The Ligandable Human Proteome

Peroxisome proliferator-activated receptor gamma

Nuclear hormone receptor, ligand-binding domain

Index	Ligand Name	Structure	PDB code	ligand desolvation
1	imn	Human PPARgamma ligand-binding domain in complex with indomethacin and nitro-233	3adx	99.71
2	imn	PPARgamma ligand binding domain in complex with indomethacin	4xum	98.94
3	edk	PPAR gamma mutant complex	6fzj	98.58
4	edk	PPAR mutant complex	6fzf	98.12
5	ctu	Crystal Structure of PPARgamma Ligand Binding Domain in complex with dibenzooxepine derivative compound-17	6k0t	98.01
6	edk	Crystal structure of PPAR gamma in complex with Mediator of RNA polymerase II transcription subunit 1	6d94	97.57
7	edk	PPAR gamma LBD complexed with the agonist GW1929	6d8x	97.29
8	edk	PPAR gamma mutant complex	6fzg	97.27
9	8a7	Crystal Structure of Human PPARgamma Ligand Binding Domain in Complex with Edaglitazone	5ugm	97.06
10	kk4	Crystal Structure of PPARgamma Ligand Binding Domain in complex with dibenzooxepine derivative compound-9	6ad9	97.03
11	eey	Crystal Structure of Human PPARgamma Ligand Binding Domain in Complex with T0070907	6c1i	97.01
12	edk	PPAR gamma complex	6fzp	96.9
13	544	The 2.3 Angstrom resolution crystal structure of the heterodimer of the human PPARgamma and RXRalpha ligand binding domains respectively bound with GW409544 and 9-cis retinoic acid and co-activator peptides.	1k74	96.52
14	m0t	Ligand binding domain of PPARgamma complexed with a benzimidazole partial agonist	3s9s	96.31
15	7mv	Peroxisome proliferator-activated receptor gamma ligand binding domain in complex with a novel selectively PPAR gamma-modulating ligand VSP-51	5two	96.02
16	ro0	A novel anti-adipogenic partial agonist of peroxisome proliferator-activated receptor-gamma (PPARG) recruits pparg-coactivator-1 alpha (PGC1A) but potentiates insulin signaling in vitro	2fvj	95.98
17	brl	Crystal Structure of Human PPARgamma Ligand Binding Domain in Complex with Rosiglitazone and Oleic acid	6md4	95.8
18	tls	Crystal Structure of PPARgamma complexed with Telmisartan	3vn2	95.59
19	drj	Crystal structure of the complex between PPARgamma and the agonist LT160 (ureidofibrate derivative)	2i4j	95.37
20	c01	Crystal Structure of Human PPAR-gamma Ligand Binding Domain Complexed with an Alpha-Aryloxyphenylacetic Acid Agonist	1zeo	95.34
21	drh	Crystal structure of the complex between PPARgamma and the partial agonist LT127 (ureidofibrate derivative). This structure has been obtained from crystals soaked for 6 hours.	2i4z	95.22
22	2pq	Crystal Structure of Human PPAR-gamma Ligand Binding Domain Complexed with a Potent and Selective Agonist	3gbk	95.19
23	5bc	Crystal structure of human PPAR-gamma ligand binding domain complex with a potency improved agonist	3noa	95.17
24	3e7	Crystal Structure of SR2067 bound to PPARgamma	4r06	95
25	nsi	Crystal Structure of PPAR Gamma with N-sulfonyl-2-indole carboxamide ligands	2hfp	94.87
26	a0l	Crystal structure of PPARgamma with compound BR102375K	6icj	94.8
27	brl	Crystal Structure of the complex between PPARgamma mutant R357A and rosiglitazone	4o8f	94.79
28	240	Crystal Structure of PPARgamma LBD bound to full agonist MRL20	2q59	94.51
29	486	Revealing a steroid receptor ligand as a unique PPARgamma agonist	3qt0	94.23
30	rrg	Crystal Structure of PPARgamma with the ligand JO21	4e4k	94.21
31	538	The X-ray Crystal Structure of PPAR-gamma in Complex with an Indole Derivative Modulator, GSK538, and an SRC-1 Peptide	3kmg	94.12
32	brl	PPARgamma-RXRalpha(S427F) heterodimer in complex with SRC-1, rosiglitazone, and 9-cis-retanoic acid	5ji0	94.05
33	570	THE 2.1 ANGSTROM RESOLUTION CRYSTAL STRUCTURE OF THE HETERODIMER OF THE HUMAN RXRALPHA AND PPARGAMMA LIGAND BINDING DOMAINS RESPECTIVELY BOUND WITH 9-CIS RETINOIC ACID AND GI262570 AND CO-ACTIVATOR PEPTIDES.	1fm9	93.99
34	zaa	X-ray crystal structure of human ppar gamma with 2-(5-(3-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)benzyl)-2-phenyl-2h-1,2,3-triazol-4-yl)acetic acid	3bc5	93.76
35	gfv	Crystal Structure of Human PPARgamma Ligand Binding Domain in Complex with Hydroxy Pioglitazone (M-IV)	6dha	93.75
36	yrg	Crystal structure of PPAR-gamma LBD complexed with a partial agonist, analogue of clofibric acid	3cdp	93.49
37	brl	Human peroxisome proliferator-activated receptor gamma in complex with rosiglitazone	4ema	93.29
38	gw4	PPARgamma Ligand binding domain complexed with a farglitazar analogue gw4709	2pob	93.17
39	ypa	LIGAND BINDING DOMAIN OF THE HUMAN PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA IN COMPLEX WITH A SYNTHETIC AGONIST	1knu	92.93
40	a9f	Human PPARgamma ligand binding domain complexed with SB1494	6ijs	92.91
41	570	Crystal Structure of a new rexinoid bound to the RXRalpha ligand binding doamin in the RXRalpha/PPARgamma heterodimer	1rdt	92.89
42	brl	Structural and Biochemical Basis for Selective Repression of the Orphan Nuclear Receptor LRH-1 by SHP	1zgy	92.81
43	brl	THE 2.1 ANGSTROM RESOLUTION CRYSTAL STRUCTURE OF THE HETERODIMER OF THE HUMAN RXRALPHA AND PPARGAMMA LIGAND BINDING DOMAINS RESPECTIVELY BOUND WITH 9-CIS RETINOIC ACID AND ROSIGLITAZONE AND CO-ACTIVATOR PEPTIDES.	1fm6	92.75
44	eha	Crystal structure of the ligand binding domain of human PPAR-gamma in complex with an agonist	2f4b	92.61
45	ek1	Human PPAR gamma ligand binding domain in complex with a gamma selective agonist mekt21	3vso	92.6
46	gh1	Crystal Structure of Human PPARgamma Ligand Binding Domain in Complex with MSDC-0602	6dh9	92.44
47	xcx	Crystal Structure of PPARgamma with an achiral ureidofibrate derivative (RT86)	3r8i	92.32
48	drf	Ligand binding domain of the human peroxisome proliferator activated receptor gamma in complex with an agonist	1nyx	92.3
49	brl	Human PPARgamma ligand binding domain complexed with Rosiglitazone	5ycp	92.19
50	3ea	Crystal structure of the ligand binding domain of human PPAR-gamma im complex with an agonist	2ath	92.18
51	bxg	Crystal Structure of Human PPARgamma Ligand Binding Domain in Complex with SR16832	6aug	92.1
52	drh	Crystal structure of the complex between PPARgamma and the partial agonist LT127 (ureidofibrate derivative). Structure obtained from crystals of the apo-form soaked for 30 days.	2i4p	91.98
53	gev	Crystal Structure of Human PPARgamma Ligand Binding Domain in Complex with Darglitazone	6dgl	91.95
54	ft7	PPARg LBD in Complex with SR1988	6d3e	91.72
55	ek8	Human PPAR gamma ligand binding domain in complex with a gamma selective agonist mekt28	3vsp	91.47
56	8lx	Structure of PPARgamma ligand binding domain - lobeglitazone complex	5y2t	91.46
57	brl	Crystal structure of the human PPARg-LBD/rosiglitazone complex obtained by dry co-crystallization and in situ diffraction	4xld	91.46
58	drd	Structural basis for the structure-activity relationships of Peroxisome Proliferator-Activated Receptor agonists	2hwr	91.3
59	eks	PPARg LBD bound to SR10171	6c5q	91.27
60	brl	Structural and Biochemical Basis for the Binding Selectivity of PPARg to PGC-1a	3cs8	91
61	8n6	Structure of PPARgamma ligand binding domain-pioglitazone complex	5y2o	90.9
62	t53	Human PPARgamma ligand binding dmain complexed with SB1453 in a covalent bonded form	5dvc	90.76
63	p1b	LIGAND BINDING DOMAIN OF HUMAN PPAR-GAMMA IN COMPLEX WITH THE AGONIST PIOGLITAZONE	2xkw	90.12
64	ctm	Design and biological evaluation of novel, balanced dual PPARa/g agonists	3fej	90.07
65	brl	LIGAND-BINDING DOMAIN OF THE HUMAN PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA	2prg	90.01
66	v77	Peroxisome proliferator-activated receptor gamma ligand binding domain in complex with a novel selective PPAR-gamma modulator VSP-77	6ms7	89.99
67	24l	Crystal structure of the PPARgamma-LBD complexed with a cercosporamide derivative modulator	3v9y	89.94
68	unt	X-ray Crystal structure of the nuclear hormone receptor PPAR-gamma in a complex with a PPAR gamma/alpha dual agonist	3ia6	89.63
69	ae0	Crystal structure of PPARgamma with compound BR101549	6ilq	89.61
70	3jx	Crystal Structure of PPARgamma in complex with SR1664	4r2u	89.25
71	az2	CRYSTAL STRUCTURE OF THE LIGAND BINDING DOMAIN OF HUMAN PPAR-GAMMA IN COMPLEX WITH THE AGONIST AZ 242	1i7i	89.03
72	208	Structure-based Design of Indole Propionic Acids as Novel PPARag CO-Agonists	2gtk	88.79
73	m7r	Human PPAR gamma ligand binding domain in complex with a gamma selective agonist MO4R	3an4	88.61
74	l92	X-ray Crystal structure of the nuclear hormone receptor PPAR-gamma in a complex with a PPAR gamma/alpha dual agonist	2q8s	88.51
75	7va	X-ray Crystal Structure of the PPARgamma Ligand Binding Domain in Complex with Rivoglitazone	5u5l	88.47
76	dry	Structural basis for the structure-activity relationships of Peroxisome Proliferator-Activated Receptor agonists	2hwq	88.17
77	8lx	Human PPARgamma ligand binding domain complexed with Lobeglitazone	5ycn	88.14
78	ro7	Aleglitaar. a new. potent, and balanced dual ppara/g agonist for the treatment of type II diabetes	3g9e	87.94
79	m7s	Human PPAR gamma ligand binding domain in complex with a gamma selective agonist MO3S	3an3	87.1
80	j53	Human PPAR gamma ligand binding domain in complex with JKPL53	3vji	87
81	3k2	Crystal structure of PPARgammma in complex with SR1663	4r6s	86.95
82	t51	Human PPARgamma ligand binding dmain complexed with SB1451 in a covalent bonded form	5dv8	86.79
83	s44	Human PPAR gamma ligand binding domain in complex with a synthetic agonist TIPP703	2zno	86.78
84	j35	Human PPAR GAMMA ligand binding domain in complex with JKPL35	3vjh	86.45
85	gbv	Crystal Structure of Human PPARgamma Ligand Binding Domain in Complex with CAY10506	6dgq	86.28
86	14r	Crystal structure of PPARgamma in complex with compound 13	4hee	85.25
87	imn	Human PPARgamma ligand-binding domain in complex with indomethacin	3ads	80.7
88	sfi	PPARgamma ligand binding domain in complex with sulindac sulfide	4xuh	79.39