| Index | Protein Name | Gene Name Primary | Gene Name Synonym | Uniprot ID | Most Potent Compound in PDB nM |
| 1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | PDE4B | DPDE4 | Q07343 | 0.00794 |
| 2 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | PDE10 | | Q9Y233 | 0.0082 |
| 3 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | PDE4D | DPDE3 | Q08499 | 0.021 |
| 4 | Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B | PDE1B | PDE1B1 PDES1B | Q01064 | 0.058 |
| 5 | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | PDE3B | | Q13370 | 0.27 |
| 6 | cGMP-specific 3',5'-cyclic phosphodiesterase | PDE5A | PDE5 | O76074 | 0.5 |
| 7 | cGMP-dependent 3',5'-cyclic phosphodiesterase | PDE2A | | O00408 | 0.5 |
| 8 | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | PDE9A | | O76083 | 0.5 |
| 9 | High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A | PDE7A | | Q13946 | 4.4 |
| 10 | cAMP-specific 3',5'-cyclic phosphodiesterase 4A | PDE4A | DPDE2 | P27815 | 7.2e+004 |
| 11 | High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A | PDE8A | | O60658 | 6.98e+005 |