The Ligandable Human Proteome

Mitogen-activated protein kinase 14

Index	Ligand Name	Structure	PDB code	ligand desolvation
1	i2o	p38 kinase crystal structure in complex with small molecule inhibitor	3rin	97.89
2	yix	Triazolopyridine Inhibitors of p38	2yix	97.35
3	9y8	p38alpha in complex with pyrazolobenzothiazine inhibitor COXP4M12	5omg	97.17
4	304	P38 alpha map kinase complexed with BMS-640994	3bx5	97.1
5	irg	Human p38 MAP kinase in complex with NP-F10 and RL87	4ehv	96.77
6	a17	P38 complex with a phthalazine inhibitor	3ds6	96.54
7	irg	Human p38 MAP kinase in complex with NP-F3 and RL87	4eh4	96.19
8	irg	Human p38 MAP kinase in complex with NP-F5 and RL87	4eh6	95.82
9	8oh	Crystal Structure of p38alpha in Complex with Lipid Pocket Ligand 9g	5n64	95.79
10	irg	Human p38 MAP kinase in complex with NP-F2 and RL87	4eh3	95.74
11	tzy	Crystal structure of P38 with triazolopyridine	1zzl	95.7
12	bw1	Crystal Structure of p38alpha in Complex with Lipid Pocket Ligand 9j	5n66	95.59
13	lie	Mutated MAP kinase P38 (Mus Musculus) in complex with Inhbitor PG-951717	2gtn	95.5
14	l10	p38 Kinase crystal structure in complex with small molecule inhibitor	1w82	95.44
15	8ow	Crystal Structure of p38alpha in Complex with Lipid Pocket Ligand 9c	5n63	95.36
16	2a8	Human p38 MAP Kinase in Complex with 2-amino-phenylamino- dibenzosuberone	3zya	95.19
17	p66	Crystal Structure of p38a Mitogen-Activated Protein Kinase in Complex with a Pyrazolopyridazine Inhibitor	3itz	95.05
18	lb5	Crystal structure of p38 alpha in complex with compound 75 (MCP33)	6sfi	94.48
19	irg	Human p38 MAP kinase in complex with RL87	4dli	94.46
20	1pp	p38alpha bound to pyrazolourea	2baj	94.37
21	gk5	Crystal Structure of P38 Kinase in Complex with a biphenyl amide inhibitor	3d7z	94.35
22	lid	Mutated Mouse P38 MAP Kinase Domain in complex with Inhibitor PG-892579	2gtm	94.21
23	lbe	MAPK14 with bound inhibitor SR-318	6sfo	94.07
24	6sh	Crystal structure of p38 alpha MAPK14 in complex with VPC00628	5lar	94.02
25	p38	Morpholino pyrrolotriazine P38 Alpha map kinase inhibitor compound 30	3bv2	93.95
26	irg	Human p38 MAP kinase in complex with NP-F7 and RL87	4eh8	93.94
27	wbt	Identification of novel p38 alpha MAP Kinase inhibitors using fragment-based lead generation.	1wbt	93.88
28	bmu	Conformational plasticity of p38 MAP kinase DFG motif mutants in response to inhibitor binding	3o8p	93.63
29	li2	Identification of novel p38 alpha MAP Kinase inhibitors using fragment-based lead generation.	1wbs	93.53
30	irg	Human p38 MAP kinase in complex with NP-F6 and RL87	4eh7	93.46
31	irg	Human p38 MAP kinase in complex with NP-F4 and RL87	4eh5	93.43
32	1ra	Crystal structure of mitogen-activated protein kinase 14 (P38-H5) complex with ETHYL 6-((5-(CYCLOPROPYLCARBAMOYL)-2-METHYLPHENYL)CARBAMOYL)-1H-INDOLE-1-CARBOXYLATE	4kiq	93.26
33	j8s	Structure-based Design, Synthesis, and Biological Evaluation of Imidazo[4,5-b]pyridine-2-one based p38 MAP Kinase Inhibitors by scaffold hopping: compound 1	6m95	93.18
34	gk4	Crystal structure of P38 in complex with biphenyl amide inhibitor	2zb1	93.09
35	nar	Human p38 MAP kinase in complex with NP-F2 and RL87	4eh3	92.93
36	irg	Human p38 MAP kinase in complex with NP-F11 and RL87	4eh9	92.77
37	bmu	Conformational plasticity of p38 MAP kinase DFG motif mutants in response to inhibitor binding	3o8u	92.72
38	irg	Human p38 MAP kinase in complex with NP-F1 and RL87	4eh2	92.69
39	lbb	Crystal structure of p38 alpha in complex with compound 77 (MCP41)	6sfj	92.57
40	edd	Crystal structure of phosphorylated P38 alpha in complex with DP802	3nnx	92.5
41	l09	fragment based p38 inhibitors	1wbn	92.12
42	fko	P38 kinase crystal structure in complex with RO3668	3fko	91.95
43	l11	p38 Kinase crystal structure in complex with small molecule inhibitor	1w83	91.52
44	edd	Crystal structure of P38 alpha in complex with DP802	3nnw	91.51
45	bmu	Conformational plasticity of p38 MAP kinase DFG mutants in response to inhibitor binding	3obj	91.49
46	xi2	P38 kinase crystal structure in complex with RO6226	3fmm	91.4
47	bax	P38 in complex with Sorafenib	3heg	91.33
48	1m8	Crystal structure of mitogen-activated protein kinase 14 (P38-H5) complex with 5-(2-CHLOROPHENYL)-N-(5-(CYCLOPROPYLCARBAMOYL)-2-METHYLPHENYL)-2-THIOPHENECARBOXAMIDE	4kin	91.33
49	dg7	Human p38 MAP Kinase in Complex with RL182	3pg3	91.16
50	yiw	triazolopyridine inhibitors of p38 kinase	2yiw	91.16
51	bmu	p38 MAP Kinase in Complex with Inhibitor 1	1kv1	91.08
52	edb	Crystal structure of P38 alpha in complex with DP1376	3nnu	90.91
53	sb4	Fragment KCL615 in complex with MAP kinase p38-alpha	6spl	90.91
54	9o5	Covalent Inhibitor 4b bound to the Lipid Pocket of p38alpha Mutant S252C	5o8u	90.87
55	1r9	Crystal structure of mitogen-activated protein kinase 14 (P38-H5) complex with 2-(2-CHLOROPHENYL)-N-(5-(CYCLOPROPYLCARBAMOYL)-2-METHYLPHENYL)-1,3-THIAZOLE-5-CARBOXAMIDE	4kip	90.84
56	bmu	Conformational plasticity of p38 MAP kinase DFG-motif mutants in response to inhibitor binding	3o8t	90.82
57	b96	Human p38 MAP Kinase in Complex with BIRB 796	1kv2	90.78
58	nk0	P38 alpha kinase complexed with a pyrazolo-triazine based inhibitor	3s4q	90.69
59	bax	Human P38 MAP kinase in complex with Sorafenib	3gcs	90.51
60	fl4	P38 kinase crystal structure in complex with RO5634	3fl4	90.49
61	hiz	Structure of Inactive Human p38 MAP Kinase in Complex with a Thiazole-Urea	3iw8	90.43
62	z83	Human p38 MAP Kinase in Complex with RL166	3lff	90.35
63	bmu	Conformational plasticity of p38 MAP kinase DFG motif mutants in response to inhibitor binding	3oc1	90.34
64	sb4	Fragments KCL_615 and KCL_802 in complex with MAP kinase p38-alpha	6sov	90.05
65	df3	Human p38 MAP Kinase in Complex with an Indole Derivative	3iw5	90.03
66	sb4	Fragment KCL802 in complex with MAP kinase p38-alpha	6sp9	89.99
67	09j	Crystal Structure of p38a Mitogen-Activated Protein Kinase in Complex with a Triazolopyridazinone inhibitor	3u8w	89.96
68	ocg	P38 Alpha kinase complexed with a 5-amino-pyrazole based inhibitor	3ocg	89.7
69	z86	Human p38 MAP Kinase in Complex with RL99	3lfc	89.7
70	r39	Human p38 MAP Kinase in Complex with RL39	3hv6	89.67
71	38p	P38 Alpha Map Kinase complexed with pyrrolotriazine inhibitor 7K	3mvl	89.54
72	358	The structure of p38 alpha in complex with a dihydroquinolinone	1ove	89.47
73	sb4	Structural basis of autoactivation of p38 alpha induced by TAB1 (Tetragonal crystal form)	4lop	89.37
74	aqy	Structure-based Design, Synthesis, and Biological Evaluation of Imidazo[1,2-b]pyridazine-based p38 MAP Kinase Inhibitors	5wjj	89.36
75	lb8	Crystal structure of p38 alpha in complex with compound 81 (MCP42)	6sfk	89.18
76	cq0	p38 kinase crystal structure in complex with small molecule inhibitor	3s3i	89.15
77	z84	Human p38 MAP Kinase in Complex with RL116	3lfe	89.07
78	f4c	P38alpha bound to novel DFG-out compound PF-00416121	3k3j	89.05
79	b96	Crystal Structure of p38alpha in Complex with Lipid Pocket Ligand 9j	5n66	89.04
80	p5k	P38 inhibitor-bound	3p5k	88.99
81	fkl	P38 kinase crystal structure in complex with RO9552	3fkl	88.78
82	n4d	P38 alpha kinase complexed with a pyrazolo-pyrimidine based inhibitor	3l8x	88.73
83	g2g	Crystal structure of p38 complex with 1-(5-tert-Butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-[4-(6-morpholin-4-ylmethyl-pyridin-3-yl)naphthalen-1-yl]urea	2puu	88.63
84	sb4	Structural basis of autoactivation of p38 alpha induced by TAB1 (Monoclinic crystal form)	4loo	88.56
85	p78	P38 inhibitor-bound	3p78	88.43
86	pgj	Mutated Mus Musculus P38 Kinase (mP38)	1yw2	88.39
87	sb0	Human P38 alpha Mitogen-Activated Kinase In Complex With SB239063	4fa2	88.38
88	ipk	Human p38 MAP Kinase in Complex with an Imidazo-pyridine	3iw7	88.37
89	fmk	P38 kinase crystal structure in complex with 6-(2,4-Difluoro-phenoxy)-8-methyl-2-((S)-1-methyl-2-tetrazol-2-yl-ethylamino)-8H-pyrido[2,3-d]pyrimidin-7-one	3fmk	88.35
90	sb4	Structural basis of autoactivation of p38 alpha induced by TAB1 (Tetragonal crystal form with bound sulphate)	4loq	88.34
91	p39	Morpholino pyrrolotriazine P38 Alpha Map Kinase inhibitor compound 2	3bv3	88.33
92	6np	Crystal Structure of p38 Alpha in Complex with a Selective Pyridazine Inhibitor	1yqj	88.28
93	p7b	p38 inhibitor-bound	3p7b	88.19
94	fi4	P38 kinase crystal structure in complex with RO4499	3fi4	88.09
95	g11	Crystal structure of p38 in complex with a biphenylamide inhibitor	3iph	87.8
96	8en	P38 ALPHA MUTANT C162S IN COMPLEX WITH CMPD2 [N-(4-Methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-3-(trifluoromethyl)benzamide]	5mz3	87.69
97	279	Phenylalanine pyrrolotriazine p38 alpha map kinase inhibitor compound 11B	2rg5	87.58
98	048	Human p38 MAP Kinase in Complex with a Benzamide Substituted Benzosuberone	3uvp	87.28
99	39p	P38 Alpha Map Kinase complexed with pyrrolotriazine inhibitor 7V	3mvm	87.18
100	p79	P38 inhibitor-bound	3p79	87.06
101	i39	p38 kinase Crystal structure in complex with small molecule inhibitor	3hrb	86.76
102	sb4	Crystal structure of a P38alpha T185G mutant in complex with TAB1 peptide.	5o90	86.63
103	fmj	P38 kinase crystal structure in complex with 4-(5-Methyl-3-phenyl-isoxazol-4-yl)-pyrimidin-2-ylamine	3fmj	86.17
104	t75	Structure-based Design, Synthesis, and Biological Evaluation of Imidazo[1,2-b]pyridazine-based p38 MAP Kinase Inhibitors	6anl	86.07
105	j9g	Structure-based Design, Synthesis, and Biological Evaluation of Imidazo[4,5-b]pyridine-2-one based p38 MAP Kinase Inhibitors by scaffold hopping - compound 10	6m9l	86.03
106	3nw	P38 Alpha kinase complexed with a 2-aminothiazol-5-yl-pyrimidine based inhibitor	3nww	85.75
107	pp0	Human p38 MAP Kinase in Complex with a Benzylpiperazin-Pyrrol	3iw6	85.47
108	lib	Mutant Mus Musculus P38 Kinase Domain in Complex with Inhibitor PG-874743	2ghl	85.39
109	sti	P38 in complex with Imatinib	3hec	85.03
110	pqb	p38alpha bound to Ro3201195	2baq	84.89
111	3fn	P38 kinase crystal structure in complex with R1487	3fln	84.85
112	9o2	Covalent Inhibitor 4a bound to the Lipid Pocket of p38alpha Mutant S251C	5o8v	84.82
113	gk6	Crystal structure of P38 kinase in complex with a biphenyl amide inhibitor	3d83	84.78
114	8ok	Crystal Structure of p38alpha in Complex with Lipid Pocket Ligand 9m	5n68	84.71
115	kq7	Structure of human p38alpha with N-[4-methyl-3-(6-{[2-(1-methylpyrrolidin-2-yl)ethyl]amino}pyridine-3-amido)phenyl]-2-(morpholin-4-yl)pyridine-4-carboxamide	3kq7	84.47
116	lic	Mutated MAP kinase P38 (Mus Musculus) in complex with Inhbitor PG-895449	2ghm	84.42
117	p7c	p38 inhibitor-bound	3p7c	84.31
118	p37	Crystal Structure of p38a Mitogen-Activated Protein Kinase in Complex with a Pyrazolopyridinone Inhibitor	3gfe	84.24
119	aa0	P38ALPHA MAP KINASE BOUND TO CMPD 2	4aa0	84.22
120	3ff	Human p38 MAP Kinase in Complex with Skepinone-L	3que	83.89
121	pqb	P38 Kinase Crystal Structure in complex with RO3201195	2gfs	83.85
122	19b	Crystal Structure of P38 Kinase in Complex with A Biaryl Amide Inhibitor	3e93	83.77
123	l9g	Crystal Structure of Human p38alpha Complexed With a Triazolopyrimidine compound	3kf7	83.75
124	p0f	The structure of p38 alpha in complex with a triazol inhibitor	5xyy	83.5
125	3gf	Crystal structure of p38 alpha MAP kinase in complex with a novel isoform selective drug candidate	4r3c	83.44
126	ftz	The structure of p38 alpha in complex with a triazol inhibitor	5xyx	83.23
127	flw	P38 kinase crystal structure in complex with pamapimod	3flw	83.1
128	1gk	Crystal structure of P38 kinase in complex with a pyrrole-2-carboxamide inhibitor	3mpt	83.02
129	b11	Two Classes of p38alpha MAP Kinase Inhibitors Having a Common Diphenylether Core but Exhibiting Divergent Binding Modes	1zz2	82.82
130	li9	Crystal Structure Analysis of inactive P38 kinase domain in complex with a Monocyclic Pyrazolone Inhibitor	1ywr	82.77
131	dqo	Crystal structure of p38 MAP kinase in complex with a dihydroquinazolinone inhibitor	1m7q	82.55
132	fly	P38 kinase crystal structure in complex with 6-(2,4-difluoro-phenoxy)-2-isopropylamino-8-methyl-8h-pyrido[2,3-d]pyrimidin-7-one	3fly	82.2
133	084	The structure of p38 alpha in complex with a pyridinylimidazole inhibitor	1ouk	81.99
134	t75	X-ray structure of p38alpha bound to TAK-715	3zsg	81.86
135	fph	P38 MITOGEN-ACTIVATED KINASE IN COMPLEX WITH 4-AZAINDOLE INHIBITOR	1oz1	81.73
136	0om	Human p38 MAP kinase in complex with NP-F4 and RL87	4eh5	81.59
137	f46	Human p38 MAP kinase in complex with a Dibenzoxepinone	4l8m	81.45
138	qc0	P38ALPHA MAP KINASE BOUND TO CMPD 22	4aa4	81.36
139	533	P38 kinase crystal structure in complex with 6-(2,4-Difluoro-phenoxy)-8-methyl-2-((R)-1-methyl-2-tetrazol-2-yl-ethylamino)-8H-pyrido[2,3-d]pyrimidin-7-one	3fmh	81.33
140	bi5	Human P38 MAP Kinase in Complex with Inhibitor 1a	1zyj	81.29
141	aav	P38ALPHA MAP KINASE BOUND TO CMPD 29	4aac	81.18
142	8on	Crystal Structure of p38alpha in Complex with Lipid Pocket Ligand 9l	5n67	81.15
143	094	The structure of p38 alpha in complex with a dihydropyrido-pyrimidine inhibitor	1ouy	80.96
144	sb5	THE COMPLEX STRUCTURE OF THE MAP KINASE P38/SB218655	1bmk	80.95
145	bff	Human p38 MAP Kinase in Complex with CP-547632	3l8s	80.78
146	530	P38 kinase crystal structure in complex with RO2530	3fmn	80.68
147	sb4	THE COMPLEX STRUCTURE OF THE MAP KINASE P38/SB220025	1bl7	80.61
148	ro6	P38 kinase crystal structure in complex with RO6257	3fsk	80.55
149	i47	Crystal Structure of Human p38alpha complexed with SD-0006	3hl7	80.45
150	p40	P38 Complexed with a quinazoline inhibitor	3dt1	80.43
151	mih	p38 kinase Crystal structure in complex with small molecule inhibitor	3mw1	80.13
152	flz	P38 kinase crystal structure in complex WITH 8-Methyl-6-phenoxy-2-(tetrahydro-pyran-4-ylamino)-8H-pyrido[2,3-d]pyrimidin-7-one	3flz	80.03
153	fml	P38 kinase crystal structure in complex with RO6224	3fml	79.63
154	sb6	THE COMPLEX STRUCTURE OF THE MAP KINASE P38/SB216995	1bl6	79.59
155	sb2	Dual binding mode of pyridinylimidazole to MAP kinase p38	2ewa	79.38
156	sb2	Human P38 MAP Kinase in Complex with SB203580	3gcp	79.32
157	nqb	P38ALPHA MAP KINASE BOUND TO CMPD 33	4aa5	79.2
158	aqz	p38alpha MAP kinase bound to MPAQ	2bak	79.06
159	aqz	P38ALPHA MAP KINASE BOUND TO CMPD 8	4a9y	79.06
160	fs8	Human p38 MAP Kinase in Complex with a Dibenzosuberone Derivative	3uvq	78.86
161	hb9	Dibenzosuberone inhibitor 8e in complex with p38 MAPK	5mty	78.73
162	fls	P38 kinase crystal structure in complex with 6-(2,4-Difluoro-phenoxy)-2-((R)-2-methanesulfonyl-1-methyl-ethylamino)-8-methyl-8H-pyrido[2,3-d]pyrimidin-7-one	3fls	78.72
163	469	Human p38 MAP Kinase in Complex with Scios-469	3hub	78.71
164	msq	THE STRUCTURE OF P38 MITOGEN-ACTIVATED PROTEIN KINASE IN COMPLEX WITH 4-[3-METHYLSULFANYLANILINO]-6,7-DIMETHOXYQUINAZOLINE	1di9	77.47
165	b45	The structure of p38alpha in complex with a dihydroquinazolinone	3gc7	77.25
166	sb2	Structural basis for kinase selectivity of three clinical p38alpha inhibitors	3zs5	77.25
167	gxh	Crystal structure of p38alpha in complex with a reduced photoswitchable 2-Azothiazol-based Inhibitor (compound 31)	6hwt	77.16
168	pqa	p38alpha MAP kinase bound to pyrazoloamine	2bal	76.71
169	0ok	Human p38 MAP kinase in complex with NP-F1 and RL87	4eh2	76.64
170	sb2	Conformational plasticity of p38 MAP kinase DFG mutants in response to inhibitor binding	3obg	75.22
171	469	X-ray structure of p38alpha bound to SCIO-469	3zsh	75.21
172	lo5	Fragment N13569a in complex with MAP kinase p38-alpha	6so1	73.68
173	891	P38 kinase crystal structure in complex with 6-(2,4-difluoro-phenoxy)-2-((s)-2-methanesulfonyl-1-methyl-ethylamino)-8-methyl-8h-pyrido[2,3-d]pyrimidin	3flq	73.61
174	sb2	THE COMPLEX STRUCTURE OF THE MAP KINASE P38/SB203580	1a9u	73.54
175	lgf	P38 Alpha Map Kinase inhibitor based on heterobicyclic scaffolds	2qd9	73.39
176	g97	Human p38 MAP Kinase in Complex with RL40	3huc	73.12
177	sb2	Conformational plasticity of p38 MAP kinase DFG motif mutants in response to inhibitor binding	3mpa	71.48
178	79q	Human p38 MAP Kinase in Complex with Dibenzosuberone Compound 1	5tco	71.18
179	fji	Dibenzooxepinone inhibitor 12b in complex with p38 MAPK	5mtx	69.52
180	1vi	Human p38alpha MAPK in complex with imidazolyl pyridine inhibitor 11b	5ml5	69.47
181	fss	P38 kinase crystal structure in complex with 3-(2,6-Dichloro-phenyl)-7-[4-(2-diethylamino-ethoxy)-phenylamino]-1-methyl-3,4-dihydro-1H-pyrimido[4,5-d]pyrimidin-2-one	3fsf	61.07
182	lo8	Fragment RZ132 in complex with MAP kinase p38-alpha	6so4	59.47
183	1n1	Human p38 MAP Kinase in Complex with Dasatinib	3lfa	58.03