The Ligandable Human Proteome

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Serine proteases, trypsin domain

IndexProtein NameGene Name PrimaryGene Name SynonymUniprot IDMost Potent Compound in PDB nM
1Prothrombin THRBP007340.0014
2Coagulation factor X FA10P007420.007
3Coagulation factor VII FA7P087090.14
4Neutrophil elastase ELNEELA2P082460.16
5Coagulation factor XI FA11P039510.3
6Urokinase-type plasminogen activator UROKP007490.62
7Chymase CMA1CYH CYMP239462.24
8Coagulation factor IX FA9P007402.4
9Suppressor of tumorigenicity 14 protein ST14PRSS14 SNC19 TADG15Q9Y5Y63
10Tryptase beta-2 TRYB2TPS2P202313
11Complement factor D CFADDF PFDP007466
12Plasma kallikrein KLKB1KLK3P03952153
13Tissue-type plasminogen activator TPAP00750500
14Kallikrein-7 KLK7PRSS6 SCCEP49862700
15Serine protease hepsin HEPSTMPRSS1P05981850
16Kallikrein-6 KLK6PRSS18 PRSS9Q928761800