| Index | Ligand Name | Structure | PDB code | ligand desolvation |
| 1 | etc | Human Estrogen Receptor alpha Ligand-binding Domain in Complex with (R,R)-5,11-cis-diethyl-5,6,11,12-tetrahydrochrysene-2,8-diol and a Glucocorticoid Receptor Interacting Protein 1 NR box II Peptide | 1l2i | 100 |
| 2 | des | Crystal Structure of the ER-alpha Ligand-binding Domain (Y537S) in complex with Diethylstilbestrol | 4zn7 | 100 |
| 3 | des | HUMAN ESTROGEN RECEPTOR ALPHA LIGAND-BINDING DOMAIN IN COMPLEX WITH DIETHYLSTILBESTROL AND A GLUCOCORTICOID RECEPTOR INTERACTING PROTEIN 1 NR BOX II PEPTIDE | 3erd | 100 |
| 4 | 7fg | Crystal Structure of the ER-alpha Ligand-binding Domain (Y537S) in Complex with the Cyclofenil-ASC derivative, ethyl (E)-3-(4-(bicyclo[3.3.1]nonan-9-ylidene(4-hydroxyphenyl)methyl)phenyl)acrylate | 5tms | 100 |
| 5 | 5j0 | Crystal Structure of the ER-alpha Ligand-binding Domain in Complex with the Cyclofenil Derivative 3-[(E)-(1s,5s)-bicyclo[3.3.1]non-9-ylidene(4-hydroxyphenyl)methyl]phenol | 5dxm | 100 |
| 6 | 27j | Crystal structure of hERa-LBD (Y537S) in complex with alpha-zearalanol | 4mg8 | 100 |
| 7 | 5g3 | Crystal Structure of the ER-alpha Ligand-binding Domain in Complex with a Resorcinyl 2-Chloro-substituted Diaryl-imine analog 4-[(E)-[(2-chlorophenyl)imino](4-hydroxyphenyl)methyl]benzene-1,3-diol | 5dwi | 100 |
| 8 | 5kf | Crystal Structure of the ER-alpha Ligand-binding Domain in Complex with the Cyclofenil Derivative 4,4'-{[(3S)-3-(2-hydroxyethyl)cyclohexylidene]methanediyl}diphenol | 5dzi | 99.92 |
| 9 | 5k1 | Crystal Structure of the ER-alpha Ligand-binding Domain in Complex with the Cyclofenil Derivative 4,4'-{[(3S)-3-(methylsulfanyl)cyclohexylidene]methanediyl}diphenol | 5dyd | 99.92 |
| 10 | 5jx | Crystal Structure of the ER-alpha Ligand-binding Domain in Complex with the Cyclofenil Derivative 4,4'-{[4-(fluoromethyl)cyclohexylidene]methanediyl}diphenol | 5dz3 | 99.91 |
| 11 | 5hz | Crystal Structure of the ER-alpha Ligand-binding Domain in Complex with the Cyclofenil Derivative 4,4'-[(1s,5s)-bicyclo[3.3.1]non-9-ylidenemethanediyl]diphenol | 5dxq | 99.91 |
| 12 | 27h | Crystal structure of hERa-LBD (Y537S) in complex with ferutinine | 4mg7 | 99.9 |
| 13 | eed | Crystal Structure of the Estrogen Receptor Alpha Ligand Binding Domain Complexed to an Ether Estradiol Compound | 2qgt | 99.89 |
| 14 | 5c6 | Crystal Structure of the ER-alpha Ligand-binding Domain in complex with a 2-naphthylamino-substituted, ethyl, triaryl-ethylene derivative 4,4'-{2-[3-(naphthalen-1-ylamino)phenyl]but-1-ene-1,1-diyl}diphenol | 5dks | 99.88 |
| 15 | 5ft | Crystal Structure of the ER-alpha Ligand-binding Domain in Complex with a Sulfoxide-bridged Oxabicyclic Heptene Sulfonate (SOBHS)-3 analog phenyl (1S,2S,4S,7S)-5,6-bis(4-hydroxy-3-methylphenyl)-7-thiabicyclo[2.2.1]hept-5-ene-2-sulfonate 7-oxide | 5duh | 99.86 |
| 16 | 5fv | Crystal Structure of the ER-alpha Ligand-binding Domain in Complex with a Sulfoxide-bridged Oxabicyclic Heptene Sulfonate (SOBHS)-2 analog phenyl (1S,2S,4S,7S)-5,6-bis(4-hydroxy-2-methylphenyl)-7-thiabicyclo[2.2.1]hept-5-ene-2-sulfonate 7-oxide | 5dug | 99.84 |
| 17 | 6wq | Crystal Structure of the ER-alpha Ligand-binding Domain (Y537S) in Complex with 4,4'-((5-bromo-2,3-dihydro-1H-inden-1-ylidene)methylene)diphenol | 5krk | 99.84 |
| 18 | 5hw | Crystal Structure of the ER-alpha Ligand-binding Domain in Complex with the Cyclofenil Derivative 4,4'-{[(3R)-3-methylcyclohexylidene]methanediyl}diphenol | 5dxr | 99.83 |
| 19 | 5j1 | Crystal Structure of the ER-alpha Ligand-binding Domain in Complex with the Cyclofenil Derivative 4,4'-[(9s)-bicyclo[3.3.1]non-9-ylmethanediyl]diphenol | 5dxk | 99.83 |
| 20 | q97 | Estrogen Receptor Alpha Ligand Binding Domain Y537S Mutant in Complex with Ethoxytriphenylethylene and GRIP Peptide | 5t1z | 99.82 |
| 21 | 5k4 | Crystal Structure of the ER-alpha Ligand-binding Domain in Complex with the Cyclofenil Derivative 4,4'-{[(3S)-3-ethylcyclohexylidene]methanediyl}diphenol | 5dy8 | 99.75 |
| 22 | 5g4 | Crystal Structure of the ER-alpha Ligand-binding Domain in Complex with the Triaryl-substituted Imine Analog, 4-{(E)-(4-hydroxyphenyl)[(2-methylphenyl)imino]methyl}benzene-1,3-diol | 5dwg | 99.75 |
| 23 | 5k0 | Crystal Structure of the ER-alpha Ligand-binding Domain in Complex with the Cyclofenil Derivative 4,4'-[(4-methylcyclohexylidene)methanediyl]diphenol | 5dz0 | 99.75 |
| 24 | 5kg | Crystal Structure of the ER-alpha Ligand-binding Domain in Complex with the Cyclofenil Derivative 4,4'-{[4-(2-hydroxyethyl)cyclohexylidene]methanediyl}diphenol | 5dzh | 99.67 |
| 25 | 5k2 | Crystal Structure of the ER-alpha Ligand-binding Domain in Complex with the Cyclofenil Derivative 4,4'-(3,4-dihydronaphthalen-2(1H)-ylidenemethanediyl)diphenol | 5dyb | 99.66 |
| 26 | est | Human estrogen receptor alpha ligand-binding domain in complex with estradiol and the E2#23 FN3 monobody | 2ocf | 99.63 |
| 27 | 5es | Crystal Structure of the ER-alpha Ligand-binding Domain in complex with a 4-fluorophenylamino-substituted triaryl-ethylene derivative 4,4'-(2-{3-[(4-fluorophenyl)amino]phenyl}ethene-1,1-diyl)diphenol | 5dp0 | 99.61 |
| 28 | 1gr | Crystal Structure of the Estrogen Receptor alpha Ligand-binding Domain in Complex with Dynamic WAY-derivative, 5a | 4iv2 | 99.58 |
| 29 | 5j2 | Crystal Structure of the ER-alpha Ligand-binding Domain in Complex with a Resorcinyl 4-Fluoro-substituted Diaryl-imine analog 4-[(E)-[(4-fluorophenyl)imino](4-hydroxyphenyl)methyl]benzene-1,3-diol | 5dwj | 99.58 |
| 30 | 5jy | Crystal Structure of the ER-alpha Ligand-binding Domain in Complex with the Cyclofenil Derivative 4,4'-[(4-ethylcyclohexylidene)methanediyl]diphenol | 5dz1 | 99.55 |
| 31 | xbr | Optimization of a novel binding motif to to (E)-3-(3,5-difluoro-4-((1R,3R)-2-(2-fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro-1H- pyrido(3,4-b)indol-1-yl)phenyl)acrylic acid (AZD9496), a potent and orally bioavailable selective estrogen receptor downregulator and antagonist | 5aau | 99.51 |
| 32 | 9xy | Estrogen Receptor Alpha Ligand Binding Domain C381S, C417S, C530S Mutant in Complex with Endoxifen | 5w9d | 99.51 |
| 33 | wst | Benzopyrans as Selective Estrogen Receptor b Agonists (SERBAs). Part 2: Structure Activity Relationship Studies on the Benzopyran Scaffold. | 2pog | 99.42 |
| 34 | est | estrogen receptor alpha in complex with a stabilized peptide antagonist 6 | 5gtr | 99.4 |
| 35 | fnj | Estrogen Receptor Alpha Ligand Binding Domain Y537S Mutant in Complex with Z2OHTPE and a glucocorticoid receptor-interacting protein 1 NR box II peptide | 6czn | 99.39 |
| 36 | 7fs | Crystal Structure of the ER-alpha Ligand-binding Domain (Y537S) in Complex with the estradiol derivative, (8S,9S,13S,14S)-17-((4-isopropylphenyl)amino)-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-3-ol | 5tn3 | 99.38 |
| 37 | 1gs | Crystal Structure of the Estrogen Receptor alpha Ligand-binding Domain in Complex with Constrained WAY-derivative, 5b | 4iv4 | 99.37 |
| 38 | 5kb | Crystal Structure of the ER-alpha Ligand-binding Domain in Complex with the Cyclofenil Derivative 4,4'-{[(3R)-3-phenylcyclohexylidene]methanediyl}diphenol | 5e14 | 99.36 |
| 39 | zer | Crystal Structure of the ER-alpha Ligand-binding Domain (Y537S) in Complex with Zearalenone | 5krc | 99.36 |
| 40 | 5ke | Crystal Structure of the ER-alpha Ligand-binding Domain in Complex with the Cyclofenil Derivative 4,4'-{[(3S)-3-(4-hydroxyphenyl)cyclohexylidene]methanediyl}diphenol | 5e0w | 99.35 |
| 41 | j3z | Crystal structure of human Estrogen Receptor Alpha Ligand-Binding Domain in complex with a Glucocorticoid Receptor Interacting Protein 1 Nr Box II Peptide and estrone ((8R,9S,13S,14S)-3-hydroxy-13-methyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-one) | 3hm1 | 99.29 |
| 42 | 6wu | Crystal Structure of the ER-alpha Ligand-binding Domain (Y537S) in Complex with the A-CD ring estrogen, (1S,7aS)-5-(2,5-difluoro-4-hydroxyphenyl)-7a-methyl-2,3,3a,4,7,7a-hexahydro-1H-inden-1-ol | 5krm | 99.28 |
| 43 | 459 | Human Estrogen Receptor Alpha Ligand-Binding Domain In Complex With OBCP-2M and A Glucocorticoid Receptor Interacting Protein 1 NR Box II Peptide | 2fai | 99.27 |
| 44 | 5ck | Crystal Structure of the ER-alpha Ligand-binding Domain in complex with a difluoro-substituted A-CD ring estrogen derivative (1S,3aR,5S,7aS)-5-(2,3-difluoro-4-hydroxyphenyl)-7a-methyloctahydro-1H-inden-1-ol | 5did | 99.27 |
| 45 | 6wr | Crystal Structure of the ER-alpha Ligand-binding Domain (Y537S) in Complex with the A-CD ring estrogen, (1S,7aS)-5-(2-chloro-4-hydroxyphenyl)-7a-methyl-2,3,3a,4,7,7a-hexahydro-1H-inden-1-ol | 5krl | 99.25 |
| 46 | g9j | Crystal structure of estrogen receptor alpha in complex with receptor degrader 16aa | 6dfn | 99.25 |
| 47 | 5k8 | Crystal Structure of the ER-alpha Ligand-binding Domain in Complex with the Cyclofenil Derivative dimethyl {(1S)-3-[bis(4-hydroxyphenyl)methylidene]cyclohexyl}propanedioate | 5e1c | 99.25 |
| 48 | ese | Crystal Structure of the Estrogen Receptor alpha Ligand-binding Domain in Complex with an A-CD ring estrogen derivative | 4pps | 99.24 |
| 49 | 5cq | Crystal Structure of the ER-alpha Ligand-binding Domain in complex with an methyl-substituted A-CD ring estrogen derivative (1S,3aR,5S,7aS)-5-(4-hydroxy-2-methylphenyl)-7a-methyloctahydro-1H-inden-1-ol | 5di7 | 99.17 |
| 50 | 5cc | Crystal Structure of the ER-alpha Ligand-binding Domain in complex with a phenylamino-substituted ethyl triaryl-ethylene derivative 4,4'-{2-[3-(phenylamino)phenyl]but-1-ene-1,1-diyl}diphenol | 5dk9 | 99.15 |
| 51 | 5hx | Crystal Structure of the ER-alpha Ligand-binding Domain in Complex with the Cyclofenil Derivative 4-[(E)-(1s,5s)-bicyclo[3.3.1]non-9-ylidene(phenyl)methyl]phenol | 5dxp | 99.14 |
| 52 | 5fy | Crystal Structure of the ER-alpha Ligand-binding Domain in Complex with a para-Hydroxyl-substituted, Sulfoxide-bridged Oxabicyclic Heptene Sulfonate (SOBHS)-2 Analog 4-hydroxyphenyl (1S,2S,4S,5S,6R,7S)-5,6-bis(4-hydroxy-2-methylphenyl)-7-thiabicyclo[2.2.1]heptane-2-sulfonate 7-oxide | 5due | 99.12 |
| 53 | 36j | Crystal structure of hERa-LBD (Y537S) in complex with alpha-zearalenol | 4tuz | 99.11 |
| 54 | 27g | Crystal structure of hERa-LBD (Y537S) in complex with benzylbutylphtalate | 4mg6 | 99 |
| 55 | est | Stapled Peptides binding to Estrogen Receptor alpha. | 2yja | 98.93 |
| 56 | 7g1 | Crystal Structure of the ER-alpha Ligand-binding Domain (Y537S) in Complex with the Spiro BC-estradiol, (1S,1'S,3a'S,7a'S)-7a'-methyl-1',2,2',3,3',3a',4',6',7',7a'-decahydro-1,5'-spirobi[indene]-1',5-diol | 5tn6 | 98.92 |
| 57 | est | Estrogen Receptor Alpha Ligand Binding Domain Y537S Mutant in Complex with Stapled Peptide SRC2-P5 | 5dxg | 98.9 |
| 58 | 5k7 | Crystal Structure of the ER-alpha Ligand-binding Domain in Complex with the Cyclofenil Derivative methyl {4-[bis(4-hydroxyphenyl)methylidene]cyclohexyl}acetate | 5e19 | 98.89 |
| 59 | gen | Crystal Structure of the Estrogen Receptor Alpha Ligand Binding Domain Mutant 537S Complexed with Genistein | 2qa8 | 98.89 |
| 60 | est | Estrogen Receptor Alpha Ligand Binding Domain Y537S Mutant in Complex with Stapled Peptide SRC2-P1 and Estradiol | 5dxb | 98.89 |
| 61 | 5kd | Crystal Structure of the ER-alpha Ligand-binding Domain in Complex with the Cyclofenil Derivative 4,4'-{[(3S)-3-(4-methoxyphenyl)cyclohexylidene]methanediyl}diphenol | 5e0x | 98.89 |
| 62 | est | Estrogen Receptor Alpha Ligand Binding Domain Y537S Mutant in Complex with Stapled Peptide SRC2-P4 and Estradiol | 5dxe | 98.89 |
| 63 | iog | Human estrogen receptor alpha ligand-binding domain in complex with compound 11F | 2iog | 98.86 |
| 64 | ezt | Crystal structure of the ER alpha ligand binding domain with the agonist ortho-trifluoromethylphenylvinyl estradiol | 2p15 | 98.86 |
| 65 | 5cj | Crystal Structure of the ER-alpha Ligand-binding Domain in complex with a trifluoro-substituted A-CD ring estrogen derivative (1S,3aR,5S,7aS)-7a-methyl-5-(2,3,5-trifluoro-4-hydroxyphenyl)octahydro-1H-inden-1-ol | 5die | 98.84 |
| 66 | 5ce | Crystal Structure of the ER-alpha Ligand-binding Domain in complex with a trifluoromethyl-substituted A-CD ring estrogen derivative (1S,3aR,5S,7aS)-5-[4-hydroxy-2-(trifluoromethyl)phenyl]-7a-methyloctahydro-1H-inden-1-ol | 5dig | 98.79 |
| 67 | est | Estrogen Receptor Alpha Ligand Binding Domain Y537S Mutant in Complex with Stapled Peptide SRC2-SP2 and Estradiol | 5hyr | 98.79 |
| 68 | 7fr | Crystal Structure of the ER-alpha Ligand-binding Domain (Y537S) in Complex with the estradiol derivative, (8S,9S,13S,14S,E)-17-((4-isopropylphenyl)imino)-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-3-ol | 5tn1 | 98.78 |
| 69 | 6ww | Crystal Structure of the ER-alpha Ligand-binding Domain (Y537S) in Complex with the Methyl(phenyl)amino-substituted Estrogen, (8R,9S,13S,14S,17S)-13-methyl-17-(methyl(phenyl)amino)-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-3-ol | 5kro | 98.77 |
| 70 | est | Crystal structure of estrogen receptor alpha in complex with a stabilized peptide antagonist | 5gs4 | 98.7 |
| 71 | drq | Human estrogen receptor alpha ligand-binding domain in complex with 2-(but-1-enyl)-17beta-estradiol and a glucocorticoid receptor interacting protein 1 NR BOX II Peptide | 2g5o | 98.67 |
| 72 | est | Estrogen Receptor Alpha Ligand Binding Domain Y537S Mutant in Complex with SRC2 Stapled Peptide 41A and Estradiol | 6pit | 98.65 |
| 73 | 7ee | Crystal Structure of the ER-alpha Ligand-binding Domain (Y537S) in Complex with the PEG-linked Dimeric Estrogen, EE2-(eg)6-EE2-amine | 5tlu | 98.64 |
| 74 | j2z | Crystal structure of human Estrogen Receptor Alpha Ligand-Binding Domain in complex with a Glucocorticoid Receptor Interacting Protein 1 Nr Box II Peptide and 16-alpha-hydroxy-estrone ((8S,9R,13S,14R,16R)-3,16-dihydroxy-13-methyl-7,8,9,11,12,14,15, 16-octahydro-6H-cyclopenta[a]phenanthren-17-one | 3hlv | 98.61 |
| 75 | 4oh | Crystal Structure of human Estrogen Receptor alpha Ligand-Binding Domain in complex with a Glucocorticoid Receptor Interacting Protein 1 Nr Box II peptide and Estetrol (Estra-1,3,5(10)-triene-3,15 alpha,16alpha,17beta-tetrol) | 3l03 | 98.61 |
| 76 | est | CRYSTAL STRUCTURE OF A WILD TYPE HER ALPHA LBD AT 2.9 ANGSTROM RESOLUTION | 1g50 | 98.56 |
| 77 | 7fj | Crystal Structure of the ER-alpha Ligand-binding Domain (Y537S) in Complex with 4,4'-((1,3-dihydro-2H-inden-2-ylidene)methylene)diphenol | 5tmt | 98.56 |
| 78 | 17m | Human estrogen receptor alpha ligand-binding domain in complex with 17methyl-17alpha-dihydroequilenin and a glucoc interacting protein 1 NR box II peptide | 2b1z | 98.55 |
| 79 | est | Estrogen Receptor Alpha Ligand Binding Domain in Complex with Estradiol and SRC2-LP1 | 5wgd | 98.53 |
| 80 | 1hp | Crystal Structure of the Estrogen Receptor Alpha Ligand Binding Domain complexed with Burned Meat Compound 4-OH-PhIP | 2qse | 98.5 |
| 81 | gen | CRYSTAL STRUCTURE OF ESTROGEN RECEPTOR ALPHA COMPLEXED WITH GENISTEIN | 1x7r | 98.41 |
| 82 | 7g0 | Crystal Structure of the ER-alpha Ligand-binding Domain (Y537S) in Complex with the AC-ring estrogen, (1S,3aS,5S,7aS)-5-(4-hydroxyphenyl)-7a-methyloctahydro-1H-inden-1-ol | 5tn5 | 98.39 |
| 83 | 7e1 | Crystal Structure of the ER-alpha Ligand-binding Domain (Y537S) in Complex with the OBHS-ASC compound, (E)-6-(4-((1R,4S,6R)-6-((3-chlorophenoxy)sulfonyl)-3-(4-hydroxyphenyl)-7-oxabicyclo[2.2.1]hept-2-en-2-yl)phenyl)hex-5-enoic acid | 5tml | 98.36 |
| 84 | g9j | Crystal structure of 8-hydroxychromene compound 30 bound to estrogen receptor alpha | 6pet | 98.31 |
| 85 | est | The Estrogen Receptor Alpha Ligand Binding Domain D538G Mutant in Complex with Estradiol and a glucocorticoid receptor-interacting protein 1 NR box II peptide | 4pxm | 98.3 |
| 86 | est | Estrogen Receptor Alpha Ligand Binding Domain Y537S Mutant in Complex with Estradiol and GRIP Peptide | 6cbz | 98.29 |
| 87 | est | Estrogen Receptor Alpha Ligand Binding Domain Y537S Mutant in Complex with Stapled Peptide SRC2-P3 and Estradiol | 5dx3 | 98.28 |
| 88 | est | Helix-stabilized cyclic peptides as selective inhibitors of steroid receptor-coactivator interactions | 1pcg | 98.26 |
| 89 | est | Estrogen Receptor Alpha Ligand Binding Domain in Complex with Estradiol and SRC2-BCP1 | 5wgq | 98.25 |
| 90 | 7fq | Crystal Structure of the ER-alpha Ligand-binding Domain (Y537S) in Complex with the estradiol derivative, (8S,9S,13S,14S,17S)-16-(3-methoxybenzyl)-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene-3,17-diol | 5tmz | 98.25 |
| 91 | esl | Crystal structure of human estrogen receptor alpha LBD in complex with GRIP peptide and estriol | 3q95 | 98.24 |
| 92 | 7fz | Crystal Structure of the ER-alpha Ligand-binding Domain (Y537S) in Complex with the ACD-ring estrogen, (S)-5-(4-hydroxy-3,5-dimethylphenyl)-2,3-dihydro-1H-inden-1-ol | 5tn4 | 98.23 |
| 93 | 5k5 | Crystal Structure of the ER-alpha Ligand-binding Domain in Complex with the Cyclofenil Derivative 4,4'-[(4aR,8aR)-octahydronaphthalen-2(1H)-ylidenemethanediyl]diphenol | 5ehj | 98.23 |
| 94 | jj3 | Estrogen receptor alpha ligand-binding domain in complex with a benzopyran agonist | 2qe4 | 98.18 |
| 95 | dc8 | Estrogen receptor alpha ligand-binding domain complxed to a benzopyran ligand | 2q70 | 98.17 |
| 96 | iok | Human estrogen receptor alpha ligand-binding domain in complex with compound 1D | 2iok | 98.16 |
| 97 | 7qn | Selective estrogen receptor downregulator antagonists: Tetrahydroisoquinoline phenols 4. | 5fqt | 98.14 |
| 98 | vqi | Selective estrogen receptor downregulator antagonists: Tetrahydroisoquinoline phenols 5. | 5fqv | 98.12 |
| 99 | i0g | Benzopyrans are Selective Estrogen Receptor beta Agonists (SERBAs) with Novel Activity in Models of Benign Prostatic Hyperplasia | 2i0j | 98.07 |
| 100 | est | Crystal structure of hERa-LBD (Y537S) in complex with estradiol | 3uud | 98.06 |
| 101 | c6v | ESTROGEN RECEPTOR ALPHA LIGAND BINDING DOMAIN IN COMPLEX WITH LSZ102 | 6b0f | 97.98 |
| 102 | est | ESTROGEN RECEPTOR ALPHA LIGAND-BINDING DOMAIN COMPLEXED TO ESTRADIOL | 1a52 | 97.97 |
| 103 | 6wv | Crystal Structure of the ER-alpha Ligand-binding Domain (Y537S) in Complex with the phenylamino-substituted estrogen, (8R,9S,13S,14S,17S)-13-methyl-17-(phenylamino)-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-3-ol, without a coactivator peptide | 5u2b | 97.95 |
| 104 | j0w | Selective estrogen receptor downregulator antagonists: Tetrahydroisoquinoline phenols 3. | 5fqs | 97.88 |
| 105 | h8w | Tricyclic indazoles a novel class of selective estrogen receptor degrader antagonists | 6iar | 97.86 |
| 106 | est | HUMAN OESTROGEN RECEPTOR ALPHA LIGAND-BINDING DOMAIN IN COMPLEX WITH 17BETA-OESTRADIOL AND TIF2 NRBOX3 PEPTIDE | 1gwr | 97.81 |
| 107 | l4g | A SERM Designed for the Treatment of Uterine Leiomyoma with Unique Tissue Specificity for Uterus and Ovaries in Rats | 2ayr | 97.8 |
| 108 | 6wn | Crystal Structure of the ER-alpha Ligand-binding Domain (Y537S) in Complex with 16-benzylidene estrone | 5krh | 97.75 |
| 109 | cm4 | Human estrogen receptor alpha ligand-binding domain in complex with compound 4 | 1yim | 97.74 |
| 110 | 5dg | Crystal Structure of the ER-alpha Ligand-binding Domain in complex with a 4-fluorophenylamino-substituted, methyl triaryl-ethylene derivative 4,4'-(2-{3-[(4-fluorophenyl)amino]phenyl}prop-1-ene-1,1-diyl)diphenol | 5dmf | 97.71 |
| 111 | qso | Crystal structure of hERa-LBD (Y537S) in complex with biochanin A | 5jmm | 97.7 |
| 112 | 7fd | Crystal Structure of the ER-alpha Ligand-binding Domain (Y537S) in Complex with the Cyclofenil-ASC derivative, ethyl (E)-3-(4-(cyclohexylidene(4-hydroxyphenyl)methyl)phenyl)acrylate | 5tmr | 97.69 |
| 113 | gqd | Selective estrogen receptor downregulator antagonists: Tetrahydroisoquinoline phenols 1. | 5fqp | 97.52 |
| 114 | aiu | HUMAN ESTROGEN RECEPTOR ALPHA LIGAND-BINDING DOMAIN IN COMPLEX WITH COMPOUND 16 | 1xp6 | 97.5 |
| 115 | 27m | Crystal structure of hERa-LBD (Y537S) in complex with benzophenone-2 | 4mgc | 97.38 |
| 116 | 6wm | Crystal Structure of the ER-alpha Ligand-binding Domain (Y537S) in Complex with 16b-benzyl 17b-estradiol | 5kri | 97.26 |
| 117 | aih | HUMAN ESTROGEN RECEPTOR ALPHA LIGAND-BINDING DOMAIN IN COMPLEX WITH COMPOUND 15 | 1xp1 | 97.19 |
| 118 | oht | Estrogen Receptor Alpha Ligand Binding Domain C381S, C417S, C530S in Complex with 4-hydroxytamoxifen | 5w9c | 97.17 |
| 119 | aij | HUMAN ESTROGEN RECEPTOR ALPHA LIGAND-BINDING DOMAIN IN COMPLEX WITH COMPOUND 18 | 1xp9 | 97.17 |
| 120 | 6wv | Crystal Structure of the ER-alpha Ligand-binding Domain (Y537S) in Complex with the phenylamino-substituted estrogen, (8R,9S,13S,14S,17S)-13-methyl-17-(phenylamino)-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-3-ol | 5tld | 97.11 |
| 121 | est | MUTANT ESTROGEN NUCLEAR RECEPTOR LIGAND BINDING DOMAIN COMPLEXED WITH ESTRADIOL | 1qkt | 97.09 |
| 122 | ait | HUMAN ESTROGEN RECEPTOR ALPHA LIGAND-BINDING DOMAIN IN COMPLEX WITH COMPOUND 19 | 1xpc | 96.91 |
| 123 | gw5 | Human Estrogen Receptor alpha Ligand-Binding Domain In Complex With GW5638 | 1r5k | 96.74 |
| 124 | 7fp | Crystal Structure of the ER-alpha Ligand-binding Domain (Y537S) in Complex with the OBHS derivative, 4-acetamidophenyl (1S,2R,4S)-5,6-bis(4-hydroxyphenyl)-7-oxabicyclo[2.2.1]hept-5-ene-2-sulfonate | 5tmw | 96.73 |
| 125 | 7ee | Crystal Structure of the ER-alpha Ligand-binding Domain (Y537S) in Complex with a Squaric Acid-linked Dimeric Estrogen | 5tlo | 96.35 |
| 126 | 5c9 | Crystal Structure of the ER-alpha Ligand-binding Domain in complex with a 3-methylphenylamino-substituted ethyl triaryl-ethylene derivative 4,4'-(2-{3-[(3-methylphenyl)amino]phenyl}but-1-ene-1,1-diyl)diphenol | 5dkb | 96.24 |
| 127 | gw5 | Optimization of a novel binding motif to to (E)-3-(3,5-difluoro-4-((1R,3R)-2-(2-fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro-1H- pyrido(3,4-b)indol-1-yl)phenyl)acrylic acid (AZD9496), a potent and orally bioavailable selective estrogen receptor downregulator and antagonist | 5aav | 96.12 |
| 128 | fys | Estrogen Receptor Alpha Ligand Binding Domain Y537S Mutant in Complex with 3OHTPE and GRIP Peptide | 6d0f | 95.86 |
| 129 | ral | Crystal Structure of Antagonizing Mutant 536S of the Estrogen Receptor Alpha Ligand Binding Domain Complexed to Raloxifene | 2qxs | 95.84 |
| 130 | 85z | Oxyphenylpropenoic acids as Oral Selective Estrogen Receptor Down- Regulators. | 5ak2 | 95.71 |
| 131 | 5ka | Crystal Structure of the ER-alpha Ligand-binding Domain in Complex with the Cyclofenil Derivative 4,4'-{[4-(2-hydroxyethyl)cyclohexylidene]methanediyl}diphenol | 5e15 | 95.6 |
| 132 | 85m | Estrogen Receptor Alpha Ligand Binding Domain in Complex with OP1156 | 6c42 | 95.37 |
| 133 | 86y | Estrogen Receptor Alpha Ligand Binding Domain in Complex with OP1074 | 5ufx | 94.97 |
| 134 | ke9 | A Novel Oral Selective Estrogen Receptor Down-regulator, AZD9496, drives Tumour Growth Inhibition in Estrogen Receptor positive and ESR1 Mutant Models | 5acc | 94.71 |
| 135 | 86v | Estrogen Receptor Alpha Ligand Binding Domain in Complex with OP1154 | 5ufw | 94.49 |
| 136 | 369 | Human Estrogen receptor alpha LBD with GW368 | 3dt3 | 94.4 |
| 137 | qhg | Selective estrogen receptor downregulator antagonists: Tetrahydroisoquinoline phenols 2. | 5fqr | 94.33 |
| 138 | nd1 | Mutant estrogen receptor alpha (ERa) Y537S covalently bound to H3B-6545. | 6owc | 93.91 |
| 139 | lrq | ERa_L536S (L536S/C381S/C471S,C530S) in complex with a bridged tetracyclic indole (compound 8) | 6sq0 | 93.54 |
| 140 | 29s | Estrogen Receptor Alpha Ligand Binding Domain in Complex with Bazedoxifene | 4xi3 | 93.35 |
| 141 | e4d | Human Estrogen Receptor Alpha Ligand-binding Domain in Complex with the Antagonist Ligand 4-D | 1sj0 | 93.01 |
| 142 | aej | X-ray structure of ERalpha LBD bound to a tetrahydroisoquinoline SERM ligand at 2.05A resolution | 1xqc | 92.97 |
| 143 | f3d | Estrogen Receptor Alpha Y537S covalently bound to antagonist H3B-5942. | 6chw | 92.96 |
| 144 | g8y | Crystal structure of estrogen receptor alpha in complex with receptor degrader 16ab | 6df6 | 92.94 |
| 145 | 7eb | Crystal Structure of the ER-alpha Ligand-binding Domain (L372S,L536S) in Complex with the OBHS-BSC, 4-bromophenyl (1R,2R,4S)-6-(4-(2-(dimethylamino)ethoxy)phenyl)-5-(4-hydroxyphenyl)-7-oxabicyclo[2.2.1]hept-5-ene-2-sulfonate | 5tnb | 91.11 |
| 146 | c3d | Crystal Structure of Estrogen Receptor alpha-lasofoxifene complex | 2ouz | 90.97 |
| 147 | cm3 | Human estrogen receptor alpha ligand-binding domain in complex with compound 3F | 1yin | 90.46 |
| 148 | ral | HUMAN ESTROGEN RECEPTOR LIGAND-BINDING DOMAIN IN COMPLEX WITH RALOXIFENE | 1err | 90.38 |
| 149 | lvh | ERa_L536S (L536S/C381S/C471S,C530S) in complex with a tricyclic indole (compound 6) | 6suo | 90.08 |
| 150 | llc | Estrogen receptor alpha ligand-binding domain in complex with a SERM | 2r6y | 89.45 |
| 151 | pti | The Structure of Estrogen Receptor in Complex with a Selective and Potent Tetrahydroisochiolin Ligand. | 1uom | 89.4 |
| 152 | 782 | ESTROGEN RECEPTOR ALPHA LIGAND BINDING DOMAIN IN COMPLEX WITH (2E)-3-(4-{(1R)-6-hydroxy-1-methyl-2-[4-(propan-2 -yl)phenyl]-1,2,3,4- tetrahydroisoquinolin-1-yl}phenyl)prop-2-enoic acid | 5t97 | 89.17 |
| 153 | 77w | ESTROGEN RECEPTOR ALPHA LIGAND BINDING DOMAIN IN COMPLEX WITH (2E)-3-{4-[(1R)-2-(4-fluorophenyl)-6-hydroxy-1-methy l-1,2,3,4- tetrahydroisoquinolin-1-yl]phenyl}prop-2-enoic acid | 5t92 | 88.76 |
| 154 | llb | Estrogen receptor alpha ligand-binding domain complexed to a SERM | 2r6w | 88.73 |
| 155 | ody | Crystal structure of 8-hydroxychromene compound 30 bound to estrogen receptor alpha | 6pet | 88.56 |
| 156 | oht | ESTROGEN RECEPTOR ALPHA LBD IN COMPLEX WITH A PHAGE-DISPLAY DERIVED PEPTIDE ANTAGONIST | 2bj4 | 87.3 |
| 157 | oht | HUMAN ESTROGEN RECEPTOR ALPHA LIGAND-BINDING DOMAIN IN COMPLEX WITH 4-HYDROXYTAMOXIFEN | 3ert | 84.76 |
| 158 | ogj | Crystal structure of GDC-0927 bound to estrogen receptor alpha | 6pfm | 83.99 |
| 159 | 7et | Crystal Structure of the ER-alpha Ligand-binding Domain (Y537S) in Complex with the OBHS-BSC Analog, 3-fluorophenyl (1R,2R,4S)-5-(4-hydroxyphenyl)-6-(4-(2-(piperidin-1-yl)ethoxy)phenyl)-7-oxabicyclo[2.2.1]hept-5-ene-2-sulfonate and 3-methyl-6-phenyl-3H-imidazo[4,5-b]pyridin-2-amine | 5tlp | 83.86 |
| 160 | g91 | Crystal structure of estrogen receptor alpha in complex with receptor degrader 16aa | 6dfn | 82.23 |
| 161 | f3d | Estrogen Receptor Alpha Y537S bound to antagonist H3B-9224. | 6chz | 79.13 |