Q9BV47[a],
Q9BV47[b]
Catalytic domain IPR016130[b] Protein-tyrosine phosphatase, active site[b] 5GTJ a/49,53; b/50,53,54,55,56,57,58,
120,122,154,156,157,189,190,191,
192
4 blue 7.575 269 273.4 0.5571 0.7324 -0.4195
Protein Phosphatases PTP4A2[a3] Q12974[a3] Catalytic domain IPR000387[a3] Tyrosine specific protein phosphatases domain[a3] 5K23 a3/71,72,73,74,75,78,79,82,118,
141,144,145,148,149,150,154
4 blue 7.045 362.2 386.1 0.5718 0.7449 -0.117
Protein Phosphatases PDXP[a],PDXP[a1] Q96GD0[a],
Q96GD0[a1]
Catalytic domain 2CFT a/163,164,166,167,169,203,204,
205,206; a1/181,188,189
4 blue a/C163(reactive:0.68) 11.74 165 180.9 0.5662 0.7631 -0.6385
Protein Phosphatases PDXP[a1] Q96GD0[a1] Catalytic domain 2OYC a1/41,44,45,47,48,49,52,53,54,
55,76,77,78,79,80,81,84
4 blue 10.3 243.3 252.3 0.5647 0.761 -0.3636
Protein Phosphatases CDC25B[a] P30305[a] Catalytic domain 1CWT a/391,392,393,394,396,400,411,
412,413,498,499,502,517,518,519,
520
4 blue a/C498(reactive:0.775) 11.77 191 192.4 0.4765 0.7618 -0.7393
Protein Phosphatases PPP2CA[c] P67775[c] Catalytic domain 2IE4 c/11,14,15,18,66,69,70,74,75,76,
99,103,106,107
4 blue 12.75 267.9 267.8 0.5648 0.7495 -0.3374
Protein Phosphatases PPP3CA[a] Q08209[a] Catalytic domain IPR004843[a] Calcineurin-like phosphoesterase domain, ApaH type[a] 2P6B a/202,203,204,206,207,247,248,
264,267,268,271
4 blue 12.59 167.1 166.8 0.646 0.8523 -0.09622
Protein Phosphatases PPP2R1A[a],PPP2CA[c] P30153[a],
P67775[c]
Catalytic domain 3K7W a/456; c/11,14,15,18,66,69,70,
74,75,76,99,103,106,107
4 blue 12.75 292.3 285.4 0.5455 0.7134 -0.4589
Protein Phosphatases PPP1CA[a],PPP1R10(rat)[b] P62136[a],
O55000[b]
Catalytic domain IPR004843[a] Calcineurin-like phosphoesterase domain, ApaH type[a] 4MOY a/164,166,167,168,183,239,240,
241; b/394,395,396,397
4 blue 14.28 200.1 236.3 0.5084 0.7363 -0.7329
Protein Phosphatases PPP3CB[a] P16298[a] Catalytic domain IPR004843[a] Calcineurin-like phosphoesterase domain, ApaH type[a] 4ORA a/245,246,247,251,252,253,255,
256,257,258,268,269,270
4 blue 7.411 166.7 177 0.5452 0.7839 -0.5967
Protein Phosphatases PTPN6[a] P29350[a] Catalytic domain 2B3O a/55,56,57,58,59,60,62,356,358,
360,419,420
4 blue 7.297 187.7 186.6 0.6113 0.8746 -0.001469
Protein Phosphatases PTPN22[a] Q9Y2R2[a] Catalytic domain IPR000387[a] Tyrosine specific protein phosphatases domain[a] 4J51 a/11,14,15,18,19,21,24,193,194,
195,196,197,198,199,201,202,277,
280,281,283,284,287,291
4 blue 10.88 268.7 327 0.4992 0.7188 -0.6054
Protein Phosphatases PTPN12[a],PTPN12[b] Q05209[a],
Q05209[b]
Catalytic domain IPR000242[a],
IPR000242[b]
PTP type protein phosphatase[a],PTP type protein phosphatase[b] 5J8R a/134,135,136,137,138,139,145,
147,149,150,167,168,169,174,176,
193,195; b/134,135,136,137,138,
139,145,147,149,150,167,168,169,
174,176,193,195
4 blue 9.347 517 596.5 0.462 0.6592 -0.441
Protein Phosphatases PTPN12[a],PTPN12[c] Q05209[a],
Q05209[c]
Catalytic domain IPR000242[a],
IPR000242[c]
PTP type protein phosphatase[a],PTP type protein phosphatase[c] 5J8R a/154,156,158,159,160,161,181,
182,183,184,185,186; c/78,79,
122,123,124,125,182,183,185,186,
187
4 blue 20.92 451.5 377 0.5496 0.8467 0.3964
Protein Phosphatases PTP4A2[a3] Q12974[a3] Catalytic domain IPR000387[a3] Tyrosine specific protein phosphatases domain[a3] 5K23 a3/71,72,73,74,75,78,79,82,118,
141,144,145,148,149,150,154
4 blue 7.045 362.2 386.1 0.5718 0.7449 -0.117
Protein Phosphatases UBASH3B[b] Q8TF42[b] Catalytic domain 5VR6 b/408,411,412,413,414,425,426,
427,428,431,432,435
4 blue 16.690001 160.7 156.6 0.5347 0.7755 -0.6805
Protein Phosphatases PTPN6[a] P29350[a] Catalytic domain IPR000242[a] PTP type protein phosphatase[a] 1GWZ a/257,258,259,260,282,284,285,
306,307,308,309,310,311,490,493,
494
4

5QDG[aws],5QDJ[jfp3],5QFN[jov2
Pocket PP5 cyan 15.45 310.5 287.9 0.6303 0.7856 0.0623
Protein Phosphatases PTPN22[a] Q9Y2R2[a] Catalytic domain IPR000242[a] PTP type protein phosphatase[a] 3OLR a/67,68,69,70,71,72,89,90,91,96,
97,120
4

5QDG[aws],5QDJ[jfp3],5QFN[jov2
Pocket PP5 cyan 15.04 172.3 208.4 0.577 0.7365 -0.6866
Protein Phosphatases PPP3CA[a],PPP3R1[b] Q08209[a],
P63098[b]
Catalytic domain 5SVE a/24,25,26,27,28,53,54,55,128,
168,169; b/135,138,139
4 Pocket PP6 green 11.94 270 229.6 0.7418 0.9456 0.8427
Protein Phosphatases PPP3CA[a],PPP3R1[b] Q08209[a],
P63098[b]
Catalytic domain 6NUU a/164,168,342,343,345,346,347,
348,349; b/132,135,136,139,140,
156
4 Pocket PP6 green 11.68 161.6 211.8 0.5515 0.7436 -0.7642
Protein Phosphatases PPP3CA[a],PPP3R1[b] Q08209[a],
P63098[b]
Catalytic domain IPR004843[a] Calcineurin-like phosphoesterase domain, ApaH type[a] 2P6B a/24,25,26,27,28,53,54,55,125,
128,164,168,169,342,343,345,346,
347,348,349,351; b/132,135,136,
138,139,140,156
4 Pocket PP6,Pocket PPI4 green 11.04 482.5 446.8 0.7332 0.8995 1.07
Protein Phosphatases PPP3CB[a],PPP3R1[b] P16298[a],
P63098[b]
Catalytic domain 4ORA a/21,32,33,34,35,36,37,58,62,63,
64,134,137,177,178,179; b/135,
137,138,139,141,142,144,146
4 Pocket PP6,Pocket PPI4 green 11.62 470.8 444.2 0.5395 0.8297 0.3377
Protein Phosphatases PPP3CB[a],PPP3R1[b] P16298[a],
P63098[b]
Catalytic domain 4ORA a/173,177,351,352,355,356,357,
358,360; b/132,135,136,139,140,
142,156
4 Pocket PP6,Pocket PPI4 green 12.24 235.3 253.9 0.628 0.7615 -0.2425
Protein Phosphatases PTPRS[a] Q13332[a] Catalytic domain IPR000242[a] PTP type protein phosphatase[a] 2FH7 a/1554,1556,1561,1562,1563,1566,
1719,1720,1740,1742,1747,1748,
1914,1917,1918
4 Pocket PP2 orange 13.1 200.6 203.3 0.5042 0.7238 -0.7895
Protein Phosphatases PTPRG[a] P23470[a] Catalytic domain IPR000242[a] PTP type protein phosphatase[a] 2NLK a/952,955,988,1023,1024,1025,
1026,1027,1028,1029,1031,1032,
1033,1034,1037,1038,1189,1190,
1210,1212,1217,1218,1385,1389
4 Pocket PP2 orange a/C988(reactive:0.81) 8.849 342.9 354 0.5698 0.8563 0.277
Protein Phosphatases PPP3CA[a] Q08209[a] Catalytic domain IPR006186[a] Serine[a] 1AUI a/193,194,247,262,263,266,267,
269,270,273,274,275,294,295,296,
297
4 Pocket PP7 orange a/C266(reactive:0.805) 16.75 242.1 283.1 0.495 0.7073 -0.7366
Protein Phosphatases PPP2CA[c] P67775[c] Catalytic domain IPR006186[c] Serine[c] 2IE4 c/162,163,226,229,230,234,235,
236,250,253,254,255,281,282,283,
284
4 Pocket PP7 orange 14.64 232 305.2 0.5385 0.7008 -0.6953
Protein Phosphatases PPP3CB[a] P16298[a] Catalytic domain IPR006186[a] Serine[a] 4OR9 a/202,203,271,275,278,279,282,
283,284,303,304,305,306
4 Pocket PP7 orange a/C275(reactive:0.81) 16.709999 231.8 250.4 0.5931 0.7639 -0.3233
Protein Phosphatases PPP1CA[a],TP53BP2[d] P62136[a],
Q13625[d]
Catalytic domain IPR006186[a] Serine[a] 6GHM a/211,229,252,253,255,256,257,
258,259,260,261,277,278,279,292,
293,295,298; d/925,927,928,931,
932,935,936,938,956,957,958,960,
965
4 Pocket PP7 orange 12.75 522 528.8 0.507 0.7594 0.063
Protein Phosphatases PPP1CA[a],PPP1R9B[c] P62136[a],
Q96SB3[c]
Catalytic domain IPR006186[a] Serine[a] 3EGG a/233,236,237,240,241,242,260,
261,262; c/440,441,442,443,444,
446,447,451
4 Pocket PP7,Pocket PPI5 orange 16.870001 306.3 318.5 0.4631 0.7027 -0.6535
Protein Phosphatases PPP1CA[a],PPP1R9A[c] P62136[a],
Q9ULJ8[c]
Catalytic domain IPR006186[a] Serine[a] 3HVQ a/168,211,229,233,236,237,240,
241,242,251,252,253,255,256,257,
258,259,260,261,262; c/442,443,
444,445,446,447,448,449,450,451,
452,453,454,455,457,459,464
4 Pocket PP7,Pocket PPI5 orange 11.89 530.3 624.1 0.4521 0.6639 -0.4263
Protein Phosphatases PPP1CA[a],PPP1R10(rat)[b] P62136[a],
O55000[b]
Catalytic domain 4MP0 a/20,21,22,23,24,25,70,73,74,77,
98; b/414,415,416,418,419
4 Pocket PP9 purple 11.19 277.6 288.6 0.5649 0.7974 -0.1223
Protein Phosphatases PPP3CB[a],PPP3R1[b] P16298[a],
P63098[b]
Catalytic domain IPR004843[a] Calcineurin-like phosphoesterase domain, ApaH type[a] 4OR9 a/31,32,33,60,61,62,105,108,109,
112,319,322,345,346,347,348,349,
350; b/127,128,131
4 Pocket PP9 purple a/C345(reactive:0.79) 8.908 337.2 405.8 0.457 0.6389 -0.8479
Protein Phosphatases PPP1CA[a] P62136[a] Catalytic domain IPR006186[a] Serine[a] 3EGH a/49,50,53,54,55,56,58,59,86,
116,117,119
4 Pocket PP8 red 13.92 176.6 194.9 0.497 0.756 -0.7733
Protein Phosphatases PPP2R1A[a],PPP2CA[c] P30153[a],
P67775[c]
Catalytic domain IPR006186[c] Serine[c] 3K7W a/532,533,534,535,537,572; c/38,
41,42,46,47,48,49,50,51,52,79,
80,81,104,108,109,110,111,112
4 Pocket PP8 red c/C50(reactive:0.55) 13.09 631.2 508.9 0.5176 0.8293 0.5027
Protein Phosphatases PPP1CC[a] P36873[a] Catalytic domain IPR006186[a] Serine[a] 5INB a/49,50,53,54,55,56,58,59,86,
116,117,119
4 Pocket PP8 red 13.78 161.5 187.9 0.5182 0.8055 -0.5962
Protein Phosphatases PPP2R1A[a],PPP2CA[c] P30153[a],
P67775[c]
Catalytic domain IPR006186[c] Serine[c] 3K7V a/532,533,534,535,537,571,
572; c/38,41,42,46,47,48,49,50,
51,52,79,80,81,104,108,109,110,
111,112
4 Pocket PP8,Pocket PPI3 red c/C50(0.495) 12.88 607.6 501.6 0.5188 0.8234 0.4539
Protein Phosphatases CDC25A[a] P30304[a] Catalytic domain 1C25 a/338,340,343,379,380,381,382,
398,400,411,412,415,416,417,418,
420,422,423,424,425,457,458,459,
460,461
4 red 13.88 350.5 385.1 0.5182 0.7602 -0.2027
Protein Phosphatases CDC25B[a] P30305[a] Catalytic domain 2IFV a/393,395,398,472,473,474,477,
478,479,480,481,514,515,516,517,
518
4 red 19.57 188.1 184.2 0.5925 0.8197 -0.2589
Protein Phosphatases CDC25C[a1] P30307[a1] Catalytic domain 3OP3 a1/283,285,288,362,363,364,367,
369,370,371,404,405,406,407,408
4 red 19.450001 193.6 178.4 0.5425 0.7909 -0.4649
Protein Phosphatases YWHAZ[b],CDC25C[c] P63104[b],
P30307[c]
Catalytic domain 5M36 b/49,50,53,56,57,60,61; c/210,
211,212,213,214,216,218,219
4 red 0 228.9 230.1 0.5355 0.7341 -0.5808
Protein Kinases KIT[b] P10721[b] Immunoglobulin(-like) domain 2E9W b/69,70,71,93,94,108,133,135,
137,167,168
4 black 0 235.2 208.6 0.5831 0.8006 -0.1908
Protein Kinases PDGFRB[x] P09619[x] Immunoglobulin(-like) domain 3MJG x/63,64,65,66,93,95,96,97,99,
113,115,117,128,129,130,148,150,
176,177
4 black 0 325.9 345.4 0.4782 0.7168 -0.518
Protein Kinases KDR[r1] P35968[r1] Immunoglobulin(-like) domain IPR003599[r1] Immunoglobulin subtype[r1] 3V6B r1/149,150,151,152,157,159,179,
200,201,202,209,210,211,214
4 black 0 210.6 196.3 0.6734 0.776 -0.1641
Protein Kinases CSF1R[e] P07333[e] Immunoglobulin(-like) domain IPR003599[e] Immunoglobulin subtype[e] 4LIQ e/53,54,55,57,76,77,105,106,107,
108,109,110,111,186,187,188,189
4 black 0 283.7 293.2 0.5799 0.7623 -0.2101
Protein Kinases CSF1R[a] P07333[a] Immunoglobulin(-like) domain IPR003599[a] Immunoglobulin subtype[a] 4WRM a/53,54,55,76,77,101,103,105,
106,107,108,109,110,111,112,113,
130,186,187,188,189
4 black 0 435.4 433.5 0.5755 0.8031 0.2569
Protein Kinases VEGFA[v],VEGFA[w],FLT1[y] P15692[v],
P15692[w],
P17948[y]
Immunoglobulin(-like) domain IPR003598[y] Immunoglobulin subtype 2[y] 5T89 v/42,43,44,45,48; w/105; y/133,
138,140,141,142,170,171,172,173,
174,175,204,205,206,208,214,215,
216,217,219
4 black 0 431.1 445.5 0.5745 0.7927 0.2063
Protein Kinases FLT1[x] P17948[x] Immunoglobulin(-like) domain 5T89 x/64,65,98,99,100,101,102,103,
104,125,130,133,135,136,137,138,
139,155,157,159,189,190
4 black 0 344.2 409.1 0.4758 0.6721 -0.6592
Protein Kinases VEGFA[w],FLT1[x] P15692[w],
P17948[x]
Immunoglobulin(-like) domain IPR003599[x] Immunoglobulin subtype[x] 5T89 w/44,48; x/170,171,172,173,174,
175,176,204,205,206,208,217,219
4 black 0 221.1 217.8 0.5681 0.7984 -0.2789
Protein Kinases KDR[n] P35968[n] Immunoglobulin(-like) domain IPR003599[n] Immunoglobulin subtype[n] 2X1W n/155,156,157,158,159,160,169,
171,172,178,179,180,181,201,202,
203
4 blue 0 198 251.9 0.5057 0.6957 -0.9069
Protein Kinases PDGFB[a],PDGFRB[y] P01127[a],
P09619[y]
Immunoglobulin(-like) domain 3MJG a/158,161,162,163,165; y/133,
134,136,137,138,139,140,145,146,
148,209
4 blue 0 217.1 271.1 0.4968 0.7009 -0.8387
Protein Kinases FLT1[x] P17948[x] Immunoglobulin(-like) domain IPR003599[x] Immunoglobulin subtype[x] 5T89 x/49,60,61,63,65,66,67,68,69,70,
71,72,73,92,93,94,101,105
4 blue 0 387.9 315.4 0.6575 0.8434 0.5165
Protein Kinases VEGFA[v],FLT1[x] P15692[v],
P17948[x]
Immunoglobulin(-like) domain 5T89 v/107,115,116,117; x/138,139,
140,141,142,143,144,145
4 blue 0 231.9 265.4 0.4956 0.6961 -0.8114
Protein Kinases KIT[b] P10721[b] Immunoglobulin(-like) domain 2E9W b/150,151,154,155,156,157,178,
179,182,183,184
4 purple 0 197.8 194.2 0.5261 0.7439 -0.6715
Protein Kinases VEGFC[b],KDR[m] P49767[b],
P35968[m]
Immunoglobulin(-like) domain IPR003599[m] Immunoglobulin subtype[m] 2X1W b/126,129,130,131,165,166,167,
171,210,211; m/142,165,166,168,
170,190,191,193,194,195,196
4 purple 0 253.6 290.8 0.4913 0.766 -0.4798
Protein Kinases VEGFC[e],KDR[r],VEGFC[e4] P49767[e],
P35968[r],
P49767[e4]
Immunoglobulin(-like) domain IPR003599[r] Immunoglobulin subtype[r] 2X1X e/155; r/165,166,168,170,190,
191,194,196; e4/126,129,130,131,
165,166,167,171,210,211,212
4 purple 0 225.3 267.9 0.5252 0.7966 -0.3693
Protein Kinases PDGFB[a],PDGFB[b],PDGFRB[y] P01127[a],
P01127[b],
P09619[y]
Immunoglobulin(-like) domain 3MJG a/121; b/94,95,96,97,98,99,133,
134,135,139,177,178,179,
180; y/162,163,164,185,186,187,
205
4 purple 0 437.3 339.9 0.6135 0.8925 0.6984
Protein Kinases IL34[a],CSF1R[c] Q6ZMJ4[a],
P07333[c]
Immunoglobulin(-like) domain IPR003599[c] Immunoglobulin subtype[c] 4DKD a/64,65,67,100,103,104,106,107,
108,111,116,120,123,149,150,151,
152,153,155; c/142,144,145,146,
147,148,149,150,151,152,153,154,
170
4 purple 0 610.5 628.8 0.5192 0.7824 0.297
Protein Kinases IL34[a],CSF1R[c] Q6ZMJ4[a],
P07333[c]
Immunoglobulin(-like) domain IPR003599[c] Immunoglobulin subtype[c] 4DKD a/92,96,99,100,103,127,130,131,
134,135,136,137,138,146,149,
150; c/142,143,144,146,172,173,
174,192,193,194
4 purple 0 548.2 447.5 0.6266 0.906 0.9482
Protein Kinases VEGFA[v],VEGFA[w],FLT1[x] P15692[v],
P15692[w],
P17948[x]
Immunoglobulin(-like) domain IPR003598[x] Immunoglobulin subtype 2[x] 5T89 v/56,58,79; w/48,49,51,52,53,54,
55,87,92,97,126,127,128,129,
130; x/171,172,173,174,175,177,
199,200,201,202,203
4 purple 0 562.2 531.1 0.5797 0.7714 0.33
Protein Kinases FGF1[a],FGFR2[b] P05230[a],
P21802[b]
Immunoglobulin(-like) domain IPR007110[b] Immunoglobulin-like domain[b] 1E0O a/65,66,67,68,101,102,103,104,
105,111,112,113,121,123,139,
140; b/255,256,257,258,260,261,
350,351,352,353,354
4 blue 0 544.3 483 0.6204 0.7946 0.4898
Protein Kinases TYRO3[a] Q06418[a] Immunoglobulin(-like) domain 1RHF a/109,112,113,114,132,133,134,
135,164,165
4 blue 0 155.9 190.3 0.6216 0.7401 -0.6449
Protein Kinases KIT[a] P10721[a] Immunoglobulin(-like) domain IPR003598[a] Immunoglobulin subtype 2[a] 2EC8 a/125,127,180,181,203,204,205,
206,207,208,238,239,240,241,263,
265,266,267,295
4 blue 0 318.8 301.1 0.5222 0.7074 -0.4715
Protein Kinases VEGFB[a],FLT1[x] P49765[a],
P17948[x]
Immunoglobulin(-like) domain IPR003599[x] Immunoglobulin subtype[x] 2XAC a/66,104,105,106,107,108,
109; x/137,138,139,140,142,143,
144,145,147,218,219,220
4 blue 0 201 242.7 0.4897 0.7185 -0.8418
Protein Kinases FLT3[e] P36888[e] Immunoglobulin(-like) domain IPR007110[e] Immunoglobulin-like domain[e] 3QS7 e/254,255,256,258,259,261,349,
373,374,375,376,377,378,396,397,
398,399,400,401,402
4 blue 0 292.4 293.7 0.4574 0.6899 -0.7514
Protein Kinases FLT4[a] P35916[a] Immunoglobulin(-like) domain IPR007110[a] Immunoglobulin-like domain[a] 4BSJ a/369,371,372,396,398,400,401,
402,404,407,409,410,411
4 blue 0 219.5 296.7 0.5317 0.667 -0.8848
Protein Kinases FLT1[a],FLT1[c] P17948[a],
P17948[c]
Immunoglobulin(-like) domain IPR003598[a],
IPR003598[c]
Immunoglobulin subtype 2[a],Immunoglobulin subtype 2[c] 4CL7 a/140,141,142,143,172,204,
219; c/140,141,142,143,170,172,
173,174,175,176,204,206,208,217,
219
4 blue 0 283.6 324.9 0.5246 0.7447 -0.4054
Protein Kinases GAS6[b],AXL[c] Q14393[b],
P30530[c]
Immunoglobulin(-like) domain IPR007110[c] Immunoglobulin-like domain[c] 4RA0 b/365,366,367,368,369; c/172,
174,177,178,179,181,182,183,184,
206,208
4 blue 0 202.2 232.2 0.4857 0.6798 -0.9995
Protein Kinases GAS6[b],AXL[d] Q14393[b],
P30530[d]
Immunoglobulin(-like) domain IPR007110[d] Immunoglobulin-like domain[d] 4RA0 b/414,416,418; d/66,67,68,69,75,
76,77,78,79,81,83,102
4 blue 0 289.7 250.7 0.5966 0.8705 0.269
Protein Kinases CSF1R[a] P07333[a] Immunoglobulin(-like) domain IPR003599[a] Immunoglobulin subtype[a] 4WRM a/315,341,342,373,376,397,398,
399,400,401,463,464,465
4 blue 0 211.1 222.9 0.5689 0.6817 -0.7708
Protein Kinases CSF1R[a] P07333[a] Immunoglobulin(-like) domain IPR003599[a] Immunoglobulin subtype[a] 4WRM a/310,311,312,395,397,400,424,
426,459,460,461,462,463,464,465,
466
4 blue 0 297.1 259 0.5721 0.7661 -0.1791
Protein Kinases FGF9[a],FGFR1[b] P31371[a],
P11362[b]
Immunoglobulin(-like) domain IPR007110[b] Immunoglobulin-like domain[b] 5W59 a/168,169; b/159,160,161,162,
163,166,175,176,177,179
4 blue 0 206.3 217.5 0.5123 0.7268 -0.739
Protein Kinases FGFR2[a1],FGF1[b1] P21802[a1],
P05230[b1]
Immunoglobulin(-like) domain IPR003598[a1] Immunoglobulin subtype 2[a1] 1DJS a1/285,286,287,288,315,316,317,
318,319,320,321,324; b1/23,24,
25,60,61,62,63,72,79
4 cyan 0 235.7 230.5 0.5306 0.8447 -0.1344
Protein Kinases FGF1[a],FGFR3[b] P05230[a],
P22607[b]
Immunoglobulin(-like) domain IPR003598[b] Immunoglobulin subtype 2[b] 1RY7 a/23,24,60,61,62,63,64; b/272,
282,283,284,285,286,287,308,309,
311,312,313,314,315,316,317,318,
319,321,322,323,324,325
4 cyan 0 556.5 529.3 0.5474 0.8059 0.3852
Protein Kinases KIT[a] P10721[a] Immunoglobulin(-like) domain IPR003599[a] Immunoglobulin subtype[a] 2EC8 a/337,342,343,344,345,346,347,
354,355,359,361,362,363,373,374,
393,394,395,400
4 cyan 0 247.8 325.3 0.4854 0.6767 -0.8619
Protein Kinases FGF1[a],FGFR1[c] P05230[a],
P11362[c]
Immunoglobulin(-like) domain IPR003598[c] Immunoglobulin subtype 2[c] 3OJV a/23,60,61,62,63,72,79; c/284,
285,286,287,314,315,316,317,318,
319,320,323
4 cyan 0 267 248.4 0.6064 0.8783 0.2617
Protein Kinases FGFR2[a],FGF1[b] P21802[a],
P05230[b]
Immunoglobulin(-like) domain IPR003598[a] Immunoglobulin subtype 2[a] 4J23 a/280,285,286,287,288,315,316,
317,319,320,321,324; b/23,60,61,
62,63
4 cyan 0 215 190.2 0.7331 0.8758 0.38
Protein Kinases FLT1[y] P17948[y] Immunoglobulin(-like) domain IPR003599[y] Immunoglobulin subtype[y] 5T89 y/461,462,463,464,465,466,491,
492,505,506,507,509,518,520
4 cyan 0 169.6 199.8 0.5156 0.7202 -0.9022
Protein Kinases SPEG[a] Q15772[a] Immunoglobulin(-like) domain IPR003598[a] Immunoglobulin subtype 2[a] 1U2H a/873,874,875,876,877,878,887,
888,889,940,955,956,957
4 Same pocket as Tyrosine-protein kinase family: Immunoglobulin(-like)-domain darkblue 0 172.9 193 0.6953 0.8935 0.2027
Protein Kinases FGF1[c],FGFR2[d] P05230[c],
P21802[d]
Immunoglobulin(-like) domain IPR007110[d] Immunoglobulin-like domain[d] 1E0O c/33,34,128,143; d/160,161,162,
163,164,167,169,174,175,176,177,
178
4 darkblue 0 302.5 313.9 0.4606 0.724 -0.5845
Protein Kinases FGF2[a],FGFR2[e] P09038[a],
P21802[e]
Immunoglobulin(-like) domain IPR007110[e] Immunoglobulin-like domain[e] 1IIL a/168,169,170,186,245,262,263,
277; e/160,161,162,163,164,167,
169,170,173,174,175,176,177,178
4 darkblue 0 410.5 397.9 0.5367 0.7626 -0.0344
Protein Kinases FGF1[a],FGFR3[b] P05230[a],
P22607[b]
Immunoglobulin(-like) domain IPR007110[b] Immunoglobulin-like domain[b] 1RY7 a/34,36,50,128,129; b/155,158,
159,160,161,162,164,171,172,173,
174,175,176,177
4 darkblue b/C176(0.395) 0 349.4 368.1 0.4831 0.6997 -0.5229
Protein Kinases KIT[b] P10721[b] Immunoglobulin(-like) domain IPR003598[b] Immunoglobulin subtype 2[b] 2E9W b/218,220,221,222,223,224,227,
228,229,230,304,306,340,341,342,
363,366,367,368,369,370,371,373
4 darkblue 0 431 470.3 0.4878 0.6902 -0.3948
Protein Kinases FGF1[a],FGFR1[c] P05230[a],
P11362[c]
Immunoglobulin(-like) domain IPR007110[c] Immunoglobulin-like domain[c] 3OJV a/30,32,33,34,36,50,109,128,129,
143,146; c/159,160,161,162,163,
166,167,168,172,173,174,175,176,
177
4 darkblue 0 460.4 452.2 0.5032 0.7001 -0.2719
Protein Kinases TEK[a] Q02763[a] Immunoglobulin(-like) domain IPR007110[a] Immunoglobulin-like domain[a] 4K0V a/354,355,356,359,366,367,368,
369,370,371,385,424,437,439
4 darkblue 0 183.1 191.4 0.5152 0.6936 -0.9511
Protein Kinases FLT1[y] P17948[y] Immunoglobulin(-like) domain 5T89 y/338,339,340,341,344,350,352,
353,354,355,356,357
4 darkblue 0 161.1 197.2 0.6166 0.8076 -0.3664
Protein Kinases FGF9[a],FGFR1[b] P31371[a],
P11362[b]
Immunoglobulin(-like) domain IPR007110[b] Immunoglobulin-like domain[b] 5W59 a/67,69,145,168,183; b/163,166,
167,168,172,173,174,175
4 darkblue 0 206.5 189.6 0.4771 0.8196 -0.4526
Protein Kinases FGFR2[b] P21802[b] Immunoglobulin(-like) domain IPR003598[b] Immunoglobulin subtype 2[b] 1E0O b/279,280,281,282,284,285,286,
287,288,315,316,321,324,325
4 green 0 270.5 299.6 0.5643 0.7573 -0.3005
Protein Kinases FGF1[a],FGFR2[b] P05230[a],
P21802[b]
Immunoglobulin(-like) domain IPR003598[b] Immunoglobulin subtype 2[b] 1E0O a/106,108; b/252,253,254,255,
256,257,281,282,283,284,346,347,
348
4 green 0 197.5 226.1 0.5938 0.8316 -0.1729
Protein Kinases FGF2[a],FGF2[d],FGFR2[e],FGFR2[h] P09038[a],
P09038[d],
P21802[e],
P21802[h]
Immunoglobulin(-like) domain IPR003598[e] Immunoglobulin subtype 2[e] 1EV2 a/239,240,241,242,243,
244; d/239,240,241,242,
244; e/171,172,250,251,253,254,
255; h/253,254,255,257,347,348
4 green 0 501.5 494.7 0.5535 0.7639 0.1568
Protein Kinases FGF2[b],FGF2[c],FGFR2[f],FGFR2[g] P09038[b],
P09038[c],
P21802[f],
P21802[g]
Immunoglobulin(-like) domain IPR007110[f],
IPR007110[g]
Immunoglobulin-like domain[f],Immunoglobulin-like domain[g] 1EV2 b/239,240,241,242,244; c/239,
240,241,242,244; f/170,171,172,
250,251,253,254,255,257,347,
348; g/170,171,172,249,250,251,
253,254,255,347,348
4 green 0 595.2 605.4 0.5792 0.791 0.4483
Protein Kinases FGFR1[c],FGFR1[d] P11362[c],
P11362[d]
Immunoglobulin(-like) domain IPR007110[c],
IPR007110[d]
Immunoglobulin-like domain[c],Immunoglobulin-like domain[d] 1EVT c/253,254,255,256,257,350,351,
352; d/253,254,255,256,257,350,
351,352
4 green 0 256.6 298 0.4904 0.6779 -0.8202
Protein Kinases FGF1[a],FGFR3[b] P05230[a],
P22607[b]
Immunoglobulin(-like) domain IPR003598[b] Immunoglobulin subtype 2[b] 1RY7 a/106,107,108,109; b/166,167,
168,169,170,247,248
4 green 0 179.9 195.9 0.6218 0.7378 -0.5481
Protein Kinases GAS6[a],AXL[d] Q14393[a],
P30530[d]
Immunoglobulin(-like) domain IPR003599[d] Immunoglobulin subtype[d] 2C5D a/392,394,397,398,399,402; d/45,
46,47,48,50,136,137,138,139,140,
211,214
4 green 0 242.9 281.6 0.4822 0.7377 -0.6436
Protein Kinases KIT[a] P10721[a] Immunoglobulin(-like) domain IPR003598[a] Immunoglobulin subtype 2[a] 2EC8 a/223,224,225,308,309,310,311,
312,340,341
4 green 0 183 176.3 0.5906 0.8301 -0.2424
Protein Kinases FGF8[m],FGFR2[p] P55075[m],
P21802[p]
Immunoglobulin(-like) domain 2FDB m/70,71,72,194,195,196,
197; p/226,249,250,251,252,254,
255,256,257,281,282,283,318,319,
320,321,322,323
4 green 0 598.6 475.6 0.5635 0.803 0.464
Protein Kinases FLT4[a],FLT4[a4] P35916[a],
P35916[a4]
Immunoglobulin(-like) domain IPR003599[a] Immunoglobulin subtype[a] 4BSJ a/421,422,423,424,425,427,428,
542,543; a4/425,428
4 green 0 174.6 220.3 0.6135 0.7612 -0.497
Protein Kinases CSF1R[e] P07333[e] Immunoglobulin(-like) domain IPR003598[e] Immunoglobulin subtype 2[e] 4LIQ e/197,198,199,200,201,202,203,
204,227,228,229,230,232,256,282,
283,284,287
4 green 0 359.1 293.5 0.5492 0.7913 0.008453
Protein Kinases GAS6[b],AXL[c] Q14393[b],
P30530[c]
Immunoglobulin(-like) domain IPR007110[c] Immunoglobulin-like domain[c] 4RA0 b/389,390,392,394,397,398,399,
402,404; c/46,47,48,50,135,136,
137,138,139,140,141,144,163,164,
165,166,209,214,215,216
4 green 0 411.6 425.8 0.5171 0.8056 0.09231
Protein Kinases FGF9[a],FGFR1[b] P31371[a],
P11362[b]
Immunoglobulin(-like) domain 5W59 a/62,64,97,105,138,146,148,188,
189,190,191; b/248,249,250,282,
283,284,285
4 green 0 269 243.3 0.6486 0.8865 0.3954
Protein Kinases FGF9[a],FGFR1[b] P31371[a],
P11362[b]
Immunoglobulin(-like) domain IPR003598[b] Immunoglobulin subtype 2[b] 5W59 a/60,61,62,63,64,191,192,
201; b/277,278,279,280,285,287,
320,321,323,324
4 green 0 237 261.8 0.4603 0.745 -0.6826
Protein Kinases GAS6[b],AXL[d] Q14393[b],
P30530[d]
Immunoglobulin(-like) domain IPR007110[d] Immunoglobulin-like domain[d] 2C5D b/314; d/71,72,74,75,76,77,78,
79,80,102,103,104,105,106,108,
111,115
4 lightblue 0 230.6 274.4 0.4795 0.748 -0.6477
Protein Kinases KIT[a] P10721[a] Immunoglobulin(-like) domain IPR003598[a] Immunoglobulin subtype 2[a] 2EC8 a/245,246,247,248,251,252,253,
254,255,257,275,288
4 lightblue 0 199.5 199.9 0.6181 0.8017 -0.2283
Protein Kinases FLT3[e],FLT3[f] P36888[e],
P36888[f]
Immunoglobulin(-like) domain 3QS7 e/388,389,390,408,410; f/361,
363,364,365,366,367,407,408,409,
410,411
4 lightblue 0 256.1 335.5 0.4726 0.6707 -0.8905
Protein Kinases FGFR1[c] P11362[c] Immunoglobulin(-like) domain IPR007110[c] Immunoglobulin-like domain[c] 1CVS c/291,292,293,294,299,309,311,
328,333,334,335,336,337,338,339,
355
4 purple 0 222.5 242.7 0.4646 0.6958 -0.9135
Protein Kinases VEGFA[w],FLT1[x] P15692[w],
P17948[x]
Immunoglobulin(-like) domain IPR003598[x] Immunoglobulin subtype 2[x] 1QTY w/48,49,51,52,53,54,87,89,92,
127,128,129,130; x/171,172,173,
174,175,199,200,202,203
4 purple 0 368.5 368 0.645 0.8202 0.3585
Protein Kinases KIT[b] P10721[b] Immunoglobulin(-like) domain 2E9W b/384,385,387,388,407,408,409,
410,411,433,467,468,469,470,471
4 purple 0 235.4 241.2 0.6338 0.7859 -0.1328
Protein Kinases KIT[a],KIT[b] P10721[a],
P10721[b]
Immunoglobulin(-like) domain IPR003599[a] Immunoglobulin subtype[a] 2E9W a/355,356,358,378,379,380,381,
382,386,390; b/330,380,381
4 purple 0 188.8 166.8 0.618 0.8486 -0.08458
Protein Kinases KIT[a] P10721[a] Immunoglobulin(-like) domain IPR003599[a] Immunoglobulin subtype[a] 2EC8 a/350,351,353,355,357,358,379,
380,381,382,383,386,390
4 purple 0 221.5 232.2 0.5551 0.7525 -0.4882
Protein Kinases VEGFB[a],FLT1[c] P49765[a],
P17948[c]
Immunoglobulin(-like) domain IPR003598[c] Immunoglobulin subtype 2[c] 2XAC a/42,46,47,48,49,82,83,87,120,
121,122,123,124; c/171,172,173,
175,199,200,202,203,204
4 purple 0 433.9 360.9 0.6401 0.84 0.5462
Protein Kinases VEGFB[a],VEGFB[b],FLT1[x] P49765[a],
P49765[b],
P17948[x]
Immunoglobulin(-like) domain IPR003598[x] Immunoglobulin subtype 2[x] 2XAC a/67,68,69,70,71,72; b/42,45,46,
47,81,82,83,123,124; x/171,172,
173,175,199,200,202,203,204
4 purple 0 301.4 285.6 0.6754 0.9466 0.7772
Protein Kinases KL[a],FGFR1[c] Q9UEF7[a],
P11362[c]
Immunoglobulin(-like) domain IPR007110[c] Immunoglobulin-like domain[c] 5W21 a/541,542,543,544,565,566,567,
568,569,571; c/291,292,293,294,
299,306,309,310,311,329,330,331,
332,334,335,336,337,338,355
4 purple 0 469.5 495.3 0.532 0.8025 0.2112
Protein Kinases FGFR1[c],FGFR1[d] P11362[c],
P11362[d]
Immunoglobulin(-like) domain IPR007110[c],
IPR007110[d]
Immunoglobulin-like domain[c],Immunoglobulin-like domain[d] 1CVS c/160,173,175,177,179,207,209,
212,214,216; d/160,172,173,175,
177,209,212,214,216
4 red 0 259 297.6 0.4868 0.6786 -0.8187
Protein Kinases FGF2[b],FGFR2[f],FGFR2[g] P09038[b],
P21802[f],
P21802[g]
Immunoglobulin(-like) domain IPR003598[f],
IPR003598[g]
Immunoglobulin subtype 2[f],Immunoglobulin subtype 2[g] 1EV2 b/242,243; f/172,173,174,208,
209,210,211,212,217,219,
220; g/255,256,257,258,265,266,
267,339,349,350,351,352,353,354,
355,356,358
4 red 0 527.8 551.1 0.5382 0.8001 0.3024
Protein Kinases GAS6[a],AXL[c] Q14393[a],
P30530[c]
Immunoglobulin(-like) domain IPR007110[c] Immunoglobulin-like domain[c] 2C5D a/293,309,311,313,317,318,320,
446,447,448,449,450,451,452,453,
454,455,456,457,458,459; c/53,
80,81,82,84,99,101,103
4 red 0 630 541.4 0.553 0.8961 0.8446
Protein Kinases TTN Q8WZ42 Immunoglobulin(-like) domain IPR003599,
IPR003598,
IPR007110
4 0 0 0 0 0 0
Protein Kinases TRIO O75962 Immunoglobulin(-like) domain IPR003599,
IPR003598,
IPR007110
4 0 0 0 0 0 0
Protein Kinases ROR2 Q01974 Immunoglobulin(-like) domain IPR003599,
IPR003598,
IPR007110
4 0 0 0 0 0 0
Protein Kinases PDGFRB P09619 Immunoglobulin(-like) domain IPR003599,
IPR003598,
IPR007110
4 0 0 0 0 0 0
Protein Kinases PDGFRA P16234 Immunoglobulin(-like) domain IPR003599,
IPR003598,
IPR007110
4 0 0 0 0 0 0
Protein Kinases OBSCN Q5VST9 Immunoglobulin(-like) domain IPR003599,
IPR003598,
IPR007110
4 0 0 0 0 0 0
Protein Kinases NTRK3 Q16288 Immunoglobulin(-like) domain IPR003599,
IPR007110
4 0 0 0 0 0 0
Protein Kinases NTRK2 Q16620 Immunoglobulin(-like) domain IPR003599,
IPR003598,
IPR007110
4 0 0 0 0 0 0
Protein Kinases NTRK1 P04629 Immunoglobulin(-like) domain IPR007110 4 0 0 0 0 0 0
Protein Kinases MYLK Q15746 Immunoglobulin(-like) domain IPR003599,
IPR003598,
IPR007110
4 0 0 0 0 0 0
Protein Kinases MUSK O15146 Immunoglobulin(-like) domain IPR003599,
IPR003598,
IPR007110
4 0 0 0 0 0 0
Protein Kinases MERTK Q12866 Immunoglobulin(-like) domain IPR003599,
IPR007110
4 0 0 0 0 0 0
Protein Kinases KDR P35968 Immunoglobulin(-like) domain IPR003599,
IPR003598,
IPR007110
4 0 0 0 0 0 0
Protein Kinases KALRN O60229 Immunoglobulin(-like) domain IPR003599,
IPR003598,
IPR007110
4 0 0 0 0 0 0
Protein Kinases FGFR4 P22455 Immunoglobulin(-like) domain IPR003599,
IPR003598,
IPR007110
4 0 0 0 0 0 0
Protein Kinases ALPK3 Q96L96 Immunoglobulin(-like) domain IPR003599,
IPR003598,
IPR007110
4 0 0 0 0 0 0
Protein Kinases ALPK2 Q86TB3 Immunoglobulin(-like) domain IPR003599,
IPR003598,
IPR007110
4 0 0 0 0 0 0
Protein Phosphatases PTPRS[a] Q13332[a] Immunoglobulin(-like) domain IPR007110[a] Immunoglobulin-like domain[a] 4PBX a/45,46,47,48,49,92,94,127,137,
139,140,141,142,143,172,213,215,
225,226,227,228,229,230,231,233
4 blue 0 446.5 527 0.4835 0.6932 -0.3665
Protein Phosphatases PTPRS[a] Q13332[a] Immunoglobulin(-like) domain 4PBX a/127,128,129,130,131,132,133,
134,135,136,159,160,161
4 blue 0 214.8 250.2 0.5385 0.7523 -0.5492
Protein Phosphatases PTPRD[a] P23468[a] Immunoglobulin(-like) domain IPR003598[a] Immunoglobulin subtype 2[a] 4RCA a/167,168,169,170,171,172,173,
174,175,176,177
4 blue 0 180.4 202.2 0.4986 0.7244 -0.8783
Protein Phosphatases PTPRD[a],IL1RAPL1[b] P23468[a],
Q9NZN1[b]
Immunoglobulin(-like) domain IPR003598[a],
IPR003598[b]
Immunoglobulin subtype 2[a],Immunoglobulin subtype 2[b] 5WY8 a/37,38,66,67,68,87,88,89,91,
117,118,119; b/278,279,280,281,
282,290,291,294,295,296,299,300,
302,303,317,337,338,339
4 blue 0 372.1 435.9 0.5278 0.7571 -0.1489
Protein Phosphatases PTPRF[a] P10586[a] Immunoglobulin(-like) domain IPR003598[a] Immunoglobulin subtype 2[a] 2YD8 a/68,75,76,77,78,79,80,92,93,94,
100,101
4 orange 0 238.1 268.7 0.5108 0.7748 -0.4474
Protein Phosphatases PTPRS[a] Q13332[a] Immunoglobulin(-like) domain IPR003598[a] Immunoglobulin subtype 2[a] 4PBX a/66,67,68,71,72,73,74,75,77,78,
79,80,91,100,101,103,105
4 orange 0 367.1 297.7 0.757 0.9096 0.9627
Protein Phosphatases PTPRD[a] P23468[a] Immunoglobulin(-like) domain IPR003598[a] Immunoglobulin subtype 2[a] 4RCA a/59,62,63,64,65,66,68,69,84,91,
92,96
4 orange 0 156 182.1 0.4873 0.7508 -0.9075
Protein Phosphatases PTPRD[a],IL1RAPL1[b] P23468[a],
Q9NZN1[b]
Immunoglobulin(-like) domain IPR003598[a] Immunoglobulin subtype 2[a] 5WY8 a/59,60,62,63,64,65,66,68,69,91,
92; b/287,288,289,291,292
4 orange 0 295.1 253.6 0.5556 0.8542 0.1256
Protein Phosphatases PTPRS[a] Q13332[a] Immunoglobulin(-like) domain IPR003598[a] Immunoglobulin subtype 2[a] 2YD2 a/37,53,55,83,166,167,168,170,
171,173,174,175,176,177,179,180,
183,184,186,201,209,210,214
4 red 0 390 417.4 0.517 0.6866 -0.4165
Protein Phosphatases PTPRS[a] Q13332[a] Immunoglobulin(-like) domain IPR003598[a] Immunoglobulin subtype 2[a] 2YD3 a/37,39,40,41,42,43,51,52,53,
167,169,217,219,220,221,222,223,
224,226
4 red 0 282.5 278.9 0.5531 0.7592 -0.2866
Protein Phosphatases PTPRF[a] P10586[a] Immunoglobulin(-like) domain IPR003598[a] Immunoglobulin subtype 2[a] 2YD5 a/37,38,39,40,41,42,43,51,52,53,
121,123,165,167,169,208,210,211,
212,213,214,215,217
4 red 0 327.9 347.5 0.5098 0.7451 -0.3303
Protein Phosphatases PTPRD[a] P23468[a] Immunoglobulin(-like) domain IPR003598[a] Immunoglobulin subtype 2[a] 5WY8 a/28,30,31,32,33,34,42,43,44,46,
74,112,114,158,159,160,165,166,
167,168,177,208,210,211,212,213,
214,215,217
4 red 0 407.1 455.9 0.5 0.7335 -0.2387
Protein Phosphatases PTPRS[a],PTPRS[a4] Q13332[a],
Q13332[a4]
Immunoglobulin(-like) domain IPR007110[a4] Immunoglobulin-like domain[a4] 2YD9 a/315,316,317,318,319; a4/139,
140,141,142,143,144,145,146,147,
150,151,152,153,154,155
4 yellow 0 274.2 335 0.5095 0.7315 -0.5168
Protein Phosphatases LRFN5[a],PTPRD[d] Q96NI6[a],
P23468[d]
Immunoglobulin(-like) domain IPR003598[d] Immunoglobulin subtype 2[d] 5XNP a/246,282,283,284,285,286,363,
364,365; d/135,136,137,138,141,
142,143,144,226,229
4 yellow 0 275.2 262.1 0.5311 0.7511 -0.3878
Protein Phosphatases PTPRT O14522 Immunoglobulin(-like) domain IPR007110 4 0 0 0 0 0 0
Protein Phosphatases PTPRS Q13332 Immunoglobulin(-like) domain IPR003599,
IPR003598,
IPR007110
4 0 0 0 0 0 0
Protein Phosphatases PTPRM P28827 Immunoglobulin(-like) domain IPR003599,
IPR007110
4 0 0 0 0 0 0
Protein Phosphatases PTPRK Q15262 Immunoglobulin(-like) domain IPR003599,
IPR007110
4 0 0 0 0 0 0
Protein Phosphatases PTPRF P10586 Immunoglobulin(-like) domain IPR003599,
IPR003598,
IPR007110
4 0 0 0 0 0 0
Protein Phosphatases PTPRD P23468 Immunoglobulin(-like) domain IPR003599,
IPR003598,
IPR007110
4 0 0 0 0 0 0
Deubiquitinases ATXN3L[a],UBB[b] Q9H3M9[a],
P0CG47[b]
Josephin domain IPR006155[a] Josephin domain[a] 3O65 a/41,44,45,61,62,64,65,66,
67; b/42
4 blue 17.49 157 155.3 0.646 0.8212 -0.2652
Deubiquitinases ATXN3L[a],UBA52[b] Q9H3M9[a],
P62987[b]
Josephin domain IPR006155[a] Josephin domain[a] 3O65 a/77,78,81,85,90,91,92,93,
96; b/7,9,10,11,13,34,36,71
4 red 12.37 273.6 240.6 0.6277 0.8711 0.3
Deubiquitinases JOSD2[a],UBA52[b] Q8TAC2[a],
P62987[b]
Josephin domain IPR006155[a] Josephin domain[a] 6PGV a/71,74,78,82,83,84,85,86,176,
179,182,184; b/7,8,9,11,13,33,
34,36,69,71
4 red 14.83 355.5 352.3 0.5365 0.8492 0.2001
Deubiquitinases USP28[a] Q96RU2[a] N-terminal domafin 2MUU a/31,32,33,34,35,36,39,42,43,46,
55,57,58,59,60,61,62,63,64,65,
66
4 blue 0 402.6 509.5 0.5296 0.7001 -0.311
Deubiquitinases USP28[a] Q96RU2[a] N-terminal domafin 2MUU a/64,65,66,67,68,69,70,71,73,74,
75,76
4 blue 0 208.8 194.9 0.574 0.7643 -0.442
Deubiquitinases USP28[a] Q96RU2[a] N-terminal domafin 2MUU a/4,5,6,7,9,10,11 4 blue 0 160.8 182.4 0.5591 0.73 -0.8036
Deubiquitinases USP28[a] Q96RU2[a] N-terminal domain 2LVA a/24,25,41,44,45,48,49 4 blue 0 170.8 197.3 0.5721 0.7209 -0.7661
Deubiquitinases USP25[a] Q9UHP3[a] N-terminal domain 2MUX a/16,17,19,20,23,40,41,44,45,47 4 blue 0 169.1 208 0.5929 0.7145 -0.7514
Deubiquitinases USP38[a] Q8NB14[a] N-terminal domain 4RXX a/140,141,142,179,180,181,182,
187,190,191,194
4 blue a/C180(reactive:0.68) 0 176.3 173.9 0.5168 0.702 -0.9424
Protein Phosphatases PTPN3[a] P26045[a] PDZ domain IPR001478[a] PDZ domain[a] 6HKS a/519,520,521,522,523,524,525,
539,541,576,579,580,583
2 6HKS[g]

6AR4[bqa]
red 0 207 208.2 0.5397 0.6918 -0.812
Protein Kinases CASK[a] O14936[a] PDZ domain IPR001478[a] PDZ domain[a] 1KWA a/495,498,500,501,502,503,504,
505,507,517,519,553,556,557,560
3

6HKS[g],6AR4[bqa]
red 0 307.3 303.7 0.4915 0.7453 -0.4192
Protein Kinases MAST2[a] Q6P0Q8[a] PDZ domain IPR001478[a] PDZ domain[a] 2KQF a/1109,1112,1113,1114,1115,1116,
1117,1118,1139,1140,1141,1170,
1174,1177,1178
3

6HKS[g],6AR4[bqa]
red 0 220.8 251.6 0.5642 0.7053 -0.6557
Protein Kinases MAST4 O15021 PDZ domain IPR001478,
IPR041489
3

6HKS[g],6AR4[bqa]
0 0 0 0 0 0
Protein Kinases MAST3 O60307 PDZ domain IPR001478,
IPR041489
3

6HKS[g],6AR4[bqa]
0 0 0 0 0 0
Protein Kinases LIMK2 P53671 PDZ domain IPR001478 3

6HKS[g],6AR4[bqa]
0 0 0 0 0 0
Protein Kinases LIMK1 P53667 PDZ domain IPR001478 3

6HKS[g],6AR4[bqa]
0 0 0 0 0 0
Protein Phosphatases PTPN13[c] Q12923[c] PDZ domain IPR001478[c] PDZ domain[c] 5GLJ c/1098,1102,1103,1104,1105,1106,
1107,1108,1127,1157,1161,1164,
1165
3

6HKS[g],6AR4[bqa]
red 0 210 212.6 0.4883 0.7872 -0.5424
Protein Phosphatases PTPN4[a] P29074[a] PDZ domain IPR001478[a] PDZ domain[a] 5EYZ a/526,527,528,529,530,531,532,
548,583,586,587
3

6HKS[g],6AR4[bqa]
red 0 187.7 183.2 0.5459 0.7966 -0.4573
Protein Kinases MAST1[a],MAST1[d] Q9Y2H9[a],
Q9Y2H9[d]
PDZ domain IPR041489[a] PDZ domain 6[a] 3PS4 a/986,988,995,996,997,998,1019,
1020,1021,1022,1027,1028,1029,
1052; d/986,987,988,989,990,995,
997,1029
4 blue 0 280.9 287.7 0.5952 0.7758 -0.1295
Protein Phosphatases PTPN13[a],PTPN13[a2] Q12923[a],
Q12923[a2]
PDZ domain IPR001478[a],
IPR001478[a2]
PDZ domain[a],PDZ domain[a2] 3LNY a/1386,1393,1394,1395,1417,1418,
1419,1425,1426,1427,1428,
1429; a2/1386,1393,1394,1395,
1417,1418,1419,1425,1426,1427,
1428,1429
4 yellow 0 214 232.7 0.6531 0.9481 0.4799
Protein Phosphatases PTPN4[a] P29074[a] PDZ domain IPR001478[a] PDZ domain[a] 5EYZ a/535,536,539,540,541,542,565,
566,567,574,575,577,602
4 yellow 0 170.7 179.1 0.6129 0.7618 -0.5127
Protein Phosphatases PTPN3[a] P26045[a] PDZ domain IPR001478[a] PDZ domain[a] 6HKS a/528,529,531,532,533,534,535,
558,559,560,567,568,569,570
4 yellow 0 172.6 183.1 0.5667 0.7682 -0.5843
Protein Kinases GRK2[a] P25098[a] Pleckstrin homology domain IPR001849[a] Pleckstrin homology domain[a] 1BAK a/579,589,590,591,592,593,594,
595,596,597,598,599,600
4 blue 0 185.4 216 0.4934 0.7769 -0.6633
Protein Kinases AKT1[a] P31749[a] Pleckstrin homology domain IPR001849[a] Pleckstrin homology domain[a] 1UNR a/8,9,10,11,12,13,24,89,90,91,
95,98,99
4 blue 0 178.3 206.4 0.5761 0.7592 -0.5742
Protein Kinases AKT3[a] Q9Y243[a] Pleckstrin homology domain IPR001849[a] Pleckstrin homology domain[a] 2X18 a/14,15,16,17,18,19,20,82,84,85,
86
4 blue 0 170.6 165.6 0.5017 0.7079 -0.9776
Protein Kinases BTK[b] Q06187[b] Pleckstrin homology domain IPR001849[b] Pleckstrin homology domain[b] 1BTK b/14,15,16,17,18,19,21,22,23,
147,148,149,150
4 blue 0 170.2 167.4 0.542 0.7832 -0.5912
Protein Kinases BTK[a],BTK[a2] Q06187[a],
Q06187[a2]
Pleckstrin homology domain IPR001849[a] Pleckstrin homology domain[a] 1BWN a/13,23,25,68,69,70,71,72,77,
114,145,146,148,153,154; a2/68,
69,70,71,145,146,153,154
4 blue a/C145(reactive:0.73),
a2/C145(reactive:0.73)
0 248.3 313.5 0.5737 0.7734 -0.279
Protein Kinases GRK2[a] P25098[a] Pleckstrin homology domain IPR001849[a] Pleckstrin homology domain[a] 1BAK a/565,567,581,588,590,601,606,
622,624,630,632,643,647,651
4 red 0 233.9 210.4 0.8442 0.9146 0.8474
Protein Kinases TRIO[a] O75962[a] Pleckstrin homology domain IPR001849[a] Pleckstrin homology domain[a] 1NTY a/1494,1496,1497,1498,1499,1505,
1507,1518,1534,1535,1537,1559,
1566,1567,1569
4 red 0 262.7 241.1 0.62 0.8322 0.09919
Protein Kinases TYK2 P29597 Pleckstrin homology domain IPR041381 4 0 0 0 0 0 0
Protein Kinases TEC P42680 Pleckstrin homology domain IPR001849 4 0 0 0 0 0 0
Protein Kinases ROCK2 O75116 Pleckstrin homology domain IPR001849 4 0 0 0 0 0 0
Protein Kinases ROCK1 Q13464 Pleckstrin homology domain IPR001849 4 0 0 0 0 0 0
Protein Kinases PRKD3 O94806 Pleckstrin homology domain IPR001849 4 0 0 0 0 0 0
Protein Kinases PRKD2 Q9BZL6 Pleckstrin homology domain IPR001849 4 0 0 0 0 0 0
Protein Kinases PRKD1 Q15139 Pleckstrin homology domain IPR001849 4 0 0 0 0 0 0
Protein Kinases PDPK1 O15530 Pleckstrin homology domain IPR033931 4 0 0 0 0 0 0
Protein Kinases OBSCN Q5VST9 Pleckstrin homology domain IPR001849 4 0 0 0 0 0 0
Protein Kinases MAP3K6 O95382 Pleckstrin homology domain IPR043969 4 0 0 0 0 0 0
Protein Kinases MAP3K5 Q99683 Pleckstrin homology domain IPR043969 4 0 0 0 0 0 0
Protein Kinases MAP3K15 Q6ZN16 Pleckstrin homology domain IPR043969 4 0 0 0 0 0 0
Protein Kinases KALRN O60229 Pleckstrin homology domain IPR001849 4 0 0 0 0 0 0
Protein Kinases JAK3 P52333 Pleckstrin homology domain IPR041381 4 0 0 0 0 0 0
Protein Kinases JAK2 O60674 Pleckstrin homology domain IPR041381 4 0 0 0 0 0 0
Protein Kinases JAK1 P23458 Pleckstrin homology domain IPR041381 4 0 0 0 0 0 0
Protein Kinases ITK Q08881 Pleckstrin homology domain IPR001849 4 0 0 0 0 0 0
Protein Kinases GRK3 P35626 Pleckstrin homology domain IPR001849 4 0 0 0 0 0 0
Protein Kinases CIT O14578 Pleckstrin homology domain IPR001849 4 0 0 0 0 0 0
Protein Kinases CDC42BPG Q6DT37 Pleckstrin homology domain IPR001849 4 0 0 0 0 0 0
Protein Kinases CDC42BPB Q9Y5S2 Pleckstrin homology domain IPR001849 4 0 0 0 0 0 0
Protein Kinases CDC42BPA Q5VT25 Pleckstrin homology domain IPR001849 4 0 0 0 0 0 0
Protein Kinases BMX P51813 Pleckstrin homology domain IPR001849 4 0 0 0 0 0 0
Protein Kinases AKT2 P31751 Pleckstrin homology domain IPR001849 4 0 0 0 0 0 0
Protein Phosphatases PHLPP1 O60346 Pleckstrin homology domain IPR001849 4 0 0 0 0 0 0
Protein Kinases MAP3K5[a] Q99683[a] Pleckstrin homology domain (MAP3K) IPR043969[a] MAP3K, PH domain[a] 5ULM a/563,564,565,566,590,602,629,
631,632,633,634
4 blue 0 223.1 215.8 0.573 0.7649 -0.3934
Protein Kinases TYK2[a] P29597[a] Pleckstrin homology-like domain (Jak1) IPR041381[a] Jak1, pleckstrin homology-like domain[a] 4PO6 a/77,81,82,83,84,104,105,106,
108,152,155,158,159,162,164,269,
270,271,272,273,274,275,276,407,
408,409,412,415,416,419,423
4 blue 0 494.4 507.3 0.4878 0.706 -0.2312
Protein Kinases PLK1[a] P53350[a] POLO-box domain IPR000959[a] POLO box domain[a] 3P37 a/412,413,414,415,416,417,421,
478,481,482,484,485,488,489,490,
491,492,493,494,496,521,533,534,
535,538,540,553,554,555,557
2

5NEI[8vb],5NJE[8z5],5NMM[8z5],
4LKL[b],4LKL[adm],
4LKM[b],4LKM[b2],
4WHH[b],4WHK[b],
4WHL[b],4X9W[b]
blue 0 511.3 578 0.5676 0.7008 -0.04557
Protein Kinases PLK3 Q9H4B4 POLO-box domain IPR000959,
IPR033695
3

5NEI[8vb],5NJE[8z5],5NMM[8z5],
0 0 0 0 0 0
Protein Kinases PLK4[a] O00444[a] POLO-box domain IPR000959[a] POLO box domain[a] 2N19 a/889,901,902,903,905,906,907,
919,920,921,922,923,924,926,938,
949,952,953,955,956,958,959,962
4 blue 0 358.3 398.4 0.5271 0.6127 -0.7472
Protein Kinases PLK1[a] P53350[a] POLO-box domain IPR033695[a] Second polo-box domain[a] 3FVH a/372,373,374,512,513,524,525,
526,528,590,593,594,597,598
4 blue a/C372(reactive:0.89) 0 165.9 185.6 0.5372 0.7173 -0.8807
Protein Kinases PLK2[a],PLK2[b] Q9NYY3[a],
Q9NYY3[b]
POLO-box domain IPR000959[b] POLO box domain[b] 4XB0 a/626,627,629; b/511,512,513,
514,515,529,530,531,568,571
4 blue 0 177.9 172.5 0.6374 0.7798 -0.3555
Protein Kinases PLK4[a],STIL[b] O00444[a],
Q15468[b]
POLO-box domain IPR000959[a] POLO box domain[a] 4YYP a/919,920,922,923,924,925,926,
940; b/736,739,740,742,743,746
4 blue 0 194.6 197.3 0.6493 0.8652 0.07454
Protein Kinases PLK1[a] P53350[a] POLO-box domain IPR000959[a] POLO box domain[a] 4O56 a/365,404,405,406,407,408,409,
410,428,429,446,492,494,495,497,
498,499,500,501,503,504,506,507,
527,529,542,543,544,547,549,550,
551,561
4 red a/C405(reactive:0.69),
a/C428(reactive:0.71),
a/C544(reactive:0.775)
0 520 576.8 0.5422 0.7534 0.1164
Protein Kinases PLK2[a] Q9NYY3[a] POLO-box domain 4RS6 a/500,501,502,592,593,594,595,
596,597,600,618,620,635,636,637
4 red a/C635(reactive:0.79) 0 248.9 251.5 0.4934 0.8414 -0.1916
Methyltransferases NSD2[a] O96028[a] PWWP domain IPR000313[a] PWWP domain[a] 6XCG a/230,233,234,236,266,267,268,
270,271,272,274,318,321
1

6UE6[q5d],6XCG[v01],7LMT[y6v],

6G24[eh2],6G25[ehq],6G27[ehe],
yellow 0 275.6 232.7 0.7762 0.8382 0.5127
Methyltransferases NSD3[a] Q9BZ95[a] PWWP domain IPR000313[a] PWWP domain[a] 6G2O a/278,281,284,312,314,316,318,
320,363,364,367
1

6G24[eh2],6G25[ehq],6G27[ehe],

6UE6[q5d],6XCG[v01],7LMT[y6v],
yellow 0 272.6 232.4 0.734 0.7833 0.1926
Methyltransferases NSD1 Q96L73 PWWP domain IPR000313 3

6UE6[q5d],6XCG[v01],7LMT[y6v],
0 0 0 0 0 0
Methyltransferases NSD3[a],NSD3[a1] Q9BZ95[a],
Q9BZ95[a1]
PWWP domain IPR000313[a] PWWP domain[a] 4RXJ a/1019,1020,1021,1022,1023,1024,
1026,1027; a1/1041,1045,1048,
1049
4 blue 0 164.4 170.1 0.5135 0.7618 -0.7659
Methyltransferases NSD3[a] Q9BZ95[a] PWWP domain IPR000313[a] PWWP domain[a] 6G27 a/277,280,281,282,284,333,334,
336,337,340,357,358,359,360,361,
364,365,368
4 red 0 276.6 297.6 0.6203 0.7425 -0.2153
Methyltransferases NSD2[a] O96028[a] PWWP domain IPR000313[a] PWWP domain[a] 6UE6 a/229,231,232,233,234,290,291,
294,306,309,310,311,312,313,314,
315,318
4 red a/C294(reactive:0.78) 0 267.7 270 0.5792 0.749 -0.3072
Protein Kinases ERN1[a],ERN1[a1] O75460[a],
O75460[a1]
Pyrrolo-quinoline quinone beta-propeller repeat domain IPR018391[a1] Pyrrolo-quinoline quinone beta-propeller repeat[a1] 6SHC a/106,108,109,110,116; a1/125,
155,156,157,159,161,181,182,183,
184,185,233,234,236,237,238,239
4 blue 0 282.7 309 0.4876 0.7048 -0.6492
Protein Kinases ERN1[a] O75460[a] Pyrrolo-quinoline quinone beta-propeller repeat domain IPR018391[a] Pyrrolo-quinoline quinone beta-propeller repeat[a] 6SHC a/187,188,189,190,191,192,193,
194,195,196,211,231,233,238,239,
240,241,273
4 blue 0 273.1 297.6 0.4763 0.6828 -0.7869
Protein Kinases EEF2K[a] O00418[a] Sel1-repeat domain IPR006597[a] Sel1-like repeat[a] 6NX4 a/635,638,642,645,646,647,648,
649,651,652,664,668,671,675,677,
678,679,680,681,682,683,684,685,
688,692,695,698,699,701,702
4 blue 0 528.9 621.2 0.4812 0.7287 -0.1072
Protein Kinases ZAP70[a] P43403[a] SH2(-like) domain 4XZ1 a/122,125,126,129,152,153,156,
157,160
2

4XZ0[4n5]
blue 0 169.2 167.7 0.5654 0.7059 -0.8472
Protein Kinases SRC[a],SRC[b] P12931[a],
P12931[b]
SH2(-like) domain IPR000980[a] SH2 domain[a] 1A09 a/155,156,157,179,180,181,182,
183,184,185,186,187; b/163,166,
167
2

1O41[300],1O42[843],1O43[821],
1A09[c]

3TL0[b]
cyan 0 228.7 279.8 0.4726 0.7373 -0.7113
Protein Phosphatases PTPN11[a] Q06124[a] SH2(-like) domain IPR000980[a] SH2 domain[a] 6CMP a/53,54,55,65,66,67,68,69,81,87,
88,89,90,91,96
2 3TL0[b]

1A09[c],1O41[300],1O42[843],1O
blue 19.98 253.6 244.2 0.5241 0.7225 -0.5767
Protein Kinases SRC[a] P12931[a] SH2(-like) domain IPR000980[a] SH2 domain[a] 1O4C a/152,155,156,157,178,179,180,
181,182,183,184,185,186,187
3

1A09[c],1O41[300],1O42[843],1O
cyan 0 213.8 240.1 0.6069 0.7482 -0.4137
Protein Kinases HCK[a] P08631[a] SH2(-like) domain IPR000980[a] SH2 domain[a] 3NHN a/151,171,173,174,175,176,179,
180,181,197,198,199,200,201,202,
210
3

1A09[c],1O41[300],1O42[843],1O
cyan 0 229.5 279.1 0.4744 0.7224 -0.7635
Protein Kinases FYN[c] P06241[c] SH2(-like) domain IPR000980[c] SH2 domain[c] 4U17 c/153,154,155,176,177,178,179,
180,181,182,183,184,185,207
3

1A09[c],1O41[300],1O42[843],1O
cyan 0 203.4 232 0.5918 0.7196 -0.597
Protein Kinases ZAP70[a] P43403[a] SH2(-like) domain IPR000980[a] SH2 domain[a] 4XZ0 a/167,168,169,170,190,191,192,
193,199,210,211,212
3

1A09[c],1O41[300],1O42[843],1O
cyan 0 206.8 239.7 0.4843 0.7101 -0.8663
Protein Kinases YES1 P07947 SH2(-like) domain IPR000980 3

1A09[c],1O41[300],1O42[843],1O
0 0 0 0 0 0
Protein Kinases TYK2 P29597 SH2(-like) domain IPR000980 3

1A09[c],1O41[300],1O42[843],1O
0 0 0 0 0 0
Protein Kinases TXK P42681 SH2(-like) domain IPR000980 3

1A09[c],1O41[300],1O42[843],1O
0 0 0 0 0 0
Protein Kinases TEC P42680 SH2(-like) domain IPR000980 3

1A09[c],1O41[300],1O42[843],1O
0 0 0 0 0 0
Protein Kinases SRMS Q9H3Y6 SH2(-like) domain IPR000980 3

1A09[c],1O41[300],1O42[843],1O
0 0 0 0 0 0
Protein Kinases PTK6 Q13882 SH2(-like) domain IPR000980 3

1A09[c],1O41[300],1O42[843],1O
0 0 0 0 0 0
Protein Kinases LYN P07948 SH2(-like) domain IPR000980 3

1A09[c],1O41[300],1O42[843],1O
0 0 0 0 0 0
Protein Kinases LCK P06239 SH2(-like) domain IPR000980 3

1A09[c],1O41[300],1O42[843],1O
0 0 0 0 0 0
Protein Kinases JAK3 P52333 SH2(-like) domain IPR000980 3

1A09[c],1O41[300],1O42[843],1O
0 0 0 0 0 0
Protein Kinases JAK2 O60674 SH2(-like) domain IPR000980 3

1A09[c],1O41[300],1O42[843],1O
0 0 0 0 0 0
Protein Kinases JAK1 P23458 SH2(-like) domain IPR000980 3

1A09[c],1O41[300],1O42[843],1O
0 0 0 0 0 0
Protein Kinases ITK Q08881 SH2(-like) domain IPR000980 3

1A09[c],1O41[300],1O42[843],1O
0 0 0 0 0 0
Protein Kinases FRK P42685 SH2(-like) domain IPR000980 3

1A09[c],1O41[300],1O42[843],1O
0 0 0 0 0 0
Protein Kinases FGR P09769 SH2(-like) domain IPR000980 3

1A09[c],1O41[300],1O42[843],1O
0 0 0 0 0 0
Protein Kinases FER P16591 SH2(-like) domain IPR000980 3

1A09[c],1O41[300],1O42[843],1O
0 0 0 0 0 0
Protein Kinases CSK P41240 SH2(-like) domain IPR000980 3

1A09[c],1O41[300],1O42[843],1O
0 0 0 0 0 0
Protein Kinases BTK Q06187 SH2(-like) domain IPR000980 3

1A09[c],1O41[300],1O42[843],1O
0 0 0 0 0 0
Protein Kinases BMX P51813 SH2(-like) domain IPR000980 3

1A09[c],1O41[300],1O42[843],1O
0 0 0 0 0 0
Protein Kinases BLK P51451 SH2(-like) domain IPR000980 3

1A09[c],1O41[300],1O42[843],1O
0 0 0 0 0 0
Protein Kinases ABL2 P42684 SH2(-like) domain IPR000980 3

1A09[c],1O41[300],1O42[843],1O
0 0 0 0 0 0
Protein Kinases ABL1 P00519 SH2(-like) domain IPR000980 3

1A09[c],1O41[300],1O42[843],1O
0 0 0 0 0 0
Protein Phosphatases TNS2 Q63HR2 SH2(-like) domain IPR000980 3

1A09[c],1O41[300],1O42[843],1O
0 0 0 0 0 0
Protein Kinases SRC[a] P12931[a] SH2(-like) domain IPR000980[a] SH2 domain[a] 1Y57 a/92,93,94,107,147,149,150,151,
152,153,154,247,248,249,250,252
4 black a/C248(0.025) 26.129999 337.4 302.6 0.6176 0.8008 0.155
Protein Kinases HCK[a] P08631[a] SH2(-like) domain IPR000980[a] SH2 domain[a] 3VS1 a/84,85,86,87,101,102,115,130,
131,133,134,140,141,142,143,145,
146,147,149,240,241,242,243
4 black a/C241(0.) 29.18 388.8 393.7 0.4814 0.7182 -0.3751
Protein Kinases SYK[a] P43405[a] SH2(-like) domain IPR000980[a] SH2 domain[a] 4FL3 a/19,43,44,45,46,47,48,49,50,
121,122,124,125,151,155
4 blue 31.99 163.5 171.1 0.5554 0.8697 -0.2495
Protein Kinases SYK[g],CD3E[h] P43405[g],
P07766[h]
SH2(-like) domain 1A81 g/46,47,65,219,221,227,228,229,
230,231,232,233,249; h/178,179,
180,181
4 purple 0 241.6 268 0.5356 0.7338 -0.5418
Protein Kinases FES[a] P07332[a] SH2(-like) domain IPR000980[a] SH2 domain[a] 3BKB a/514,515,516,517,518,520,526,
529,530,535,536,537,538,539
4 purple 44.59 192.4 181.2 0.6094 0.8283 -0.1701
Protein Kinases MATK[a],MATK[a1] P42679[a],
P42679[a1]
SH2(-like) domain IPR000980[a],
IPR000980[a1]
SH2 domain[a],SH2 domain[a1] 3US4 a/181,183,184,186,191,194,195,
196,198,199,201,202; a1/181,183,
184,186,191,194,195,196,198,199,
201,202
4 purple 0 391.7 345.5 0.7148 0.8375 0.6302
Protein Kinases ZAP70[a] P43403[a] SH2(-like) domain IPR000980[a] SH2 domain[a] 4XZ0 a/16,17,37,39,40,41,47,58,60,
238,241,242
4 purple a/C39(reactive:0.76) 0 163 167.8 0.607 0.9298 0.1019
Protein Kinases ZAP70[a] P43403[a] SH2(-like) domain IPR000980[a] SH2 domain[a] 4XZ1 a/14,15,16,38,39,40,42,43,44,
111,113,114,115,116,119,233,234,
237,238,241
4 purple a/C39(reactive:0.75) 0 266.7 261.5 0.5844 0.8175 -0.02823
Protein Phosphatases PTPN6[a] P29350[a] SH2(-like) domain IPR000980[a] SH2 domain[a] 2B3O a/6,7,8,9,102,103,104,105,111,
137,138,142,143,144,145,176,185,
186,187
4 blue a/C102(reactive:0.885) 28.93 294.5 306 0.4787 0.6939 -0.6822
Protein Phosphatases PTPN6[a] P29350[a] SH2(-like) domain 2B3O a/69,74,77,78,81,83,259,260,261,
262,263,265,266,267,268,271,274,
277,278,280
4 blue 13.92 355.5 357.8 0.519 0.7717 -0.1449
Protein Phosphatases PTPN6[a] P29350[a] SH2(-like) domain 2B3O a/55,56,57,58,59,60,62,356,358,
360,419,420
4 blue 7.297 187.7 186.6 0.6113 0.8746 -0.001469
Glycosyltransferases FUT8 Q9BYC5 SH3 domain IPR001452 4 0 0 0 0 0 0
Methyltransferases PRMT2 P55345 SH3 domain IPR001452 4 0 0 0 0 0 0
Protein Kinases HCK[a],HCK[f] P08631[a],
P08631[f]
SH3 domain IPR001452[a] SH3 domain[a] 1BU1 a/87,88,89,90,92,101,132; f/88,
89,90,92,132
4 blue 0 263.8 251 0.6215 0.7789 -0.1039
Protein Kinases FYN[a] P06241[a] SH3 domain IPR035750[a] Fyn[a] 1G83 a/88,89,90,105,106,141,142,143,
145,146,147,148,150,151,152
4 blue 0 290.3 309.6 0.5162 0.682 -0.6542
Protein Kinases FYN[b1] P06241[b1] SH3 domain IPR035750[b1] Fyn[b1] 1SHF b1/110,111,112,113,114,115,120,
121,122,123,130,132
4 blue 0 174.1 184.8 0.4773 0.7288 -0.9359
Protein Kinases YES1 P07947 SH3 domain IPR001452 4 0 0 0 0 0 0
Protein Kinases TXK P42681 SH3 domain IPR001452 4 0 0 0 0 0 0
Protein Kinases TRIO O75962 SH3 domain IPR001452 4 0 0 0 0 0 0
Protein Kinases TNK2 Q07912 SH3 domain IPR001452 4 0 0 0 0 0 0
Protein Kinases TNK1 Q13470 SH3 domain IPR001452 4 0 0 0 0 0 0
Protein Kinases TEC P42680 SH3 domain IPR001452 4 0 0 0 0 0 0
Protein Kinases SRMS Q9H3Y6 SH3 domain IPR001452 4 0 0 0 0 0 0
Protein Kinases SRC P12931 SH3 domain IPR001452 4 0 0 0 0 0 0
Protein Kinases PTK6 Q13882 SH3 domain IPR001452 4 0 0 0 0 0 0
Protein Kinases OBSCN Q5VST9 SH3 domain IPR001452 4 0 0 0 0 0 0
Protein Kinases MATK P42679 SH3 domain IPR001452 4 0 0 0 0 0 0
Protein Kinases MAP3K9 P80192 SH3 domain IPR001452 4 0 0 0 0 0 0
Protein Kinases MAP3K21 Q5TCX8 SH3 domain IPR001452 4 0 0 0 0 0 0
Protein Kinases MAP3K11 Q16584 SH3 domain IPR001452 4 0 0 0 0 0 0
Protein Kinases MAP3K10 Q02779 SH3 domain IPR001452 4 0 0 0 0 0 0
Protein Kinases LYN P07948 SH3 domain IPR001452 4 0 0 0 0 0 0
Protein Kinases LCK P06239 SH3 domain IPR001452 4 0 0 0 0 0 0
Protein Kinases KALRN O60229 SH3 domain IPR001452 4 0 0 0 0 0 0
Protein Kinases ITK Q08881 SH3 domain IPR001452 4 0 0 0 0 0 0
Protein Kinases FRK P42685 SH3 domain IPR001452 4 0 0 0 0 0 0
Protein Kinases FGR P09769 SH3 domain IPR001452 4 0 0 0 0 0 0
Protein Kinases CSK P41240 SH3 domain IPR001452 4 0 0 0 0 0 0
Protein Kinases CASK O14936 SH3 domain IPR001452 4 0 0 0 0 0 0
Protein Kinases BTK Q06187 SH3 domain IPR001452 4 0 0 0 0 0 0
Protein Kinases BLK P51451 SH3 domain IPR001452 4 0 0 0 0 0 0
Protein Kinases ABL2 P42684 SH3 domain IPR001452 4 0 0 0 0 0 0
Protein Kinases ABL1 P00519 SH3 domain IPR001452 4 0 0 0 0 0 0
Protein Phosphatases UBASH3B Q8TF42 SH3 domain IPR001452 4 0 0 0 0 0 0
Protein Kinases EPHB2[a],EPHB2[b] P29323[a],
P29323[b]
Sterile alpha motif domain IPR001660[a] Sterile alpha motif domain[a] 1B4F a/950,961,964,965,968,969,971,
972,975; b/972,975,976,979,980,
983
4 blue 0 259.5 245.5 0.6005 0.7742 -0.1824
Demethylases KDM1A[a] O60341[a] SWIRM domain IPR007526[a] SWIRM domain[a] 2L3D a/180,181,182,217,218,221,222,
224,225,226,227,228,229,253,256,
257,261,262,263,264,265,266
4 blue 0 382.9 427.4 0.6108 0.7704 0.1133
Demethylases KDM1A[a],KDM1A[a1] O60341[a],
O60341[a1]
SWIRM domain IPR007526[a],
IPR007526[a1]
SWIRM domain[a],SWIRM domain[a1] 5IT3 a/205,206,208,209,241,242,244,
245; a1/205,206,208,209,241,242,
244,245
4 blue 0 208.4 226.9 0.7416 0.901 0.4757
Demethylases KDM1A[a] O60341[a] SWIRM domain IPR007526[a] SWIRM domain[a] 5LGU a/174,175,185,186,187,188,200,
204,205,207,208,209,211,212,215,
242
4 blue 0 314.6 316.8 0.5064 0.7279 -0.4361
Demethylases KDM1B Q8NB78 SWIRM domain IPR007526 4 0 0 0 0 0 0
Deubiquitinases MYSM1 Q5VVJ2 SWIRM domain IPR007526 4 0 0 0 0 0 0
Glycosyltransferases OGT[a] O15294[a] Tetratricopeptide repeat domain IPR019734[a] Tetratricopeptide repeat[a] 1W3B a/236,260,263,264,267,282,289,
291,292,293,294,295,297,298,301,
323,325,326,327,328,356,357,359,
360,361,362,390,391
2 1ELR[b],2L6J[b] blue a/C267(reactive:0.815),
a/C297(reactive:0.87),
a/C323(reactive:0.895)
0 421.9 539.5 0.5085 0.6926 -0.3538
Demethylases UTY O14607 Tetratricopeptide repeat domain IPR019734,
IPR013026
3

1ELR[b],2L6J[b]
0 0 0 0 0 0
Demethylases KDM6A O15550 Tetratricopeptide repeat domain IPR019734,
IPR013026
3

1ELR[b],2L6J[b]
0 0 0 0 0 0
Glycosyltransferases TMTC4 Q5T4D3 Tetratricopeptide repeat domain IPR019734,
IPR013026
3

1ELR[b],2L6J[b]
0 0 0 0 0 0
Glycosyltransferases TMTC3 Q6ZXV5 Tetratricopeptide repeat domain IPR019734,
IPR013026
3

1ELR[b],2L6J[b]
0 0 0 0 0 0
Glycosyltransferases TMTC2 Q8N394 Tetratricopeptide repeat domain IPR019734,
IPR001440,
IPR013026
3

1ELR[b],2L6J[b]
0 0 0 0 0 0
Glycosyltransferases TMTC1 Q8IUR5 Tetratricopeptide repeat domain IPR019734,
IPR013026
3

1ELR[b],2L6J[b]
0 0 0 0 0 0
Methyltransferases PRMT9 Q6P2P2 Tetratricopeptide repeat domain IPR019734,
IPR013026
3

1ELR[b],2L6J[b]
0 0 0 0 0 0
Protein Kinases EEF2K O00418 Tetratricopeptide repeat domain IPR006597 3

1ELR[b],2L6J[b]
0 0 0 0 0 0
Protein Phosphatases PPP5C P53041 Tetratricopeptide repeat domain IPR019734,
IPR001440,
IPR013026
3

1ELR[b],2L6J[b]
0 0 0 0 0 0
Glycosyltransferases OGT[a] O15294[a] Tetratricopeptide repeat domain IPR019734[a] Tetratricopeptide repeat[a] 1W3B a/236,237,239,241,267,268,270,
271,282,298,301,302
4 blue a/C267(reactive:0.815) 0 224.7 240.3 0.615 0.8305 -0.03393
Glycosyltransferases OGT[a] O15294[a] Tetratricopeptide repeat domain IPR019734[a] Tetratricopeptide repeat[a] 1W3B a/24,25,26,28,29,32,44,47,51,53,
54,55,56,57,59,60,63,84
4 blue a/C44(reactive:0.745) 0 336.4 301.4 0.6746 0.7676 0.151
Glycosyltransferases OGT[a] O15294[a] Tetratricopeptide repeat domain IPR019734[a] Tetratricopeptide repeat[a] 1W3B a/79,82,83,92,95,110,111,113,
114,116,117,120,126,129,133,141,
144,145,148
4 blue 0 328.8 431.8 0.5544 0.6003 -0.7978
Glycosyltransferases OGT[a] O15294[a] Tetratricopeptide repeat domain IPR019734[a] Tetratricopeptide repeat[a] 1W3B a/32,33,35,36,37,59,60,63,64,66,
67,90,93,94,97,122,124,128
4 blue 0 276.3 308.4 0.5508 0.7622 -0.2964
Glycosyltransferases OGT[a] O15294[a] Tetratricopeptide repeat domain IPR013026[a] Tetratricopeptide repeat-containing domain[a] 1W3B a/45,48,52,53,54,57,58,61,76,77,
80,81,83,84
4 blue 0 268.4 259.5 0.6868 0.7808 0.06414
Glycosyltransferases OGT[a],OGT[b] O15294[a],
O15294[b]
Tetratricopeptide repeat domain IPR013026[a] Tetratricopeptide repeat-containing domain[a] 1W3B a/215,218,219,222,228,231,235,
243,246,247,250; b/208
4 blue 0 177.6 200.5 0.5342 0.7564 -0.683
Glycosyltransferases OGT[a] O15294[a] Tetratricopeptide repeat domain IPR019734[a] Tetratricopeptide repeat[a] 1W3B a/335,338,339,350,365,366,369,
370,384,394,396,400
4 blue 0 165.2 181.1 0.4658 0.7508 -0.914
Glycosyltransferases OGT[a] O15294[a] Tetratricopeptide repeat domain 5BNW a/373,374,375,376,534,535,537,
538,619,620,621,622,649
4 blue a/C620(reactive:0.76) 16.690001 221.6 201.9 0.5042 0.7113 -0.7656
Glycosyltransferases OGT[a] O15294[a] Tetratricopeptide repeat domain IPR019734[a] Tetratricopeptide repeat[a] 6EOU a/215,218,219,222,228,231,235,
243,246,247,249,250,252,253,256,
257,262,265,269,277,280,281,284
4 blue 0 356.3 480.3 0.4988 0.6639 -0.614
Methyltransferases PRMT5[a],PRMT5[a3] O14744[a],
O14744[a3]
TIM barrel domain IPR035247[a] PRMT5, TIM barrel domain[a] 5EMJ a/112,115,116,141,144,145,146,
147; a3/312,313,317,318,319,320
4 blue 7.408 236.1 217.3 0.5761 0.7848 -0.2659
Methyltransferases PRMT5[a] O14744[a] TIM barrel domain IPR035247[a] PRMT5, TIM barrel domain[a] 6K1S a/212,215,218,249,252,253,255,
256
4 blue 30.879999 157.4 174.1 0.6403 0.8387 -0.207
Methyltransferases PRMT5[a],WDR77[b] O14744[a],
Q9BQA1[b]
TIM barrel domain IPR035247[a] PRMT5, TIM barrel domain[a] 4X61 a/18,19,20,21,22,24,29,33,36,85,
86,88,123,124,125,154,232,234,
267,268,269,270,277; b/99,100,
101,122,124,125,126,127,146,164
4 blue a/C22(reactive:0.81) 44.060001 561.6 573.9 0.5 0.692 -0.1643
Methyltransferases PRMT5[a] O14744[a] TIM barrel domain 6RLQ a/21,22,23,24,43,44,45,46,47,48,
49,50,63,64,65,66,67,68
4 blue a/C22(reactive:0.805) 53.540001 312.7 351.5 0.5656 0.755 -0.1998
Methyltransferases SETDB1[a] Q15047[a] Tudor domain IPR041292[a] Histone methyltransferase, Tudor domain 2[a] 3DLM a/269,270,271,272,292,296,299,
300,301,302,303,304,328,329,332,
333,371,374,376,385,386,387,388,
389,392,393,394
1

5KCH[6rn],5KCO[6ro],5KE2[6s4],
blue a/C329(reactive:0.8),
a/C385(reactive:0.785)
0 478.3 495.6 0.4898 0.7537 -0.06322
Demethylases KDM4C Q9H3R0 Tudor domain IPR002999 3

5KCH[6rn],5KCO[6ro],5KE2[6s4],
0 0 0 0 0 0
Demethylases KDM4B O94953 Tudor domain IPR002999 3

5KCH[6rn],5KCO[6ro],5KE2[6s4],
0 0 0 0 0 0
Protein Kinases STK31 Q9BXU1 Tudor domain IPR002999 3

5KCH[6rn],5KCO[6ro],5KE2[6s4],
0 0 0 0 0 0
Demethylases KDM4A[a] O75164[a] Tudor domain 2QQS a/932,933,934,936,937,938,967,
973,974
4 blue 0 190.7 190.6 0.6939 0.797 -0.1081
Methyltransferases SETDB1[a] Q15047[a] Tudor domain IPR002999[a] Tudor domain[a] 6BHE a/358,363,379,381,382,384,385,
386
4 blue a/C385(reactive:0.77) 0 225.2 193.3 0.7485 0.8673 0.4155
Methyltransferases SETDB1[a] Q15047[a] Tudor domain IPR002999[a] Tudor domain[a] 6BHG a/332,335,336,339,342,343,344,
389,391,392,393,398,402
4 blue 0 168 156.8 0.6822 0.8885 0.1319
Acetyltransferases GTF3C4 Q9UKN8 WD40 repeat domain IPR036322 3

3SMR[np7],3UR4[0bw],4IA9[ia9],
0 0 0 0 0 0
Deubiquitinases PAN2 Q504Q3 WD40 repeat domain IPR036322,
IPR015943
3

3SMR[np7],3UR4[0bw],4IA9[ia9],
0 0 0 0 0 0
Protein Kinases MET[b] P08581[b] WD40 repeat domain IPR015943[b] WD40[b] 2UZY b/51,52,53,54,55,56,57,58,116,
117,118,119,120,121,122,123,124,
181,182,183,184,185,186,246,247,
248,249,250,251,252,253,264,265,
274,316,317,318,319,320,321,322,
354,355,356,438,440,442,484,485,
486,487,488,489,490,491,505,507
3

3SMR[np7],3UR4[0bw],4IA9[ia9],
orange 0 824 1001 0.4511 0.6636 -0.1041
Protein Kinases MST1R[a] Q04912[a] WD40 repeat domain IPR015943[a] WD40[a] 4FWW a/55,56,57,58,59,120,121,122,
123,124,125,127,182,183,184,185,
186,187,188,202,248,249,250,251,
252,323,324,325,451,452,499,500,
501,502,503,512
3

3SMR[np7],3UR4[0bw],4IA9[ia9],
orange 0 590.7 613.7 0.4648 0.7769 0.1272
Protein Kinases MST1R[a],MST1[c] Q04912[a],
P26927[c]
WD40 repeat domain IPR015943[a] WD40[a] 4QT8 a/57,58,59,121,122,123,124,125,
127,128,185,186,187,188,189,190,
251,252,253,323,324,325,451,452,
500,501,502,503; c/639
3

3SMR[np7],3UR4[0bw],4IA9[ia9],
orange 0 368.7 421.7 0.4475 0.7088 -0.5283
Protein Kinases PIK3R4 Q99570 WD40 repeat domain IPR001680,
IPR019775,
IPR017986,
IPR036322,
IPR015943
3

3SMR[np7],3UR4[0bw],4IA9[ia9],
0 0 0 0 0 0
Protein Kinases LRRK2 Q5S007 WD40 repeat domain IPR036322,
IPR015943
3

3SMR[np7],3UR4[0bw],4IA9[ia9],
0 0 0 0 0 0
Protein Kinases LRRK1 Q38SD2 WD40 repeat domain IPR036322 3

3SMR[np7],3UR4[0bw],4IA9[ia9],
0 0 0 0 0 0
Protein Phosphatases PPP2R2D Q66LE6 WD40 repeat domain IPR001680,
IPR036322,
IPR015943
3

3SMR[np7],3UR4[0bw],4IA9[ia9],
0 0 0 0 0 0
Protein Phosphatases PPP2R2C Q9Y2T4 WD40 repeat domain IPR001680,
IPR036322,
IPR015943
3

3SMR[np7],3UR4[0bw],4IA9[ia9],
0 0 0 0 0 0
Protein Phosphatases PPP2R2B Q00005 WD40 repeat domain IPR001680,
IPR019775,
IPR036322,
IPR015943
3

3SMR[np7],3UR4[0bw],4IA9[ia9],
0 0 0 0 0 0
Protein Phosphatases PPP2R2A P63151 WD40 repeat domain IPR001680,
IPR036322,
IPR015943
3

3SMR[np7],3UR4[0bw],4IA9[ia9],
0 0 0 0 0 0
Protein Kinases MET[b] P08581[b] WD40 repeat domain 1SHY b/445,447,448,449,450,452,464,
476,515,516,519,535,536,537,547,
548,549
4 blue 0 192.2 226.8 0.5612 0.801 -0.3878
Protein Kinases MET[b] P08581[b] WD40 repeat domain IPR015943[b] WD40[b] 4K3J b/90,92,94,95,99,101,103,104,
105,106,107,108,109,110
4 blue 0 185.8 176.9 0.6111 0.8186 -0.2301
Protein Kinases HGF[a],MET[b] P14210[a],
P08581[b]
WD40 repeat domain IPR015943[b] WD40[b] 4O3T a/647,649; b/58,59,61,127,128,
145,146,147,148,149,150,151,152
4 blue 0 264.6 280.9 0.5318 0.7633 -0.3671
Protein Kinases MET[b] P08581[b] WD40 repeat domain IPR015943[b] WD40[b] 4O3U b/96,97,98,99,162,163,164,165,
169,171,172,173,174,208,209
4 blue 0 188.3 216.9 0.5377 0.6727 -0.9617
Protein Kinases MST1R[a],MST1[c] Q04912[a],
P26927[c]
WD40 repeat domain IPR015943[a] WD40[a] 4QT8 a/60,61,62,63,64,125,127,128,
129,130,147,148,193,194,195,221,
222,223,225; c/636,637,639,682,
683,684,690
4 blue 0 396.4 460 0.5455 0.753 -0.07786
Protein Kinases MST1R[a],MST1[c] Q04912[a],
P26927[c]
WD40 repeat domain IPR015943[a] WD40[a] 4QT8 a/189,190,191,192,196,254,285,
286,287,288,289; c/521,522,528,
562,563,564,565,566,567,568,569
4 blue 0 297.6 319.8 0.5145 0.7547 -0.3534
Protein Kinases MET[b] P08581[b] WD40 repeat domain IPR015943[b] WD40[b] 4O3U b/66,68,69,70,84,85,86,88,89,90,
91,92,93,94,95,96,97,98,99,100,
101,102,112,113,115,116,117,118,
132,133,134,135,136,137,138,139,
140,141,142,178,179,180,201,202,
203,204,205,206,207,209,210,211,
242
4 red 0 965 929.2 0.5444 0.8108 0.8041
Protein Kinases MST1R[a] Q04912[a] WD40 repeat domain IPR015943[a] WD40[a] 4QT8 a/114,115,116,117,136,137,138,
139,140,141,177,179,180,181,206,
207,209,210,211,212,213
4 red 0 209.9 234.8 0.4544 0.7314 -0.8393
Protein Kinases MET[b] P08581[b] WD40 repeat domain IPR015943[b] WD40[b] 2UZY b/163,164,165,167,168,171,173,
174,220,225,226,227,228,229,230,
231,234
4 yellow 0 217.8 244.3 0.5789 0.7476 -0.4656
Protein Kinases MST1R[a],MST1[c] Q04912[a],
P26927[c]
WD40 repeat domain IPR015943[a] WD40[a] 4QT8 a/196,218,219,220,222,229,230,
231,232,233,288,289,290; c/500,
501,502,506,507,521,522,523,524,
525,526,529,534,658,659,661
4 yellow 0 537.4 430.2 0.5841 0.8415 0.5829
Glycosyltransferases GALNT9 Q9HCQ5 WW domain IPR001202 4 0 0 0 0 0 0
Methyltransferases SETD2[a] Q9BYW2[a] WW domain IPR001202[a] WW domain[a] 2MDJ a/2382,2383,2384,2385,2387,2388,
2389,2391,2409,2412,2413,2414,
2416,2419,2420,2422
4 blue 0 224.6 245.9 0.5178 0.7589 -0.5369
Methyltransferases CMTR1 Q8N1G2 WW domain IPR001202 4 0 0 0 0 0 0
Acetyltransferases KAT6A[a] Q92794[a] Zinc-finger, PHD-type domain 4LK9 a/260,261,263,271,272,273,274,
275,276,277,278,279,280,282,290,
300,301,303,304,305
4 blue 0 308.9 333.9 0.5953 0.7799 -0.04306
Acetyltransferases KAT6A[a],H3-3B[b] Q92794[a],
K7EMV3[b]
Zinc-finger, PHD-type domain 5B76 a/242,243,244,245,248,257,260,
263,280,282,285,304; b/3,8,11,
12
4 blue 0 165.4 193.1 0.5577 0.8107 -0.4685
Acetyltransferases KAT6B[a] Q8WYB5[a] Zinc-finger, PHD-type domain 6OIE a/259,262,263,264,265,270,271,
273,276,291,292,293,294
4 blue 0 204 188.1 0.5653 0.8571 -0.1133
Deacetylases HDAC6[a] Q9UBN7[a] Zinc-finger, UBD-type IPR001607[a] Zinc finger, UBP-type[a] 5B8D a/1141,1142,1143,1154,1155,1156,
1161,1162,1173,1175,1176,1177,
1178,1182,1184,1187,1189
1

5B8D[6t4],5KH3[6u6],5KH7[6t7],

6DXH[hh4],6DXT[hhy],6NFT[kkg],
blue 0 250.8 261.3 0.5966 0.7962 -0.1299
Deubiquitinases USP51 Q70EK9 Zinc-finger, UBD-type IPR001607 3

5B8D[6t4],5KH3[6u6],5KH7[6t7],
0 0 0 0 0 0
Deubiquitinases USP5 P45974 Zinc-finger, UBD-type IPR001607 3

5B8D[6t4],5KH3[6u6],5KH7[6t7],
0 0 0 0 0 0
Deubiquitinases USP49 Q70CQ1 Zinc-finger, UBD-type IPR001607 3

5B8D[6t4],5KH3[6u6],5KH7[6t7],
0 0 0 0 0 0
Deubiquitinases USP45 Q70EL2 Zinc-finger, UBD-type IPR001607 3

5B8D[6t4],5KH3[6u6],5KH7[6t7],
0 0 0 0 0 0
Deubiquitinases USP44 Q9H0E7 Zinc-finger, UBD-type IPR001607 3

5B8D[6t4],5KH3[6u6],5KH7[6t7],
0 0 0 0 0 0
Deubiquitinases USP39 Q53GS9 Zinc-finger, UBD-type IPR001607 3

5B8D[6t4],5KH3[6u6],5KH7[6t7],
0 0 0 0 0 0
Deubiquitinases USP33 Q8TEY7 Zinc-finger, UBD-type IPR001607 3

5B8D[6t4],5KH3[6u6],5KH7[6t7],
0 0 0 0 0 0
Deubiquitinases USP3 Q9Y6I4 Zinc-finger, UBD-type IPR001607 3

5B8D[6t4],5KH3[6u6],5KH7[6t7],
0 0 0 0 0 0
Deubiquitinases USP22 Q9UPT9 Zinc-finger, UBD-type IPR001607 3

5B8D[6t4],5KH3[6u6],5KH7[6t7],
0 0 0 0 0 0
Deubiquitinases USP20 Q9Y2K6 Zinc-finger, UBD-type IPR001607 3

5B8D[6t4],5KH3[6u6],5KH7[6t7],
0 0 0 0 0 0
Deubiquitinases USP16 Q9Y5T5 Zinc-finger, UBD-type IPR001607 3

5B8D[6t4],5KH3[6u6],5KH7[6t7],
0 0 0 0 0 0
Deubiquitinases USP13 Q92995 Zinc-finger, UBD-type IPR001607 3

5B8D[6t4],5KH3[6u6],5KH7[6t7],
0 0 0 0 0 0
Deubiquitinases USP5[a] P45974[a] Zinc-finger, UBP-type domain IPR001607[a] Zinc finger, UBP-type[a] 2G43 a/207,209,220,221,223,229,233,
234,245,247,259,261,266
1

6DXH[hh4],6DXT[hhy],6NFT[kkg],

5B8D[6t4],5KH3[6u6],5KH7[6t7],
blue 0 180.1 172 0.6498 0.9007 0.158
Deubiquitinases USP33[a] Q8TEY7[a] Zinc-finger, UBP-type domain IPR001607[a] Zinc finger, UBP-type[a] 2UZG a/63,72,73,74,75,81,82,83,91,92,
94,95,96,98,99,101,103,104,115
4 blue 0 190.8 218.3 0.7119 0.8863 0.285
Deubiquitinases USP20[a] Q9Y2K6[a] Zinc-finger, UBP-type domain IPR001607[a] Zinc finger, UBP-type[a] 6KCZ a/11,12,14,15,16,22,44,74,79,80,
81,90,91,92,93
4 blue 0 156.8 178.7 0.6207 0.7257 -0.6998