The Ligandable Human Proteome

Nuclear receptor ROR-gamma

Nuclear hormone receptor, ligand-binding domain

Index	Ligand Name	Structure	PDB code	ligand desolvation
1	4y6	Identification of a Novel Allosteric Binding Site for RORgt Inhibitors	5c4t	99.87
2	4y5	Identification of a Novel Allosteric Binding Site for RORgt Inhibitors	5c4s	99.78
3	4y7	Identification of a Novel Allosteric Binding Site for RORgt Inhibitors	5c4u	99.78
4	39k	Crystal structure of RORc in complex with a tertiary sulfonamide inverse agonist	4qm0	99.18
5	3sx	Crystal structure of RORc in complex with a benzyl sulfonamide inverse agonist	4wqp	98.84
6	l7p	RORgamma Ligand Binding Domain	6nwt	98.4
7	l8a	Crystal structure of RAR-related orphan receptor C in complex with a phenyl (3-phenylpyrrolidin-3-yl)sulfone inhibitor	6o98	97.93
8	92a	X-ray co-structure of nuclear receptor ROR-gammat Ligand Binding Domain with an inverse agonist and SRC2 peptide	5vb5	97.49
9	vyi	Ligand complex of RORg LBD	5aph	97.31
10	98n	Structural states of RORgt: X-ray elucidation of molecular mechanisms and binding interactions for natural and synthetic compounds	5ntw	96.53
11	c3s	Structural states of RORgt: X-ray elucidation of molecular mechanisms and binding interactions for natural and synthetic compounds	5nti	96.3
12	4cz	Crystal structure of RORgamma complexed with SRC2 and compound 5d	5yp5	96.1
13	79u	Discovery of phenoxyindazoles and phenylthioindazoles as RORg inverse agonists	5lwp	96.04
14	hc9	Crystal structure of orphan nuclear receptor RORgamma in complex with natural ligand	3l0j	95.98
15	hbw	Crystal structure of human ROR gamma LBD in complex with a quinoline sulfonamide inverse agonist	6q2w	95.96
16	hc2	Crystal structure of orphan nuclear receptor RORgamma in complex with natural ligand	3kyt	95.94
17	f7j	RORC2 LBD complexed with compound 34	6cn6	95.82
18	927	X-ray co-structure of nuclear receptor ROR-gammat Ligand Binding Domain with an inverse agonist and SRC2 peptide	5vb6	95.81
19	3qq	Crystal structure of RORc in complex with a partial inverse agonist compound	4wlb	95.63
20	f7m	HUMAN RETENOID-RELATED ORPHAN RECEPTOR-GAMMA LIGAND- BINDING DOMAIN IN COMPLEX WITH INDOLE LIGAND CP9b IN INVERSE AGONIST CONFORMATION	6cn5	95.48
21	8y2	Ligand complex of RORg LBD	5ni8	95.44
22	hc3	Crystal structure of orphan nuclear receptor RORgamma in complex with natural ligand	3l0l	95.35
23	8y5	Ligand complex of RORg LBD	5nib	95.3
24	q6y	Synthesis and biological evaluation of new triazolo and imidazolopyridine RORgt inverse agonists	5m96	95.29
25	921	X-ray co-structure of nuclear receptor ROR-gammat Ligand Binding Domain with an agonist and SRC2 peptide	5vb7	95.25
26	nbh	Crystal structure of the orphan nuclear receptor ROR(gamma)t ligand-binding domain in complex with small molecule ligand	4nie	94.9
27	b6l	Crystal Structure Analysis of the ROR gamma(C455E)	6j1l	94.62
28	98h	Structural states of RORgt: X-ray elucidation of molecular mechanisms and binding interactions for natural and synthetic compounds	5ntn	94.53
29	xgh	IDENTIFICATION OF BICYCLIC HEXAFLUOROISOPROPYL ALCOHOL SULFONAMIDES AS RORGT/RORC INVERSE AGONISTS	6bn6	94.31
30	cf7	Structure of RORgt in complex with a novel inverse agonist 3	6b33	94.08
31	l77	RORgamma Ligand Binding Domain	6nws	93.94
32	98e	Structural states of RORgt: X-ray elucidation of molecular mechanisms and binding interactions for natural and synthetic compounds	5ntp	93.85
33	76e	Ligand complex of RORg LBD	5apk	93.73
34	hoj	Structure of RORgt in complex with a novel agonist.	6e3g	93.48
35	zbd	X-ray co-structure of nuclear receptor ROR-GAMMAT + SRC2 peptide with a benzothiadiazole dioxide inverse agonist	4ymq	93.07
36	76e	Ligand complex of RORg LBD	5apj	92.59
37	6qp	Crystal structure of Retinoic acid receptor-related orphan receptor (ROR) gamma ligand binding domain complex with SBI0654919	5k6e	92.44
38	4p1	RORgamma in complex with inverse agonist 16	4zjw	90.28
39	4q3	RORgamma in complex with inverse agonist 4j.	4zom	90.08