The Ligandable Human Proteome

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High affinity nerve growth factor receptor

Protein kinase domain

IndexLigand NameStructurePDB codeligand desolvation
131wThe structure of TrkA kinase bound to the inhibitor 1-cyclopropyl-1-[3-(1,3-thiazol-2-yl)benzyl]-3-[4-(trifluoromethoxy)phenyl]urea4pmp93.19
26ukTrkA JM-kinase with 1-(2-methyl-4-phenyl-pyrimidin-5-yl)-3-[[2-(trifluoromethyl)phenyl]methyl]urea5kmn91.92
331xThe structure of TrkA kinase bound to the inhibitor 4-naphthalen-1-yl-1-[(5-phenyl-1,2,4-oxadiazol-3-yl)methyl]-1H-pyrrolo[3,2-c]pyridine-2-carboxylic acid4pms91.84
4v4zHuman TrkA in complex with the inhibitor AZ-234aoj91.24
56k1Crystal structure of TrkA in complex with PF-052062835jfv91.13
66k2Crystal structure of TrkA in complex with PF-052474525jfw91.01
76uhTrkA JM-kinase with 1-(5-methyl-3-phenyl-1,2-oxazol-4-yl)-3-[[2-(trifluoromethyl)phenyl]methyl]urea5kml90.87
86k4Crystal structure of TrkA in complex with PF-062733405jfx90.38
9godCrystal structure of Trk-A in complex with the Pan-Trk Kinase Inhibitor, compound 19.6dki90.3
10gxaCrystal structure of Trk-A in complex with the Pan-Trk Kinase Inhibitor, compound 3.6dkw89.7
116k0Crystal structure of TrkA in complex with PF-005931745jfs89.59
12oojTRK-A IN COMPLEX WITH LIGAND 1B6pl189.52
13oomTRK-A IN COMPLEX WITH LIGAND 1a6pl288.35
14fkyCrystal structure of Trk-A in complex with the Pan-Trk Kinase Inhibitor, compound 10b.6dkb86.3
15go7Crystal structure of Trk-A in complex with the Pan-Trk Kinase Inhibitor, compound 13b.6dkg86.26
16oodTRK-A IN COMPLEX WITH LIGAND 2a6pl385.08
176umTrkA JM-kinase with 1-(2-methyl-4-phenyl-pyrimidin-5-yl)-3-(2-pyridyl)urea5kmo83.01
1869cTrkA with (6~{R})-3-methylsulfanyl-6-phenyl-1-(1~{H}-pyrazol-3-yl)-6,7-dihydro-5~{H}-thieno[3,4-c]pyridin-4-one5i8a82.41
19l0pTRK-A IN COMPLEX WITH LIGAND 96nsp81.89
2031yThe structure of TrkA kinase bound to the inhibitor N~4~-(4-morpholin-4-ylphenyl)-N~6~-(pyridin-3-ylmethyl)pyrido[3,2-d]pyrimidine-4,6-diamine4pmt81.83
21ymxTHE STRUCTURE OF TRKA KINASE DOMAIN BOUND TO THE INHIBITOR ENTRECTINIB5kvt79.78