| Index | Ligand Name | Structure | PDB code | Compound Potency nM |
| 1 | 4vg | Tetrahydropyrrolo-diazepenones as inhibitors of ERK2 kinase | 5bve | 0.01 |
| 2 | 4vf | Tetrahydropyrrolo-diazepenones as inhibitors of ERK2 kinase | 5bvd | 0.16 |
| 3 | 4vj | Tetrahydropyrrolo-diazepenones as inhibitors of ERK2 kinase | 5bvf | 0.19 |
| 4 | 6s9 | Discovery of 1-1H-Pyrazolo 4,3-c pyridine-6-yl urea Inhibitors of Extracellular Signal Regulated Kinase ERK for the Treatment of Cancers | 5ke0 | 0.2 |
| 5 | 41b | Crystal structure of ERK2 in complex with an inhibitor 14K | 4xj0 | 0.3 |
| 6 | 8xb | Human Erk2 with an Erk1/2 inhibitor | 5nhl | 0.3 |
| 7 | 8xn | Human Erk2 with an Erk1/2 inhibitor | 5nho | 0.3 |
| 8 | 8x5 | Human Erk2 with an Erk1/2 inhibitor | 5nhf | 0.32 |
| 9 | 2sh | Discovery of 5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine Inhibitors of Erk2 | 4o6e | 1 |
| 10 | 8xh | Human Erk2 with an Erk1/2 inhibitor | 5nhh | 1.13 |
| 11 | g17 | Crystal Structure of a Double Mutant Rat Erk2 Complexed With a Type II Quinazoline Inhibitor | 4i5h | 2 |
| 12 | 82a | Crystal structure of ERK2 in complex with (S)-N-(1-(3-chloro-4-fluorophenyl)-2-hydroxyethyl)-4-(4-(3-chlorophenyl)-1H-pyrazol-3-yl)-1H-pyrrole-2-carboxamide | 2ojj | 2 |
| 13 | z48 | Crystal structure of ERK2 bound to (S)-N-(2-hydroxy-1-phenylethyl)-4-(5-methyl-2-(phenylamino)pyrimidin-4-yl)-1H-pyrrole-2-carboxamide | 3i5z | 2 |
| 14 | e86 | Crystal structure of ERK2 bound to (S)-4-(2-(2-chlorophenylamino)-5-methylpyrimidin-4-yl)-N-(2-hydroxy-1-phenylethyl)-1H-pyrrole-2-carboxamide | 3i60 | 2 |
| 15 | 8qb | Human Erk2 with an Erk1/2 inhibitor | 5nhv | 2.8 |
| 16 | 4v8 | ERK2 complexed with N-benzylpyridone tetrahydroazaindazole | 5bue | 3 |
| 17 | 6qb | Crystal Structure of ERK2 in complex with compound 22 | 5k4i | 3.1 |
| 18 | 4vb | ERK2 complexed with a N-H tetrahydroazaindazole | 5buj | 5 |
| 19 | 8xe | Human Erk2 with an Erk1/2 inhibitor | 5nhj | 5.4 |
| 20 | 6tt | A Clickable Covalent ERK 1/2 Inhibitor | 5lck | 8 |
| 21 | 8xk | Human Erk2 with an Erk1/2 inhibitor | 5nhp | 23 |
| 22 | 8x2 | Human Erk2 with an Erk1/2 inhibitor | 5ngu | 36 |
| 23 | 35w | Crystal Structure of ERK2 in complex with 7-(1-benzyl-1H-pyrazol-4-yl)-2-(pyridin-4-yl)-5H-pyrrolo[2,3-b]pyrazine | 4qpa | 37 |
| 24 | 3g7 | Discovery of Novel, Dual Mechanism ERK Inhibitors by Affinity Selection Screening of an Inactive Kinase State | 4qyy | 50 |
| 25 | 35x | Crystal Structure of ERK2 in complex with 7-(1-propyl-1H-pyrazol-4-yl)-2-(pyridin-4-yl)-5H-pyrrolo[2,3-b]pyrazine | 4qp9 | 71 |
| 26 | 1fm | The structure of ERK2 in complex with FR148083 | 3w55 | 80 |
| 27 | 4v9 | ERK2 complexed with 2-pyridiyl tetrahydroazaindazole | 5bui | 89 |
| 28 | 2h1 | A Double Mutant Rat Erk2 in Complex With a Pyrazolo[3,4-d]pyrimidine Inhibitor | 4n4s | 133 |
| 29 | 38z | Structure of human ERK2 in complex with SCH772984 revealing a novel inhibitor-induced binding pocket | 4qta | 200 |
| 30 | 6ts | In-Gel Activity-Based Protein Profiling of a Clickable Covalent Erk 1/2 Inhibitor | 5lcj | 230 |
| 31 | 5id | Crystal structure of ERK2 complexed with allosteric and ATP-competitive inhibitors. | 5ax3 | 1200 |
| 32 | sb4 | THE COMPLEX STRUCTURE OF THE MAP KINASE ERK2/SB220025 | 3erk | 1.8e+004 |
| 33 | olo | THE COMPLEX STRUCTURE OF THE MAP KINASE ERK2/OLOMOUCINE | 4erk | 2.7e+004 |