The Ligandable Human Proteome

Protein kinase domain

Index	Protein Name	Gene Name Primary	Gene Name Synonym	Uniprot ID	Most Potent Compound in PDB nM
1	Serine/threonine-protein kinase pim-1	PIM1		P11309	0.001
2	Casein kinase II subunit alpha 3	CSK23	CSNK2A1P	Q8NEV1	0.00491
3	Aurora kinase A	AURKA	AIK AIRK1 ARK1 AURA AYK1 BTAK IAK1 STK15 STK6	O14965	0.01
4	Mitogen-activated protein kinase 1	MK01	ERK2 PRKM1 PRKM2	P28482	0.01
5	Vascular endothelial growth factor receptor 2	VGFR2	FLK1 VEGFR2	P35968	0.01
6	Proto-oncogene tyrosine-protein kinase ROS	ROS1	MCF3 ROS	P08922	0.025
7	Serine/threonine-protein kinase B-raf	BRAF	BRAF1 RAFB1	P15056	0.03
8	Dual specificity mitogen-activated protein kinase kinase 1	MP2K1	MEK1 PRKMK1	Q02750	0.05
9	Serine/threonine-protein kinase Chk1	CHK1	CHK1	O14757	0.05
10	Tyrosine-protein kinase Mer	MERTK	MER	Q12866	0.05
11	ALK tyrosine kinase receptor	ALK		Q9UM73	0.08
12	Tyrosine-protein kinase ITK/TSK	ITK	EMT LYK	Q08881	0.09
13	Mitogen-activated protein kinase 14	MK14	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	Q16539	0.1
14	Tyrosine-protein kinase ABL1	ABL1	ABL JTK7	P00519	0.1
15	Tyrosine-protein kinase JAK1	JAK1	JAK1A JAK1B	P23458	0.1
16	Cyclin-dependent kinase 2	CDK2	CDKN2	P24941	0.11
17	Tyrosine-protein kinase receptor UFO	UFO	UFO	P30530	0.13
18	Serine/threonine-protein kinase Chk2	CHK2	CDS1 CHK2 RAD53	O96017	0.14
19	Tyrosine-protein kinase JAK3	JAK3		P52333	0.16
20	Fibroblast growth factor receptor 1	FGFR1	BFGFR CEK FGFBR FLG FLT2 HBGFR	P11362	0.2
21	Tyrosine-protein kinase Lck	LCK		P06239	0.2
22	Interleukin-1 receptor-associated kinase 4	IRAK4		Q9NWZ3	0.2
23	Glycogen synthase kinase-3 beta	GSK3B		P49841	0.22
24	Tyrosine-protein kinase BTK	BTK	AGMX1 ATK BPK	Q06187	0.27
25	cAMP-dependent protein kinase catalytic subunit alpha	KAPCA	PKACA	P17612	0.3
26	Activated CDC42 kinase 1	ACK1	ACK1	Q07912	0.3
27	Eukaryotic translation initiation factor 2-alpha kinase 3	E2AK3	PEK PERK	Q9NZJ5	0.4
28	Hepatocyte growth factor receptor	MET		P08581	0.4
29	Tyrosine-protein kinase HCK	HCK		P08631	0.43
30	Protein kinase C theta type	KPCT	PRKCT	Q04759	0.46
31	Tyrosine-protein kinase JAK2	JAK2		O60674	0.48
32	RAC-alpha serine/threonine-protein kinase	AKT1	PKB RAC	P31749	0.5
33	Serine/threonine-protein kinase MARK2	MARK2	EMK1	Q7KZI7	0.5
34	Mitogen-activated protein kinase kinase kinase 12	M3K12	ZPK	Q12852	0.5
35	Proto-oncogene tyrosine-protein kinase Src	SRC	SRC1	P12931	0.53
36	Dual specificity protein kinase TTK	TTK	MPS1 MPS1L1	P33981	0.56
37	3-phosphoinositide-dependent protein kinase 1	PDPK1	PDK1	O15530	0.6
38	Tyrosine-protein kinase SYK	KSYK		P43405	0.7
39	Mitogen-activated protein kinase 10	MK10	JNK3 JNK3A PRKM10 SAPK1B	P53779	0.75
40	Ephrin type-A receptor 2	EPHA2	ECK	P29317	0.76
41	Epidermal growth factor receptor	EGFR	ERBB ERBB1 HER1	P00533	0.8
42	Macrophage colony-stimulating factor 1 receptor	CSF1R	FMS	P07333	0.8
43	Cyclin-dependent kinase 8	CDK8		P49336	0.9
44	Angiopoietin-1 receptor	TIE2	TIE2 VMCM VMCM1	Q02763	1
45	Non-receptor tyrosine-protein kinase TYK2	TYK2		P29597	1.4
46	Serine/threonine-protein kinase PLK1	PLK1	PLK	P53350	1.5
47	Focal adhesion kinase 1	FAK1	FAK FAK1	Q05397	1.5
48	Protein-tyrosine kinase 2-beta	FAK2	FAK2 PYK2 RAFTK	Q14289	1.5
49	Epithelial discoidin domain-containing receptor 1	DDR1	CAK EDDR1 NEP NTRK4 PTK3A RTK6 TRKE	Q08345	1.5
50	Ephrin type-A receptor 3	EPHA3	ETK ETK1 HEK TYRO4	P29320	1.6
51	Maternal embryonic leucine zipper kinase	MELK	KIAA0175	Q14680	2
52	Protein kinase C beta type	KPCB	PKCB PRKCB1	P05771	2
53	Ephrin type-B receptor 4	EPHB4	HTK MYK1 TYRO11	P54760	2
54	Protein kinase C alpha type	KPCA	PKCA PRKACA	P17252	2.1
55	Mitogen-activated protein kinase kinase kinase 7	M3K7	TAK1	O43318	2.3
56	Mitogen-activated protein kinase 8	MK08	JNK1 PRKM8 SAPK1 SAPK1C	P45983	3
57	Serine/threonine-protein kinase 24	STK24	MST3 STK3	Q9Y6E0	3
58	MAP kinase-activated protein kinase 2	MAPK2		P49137	3
59	Ephrin type-B receptor 1	EPHB1	ELK EPHT2 HEK6 NET	P54762	3
60	Serine/threonine-protein kinase PAK 4	PAK4	KIAA1142	O96013	3.3
61	Serine/threonine-protein kinase PAK 1	PAK1		Q13153	3.7
62	Mitogen-activated protein kinase kinase kinase kinase 4	M4K4	HGK KIAA0687 NIK	O95819	3.7
63	Ribosomal protein S6 kinase alpha-3	KS6A3	ISPK1 MAPKAPK1B RSK2	P51812	4
64	RAC-beta serine/threonine-protein kinase	AKT2		P31751	4
65	Serine/threonine-protein kinase MRCK beta	MRCKB	KIAA1124	Q9Y5S2	4
66	BDNF/NT-3 growth factors receptor	NTRK2	TRKB	Q16620	4
67	Insulin receptor	INSR		P06213	4
68	Tyrosine-protein kinase ABL2	ABL2	ABLL ARG	P42684	4
69	Proto-oncogene tyrosine-protein kinase receptor Ret	RET	CDHF12 CDHR16 PTC RET51	P07949	4.5
70	Mitogen-activated protein kinase 9	MK09	JNK2 PRKM9 SAPK1A	P45984	4.6
71	MAP/microtubule affinity-regulating kinase 4	MARK4	KIAA1860 MARKL1	Q96L34	4.6
72	Serine/threonine-protein kinase PLK2	PLK2	SNK	Q9NYY3	5
73	Casein kinase I isoform gamma-3	KC1G3		Q9Y6M4	5
74	Mitogen-activated protein kinase kinase kinase 5	M3K5	ASK1 MAPKKK5 MEKK5	Q99683	5.01
75	Insulin-like growth factor 1 receptor	IGF1R		P08069	5.3
76	Casein kinase I isoform delta	KC1D	HCKID	P48730	6
77	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	DYR1A	DYRK MNB MNBH	Q13627	6
78	Fibroblast growth factor receptor 4	FGFR4	JTK2 TKF	P22455	6
79	Mast/stem cell growth factor receptor Kit	KIT	SCFR	P10721	6
80	Ephrin type-B receptor 3	EPHB3	ETK2 HEK2 TYRO6	P54753	6
81	Beta-adrenergic receptor kinase 1	ARBK1	ADRBK1 BARK BARK1	P25098	6.1
82	Cyclin-dependent kinase 9	CDK9	CDC2L4 TAK	P50750	6.4
83	Protein-tyrosine kinase 6	PTK6	BRK	Q13882	7
84	High affinity nerve growth factor receptor	NTRK1	MTC TRK TRKA	P04629	7.9
85	Serine/threonine-protein kinase ULK1	ULK1	KIAA0722	O75385	8
86	Receptor-interacting serine/threonine-protein kinase 2	RIPK2	CARDIAK RICK RIP2	O43353	8
87	Cyclin-G-associated kinase	GAK		O14976	8.9
88	Protein kinase C eta type	KPCL	PKCL PRKCL	P24723	9
89	Tyrosine-protein kinase Lyn	LYN	JTK8	P07948	9
90	Rho-associated protein kinase 1	ROCK1		Q13464	10
91	Receptor-interacting serine/threonine-protein kinase 1	RIPK1	RIP RIP1	Q13546	10
92	Dual specificity tyrosine-phosphorylation-regulated kinase 2	DYRK2		Q92630	10.8
93	Wee1-like protein kinase	WEE1		P30291	11
94	Receptor tyrosine-protein kinase erbB-2	ERBB2	HER2 MLN19 NEU NGL	P04626	11
95	Casein kinase II subunit alpha'	CSK22	CK2A2	P19784	13
96	Serine/threonine-protein kinase pim-2	PIM2		Q9P1W9	14
97	Ribosomal protein S6 kinase beta-1	KS6B1	STK14A	P23443	15
98	Cyclin-dependent kinase 6	CDK6	CDKN6	Q00534	15
99	Activin receptor type-1	ACVR1	ACVRLK2	Q04771	15
100	Serine/threonine-protein kinase PRP4 homolog	PRP4B	KIAA0536 PRP4 PRP4H PRP4K	Q13523	16
101	Serine/threonine-protein kinase TBK1	TBK1	NAK	Q9UHD2	19
102	Serine/threonine-protein kinase/endoribonuclease IRE1	ERN1	IRE1	O75460	20
103	TRAF2 and NCK-interacting protein kinase	TNIK	KIAA0551	Q9UKE5	21
104	TGF-beta receptor type-1	TGFR1	ALK5 SKR4	P36897	25
105	Ephrin type-A receptor 4	EPHA4	HEK8 SEK TYRO1	P54764	25
106	Mitogen-activated protein kinase kinase kinase 20	M3K20	MLTK ZAK	Q9NYL2	29
107	Dual specificity protein kinase CLK3	CLK3		P49761	29.2
108	Aurora kinase B	AURKB	AIK2 AIM1 AIRK2 ARK2 STK1 STK12 STK5	Q96GD4	31
109	Casein kinase I isoform epsilon	KC1E		P49674	32
110	BMP-2-inducible protein kinase	BMP2K	BIKE	Q9NSY1	33.1
111	Mitogen-activated protein kinase 11	MK11	PRKM11 SAPK2 SAPK2B	Q15759	36
112	Serine/threonine-protein kinase 3	STK3	KRS1 MST2	Q13188	38.1
113	Serine/threonine-protein kinase Sgk1	SGK1	SGK	O00141	40
114	Mitogen-activated protein kinase kinase kinase 14	M3K14	NIK	Q99558	40
115	Mitogen-activated protein kinase 7	MK07	BMK1 ERK5 PRKM7	Q13164	42
116	Serine/threonine-protein kinase N1	PKN1	PAK1 PKN PRK1 PRKCL1	Q16512	43
117	Serine/threonine-protein kinase Nek2	NEK2	NEK2A NLK1	P51955	59
118	Receptor tyrosine-protein kinase erbB-4	ERBB4	HER4	Q15303	66
119	LIM domain kinase 2	LIMK2		P53671	92
120	Mitogen-activated protein kinase kinase kinase kinase 3	M4K3	RAB8IPL1	Q8IVH8	110
121	Mixed lineage kinase domain-like protein	MLKL		Q8NB16	116
122	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	PMYT1	MYT1	Q99640	150
123	Cyclin-dependent kinase 12	CDK12	CRK7 CRKRS KIAA0904	Q9NYV4	158
124	Cyclin-dependent-like kinase 5	CDK5	CDKN5	Q00535	160
125	Vascular endothelial growth factor receptor 1	VGFR1	FLT FRT VEGFR1	P17948	180
126	Mitogen-activated protein kinase 3	MK03	ERK1 PRKM3	P27361	200
127	Death-associated protein kinase 1	DAPK1	DAPK	P53355	240
128	Tau-tubulin kinase 1	TTBK1	BDTK KIAA1855	Q5TCY1	240
129	Cyclin-dependent kinase 1	CDK1	CDC2 CDC28A CDKN1 P34CDC2	P06493	250
130	Casein kinase II subunit alpha	CSK21	CK2A1	P68400	320
131	Protein kinase C iota type	KPCI	DXS1179E	P41743	341
132	G protein-coupled receptor kinase 5	GRK5	GPRK5	P34947	380
133	Tyrosine-protein kinase receptor TYRO3	TYRO3	BYK DTK RSE SKY TIF	Q06418	476
134	Mitogen-activated protein kinase 13	MK13	PRKM13 SAPK4	O15264	620
135	G protein-coupled receptor kinase 6	GRK6	GPRK6	P43250	1000
136	MAP kinase-activated protein kinase 3	MAPK3		Q16644	1100
137	Fibroblast growth factor receptor 2	FGFR2	BEK KGFR KSAM	P21802	5000
138	Putative 3-phosphoinositide-dependent protein kinase 2	PDPK2	PDPK2	Q6A1A2	8400