The Ligandable Human Proteome

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Hepatocyte growth factor receptor

Protein kinase domain

IndexLigand NameStructurePDB codeCompound Potency nM
188zStructure of the kinase domain of c-Met bound to XL880 (GSK1363089)3lq80.4
20j3Crystal structure of CMET in complex with novel inhibitor4gg50.93
31jcStructure of dually phosphorylated c-MET receptor kinase in complex with an MK-8033 analog4iwd1
4044Crystal structure of c-Met in complex with pyrazolone inhibitor 58a3u6i1
503xCrystal structure of c-Met in complex with pyrazolone inhibitor 263u6h1
60jlCrystal structure of c-Met in complex with triazolopyridinone inhibitor 244dei1
73e8Identification and optimization of pyridazinones as potent and selective c-Met kinase inhibitors4r1v1
844xCrystal structure of c-Met in complex with (S)-5-(8-fluoro-3-(1-(3-(2-methoxyethoxy)quinolin-6-yl)ethyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)-3-methylisoxazole4xyf1
95t1Crystal structure of c-Met in complex with AMG 3375eyd1
106xpCrystal structure of C-MET kinase domain in complex with N'-((3Z)-4- chloro-7-methyl-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-2-(4- hydroxyphenyl)propanohydrazide3zze1.3
111fnCrystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor C-MET in complex with a Pyrrolopyridinepyridone based inhibitor3ce31.8
12vghX-ray Structure of PF-02341066 bound to the kinase domain of c-Met2wgj2
135szCrystal structure of c-Met in complex with naphthyridinone inhibitor 55eyc3
144k0Crystal structure of C-MET kinase domain in complex with 4-(3-((1H- pyrrolo(2,3-b)pyridin-3-yl)methyl)-(1,2,4)triazolo(4,3-b)(1,2,4) triazin-6-yl)benzonitrile4aoi4
15m61Structure of dually phosphorylated c-MET receptor kinase in complex with an MK-2461 analog3r7o4.4
16353Crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor C-MET in complex with N-(4-(2-amino-3-chloropyridin-4-yloxy)-3-fluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide3f824.6
17am7x-ray structure of c-Met with inhibitor.2rfn5
1863kCrystal structure of c-Met-M1250T in complex with SAR125844.5hor6
196xeX-ray Structure of c-Met kinase in complex with inhibitor 6-((6-(4- fluorophenyl)-(1,2,4)triazolo(4,3-b)(1,2,4)triazin-3-yl)methyl) quinoline.3zbx6
200jjCrystal structure of c-Met in complex with triazolopyridazine inhibitor 24deg6
210j8Crystal structure of cMET in complex with novel inhibitor4gg76.3
22dwfCrystal structure of CMET in complex with novel inhibitor4mxc6.7
23l8vCrystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor C-MET in complex with a biarylamine based inhibitor3l8v8
24l5gX-ray Structure of c-Met with triazolopyridazine Inhibitor.3cd89
255tfX-ray Structure of c-Met kinase in complex with inhibitor (S)-3-(1-(1H-pyrrolo(2,3-b)pyridin-3-yl)ethyl)-N-isopropyl-(1,2,4)triazolo(4,3- b)pyridazin-6-amine3zcl10.1
26f47Crystal structure of C-MET kinase domain in complex with 4-((6-(4- fluorophenyl)-(1,2,4)triazolo(4,3-b)(1,2,4)triazin-3-yl)methyl)phenol4ap711
27mt4Structure of c-Met with pyrimidone inhibitor 503efk14
28b2dCrystal structure of c-Met with triazolopyridazine inhibitor 133i5n14
293qtc-Met Kinase in Complex with NVP-BVU9723qti14
3062eCrystal structure of c-Met mutant Y1230H in complex with compound 145hlw23
31q6wStructure of dually-phosphorylated MET receptor kinase in complex with an MK-2461 analog with specificity for the activated receptor3q6w27
32dfqhuman c-MET kinase domain complexed with 6-benzyloxyquinoline inhibitor3a4p28
33320Crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor c-met in complex with a aminopyridine based inhibitor3ctj35
34mt3Structure of c-Met with pyrimidone inhibitor 73efj39
35ckkCrystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor c-MET in complex with a Pyrrolotriazine based inhibitor3c1x45
361ruC-Met in complex with OSI ligand4knb47
3763kCrystal structure of c-Met L1195V in complex with SAR1258445hoa64
38w9zX-ray Structure of c-Met kinase in complex with inhibitor (S)-6-(1-(6- (1-methyl-1H-pyrazol-4-yl)-(1,2,4)triazolo(4,3-b)pyridazin-3-yl)ethyl) quinoline.3zc574
39319Crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor c-met in complex with a aminopyridine based inhibitor3cth110
40lkgX-ray structure of c-Met with triazolopyridazine inhibitor.3ccn120
4163kCRYSTAL STRUCTURE OF CMET IN COMPLEX WITH CMPD.5ho6204
423ehIdentification and optimization of pyridazinones as potent and selective c-Met kinase inhibitor4r1y400
430jkCrystal structure of c-Met in complex with triazolopyridinone inhibitor 34deh612
44ihxHuman c-Met Kinase in complex with quinoxaline inhibitor3f66900