The Ligandable Human Proteome

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Fibroblast growth factor receptor 4

Protein kinase domain

IndexLigand NameStructurePDB codeligand desolvation
10liCrystal Structure of the Tyrosine Kinase Domain of FGF Receptor 4 in Complex with Ponatinib4qrc92.68
29ctFIBROBLAST GROWTH FACTOR RECEPTOR 4 KINASE DOMAIN (449-753) IN COMPLEX WITH IRREVERSIBLE LIGAND CGA1595275nwz89.93
30liFGFR4 in complex with Ponatinib4uxq89.18
40liStructural analysis of the human Fibroblast Growth Factor Receptor 4 Kinase4tyj87.39
5xl5FGFR4 complex with N-(2-((5-((2,6-dichloro-3,5-dimethoxybenzyl)oxy)pyrimidin-2-yl)amino)-3-fluorophenyl)acrylamide6nvj83.41
6xl9FGFR4 complex with BLU-554, N-((3S,4S)-3-((6-(2,6-dichloro-3,5-dimethoxyphenyl)quinazolin-2-yl)amino)tetrahydro-2H-pyran-4-yl)acrylamide6nvk82.83
7xl6FGFR4 complex with N-(2-((5-((2,6-dichloro-3,5-dimethoxybenzyl)oxy)pyrimidin-2-yl)amino)-3-methylphenyl)acrylamide6nvh82.48
840mCrystal Structure of FGFR4 with an Irreversible Inhibitor4xcu81.74
9xl7FGFR4 complex with N-(3-chloro-2-((5-((2,6-dichloro-3,5-dimethoxybenzyl)oxy)pyrimidin-2-yl)amino)-5-fluorophenyl)acrylamide6nvi80.89
106lfThe crystal structure of FGFR4 kinase domain in complex with LY28744555jkg79.6
11xl8FGFR4 complex with N-(3,5-dichloro-2-((5-((2,6-dichloro-3,5-dimethoxybenzyl)oxy)pyrimidin-2-yl)amino)phenyl)acrylamide6nvg79.44
126lfCrystal structure of LY2874455 in complex of FGFR4 gatekeeper mutation (V550L)5xff75.48
13fgfCrystal structure of FGF401 in complex of FGFR46jpj67.49