The Ligandable Human Proteome

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Nuclear receptor ROR-gamma

Nuclear hormone receptor, ligand-binding domain

IndexLigand NameStructurePDB codeCompound Potency nM
198nStructural states of RORgt: X-ray elucidation of molecular mechanisms and binding interactions for natural and synthetic compounds5ntw0.6
298eStructural states of RORgt: X-ray elucidation of molecular mechanisms and binding interactions for natural and synthetic compounds5ntp0.7
34y7Identification of a Novel Allosteric Binding Site for RORgt Inhibitors5c4u1.9
44q3RORgamma in complex with inverse agonist 4j.4zom3
54y5Identification of a Novel Allosteric Binding Site for RORgt Inhibitors5c4s3.8
6nbhCrystal structure of the orphan nuclear receptor ROR(gamma)t ligand-binding domain in complex with small molecule ligand4nie20
74y6Identification of a Novel Allosteric Binding Site for RORgt Inhibitors5c4t21.8
876eLigand complex of RORg LBD5apj40
9vyiLigand complex of RORg LBD5aph60
103qqCrystal structure of RORc in complex with a partial inverse agonist compound4wlb180
11921X-ray co-structure of nuclear receptor ROR-gammat Ligand Binding Domain with an agonist and SRC2 peptide5vb7190
124p1RORgamma in complex with inverse agonist 164zjw220
1392aX-ray co-structure of nuclear receptor ROR-gammat Ligand Binding Domain with an inverse agonist and SRC2 peptide5vb5350
14927X-ray co-structure of nuclear receptor ROR-gammat Ligand Binding Domain with an inverse agonist and SRC2 peptide5vb6430
15zbdX-ray co-structure of nuclear receptor ROR-GAMMAT + SRC2 peptide with a benzothiadiazole dioxide inverse agonist4ymq1600