The Ligandable Human Proteome

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Serine/threonine-protein kinase B-raf

Protein kinase domain

IndexLigand NameStructurePDB codeligand desolvation
1324Crystal structure of a BRAF kinase domain monomer4wo597.3
21ooB-Raf Kinase domain in complex with PLX55684xv994.16
36dcCrystal Structure of BRAF Kinase Domain Bound to AZ-VEM5ita93.31
4p06BRAF Kinase domain b3aC loop deletion mutant in complex with dabrafenib5hie93.13
54z5CRYSTAL STRUCTURE OF BRAF(V600E) IN COMPLEX WITH LY3009120 COMPND5c9c92.35
66n9BRAFV600E Kinase Domain In Complex with Chemically Linked Vemurafenib Inhibitor VEM-6-VEM5jrq91.41
78enCrystals Structure of B-Raf kinase domain in complex with an Imidazopyridinyl benzamide inhibitor6b8u91.27
8l1eB-Raf V600E kinase domain in complex with an aminoisoquinoline inhibitor3idp91.24
95xjB-Raf wild-type kinase domain in complex with a purinylpyridinylamino-based inhibitor5fd291.05
1092jBRAF in Complex with RAF7095vam90.99
11baxThe complex of wild type B-RAF and BAY439006.1uwh90.75
12032Crystal structure of the BRAF (R509H) kinase domain monomer bound to Vemurafenib4rzv90.65
13p06B-RAF in complex with Dabrafenib5csw90.33
14p06B-Raf Kinase V600E oncogenic mutant in complex with Dabrafenib4xv290.29
15k81BRAF in complex with N-(3-(2-(2-hydroxyethoxy)-6-morpholinopyridin-4-yl)-4-methylphenyl)-2-(trifluoromethyl)isonicotinamide (LXH254)6n0p89.65
16b1eBRAF Kinase domain b3aC loop deletion mutant in complex with AZ6285hid89.23
1729lBRAF dimer bound to 14-3-36u2h89.01
18324B-Raf Kinase in Complex with PLX47203c4c88.96
19baxBRAF Kinase domain b3aC loop deletion mutant in complex with sorafenib5hi288.91
20p02B-Raf Kinase V600E oncogenic mutant in complex with PLX79224xv388.12
2129lCrystal structure of BRAF-V600E bound to GDC08794mnf87.18
220t2Crystal Structure of Human Kinase Domain of B-raf with a DFG-out Inhibitor4fc086.17
231suCrystal Structure of Human B-raf bound to a DFG-out Inhibitor TAK-6324ksp85.91
24325B-Raf Kinase V600E Oncogenic Mutant in Complex with PLX32034fk385.51
25fp3Crystal Structure of Human B-Raf Kinase Domain in Complex with a Non-Oxime Furopyridine Inhibitor3prf84.23
26032B-Raf Kinase V600E oncogenic mutant in complex with PLX40323og784.1
27fniHuman B-Raf Kinase in Complex with a Non-Oxime Furopyridine Inhibitor3ppk82.45
28904B-Raf Kinase V600E oncogenic mutant in complex with PLX79044xv181.61
29sm5Pyrazole-based inhibitors of B-Raf kinase3d4q81.51
3054jCRYSTAL STRUCTURE OF B-RAF IN COMPLEX WITH BI 8823705csx79.7
31831The Complex of wild-type B-RAF with Pyrazolo pyrimidine inhibitor3ii573.87
32734BRAF in complex with an organic inhibitor 78987344e2670.76
33215Structure of the B-Raf kinase domain bound to SB-5908852fb867.65