The Ligandable Human Proteome

Protein kinase domain

Index	Protein Name	Gene Name Primary	Gene Name Synonym	Uniprot ID	Highest desolvation of bound compounds in the PDB
1	Tyrosine-protein kinase ITK/TSK	ITK	EMT LYK	Q08881	99.68
2	Receptor-interacting serine/threonine-protein kinase 1	RIPK1	RIP RIP1	Q13546	98.91
3	Casein kinase II subunit alpha	CSK21	CK2A1	P68400	98.64
4	Tyrosine-protein kinase ABL1	ABL1	ABL JTK7	P00519	98.46
5	LIM domain kinase 2	LIMK2		P53671	98.08
6	Cyclin-dependent kinase 8	CDK8		P49336	97.93
7	Mitogen-activated protein kinase 14	MK14	CSBP CSBP1 CSBP2 CSPB1 MXI2 SAPK2A	Q16539	97.89
8	Epidermal growth factor receptor	EGFR	ERBB ERBB1 HER1	P00533	97.87
9	STE20-like serine/threonine-protein kinase	SLK	KIAA0204 STK2	Q9H2G2	97.56
10	Receptor-interacting serine/threonine-protein kinase 2	RIPK2	CARDIAK RICK RIP2	O43353	97.53
11	3-phosphoinositide-dependent protein kinase 1	PDPK1	PDK1	O15530	97.5
12	Calcium/calmodulin-dependent protein kinase kinase 2	KKCC2	CAMKKB KIAA0787	Q96RR4	97.37
13	Serine/threonine-protein kinase B-raf	BRAF	BRAF1 RAFB1	P15056	97.3
14	Tyrosine-protein kinase JAK1	JAK1	JAK1A JAK1B	P23458	97.26
15	Fibroblast growth factor receptor 1	FGFR1	BFGFR CEK FGFBR FLG FLT2 HBGFR	P11362	97.15
16	Dual specificity mitogen-activated protein kinase kinase 1	MP2K1	MEK1 PRKMK1	Q02750	97.08
17	cAMP-dependent protein kinase catalytic subunit alpha	KAPCA	PKACA	P17612	96.73
18	Receptor tyrosine-protein kinase erbB-2	ERBB2	HER2 MLN19 NEU NGL	P04626	96.58
19	Serine/threonine-protein kinase/endoribonuclease IRE1	ERN1	IRE1	O75460	96.47
20	Mitotic checkpoint serine/threonine-protein kinase BUB1	BUB1	BUB1L	O43683	96.28
21	Death-associated protein kinase 1	DAPK1	DAPK	P53355	96.16
22	Casein kinase II subunit alpha'	CSK22	CK2A2	P19784	96.13
23	Hepatocyte growth factor receptor	MET		P08581	96.12
24	Vascular endothelial growth factor receptor 2	VGFR2	FLK1 VEGFR2	P35968	96.08
25	Mitogen-activated protein kinase 1	MK01	ERK2 PRKM1 PRKM2	P28482	96
26	Ephrin type-B receptor 4	EPHB4	HTK MYK1 TYRO11	P54760	95.94
27	Mast/stem cell growth factor receptor Kit	KIT	SCFR	P10721	95.84
28	Vascular endothelial growth factor receptor 1	VGFR1	FLT FRT VEGFR1	P17948	95.82
29	Dual specificity protein kinase CLK1	CLK1	CLK	P49759	95.72
30	Mitogen-activated protein kinase 7	MK07	BMK1 ERK5 PRKM7	Q13164	95.69
31	Tyrosine-protein kinase Lck	LCK		P06239	95.63
32	Interleukin-1 receptor-associated kinase 4	IRAK4		Q9NWZ3	95.46
33	Cyclin-dependent kinase-like 5	CDKL5	STK9	O76039	95.39
34	Mitogen-activated protein kinase kinase kinase kinase 4	M4K4	HGK KIAA0687 NIK	O95819	95.36
35	RAC-alpha serine/threonine-protein kinase	AKT1	PKB RAC	P31749	95.34
36	Cyclin-dependent kinase-like 3	CDKL3	NKIAMRE	Q8IVW4	95.34
37	TGF-beta receptor type-1	TGFR1	ALK5 SKR4	P36897	95.34
38	Receptor tyrosine-protein kinase erbB-4	ERBB4	HER4	Q15303	95.3
39	Mitogen-activated protein kinase 9	MK09	JNK2 PRKM9 SAPK1A	P45984	95.29
40	Tyrosine-protein kinase JAK3	JAK3		P52333	95.16
41	Serine/threonine-protein kinase pim-1	PIM1		P11309	95
42	Eukaryotic translation initiation factor 2-alpha kinase 3	E2AK3	PEK PERK	Q9NZJ5	94.92
43	Aurora kinase A	AURKA	AIK AIRK1 ARK1 AURA AYK1 BTAK IAK1 STK15 STK6	O14965	94.91
44	Mitogen-activated protein kinase 13	MK13	PRKM13 SAPK4	O15264	94.9
45	Epithelial discoidin domain-containing receptor 1	DDR1	CAK EDDR1 NEP NTRK4 PTK3A RTK6 TRKE	Q08345	94.89
46	Tyrosine-protein kinase JAK2	JAK2		O60674	94.84
47	RAC-beta serine/threonine-protein kinase	AKT2		P31751	94.8
48	Cyclin-dependent kinase 2	CDK2	CDKN2	P24941	94.7
49	Mitogen-activated protein kinase kinase kinase 14	M3K14	NIK	Q99558	94.53
50	Beta-adrenergic receptor kinase 1	ARBK1	ADRBK1 BARK BARK1	P25098	94.52
51	Discoidin domain-containing receptor 2	DDR2	NTRKR3 TKT TYRO10	Q16832	94.48
52	Mitogen-activated protein kinase 3	MK03	ERK1 PRKM3	P27361	94.44
53	Non-receptor tyrosine-protein kinase TYK2	TYK2		P29597	94.29
54	Protein kinase C theta type	KPCT	PRKCT	Q04759	94.28
55	Ribosomal protein S6 kinase beta-1	KS6B1	STK14A	P23443	94.16
56	Dual specificity protein kinase TTK	TTK	MPS1 MPS1L1	P33981	93.89
57	Ephrin type-B receptor 3	EPHB3	ETK2 HEK2 TYRO6	P54753	93.81
58	BDNF/NT-3 growth factors receptor	NTRK2	TRKB	Q16620	93.58
59	Mitogen-activated protein kinase kinase kinase 20	M3K20	MLTK ZAK	Q9NYL2	93.56
60	Aurora kinase C	AURKC	AIE2 AIK3 AIRK3 ARK3 STK13	Q9UQB9	93.51
61	Ephrin type-A receptor 2	EPHA2	ECK	P29317	93.47
62	Cyclin-dependent kinase 6	CDK6	CDKN6	Q00534	93.45
63	MAP kinase-interacting serine/threonine-protein kinase 2	MKNK2	GPRK7 MNK2	Q9HBH9	93.36
64	Tyrosine-protein kinase SYK	KSYK		P43405	93.21
65	High affinity nerve growth factor receptor	NTRK1	MTC TRK TRKA	P04629	93.19
66	Serine/threonine-protein kinase PAK 1	PAK1		Q13153	93.09
67	eIF-2-alpha kinase GCN2	E2AK4	GCN2 KIAA1338	Q9P2K8	92.92
68	Calcium/calmodulin-dependent protein kinase kinase 1	KKCC1	CAMKKA	Q8N5S9	92.73
69	Fibroblast growth factor receptor 4	FGFR4	JTK2 TKF	P22455	92.68
70	TGF-beta receptor type-2	TGFR2		P37173	92.67
71	Casein kinase II subunit alpha 3	CSK23	CSNK2A1P	Q8NEV1	92.65
72	Tyrosine-protein kinase BTK	BTK	AGMX1 ATK BPK	Q06187	92.58
73	Maternal embryonic leucine zipper kinase	MELK	KIAA0175	Q14680	92.41
74	Macrophage colony-stimulating factor 1 receptor	CSF1R	FMS	P07333	92.4
75	Cytoplasmic tyrosine-protein kinase BMX	BMX		P51813	92.28
76	Mitogen-activated protein kinase 10	MK10	JNK3 JNK3A PRKM10 SAPK1B	P53779	92.27
77	Insulin-like growth factor 1 receptor	IGF1R		P08069	92.19
78	Glycogen synthase kinase-3 beta	GSK3B		P49841	92.13
79	Serine/threonine-protein kinase WNK1	WNK1	HSN2 KDP KIAA0344 PRKWNK1	Q9H4A3	92.04
80	Serine/threonine-protein kinase Chk1	CHK1	CHK1	O14757	91.78
81	Cell division cycle 7-related protein kinase	CDC7	CDC7L1	O00311	91.78
82	ALK tyrosine kinase receptor	ALK		Q9UM73	91.78
83	Serine/threonine-protein kinase 17B	ST17B	DRAK2	O94768	91.77
84	Protein kinase C eta type	KPCL	PKCL PRKCL	P24723	91.72
85	Serine/threonine-protein kinase PAK 4	PAK4	KIAA1142	O96013	91.64
86	Protein-tyrosine kinase 2-beta	FAK2	FAK2 PYK2 RAFTK	Q14289	91.5
87	Ephrin type-A receptor 7	EPHA7	EHK3 HEK11	Q15375	91.42
88	Casein kinase I isoform delta	KC1D	HCKID	P48730	91.35
89	Mitogen-activated protein kinase kinase kinase 7	M3K7	TAK1	O43318	91.34
90	Proto-oncogene tyrosine-protein kinase Src	SRC	SRC1	P12931	91.13
91	G protein-coupled receptor kinase 5	GRK5	GPRK5	P34947	91.12
92	Activin receptor type-1	ACVR1	ACVRLK2	Q04771	91.01
93	Serine/threonine-protein kinase Chk2	CHK2	CDS1 CHK2 RAD53	O96017	90.96
94	Cyclin-dependent kinase 1	CDK1	CDC2 CDC28A CDKN1 P34CDC2	P06493	90.87
95	Tyrosine-protein kinase HCK	HCK		P08631	90.87
96	Serine/threonine-protein kinase 3	STK3	KRS1 MST2	Q13188	90.75
97	Proto-oncogene tyrosine-protein kinase receptor Ret	RET	CDHF12 CDHR16 PTC RET51	P07949	90.19
98	Mixed lineage kinase domain-like protein	MLKL		Q8NB16	90.16
99	Serine/threonine-protein kinase pim-2	PIM2		Q9P1W9	90.06
100	Serine/threonine-protein kinase MRCK beta	MRCKB	KIAA1124	Q9Y5S2	90.04
101	Ephrin type-A receptor 3	EPHA3	ETK ETK1 HEK TYRO4	P29320	89.93
102	Mitogen-activated protein kinase 11	MK11	PRKM11 SAPK2 SAPK2B	Q15759	89.91
103	Mitogen-activated protein kinase kinase kinase 5	M3K5	ASK1 MAPKKK5 MEKK5	Q99683	89.88
104	G protein-coupled receptor kinase 6	GRK6	GPRK6	P43250	89.83
105	Serine/threonine-protein kinase WNK3	WNK3	KIAA1566 PRKWNK3	Q9BYP7	89.72
106	MAP kinase-activated protein kinase 3	MAPK3		Q16644	89.59
107	BMP-2-inducible protein kinase	BMP2K	BIKE	Q9NSY1	89.45
108	Serine/threonine-protein kinase N1	PKN1	PAK1 PKN PRK1 PRKCL1	Q16512	89.42
109	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	DYR1A	DYRK MNB MNBH	Q13627	89.42
110	Cyclin-dependent kinase 9	CDK9	CDC2L4 TAK	P50750	89.17
111	Mitogen-activated protein kinase 8	MK08	JNK1 PRKM8 SAPK1 SAPK1C	P45983	88.99
112	Insulin receptor	INSR		P06213	88.98
113	Serine/threonine-protein kinase 10	STK10	LOK	O94804	88.84
114	Protein kinase C alpha type	KPCA	PKCA PRKACA	P17252	88.83
115	Angiopoietin-1 receptor	TIE2	TIE2 VMCM VMCM1	Q02763	88.78
116	Activin receptor type-2A	AVR2A	ACVR2	P27037	88.73
117	Ephrin type-B receptor 1	EPHB1	ELK EPHT2 HEK6 NET	P54762	88.71
118	Protein-tyrosine kinase 6	PTK6	BRK	Q13882	88.63
119	Wee1-like protein kinase	WEE1		P30291	88.56
120	Fibroblast growth factor receptor 2	FGFR2	BEK KGFR KSAM	P21802	88.49
121	TRAF2 and NCK-interacting protein kinase	TNIK	KIAA0551	Q9UKE5	88.43
122	Casein kinase I isoform gamma-3	KC1G3		Q9Y6M4	88.37
123	Cyclin-dependent kinase-like 2	CDKL2		Q92772	88.27
124	Rho-associated protein kinase 1	ROCK1		Q13464	88.27
125	Rho-associated protein kinase 2	ROCK2	KIAA0619	O75116	88.17
126	Dual specificity tyrosine-phosphorylation-regulated kinase 2	DYRK2		Q92630	88.06
127	Tyrosine-protein kinase Lyn	LYN	JTK8	P07948	87.88
128	Serine/threonine-protein kinase PLK2	PLK2	SNK	Q9NYY3	87.78
129	Serine/threonine-protein kinase VRK2	VRK2		Q86Y07	87.52
130	Dual specificity mitogen-activated protein kinase kinase 7	MP2K7	JNKK2 MEK7 MKK7 PRKMK7 SKK4	O14733	87.39
131	Focal adhesion kinase 1	FAK1	FAK FAK1	Q05397	87.35
132	Dual specificity protein kinase CLK3	CLK3		P49761	87.31
133	Calcium/calmodulin-dependent protein kinase type II subunit delta	KCC2D	CAMKD	Q13557	87.24
134	Cyclin-dependent-like kinase 5	CDK5	CDKN5	Q00535	87.17
135	Serine/threonine-protein kinase PLK1	PLK1	PLK	P53350	87.16
136	Serine/threonine-protein kinase VRK1	VRK1		Q99986	86.52
137	Cyclin-dependent kinase-like 1	CDKL1		Q00532	86.43
138	Activated CDC42 kinase 1	ACK1	ACK1	Q07912	86.26
139	Tau-tubulin kinase 1	TTBK1	BDTK KIAA1855	Q5TCY1	86.22
140	Casein kinase I isoform epsilon	KC1E		P49674	86.07
141	Serine/threonine-protein kinase 24	STK24	MST3 STK3	Q9Y6E0	86.06
142	MAP kinase-activated protein kinase 2	MAPK2		P49137	85.76
143	Tyrosine-protein kinase Mer	MERTK	MER	Q12866	85.38
144	Protein kinase C beta type	KPCB	PKCB PRKCB1	P05771	84.87
145	Death-associated protein kinase 3	DAPK3	ZIPK	O43293	84.69
146	Tyrosine-protein kinase Fes/Fps	FES	FPS	P07332	84.66
147	cGMP-dependent protein kinase 1	KGP1	PRKG1B PRKGR1A PRKGR1B	Q13976	84.5
148	Dual specificity protein kinase CLK2	CLK2		P49760	84.46
149	Serine/threonine-protein kinase ULK2	ULK2	KIAA0623	Q8IYT8	84.46
150	Ephrin type-A receptor 4	EPHA4	HEK8 SEK TYRO1	P54764	84.45
151	Dual specificity protein kinase CLK4	CLK4		Q9HAZ1	83.72
152	Serine/threonine-protein kinase Nek2	NEK2	NEK2A NLK1	P51955	82.89
153	Protein kinase C iota type	KPCI	DXS1179E	P41743	82.79
154	LIM domain kinase 1	LIMK1	LIMK	P53667	82.68
155	Casein kinase I isoform alpha	KC1A		P48729	82.55
156	MAP/microtubule affinity-regulating kinase 4	MARK4	KIAA1860 MARKL1	Q96L34	82.52
157	Serine/threonine-protein kinase 26	STK26	MASK MST4	Q9P289	82.4
158	Tyrosine-protein kinase ABL2	ABL2	ABLL ARG	P42684	82.21
159	Serine/threonine-protein kinase ULK1	ULK1	KIAA0722	O75385	81.97
160	Putative 3-phosphoinositide-dependent protein kinase 2	PDPK2	PDPK2	Q6A1A2	81.57
161	Serine/threonine-protein kinase PLK4	PLK4	SAK STK18	O00444	81.45
162	Serine/threonine-protein kinase MARK2	MARK2	EMK1	Q7KZI7	81.37
163	NT-3 growth factor receptor	NTRK3	TRKC	Q16288	81.23
164	Serine/threonine-protein kinase PLK3	PLK3	CNK FNK PRK	Q9H4B4	81.13
165	Cyclin-G-associated kinase	GAK		O14976	80.58
166	Proto-oncogene tyrosine-protein kinase ROS	ROS1	MCF3 ROS	P08922	80.49
167	Tyrosine-protein kinase receptor UFO	UFO	UFO	P30530	80.26
168	MAP kinase-interacting serine/threonine-protein kinase 1	MKNK1	MNK1	Q9BUB5	80.14
169	Ribosomal protein S6 kinase alpha-3	KS6A3	ISPK1 MAPKAPK1B RSK2	P51812	79.94
170	AP2-associated protein kinase 1	AAK1	KIAA1048	Q2M2I8	79.93
171	Serine/threonine-protein kinase Sgk1	SGK1	SGK	O00141	79.78
172	Serine/threonine-protein kinase PRP4 homolog	PRP4B	KIAA0536 PRP4 PRP4H PRP4K	Q13523	79.6
173	Tyrosine-protein kinase receptor TYRO3	TYRO3	BYK DTK RSE SKY TIF	Q06418	79.52
174	Homeodomain-interacting protein kinase 2	HIPK2		Q9H2X6	78.8
175	Mitogen-activated protein kinase kinase kinase kinase 3	M4K3	RAB8IPL1	Q8IVH8	78.55
176	Serine/threonine-protein kinase ULK3	ULK3		Q6PHR2	78.34
177	Mitogen-activated protein kinase kinase kinase 12	M3K12	ZPK	Q12852	78.26
178	Serine/threonine-protein kinase PAK 6	PAK6	PAK5	Q9NQU5	77.71
179	Aurora kinase B	AURKB	AIK2 AIM1 AIRK2 ARK2 STK1 STK12 STK5	Q96GD4	77.33
180	Serine/threonine-protein kinase TBK1	TBK1	NAK	Q9UHD2	77.24
181	Receptor-interacting serine/threonine-protein kinase 4	RIPK4	ANKRD3 DIK	P57078	77.04
182	Serine/threonine-protein kinase 25	STK25	SOK1 YSK1	O00506	76.66
183	5'-AMP-activated protein kinase catalytic subunit alpha-2	AAPK2	AMPK AMPK2	P54646	76.57
184	Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	PMYT1	MYT1	Q99640	76.18
185	Mitogen-activated protein kinase kinase kinase kinase 1	M4K1	HPK1	Q92918	75.6
186	Casein kinase I isoform gamma-2	KC1G2	CK1G2	P78368	75
187	Calcium/calmodulin-dependent protein kinase type 1D	KCC1D	CAMKID	Q8IU85	74.33
188	Ribosomal protein S6 kinase alpha-1	KS6A1	MAPKAPK1A RSK1	Q15418	73
189	Cyclin-dependent kinase 12	CDK12	CRK7 CRKRS KIAA0904	Q9NYV4	72.73
190	Serine/threonine-protein kinase MRCK alpha	MRCKA	KIAA0451	Q5VT25	71.64
191	Receptor tyrosine-protein kinase erbB-3	ERBB3	HER3	P21860	68.41
192	Calcium/calmodulin-dependent protein kinase type IV	KCC4	CAMK CAMK-GR CAMKIV	Q16566	68.12
193	Phosphorylase b kinase gamma catalytic chain, liver/testis isoform	PHKG2		P15735	67.96
194	Receptor-type tyrosine-protein kinase FLT3	FLT3	CD135 FLK2 STK1	P36888	64.7
195	Calcium/calmodulin-dependent protein kinase type 1G	KCC1G	CLICK3 VWS1	Q96NX5	60.63