The Ligandable Human Proteome

Cyclin-dependent kinase 2

Index	Ligand Name	Structure	PDB code	ligand desolvation
1	hhb	CDK2 in complex with FragLite34	6q4j	94.7
2	wy3	Crystal structure of CDK2 in complex with 7-hydroxy-4-(morpholinomethyl)chromen-2-one processed with the CrystalDirect automated mounting and cryo-cooling technology	5ang	93.92
3	x0a	CDK2 in complex with inhibitor L2-2	3qqh	93.66
4	scx	Crystal Structure of Cyclin-Dependent Kinase 2 with inhibitor	2r3m	93.45
5	1qk	The X-ray co-crystal structure of human CDK2/CyclinE and Dinaciclib.	5l2w	93.42
6	mhr	Structure of phosphorylated Thr160 CDK2/cyclin A in complex with the inhibitor meriolin 5	3bhu	92.95
7	aeq	Cdk2(F80C, C177A) with covalent adduct at C80	5osm	92.88
8	un4	Human cyclin dependent protein kinase 2 in complex with the inhibitor 2-Amino-6-[(R)-pyrrolidino-5'-yl]methoxypurine	1h0v	92.53
9	cmg	HUMAN CYCLIN DEPENDENT KINASE 2 COMPLEXED WITH THE INHIBITOR NU2058	1e1v	92.45
10	2kd	Modulating the interaction between CDK2 and Cyclin A with a Quinoline-based inhibitor	4nj3	92.44
11	x3a	CDK2 in complex with inhibitor RC-2-13	3qtw	91.98
12	1qk	CDK2 in complex with Dinaciclib	4kd1	91.83
13	ck6	HUMAN CYCLIN DEPENDENT KINASE 2 COMPLEXED WITH THE INHIBITOR 4-[4-(4-Methyl-2-methylamino-thiazol-5-yl)-pyrimidin-2-ylamino]-phenol	1pxn	91.71
14	sc8	Crystal Structure of Cyclin-Dependent Kinase 2 with inhibitor	2r3f	91.52
15	6qb	Crystal Structure of CDK2 in complex with compound 22	5k4j	91.34
16	scz	Crystal Structure of Cyclin-Dependent Kinase 2 with inhibitor	2r3n	91.12
17	2sc	Crystal Structure of Cyclin-Dependent Kinase 2 with inhibitor	2r3o	91.05
18	fbl	CDK2 in complex with a disubstituted 2, 4-bis anilino pyrimidine CDK4 inhibitor	1h01	90.97
19	z63	CDK2 in complex with inhibitor RC-1-136	3r8z	90.65
20	rji	Crystal structure of CDK2 in complex with 2,4,6-trioxo-1-phenyl- hexahydropyrimidine-5-carboxamide processed with the CrystalDirect automated mounting and cryo-cooling technology	5ank	90.65
21	sc9	Crystal Structure of Cyclin-Dependent Kinase 2 with inhibitor	2r3g	90.62
22	a07	Crystal structure of CDK2 with SAR37, an aminoindazole type inhibitor	3lfs	90.6
23	1pu	HUMAN CYCLIN DEPENDENT KINASE 2 COMPLEXED WITH THE CDK4 INHIBITOR	1gih	90.51
24	ns9	Crystal structure of CDK2 in complex with inhibitor BS-194	3ns9	90.47
25	371	Structure of CDK2 with a 3-hydroxychromones	2duv	90.41
26	hjk	CDK2 in complex with FragLite37	6q4g	90.32
27	6sc	Crystal Structure of Cyclin-Dependent Kinase 2 with inhibitor	2r3r	90.18
28	ct8	Crystal structure of the human CDK2 complexed with the triazolopyrimidine inhibitor	2c69	90.05
29	x36	CDK2 in complex with inhibitor RC-1-148	3qtr	89.99
30	x35	CDK2 in complex with inhibitor RC-1-137	3qtq	89.98
31	z31	CDK2 in complex with inhibitor RC-1-132	3r8u	89.94
32	x1n	Truncation and Optimisation of Peptide Inhibitors of CDK2, Cyclin A Through Structure Guided Design	2x1n	89.93
33	x02	CDK2 in complex with inhibitor L4	3qqk	89.92
34	8qt	CCT068127 in complex with CDK2	5mhq	89.81
35	5sc	Crystal Structure of Cyclin-Dependent Kinase 2 with inhibitor	2r3q	89.74
36	i73	Crystal structure of CDK2 in complex with inhibitor ICEC0943	5jq8	89.7
37	bwp	CDK2 in complex with a disubstituted 2, 4-bis anilino pyrimidine CDK4 inhibitor	1h08	89.7
38	z68	CDK2 in complex with inhibitor RC-2-21	3r9n	89.39
39	x46	CDK2 in complex with inhibitor RC-2-12	3qts	89.36
40	z46	CDK2 in complex with inhibitor NSK-MC1-6	3r8p	89.27
41	3sc	Crystal Structure of Cyclin-Dependent Kinase 2 with inhibitor	2r3p	89.25
42	x19	CDK2 in complex with inhibitor NSK-MC1-12	3qru	89.23
43	56h	CRYSTAL STRUCTURE OF CYCLIN-DEPENDENT KINASE 2 (CDK2-WT) COMPLEX WITH N-[5-[[[5-(1,1-DIMETHYLETHYL)-2-OXAZOLYL] METHYL]THIO]-2-THIAZOLYL]-4-PIPERIDINECARBOXAMIDE (BMS-387032)	5d1j	89.03
44	09z	CDK2 in complex with inhibitor RC-2-74	3rk9	88.99
45	0bx	CDK2 in complex with inhibitor YL1-038-31	3unj	88.9
46	cmg	Structure of human Thr160-phospho CDK2/cyclin A complexed with the inhibitor NU2058	1h1p	88.88
47	hgh	CDK2 in complex with FragLite36	6q4h	88.87
48	ryu	HUMAN CYCLIN DEPENDENT PROTEIN KINASE 2 IN COMPLEX WITH THE INHIBITOR 4-HYDROXYPIPERINDINESULFONYL-INDIRUBINE	2bhh	88.75
49	404	Structure of CDK2 in complex with a Pyrazolo[4,3-d]pyrimidine Bioisostere of Roscovitine.	3pj8	88.75
50	0by	CDK2 in complex with inhibitor YL5-083	3unk	88.74
51	fb8	CDK2/CyclinA in complex with AZD5438	6gue	88.67
52	889	Optimisation of 6,6-Dimethyl Pyrrolo 3,4-c pyrazoles: Identification of PHA-793887, a Potent CDK Inhibitor Suitable for Intravenous Dosing	2wpa	88.64
53	o1z	CDK2 in complex with inhibitor RC-2-22	3rah	88.64
54	f9z	CDK2/CyclinA in complex with Flavopiridol	6gub	88.61
55	nw1	HUMAN CYCLIN DEPENDENT KINASE 2 COMPLEXED WITH THE INHIBITOR NU6027	1e1x	88.39
56	50z	CDK2 in complex with inhibitor RC-1-138	3s0o	88.36
57	lzc	Identification of N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H- pyrazole-3-carboxamide (AT7519), a Novel Cyclin Dependent Kinase Inhibitor Using Fragment-Based X-Ray Crystallography and Structure Based Drug Design.	2vts	88.34
58	i74	Crystal structure of CDK2 in complex with inhibitor ICEC0942	5jq5	88.33
59	l0f	Fragment-Based Discovery of the Pyrazol-4-yl urea (AT9283), a Multi- targeted Kinase Inhibitor with Potent Aurora Kinase Activity	2w1h	88.32
60	d31	Human cyclin dependent kinase 2 (cdk2) complexed with indenopyraxole DIN-101312	2b55	88.24
61	9z2	Cdk2(F80C, C177A) covalent adduct with C37 at F80C	5oo1	88.08
62	pm1	Crystal structure of CDK2 with inhibitor	1pye	88.06
63	04z	CDK2 in complex with inhibitor RC-2-34	3ral	88.04
64	dt1	Crystal structure of the human CDK2 complexed with the triazolopyrimidine inhibitor	2c6i	88.01
65	fb8	CDK2 in complex with AZD5438	6guh	88
66	lz7	Identification of N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H- pyrazole-3-carboxamide (AT7519), a Novel Cyclin Dependent Kinase Inhibitor Using Fragment-Based X-Ray Crystallography and Structure Based Drug Design.	2vtn	87.99
67	blz	Cdk2/Cyclin A complexed with a thiophene carboxamide inhibitor	2i40	87.95
68	scf	Crystal Structure of Cyclin-Dependent Kinase 2 with inhibitor	2r3i	87.92
69	20z	CDK2 in complex with inhibitor RC-2-33	3rmf	87.9
70	x03	CDK2 in complex with inhibitor L3	3qql	87.85
71	ck5	HUMAN CYCLIN DEPENDENT KINASE 2 COMPLEXED WITH THE INHIBITOR 3-[4-(2,4-Dimethyl-thiazol-5-yl)-pyrimidin-2-ylamino]-phenol	1pxm	87.8
72	56z	CDK2 in complex with inhibitor RC-2-39	3s1h	87.75
73	hdu	Imidazopyridines: a potent and selective class of Cyclin-dependent Kinase inhibitors identified through Structure-based hybridisation	1oiq	87.68
74	z30	CDK2 in complex with inhibitor L3-4	3r8l	87.47
75	a28	Crystal structure of CDK2 with SAR60, an aminoindazole type inhibitor	3lfq	87.42
76	x40	CDK2 in complex with inhibitor RC-2-38	3qu0	87.25
77	ck9	Human CDK2 in complex with olomoucine II, a novel 2,6,9-trisubstituted purine cyclin-dependent kinase inhibitor	2a0c	87.21
78	26z	CDK2 in complex with inhibitor RC-2-88	3rpv	87.05
79	1yg	Crystal structure of cyclin-dependent kinase 2 (cdk2-wt) complex with (2s)-n-(5-(((5-tert-butyl-1,3-oxazol-2-yl)methyl)sulfanyl)-1,3-thiazol-2-yl)-2-phenylpropanamide	4lyn	87
80	12z	CDK2 in complex with inhibitor RC-2-73	3rkb	86.98
81	62k	Crystal structure of the cdk2 in complex with oxindole inhibitor	4fkw	86.95
82	x42	CDK2 in complex with inhibitor RC-2-36	3qtz	86.52
83	p49	STRUCTURE OF CDK2-CYCLIN A COMPLEXED WITH 8-ANILINO-1-METHYL-4,5-DIHYDRO- 1H-PYRAZOLO[4,3-H] QUINAZOLINE-3-CARBOXYLIC ACID	2wip	86.49
84	lzd	Identification of N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H- pyrazole-3-carboxamide (AT7519), a Novel Cyclin Dependent Kinase Inhibitor Using Fragment-Based X-Ray Crystallography and Structure Based Drug Design.	2vtt	86.48
85	1n3	Human Cyclin Dependent Kinase 2 (CDK2) bound to azabenzimidazole derivative	3uli	86.37
86	bry	HUMAN CYCLIN DEPENDENT PROTEIN KINASE 2 IN COMPLEX WITH THE INHIBITOR 5-BROMO-INDIRUBINE	2bhe	86.31
87	3i6	Crystal Structure of CDK2 in complex with pan-CDK Inhibitor	4bgh	86.26
88	99z	CDK2 in complex with inhibitor RC-3-96	3sqq	86.25
89	6cp	Structure of human Thr160-phospho CDK2/cyclin A complexed with the inhibitor NU6086	1h1r	86.23
90	z71	CDK2 in complex with inhibitor RC-2-143	3r9o	86.22
91	lz8	Identification of N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H- pyrazole-3-carboxamide (AT7519), a Novel Cyclin Dependent Kinase Inhibitor Using Fragment-Based X-Ray Crystallography and Structure Based Drug Design.	2vto	86.2
92	1pu	HUMAN CYCLIN DEPENDENT KINASE 2 COMPLEXED WITH THE CDK4 INHIBITOR	1gii	86.18
93	rrc	Human cyclin-dependent kinase 2 in complex with roscovitine	2a4l	86.15
94	2a6	Structure of human Thr160-phospho CDK2/cyclin A complexed with the inhibitor NU6094	1h1q	86.11
95	n5b	Structure of CDK2 complexed with PNU-181227	1vyz	86.01
96	07z	CDK2 in complex with inhibitor RC-2-72	3rk5	85.98
97	rrc	Structure of phosphorylated Thr160 CDK2/cyclin A in complex with the inhibitor roscovitine	3ddq	85.93
98	dt2	Crystal structure of the human CDK2 complexed with the triazolopyrimidine inhibitor	2c6k	85.78
99	n41	Structure of human Thr160-phospho CDK2/cyclin A complexed with a 6-cyclohexylmethyloxy-2-anilino-purine inhibitor	1oiy	85.78
100	z67	CDK2 in complex with inhibitor RC-2-142	3r9h	85.72
101	z04	CDK2 in complex with inhibitor KVR-2-88	3r7y	85.69
102	rfz	CDk2/cyclinA in complex with DRB	3my5	85.52
103	a27	Crystal structure of CDK2 with SAR57, an aminoindazole type inhibitor	3lfn	85.41
104	06z	CDK2 in complex with inhibitor L4-12	3rjc	85.35
105	st8	STRUCTURE OF HUMAN THR160-PHOSPHO CDK2/CYCLIN A COMPLEXED WITH A 2-ARYLAMINO-4-CYCLOHEXYLMETHYL-5-NITROSO-6-AMINOPYRIMIDINE INHIBITOR	1ogu	85.31
106	4sp	Crystal structure of the human CDK2 complexed with the triazolopyrimidine inhibitor	2c6o	85.27
107	x6b	CDK2 in complex with inhibitor RC-2-135	3r9d	85.19
108	dt4	Crystal structure of the human CDK2 complexed with the triazolopyrimidine inhibitor	2c6l	85.15
109	jym	Structure-based design of C8-substituted O6-cyclohexylmethoxyguanine CDK1 and 2 inhibitors.	4cfn	85.14
110	x86	CDK2 in complex with inhibitor KVR-1-162	3r71	85.09
111	27z	CDK2 in complex with inhibitor RC-2-40	3rpy	85.07
112	fcp	CDK2 in complex with a disubstituted 4, 6-bis anilino pyrimidine CDK4 inhibitor	1h00	85.06
113	6ae	Crystal structure of a CDK inhibitor bound to CDK2	5iey	84.94
114	z60	CDK2 in complex with inhibitor L4-14	3s00	84.86
115	lze	Identification of N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H- pyrazole-3-carboxamide (AT7519), a Novel Cyclin Dependent Kinase Inhibitor Using Fragment-Based X-Ray Crystallography and Structure Based Drug Design.	2vu3	84.72
116	lz9	Identification of N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H- pyrazole-3-carboxamide (AT7519), a Novel Cyclin Dependent Kinase Inhibitor Using Fragment-Based X-Ray Crystallography and Structure Based Drug Design.	2vtp	84.7
117	03z	CDK2 in complex with inhibitor RC-2-32	3rak	84.69
118	lz3	Identification of N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H- pyrazole-3-carboxamide (AT7519), a Novel Cyclin Dependent Kinase Inhibitor Using Fragment-Based X-Ray Crystallography and Structure Based Drug Design.	2vti	84.65
119	ls5	Crystal structure of the cdk2 in complex with oxindole inhibitor	4fkp	84.6
120	60k	Crystal Structure of the CDK2/Cyclin A complex with oxindole inhibitor	4fx3	84.54
121	dt5	Crystal structure of the human CDK2 complexed with the triazolopyrimidine inhibitor	2c6t	84.52
122	dtq	THE STRUCTURE OF CYCLIN-DEPENDENT KINASE 2 (CDK2) IN COMPLEX WITH 4-[3-HYDROXYANILINO]-6,7-DIMETHOXYQUINAZOLINE	1di8	84.48
123	d42	Human cyclin dependent kinase 2 (CDK2) complexed with DPH-042562	2b52	84.46
124	nnn	Structure of Thr 160 phosphorylated CDK2/cyclin A in complex with the inhibitor N-&-N1	3dog	84.44
125	n69	CO-CRYSTAL STRUCTURE OF 6-CYCLOHEXYLMETHOXY-8-ISOPROPYL-9H-PURIN-2- YLAMINE AND MONOMERIC CDK2	1w8c	84.4
126	dt5	Crystal structure of the human CDK2 complexed with the triazolopyrimidine inhibitor	2c6m	84.37
127	scj	Crystal Structure of Cyclin-Dependent Kinase 2 with inhibitor	2r3j	84.33
128	207	Human cyclin dependent protein kinase 2 in complex with the inhibitor 2-Amino-6-[cyclohex-3-enyl]methoxypurine	1h0w	84.26
129	09k	Crystal Structure of the Cdk2 in Complex with Aminopyrazole Inhibitor	4fki	84.21
130	lza	Identification of N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H- pyrazole-3-carboxamide (AT7519), a Novel Cyclin Dependent Kinase Inhibitor Using Fragment-Based X-Ray Crystallography and Structure Based Drug Design.	2vtq	84.18
131	pvb	HUMAN CYCLIN DEPENDENT KINASE 2 COMPLEXED WITH THE INHIBITOR PURVALANOL B	1ckp	84.12
132	08z	CDK2 in complex with inhibitor RC-2-71	3rk7	84.12
133	18k	Crystal Structure of the CDK2 in complex with thiazolylpyrimidine inhibitor	3sw4	84.08
134	4sp	Thr 160 phosphorylated CDK2 H84S, Q85M, K89D - human cyclin A3 complex with the inhibitor NU6102	4eok	84.01
135	efp	Novel CDK-5 inhibitors - crystal structure of inhibitor EFP with CDK-2	3ig7	84
136	frv	Structure of CDK2 in complex with an imidazolyl pyrimidine, compound 5c	2w06	83.98
137	3qs	CDK2 with EGFR inhibitor compound 8	4rj3	83.92
138	n20	Structure of human Thr160-phospho CDK2/cyclin A complexed with a 6-cyclohexylmethyloxy-2-anilino-purine inhibitor	1oi9	83.85
139	efq	Novel CDK-5 inhibitors - crystal structure of inhibitor EFQ with CDK-2	3igg	83.61
140	4qe	Structure-based design of C8-substituted O6-cyclohexylmethoxyguanine CDK1 and 2 inhibitors.	4cfm	83.59
141	zxc	Crystal structure of CDK2 in complex with N-(9H-purin-6-yl)thiophene- 2-carboxamide processed with the CrystalDirect automated mounting and cryo-cooling technology	5anj	83.46
142	292	Structure of CDK2/Cyclin A with PNU-292137	1vyw	83.4
143	d23	Human cyclin dependent kinase 2 (CDK2) complexed with DIN-234325	2b53	83.33
144	byp	CDK2 in complex with a disubstituted 2, 4-bis anilino pyrimidine CDK4 inhibitor	1h08	83.29
145	628	Crystal structure of cdk2 with an aminoimidazo pyridine inhibitor	1ykr	83.22
146	ezr	CDK-2 with indazole inhibitor 17 bound at its active site	3ezr	83.19
147	4sp	Thr 160 phosphorylated CDK2 WT - human cyclin A3 complex with the inhibitor NU6102	4eor	83.18
148	olo	Crystal structure of human CDK2 in complex with the inhibitor olomoucine.	1w0x	83.15
149	u32	STRUCTURE OF CDK2 COMPLEXED WITH PNU-230032	2bts	83.09
150	x4b	CDK2 in complex with inhibitor KVR-1-78	3qx4	83.06
151	ajr	Crystal structure of CDK2 IN complex with Inhibitor CVT-313	6inl	83
152	sce	Crystal Structure of Cyclin-Dependent Kinase 2 with inhibitor	2r3h	82.82
153	4sp	STRUCTURE OF HUMAN THR160-PHOSPHO CDK2-CYCLIN A F82H-L83V-H84D MUTANT WITH AN O6-CYCLOHEXYLMETHYLGUANINE INHIBITOR	2iw8	82.78
154	d05	Human cyclin dependent kinase 2 (CKD2)complexed with DIN-232305	2b54	82.66
155	ct9	Crystal structure of human CDK2 complexed with a pyrazolo[1,5-a]pyrimidine inhibitor	1y91	82.63
156	ls3	CYCLIN-DEPENDENT KINASE 2 (CDK2) COMPLEXED WITH 3-{[(2,2-DIOXIDO-1,3-DIHYDRO-2-BENZOTHIEN-5-YL)AMINO]METHYLENE}-5-(1,3-OXAZOL-5-YL)-1,3-DIHYDRO-2H-INDOL-2-ONE	1ke7	82.58
157	u73	STRUCTURE OF CDK2 COMPLEXED WITH PNU-198873	2btr	82.49
158	wxv	Structure of CDK2-CYCLIN A with a Pyrazolo(4,3-h) quinazoline-3- carboxamide inhibitor	2wxv	82.48
159	x6a	CDK2 in complex with inhibitor KVR-1-142	3qwj	82.44
160	fc8	CDK2 in complex with CGP74514A	6guk	82.37
161	i17	CRYSTAL STRUCTURE OF HUMAN CYCLIN DEPENDENT KINASE 2 (CDK2) IN COMPLEX WITH THE INHIBITOR H717	1g5s	82.34
162	18z	CDK2 in complex with inhibitor KVR-2-80	3rm6	82.32
163	2pu	HUMAN CYCLIN DEPENDENT KINASE 2 COMPLEXED WITH THE CDK4 INHIBITOR	1gij	82.23
164	pdy	Crystal structure of CDK2 in complex with pyrazolopyrimidine inhibitor	3wbl	82.13
165	u55	The structure of cyclin-dependent kinase 2 (CDK2) in complex with 4-[(6-amino-4-pyrimidinyl)amino]benzenesulfonamide	1jsv	82.1
166	6af	Crystal structure of (R,S)-S-{4-[(5-Bromo-4-{[(2R,3R)-2-hydroxy-1-methylpropyl]oxy}- pyrimidin-2-yl)amino]phenyl}-S-cyclopropylsulfoximide bound to CDK2	5iex	82.09
167	1ck	Crystal structure of the cdk2 in complex with aminopyrazole inhibitor	4ek4	82.02
168	ls1	CDK2 complexed with N-methyl-4-{[(2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]amino}benzenesulfonamide	1ke5	81.96
169	x76	CDK2 in complex with inhibitor KVR-1-134	3r1y	81.94
170	4sp	Structure of human Thr160-phospho CDK2/cyclin A complexed with the inhibitor NU6102	1h1s	81.92
171	03k	Crystal structure of the cdk2 in complex with aminopyrazole inhibitor	4ek5	81.88
172	r0n	Crystal structure of BAY 1000394 (Roniciclib) bound to CDK2	5iev	81.85
173	n76	Structure of human Thr160-phospho CDK2/cyclin A complexed with a 6-cyclohexylmethyloxy-2-anilino-purine inhibitor	1oiu	81.71
174	lia	Cyclin Dependent Kinase 2 (CDK2) with diaminopyrimidine inhibitor	2fvd	81.44
175	y8l	Discovery and Characterisation of 2-Anilino-4-(thiazol-5-yl) pyrimidine Transcriptional CDK Inhibitors as Anticancer Agents	2xnb	81.41
176	x63	CDK2 in complex with inhibitor KVR-1-190	3qx2	81.24
177	23d	CDK2/CyclinA in complex with CGP74514A	6guf	81.22
178	55s	CDK2/Cyclin A covalent complex with 6-(cyclohexylmethoxy)-N-(4-(vinylsulfonyl)phenyl)-9H-purin-2-amine (NU6300)	5cyi	81.19
179	rc8	Structure of phosphorylated Thr160 CDK2/cyclin A in complex with the inhibitor CR8	3ddp	81.18
180	2wc	Structure-based design of C8-substituted O6-cyclohexylmethoxyguanine CDK1 and 2 inhibitors.	4cfu	81.13
181	fap	CDK2 in complex with a disubstituted 4, 6-bis anilino pyrimidine CDK4 inhibitor	1h00	81.12
182	4ck	Crystal structure of the cdk2 in complex with aminopyrazole inhibitor	4fkg	81.08
183	ls4	CYCLIN-DEPENDENT KINASE 2 (CDK2) COMPLEXED WITH 4-{[(2-OXO-1,2-DIHYDRO-3H-INDOL-3-YLIDENE)METHYL]AMINO}-N-(1,3-THIAZOL-2-YL)BENZENESULFONAMIDE	1ke8	80.99
184	ct7	Crystal structure of human CDK2 complexed with a pyrazolo[1,5-a]pyrimidine inhibitor	1y8y	80.83
185	x07	CDK2 in complex with inhibitor L1	3qqf	80.77
186	ls5	CYCLIN-DEPENDENT KINASE 2 (CDK2) COMPLEXED WITH 3-{[4-({[AMINO(IMINO)METHYL]AMINOSULFONYL)ANILINO]METHYLENE}-2-OXO-2,3-DIHYDRO-1H-INDOLE	1ke9	80.66
187	fal	CDK2 in complex with a disubstituted 2, 4-bis anilino pyrimidine CDK4 inhibitor	1h01	80.3
188	z14	CDK2 in complex with inhibitor KVR-2-92	3r83	80.26
189	t7z	Structure of CDK2 in complex with cyclin A and a 2-amino-4-heteroaryl- pyrimidine inhibitor	4bcm	80.13
190	lz4	Identification of N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H- pyrazole-3-carboxamide (AT7519), a Novel Cyclin Dependent Kinase Inhibitor Using Fragment-Based X-Ray Crystallography and Structure Based Drug Design	2vtj	79.92
191	740	Crystal structure of a 3-aminoindazole compound with CDK2	2r64	79.47
192	4sp	STRUCTURE OF HUMAN THR160-PHOSPHO CDK2-CYCLIN A COMPLEXED WITH A BISANILINOPYRIMIDINE INHIBITOR	2iw9	79.42
193	b49	CDK2 in complex with SUNITINIB	3ti1	79.37
194	x87	CDK2 in complex with inhibitor KVR-1-164	3r73	78.79
195	75x	Structure-based design of C8-substituted O6-cyclohexylmethoxyguanine CDK1 and 2 inhibitors.	4cfv	78.73
196	x14	CDK2 in complex with inhibitor NSK-MC2-55	3qrt	78.5
197	x69	CDK2 in complex with inhibitor KVR-1-124	3qzh	78.38
198	24z	CDK2 in complex with inhibitor KVR-1-156	3rpo	77.88
199	fcq	CDK2/cyclin A2 in complex with pyrazolo[4,3-d]pyrimidine inhibitor LGR4455	6gva	77.82
200	10k	Crystal structure of the cdk2 in complex with aminopyrazole inhibitor	4ek6	77.74
201	p48	STRUCTURE OF CDK2-CYCLIN A WITH PHA-848125	2wih	77.68
202	nu5	Structure of Thr 160 phosphorylated CDK2/cyclin A in complex with the inhibitor NU6271	2g9x	77.59
203	48k	Crystal structure of the cdk2 in complex with oxindole inhibitor	4fkt	77.49
204	i19	CDK2 in complex with the imidazole pyrimidine amide, compound (S)-8b	2w17	77.47
205	x84	CDK2 in complex with inhibitor KVR-1-158	3r6x	76.91
206	ls2	CYCLIN-DEPENDENT KINASE 2 (CDK2) COMPLEXED WITH N-METHYL-{4-[2-(7-OXO-6,7-DIHYDRO-8H-[1,3]THIAZOLO[5,4-E]INDOL-8-YLIDENE)HYDRAZINO]PHENYL}METHANESULFONAMIDE	1ke6	76.62
207	7yg	CDK2 IN COMPLEX WITH 3-AMINO-6-(4-{[2-(DIMETHYLAMINO)ETHYL]SULFAMOYL}-PHENYL)-N-PYRIDIN-3-YLPYRAZINE-2-CARBOXAMIDE	4acm	76.5
208	cdk	Discovery and Characterisation of 2-Anilino-4-(thiazol-5-yl) pyrimidine Transcriptional CDK Inhibitors as Anticancer Agents	2xmy	76.41
209	x85	CDK2 in complex with inhibitor KVR-1-160	3rai	75.73
210	529	STRUCTURE OF CDK2-CYCLIN A WITH PHA-630529	2bpm	75.56
211	d6i	Structure of CDK2 in complex with a benzimidazopyrimidine	4bzd	75.55
212	sq9	Structure-based design of C8-substituted O6-cyclohexylmethoxyguanine CDK1 and 2 inhibitors.	4cfw	74.99
213	frt	Structure of CDK2 in complex with an imidazolyl pyrimidine, compound 5b	2w05	74.98
214	6zk	Structure of phopsho-CDK2-cyclin A in complex with an ATP-competitive inhibitor	5lmk	74.8
215	tjf	Structure of CDK2 in complex with cyclin A and a 2-amino-4-heteroaryl- pyrimidine inhibitor	4bcq	74.4
216	x75	CDK2 in complex with inhibitor KVR-1-102	3r1q	74.11
217	im9	CDK2 in complex with an imidazole piperazine	2vv9	72.33
218	22z	CDK2 in complex with inhibitor KVR-1-154	3roy	71.97
219	i1p	CDK2 IN COMPLEX WITH AN IMIDAZO[1,2-b]PYRIDAZINE	1urw	70.75
220	3fp	CDK2 IN COMPLEX WITH A DISUBSTITUTED 4, 6-BIS ANILINO PYRIMIDINE CDK4 INHIBITOR	1v1k	70.65
221	qq2	STRUCTURE OF HUMAN THR160-PHOSPHO CDK2-CYCLIN A COMPLEXED WITH A BISANILINOPYRIMIDINE INHIBITOR	2iw6	70.4
222	hdy	Imidazopyridines: a potent and selective class of Cyclin-dependent Kinase inhibitors identified through Structure-based hybridisation	1oir	69.58
223	11k	Crystal structure of the cdk2 in complex with aminopyrazole inhibitor	4fkj	69.09
224	hhw	CDK2 in complex with FragLite38	6q4k	50.26
225	60k	Crystal structure of the cdk2 in complex with oxindole inhibitor	4fku	26.38