The Ligandable Human Proteome

Dual specificity mitogen-activated protein kinase kinase 1

Index	Ligand Name	Structure	PDB code	ligand desolvation
1	573	Crystal structure of the BRAF:MEK1 complex	4mne	97.08
2	3or	Mitogen-activated protein kinase kinase 1 (MEK1) in complex with CH4987655 and MgAMP-PNP	3orn	96.24
3	lcj	Crystal structure of BRAF:MEK1 complex	6pp9	95.59
4	3ex	MEK 1 kinase bound to G799	4u80	95.37
5	3ey	MEK1 Kinase bound to small molecule inhibitor G659	4u81	95.33
6	1cx	X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) in a complex with ligand and MgATP	3dy7	95.19
7	3os	Mitogen-activated protein kinase kinase 1 (MEK1) in complex with CH4858061 and MgATP	3os3	95.16
8	4bm	X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) in complex with an inhibitor and MgATP	3vvh	94.99
9	v04	Discovery of Novel Allosteric MEK Inhibitors Possessing Classical and Non-classical Bidentate Ser212 Interactions.	3v04	94.86
10	5y0	Crystal structures of human MEK1 with carboxamide-based allosteric inhibitor XL518 (GDC-0973), or related analogs.	4an3	94.77
11	mra	X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) in a complex with ligand and MgATP	2p55	94.73
12	mek	MEK1 with PF-04622664 Bound	3dv3	94.41
13	eui	Crystal structures of human MEK1 with carboxamide-based allosteric inhibitor XL518 (GDC-0973), or related analogs.	4an2	94.39
14	3v0	Discovery of Novel Allosteric MEK Inhibitors Possessing Classical and Non-classical Bidentate Ser212 Interactions.	3v01	94.37
15	3bm	X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) in a ternary complex with compound 1, ATP-GS AND MG2P	3eqc	94.34
16	yqy	Crystal structures of human MEK1 with carboxamide-based allosteric inhibitor XL518 (GDC-0973), or related analogs.	4anb	94.24
17	e62	Mek1 adopts DFG-out conformation when bound to an analog of E6201.	5hze	94.06
18	izg	Crystal Structure of the Human Mitogen-activated protein kinase kinase 1 (MEK 1) in complex with ligand and MgATP	3pp1	93.63
19	lsg	Crystal Structure of the human mitogen-activated protein kinase kinase 1 (MEK 1) in complex with ligand and MgADP	3mbl	93.58
20	3ew	Mitogen-Activated Protein Kinase Kinase (MEK1) bound to G805	4u7z	93.31
21	22t	Crystal structure of MEK1 in complex with fragment 1	3zm4	93.1
22	4bm	X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) in a ternary complex with PD, ADP AND MG2P	3eqg	92.99
23	2p7	Crystal structures of human MEK1 with carboxamide-based allosteric inhibitor XL518 (GDC-0973), or related analogs.	4an9	92.81
24	chu	Human MEK1 kinase in complex with CH5126766 and MgAMP-PNP	3wig	91.58
25	m3k	CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF HUMAN MAP KINASE KINASE 1 (MEK1) IN COMPLEX WITH A SMALL MOLECULE INHIBITOR AND ADP	4ark	91.06
26	bbm	X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) in a complex with ligand and MgATP	1s9j	91.05
27	eui	Crystal Structure of MEK1 kinase bound to GDC0973	4lmn	90.94
28	vra	X-ray structure of the human mitogen-activated protein kinase kinase 1 (MEK1) complexed with a potent inhibitor RDEA119 and MgATP	3e8n	90.2
29	5ez	Crystal structure of MEK1 in complex with fragment 18	3zlx	90.13
30	77d	Crystal Structure of human MEK-1 kinase in complex with UCB1353770 and AMPPNP	3sls	86.76
31	5u5	MEK1 IN COMPLEX WITH BI 847325	5eym	79.55