The Ligandable Human Proteome

Serine/threonine-protein kinase Chk1

Index	Ligand Name	Structure	PDB code	ligand desolvation
1	1hk	Crystal Structure of the CHK1	4ftm	91.78
2	1ao	X-RAY Crystal structure of compound 40 bound to human chk1 kinase domain	4hyi	91.6
3	09h	X-ray crystal structure of compound 1 bound to human CHK1 kinase domain	3u9n	90.28
4	12c	4-(Aminoalkylamino)-3-Benzimidazole-Quinolinones As Potent CHK1 Inhibitors	2gdo	89.51
5	77a	Structure of h-CHK1 complexed with A771129	2e9p	88.19
6	a25	Structure of h-CHK1 complexed with A780125	2e9u	87.91
7	zyr	Crystal structure of checkpoint kinase 1 (Chk1) in complex with inhibitors	2wmr	86.74
8	1am	X-RAY Crystal structure of compound 39 bound to human chk1 kinase domain	4hyh	86.65
9	3d3	Identification of chemically diverse Chk1 inhibitors by receptor- based virtual screening	2cgx	86.37
10	4ym	Crystal structure of checkpoint kinase 1 (Chk1) in complex with inhibitors	2ym4	85.81
11	22k	X-ray crystal structure of compound 22k bound to human Chk1 kinase domain	3ot3	85.1
12	7cs	crystal structure of Chek1 in complex with inhibitor 2a	2qhm	85.08
13	h2k	Crystal Structure of the CHK1	4ft5	85.01
14	ym8	Crystal structure of checkpoint kinase 1 (Chk1) in complex with inhibitors	2ym8	84.59
15	h0k	Crystal Structure of the CHK1	4ftl	84.51
16	3dv	CHK1 kinase domain in complex with aminopyrazine compound 13	4qyf	84.49
17	3dl	CHK1 kinase domain in complex with diarylpyrazine compound 1	4qye	84.44
18	ym6	Crystal structure of checkpoint kinase 1 (Chk1) in complex with inhibitors	2ym6	83.65
19	mi5	X-ray crystal structure of compound 17r bound to human Chk1 kinase domain	3ot8	82.71
20	zyv	Crystal structure of checkpoint kinase 1 (Chk1) in complex with inhibitors	2wmv	82.67
21	ydk	Discovery of Checkpoint Kinase Inhibitor AZD7762 by Structure Based Design and Optimization of Thiophene Carboxamide Ureas	2ydk	82.54
22	hk7	Crystal Structure of the CHK1	4fsy	82.53
23	x8i	Discovery of a Novel Class of triazolones as Checkpoint Kinase Inhibitors - Hit to Lead Exploration	2x8i	82.36
24	h1k	Crystal Structure of the CHK1	4ft3	82.29
25	m54	Crystal Structure of Chek1 in Complex with Inhibitor 54	2r0u	82.1
26	d58	CHK1 KINASE IN COMPLEX WITH COMPOUND 44	6fcf	81.86
27	df2	Structure-based Design of Novel Chk1 Inhibitors: Insights into Hydrogen Bonding and Protein-Ligand Affinity	2bro	81.71
28	df1	Structure-based Design of Novel Chk1 Inhibitors: Insights into Hydrogen Bonding and Protein-Ligand Affinity	2brn	81.6
29	d4z	CHK1 KINASE IN COMPLEX WITH COMPOUND 13	6fck	81.31
30	ym5	Crystal structure of checkpoint kinase 1 (Chk1) in complex with inhibitors	2ym5	81.06
31	hk1	Crystal Structure of the CHK1	4fsm	80.85
32	zyq	Crystal structure of checkpoint kinase 1 (Chk1) in complex with inhibitors	2wmq	80.83
33	d4q	CHK1 KINASE IN COMPLEX WITH COMPOUND 13	6fc8	80.73
34	hk9	Crystal Structure of the CHK1	4ft0	80.07
35	7hk	Crystal Structure of the CHK1	4ftu	79.98
36	c73	X-ray crystal structure of compound 1 bound to human CHK1 kinase domain	3pa5	79.39
37	hk5	Crystal Structure of the CHK1	4fsu	79.05
38	pfq	Structure-based Design of Novel Chk1 Inhibitors: Insights into Hydrogen Bonding and Protein-Ligand Affinity	2brb	78.9
39	ydj	Discovery of Checkpoint Kinase Inhibitor AZD7762 by Structure Based Design and Optimization of Thiophene Carboxamide Ureas	2ydj	78.68
40	x8e	Discovery of a Novel Class of triazolones as Checkpoint Kinase Inhibitors - Hit to Lead Exploration	2x8e	78.18
41	c70	X-ray crystal structure of compound 70 bound to human CHK1 kinase domain	3pa3	78
42	1ko	X-RAY Crystal structure of compound 22a (R)-2-(4-chlorophenyl)-8-(piperidin-3-ylamino)imidazo[1,2-c]pyrimidine-5-carboxamide bound to human chk1 kinase domain	4jik	77.64
43	2hk	Crystal Structure of the CHK1	4ftn	77.6
44	dfy	Structure-based Design of Novel Chk1 Inhibitors: Insights into Hydrogen Bonding and Protein-Ligand Affinity	2brg	77.59
45	zyw	Crystal structure of checkpoint kinase 1 (Chk1) in complex with inhibitors	2wmw	77.51
46	c72	X-ray crystal structure of compound 2a bound to human CHK1 kinase domain	3pa4	77.2
47	s25	Crystal structure of Chk1 in complex with inhibitor S25	3tki	76.96
48	5be	Novel kinase profile highlights the temporal basis of context dependent checkpoint pathways to cell death	3nlb	75.71
49	hk6	Crystal Structure of the CHK1	4fsw	75.55
50	dfw	Structure-based Design of Novel Chk1 Inhibitors: Insights into Hydrogen Bonding and Protein-Ligand Affinity	2brh	75.03
51	zy6	Crystal structure of checkpoint kinase 1 (Chk1) in complex with inhibitors	2wmx	74.83
52	ym3	Crystal structure of checkpoint kinase 1 (Chk1) in complex with inhibitors	2ym3	74.44
53	710	crystal structure of Chek1 in complex with inhibitor 20	2hog	74.31
54	4hk	Crystal Structure of the CHK1	4ftq	73.89
55	3x7	CHK1 kinase domain with diazacarbazole compound 19	4rvm	73.87
56	85a	Structure of h-CHK1 complexed with A859017	2e9v	73.48
57	6hk	Crystal Structure of the CHK1	4ftt	72.64
58	hk8	Crystal Structure of the CHK1	4fsz	72.46
59	a58	Crystal Structure of the CHK1	4fsn	72.39
60	a58	Structure of h-CHK1 complexed with AA582939	2e9o	71.34
61	pfp	Structure-based Design of Novel Chk1 Inhibitors: Insights into Hydrogen Bonding and Protein-Ligand Affinity	2br1	71.25
62	199	Co-crystal structure of Checkpoint Kinase Chk1 with a pyrrolo-pyridine inhibitor	1zys	70.84
63	306	crystal structure of chek1 in complex with inhibitor 22	2hy0	70.81
64	5cv	Identification of Novel, in vivo Active Chk1 Inhibitors Utilizing Structure Guided Drug Design	5dls	70.15
65	3dw	CHK1 kinase domain in complex with diazacarbazole compound 14	4qyg	69.71
66	hk0	Crystal Structure of the CHK1	4gh2	68.73
67	76a	Structure of h-CHK1 complexed with A767085	2e9n	68.46
68	422	crystal structure of Chek1 in complex with inhibitor 1	2hxl	66.68
69	h8k	Crystal Structure of the CHK1	4ftj	66.3
70	h7k	Crystal Structure of the CHK1	4fti	65.83
71	3hk	Crystal Structure of the CHK1	4fto	65.64
72	373	crystal structure of Chek1 in complex with inhibitor 2	2hxq	65.29
73	agx	Characterization of the Chk1 allosteric inhibitor binding site	3jvr	64.46
74	38m	Crystal structure of chk1 kinase in complex with inhibitor 38	3f9n	62.95
75	ydi	Discovery of Checkpoint Kinase Inhibitor AZD7762 by Structure Based Design and Optimization of Thiophene Carboxamide Ureas	2ydi	62.07
76	07s	Crystal structure of Chk1 in complex with inhibitor S01	3tkh	55.89