The Ligandable Human Proteome

Carbonic anhydrase 2

Index	Ligand Name	Structure	PDB code	ligand desolvation
1	i7b	The crystal structure of the human carbonic anhydrase II in complex with 4-amino-6-chloro-benzene-1,3-disulfonamide	2pov	88.9
2	i7b	Human Carbonic Anhydrase II complexed with Althiazide	3l14	88.74
3	1go	structure of hCAII in complex with an acetazolamide derivative	4iwz	88.65
4	5du	Crystal structure of human carbonic anhydrase isozyme II with 2-[(1S)-2,3-Dihydro-1H-inden-1-ylamino]-3,5,6-trifluoro-4-[(2-hydroxyethyl)thio]benzenesulfonamide	5doh	87.13
5	i7c	The crystal structure of the human carbonic anhydrase II in complex with 4-amino-6-trifluoromethyl-benzene-1,3-disulfonamide	2pow	87.05
6	vz4	Human Carbonic Anhydrase II A65S, N67Q (CA IX mimic) bound with 2-Ethylestrone 3-O-sulfamate	3okv	86.54
7	1vq	The crystal structure of the human carbonic anhydrase II in complex with a nitroimidazole sulfamate inhibitor	5o07	86.15
8	2vq	The crystal structure of the human carbonic anhydrase II in complex with N-[2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl]sulfamide	4mo8	85.77
9	fc4	Human carbonic anhydrase II in complex with ligand	5j8z	84.96
10	e50	Crystal structure of human carbonic anhydrase isozyme II with 2-chloro-5-{[(5-ethyl-2-pyrimidinyl)sulfanyl]acetyl}benzenesulfonamide	3sax	84.85
11	fun	carbonic anhydrase II in complex with furosemide as sulfonamide inhibitor	1z9y	84.28
12	ets	Joint X-ray/neutron structure of human carbonic anhydrase II in complex with dorzolamide	6bc9	84.08
13	azm	Effect of Sucrose and Glycerol as Cryoprotectans, on the Inhibition of Human Carbonic Anhydrase II	3v2m	83.85
14	cox	Carbonic anhydrase inhibitors: Valdecoxib binds to a different active site region of the human isoform II as compared to the structurally related cyclooxygenase II ""selective"" inhibitor Celecoxib	2aw1	83.69
15	azm	STRUCTURAL BASIS OF INHIBITOR AFFINITY TO VARIANTS OF HUMAN CARBONIC ANHYDRASE II	1ydd	83.55
16	azm	Structure of HCAIX mimic (HCAII with 5 mutations in active site) in complex with acetazolamide	4k0s	83.54
17	azm	STRUCTURAL BASIS OF INHIBITOR AFFINITY TO VARIANTS OF HUMAN CARBONIC ANHYDRASE II	1yda	83.32
18	azm	CARBONIC ANHYDRASE II MUTANT E117Q, TRANSITION STATE ANALOGUE ACETAZOLAMIDE	1zsb	83.02
19	9eb	Carbonic Anhydrase II Inhibitor RA12	5ny6	83.01
20	75y	Human carboanhydrase F131C_C206S double mutant in complex with 14	5t74	82.55
21	dt9	Crystal structure of human carbonic anhydrase II with 6,7-Dimethoxy-1-methyl-3,4-dihydroisoquinoline-2(1H)-sulfonamide	3po6	82.07
22	pts	THE POSITIONS OF HIS-64 AND A BOUND WATER IN HUMAN CARBONIC ANHYDRASE II UPON BINDING THREE STRUCTURALLY RELATED INHIBITORS	1cim	81.91
23	azm	Use of Carbonic Anhydrase II, IX Active-Site Mimic, for the Purpose of Screening Inhibitors for Possible Anti-Cancer Properties	3dc3	81.48
24	azm	STRUCTURAL BASIS OF INHIBITOR AFFINITY TO VARIANTS OF HUMAN CARBONIC ANHYDRASE II	1ydb	81.28
25	5un	Human CAII bound to N-(4-sulfamoylphenyl)-2-(thiophen-2-yl) acetamide	3r16	81.08
26	enn	Crystal structure of human carbonic anhydrase isozyme II with N-butyl-2,4-dichloro-5-sulfamoyl-benzamide	6g6t	81.03
27	azm	Neutron structure of acetazolamide-bound human carbonic anhydrase II reveal molecular details of drug binding.	4g0c	80.83
28	azm	Effect of Sucrose and Glycerol as Cryoprotectans, on the Inhibition of Human Carbonic Anhydrase II	3v2j	80.76
29	al4	CARBONIC ANHYDRASE II INHIBITOR	1bnq	80.69
30	ets	Carbonic Anhydrase II in complex with Dorzolamide	4m2u	80.58
31	oe2	An unusual natural product primary sulfonamide: synthesis, carbonic anhydrase inhibition and protein x-ray structure of Psammaplin C	5g03	80.57
32	wzc	Structures of human carbonic anhydrase II inhibitor complexes reveal a second binding site for steroidal and non-steroidal inhibitors.	2x7s	80.51
33	mts	THE POSITIONS OF HIS-64 AND A BOUND WATER IN HUMAN CARBONIC ANHYDRASE II UPON BINDING THREE STRUCTURALLY RELATED INHIBITORS	1cin	80.2
34	j43	Crystal structure of human carbonic anhydrase isozyme II with 4-[N-(6-chloro-5-formyl-2-methylthiopyrimidin-4-yl)amino]benzenesulfonamide	3mho	80.13
35	ets	Genetically engineered Carbonic Anhydrase IX in complex with Dorzolamide	4m2w	80.09
36	ets	THE POSITIONS OF HIS-64 AND A BOUND WATER IN HUMAN CARBONIC ANHYDRASE II UPON BINDING THREE STRUCTURALLY RELATED INHIBITORS	1cil	79.7
37	e49	Crystal structure of human carbonic anhydrase isozyme II with 2-chloro-5-{[(4,6-dimethyl-2-pyrimidinyl)sulfanyl]acetyl}benzenesulfonamide	3s9t	79.55
38	ets	Structure of HCAIX mimic (HCAII with 5 mutations in active site) in complex with dorzolamide	4k13	79.52
39	e27	Crystal structure of human carbonic anhydrase isozyme II with 2-chloro-5-[(1H-imidazo[4,5-c]quinolin-2-ylsulfanyl)acetyl]benzenesulfonamide	3myq	79.5
40	ryv	Carbonic Anhydrase complexed with N-ethyl-4-sulfamoylbenzamide	3ryv	79.38
41	tru	carbonic anhydrase II in complex with trichloromethiazide as sulfonamide inhibitor	1zgf	79.38
42	azm	H94N CARBONIC ANHYDRASE II COMPLEXED WITH ACETAZOLAMIDE	2h4n	79.37
43	bzu	HUMAN CARBONIC ANHYDRASE II COMPLEXED WITH BRINZOLAMIDE	1a42	78.36
44	51j	Three dimensional structure of human carbonic anhydrase II in complex with 2-(But-2-yn-1-ylsulfamoyl)-4-sulfamoylbenzoic acid	5aml	78.26
45	al3	CARBONIC ANHYDRASE II INHIBITOR	1bnu	78.25
46	ryy	Fluoroalkyl and Alkyl Chains Have Similar Hydrophobicities in Binding to the Hydrophobic Wall of Carbonic Anhydrase	3ryy	78.14
47	bz1	Genetically engineered Carbonic Anhydrase IX in complex with Brinzolamide	4m2v	77.68
48	bz1	Human Carbonic Anhydrase II in complex with Brinzolamide	4m2r	77.58
49	daw	Carbonic Anhydrase II H64C mutant in complex with an in situ formed triazole	3kne	77.53
50	4wa	Human carboanhydrase F131C_C206S double mutant in complex with 2	5t72	77.47
51	s6i	Human carbonic ahydrase II in complex with a benzenesulfonamide inhibitor	3mzc	77.46
52	45i	Three dimensional structure of human carbonic anhydrase II in complex with 2-((2-Phenylethyl)sulfamoyl)-4-sulfamoylbenzoic acid	5amd	77.11
53	e90	Crystal structure of human carbonic anhydrase isozyme II with 4-[(2-pyrimidinylsulfanyl)acetyl]benzenesulfonamide	3sbi	76.94
54	ryj	Carbonic Anhydrase complexed with 4-sulfamoyl-N-(2,2,2-trifluoroethyl)benzamide	3ryj	76.82
55	rz0	Fluoroalkyl and Alkyl Chains Have Similar Hydrophobicities in Binding to the Hydrophobic Wall of Carbonic Anhydrase	3rz0	76.78
56	5ef	Crystal structure of human carbonic anhydraseisozyme II with 3-[(1S)-2,3-Dihydro-1H-inden-1-ylamino]-2,5,6-trifluoro-4-[(2-hydroxyethyl)sulfonyl]benzenesulfonamide	5drs	76.72
57	8js	Discovery of new selenoureido analogs of 4-(4-fluorophenylureido) benzenesulfonamides as carbonic anhydrase inhibitors	5wex	76.53
58	klt	Carbonic anhydrase inhibitors. Comparison of chlorthalidone and indapamide X-ray crystal structures in adducts with isozyme II: when three water molecules make the difference	3f4x	76.33
59	oys	Human Carbonic Anhydrase II complexed with 2-{[4-AMINO-3-(3-HYDROXYPROP-1-YN-1-YL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-1-YL]METHYL}-5-METHYL-3-(2-METHYLPHENYL)QUINAZOLIN-4(3H)-ONE	3oys	76.29
60	8js	Synthesis of novel seleno ureido containing compounds as SLC-0111 analogs. Investigations on carbonic anhydrases activity, glutathione peroxidase and X-ray crystallography	5uln	76.25
61	bz1	Joint X-ray/neutron structure of human carbonic anhydrase II in complex with brinzolamide	6bbs	76.24
62	oyq	Structure of Human Carbonic Anhydrase II complexed with 5,6-DIHYDRO-BENZO[H]CINNOLIN-3-YLAMINE	3oyq	76.19
63	8f2	Crystal structure of human carbonic anhydrase II in complex with (R)-4-(6,7-dihydroxy-1-phenyl-3,4-tetrahydroisoquinoline-1H-2-carbonyl)benzenesulfonamide.	5n0d	75.97
64	fkk	The crystal structure of human carbonic anhydrase II in complex with 4-[(4-fluorophenyl)methyl]-1-piperazinyl]benzenesulfonamide.	6h34	75.93
65	bl1	Carbonic anhydrase inhibitors. Sulfonamide diuretics revisited old leads for new applications	3bl1	75.68
66	inm	CARBONIC ANHYDRASE II COMPLEXED WITH AL-8520 2H-THIENO[3,2-E]-1,2-THIAZINE-6-SULFONAMIDE, 4-AMINO-3,4-DIHYDRO-2-(3-METHOXYPROPYL)-, 1,1-DIOXIDE, (R)	1i90	75.65
67	wwz	Crystal structure of human carbonic anhydrase II in complex with a benzenesulfonamide inhibitor	3n4b	75.63
68	ewz	Crystal structure of human carbonic anhydrase isozyme II with 5-{[(4-tert-buthyl-6-oxo-1,6-dihydropyrimidin-2-yl)thio]acetyl}-2-chlorobenzenesulfonamide	4qsi	75.47
69	ms5	A chimeric microtubule disruptor with efficacy on a taxane resistant cell line	2wd2	74.97
70	kr5	Crystal structure of human carbonic anhydrase isozyme II with 4-{[3-(3,5-Dimethyl-1H-pyrazol-1-yl)-3-oxopropyl]amino}benzene-1-sulfonamide	4q6e	74.63
71	j74	Crystal structure of human carbonic anhydrase isozyme II with 4-{2-[N-(6-chloro-5-nitropyrimidin-4-yl)amino]ethyl}benzenesulfonamide	3m2n	74.49
72	rz5	Fluoroalkyl and Alkyl Chains Have Similar Hydrophobicities in Binding to the Hydrophobic Wall of Carbonic Anhydrase	3rz5	74.4
73	vz4	Human Carbonic Anhydrase II in complex with 2-Ethylestrone-3-O-sulfamate	3oku	74.38
74	ryx	Fluoroalkyl and Alkyl Chains Have Similar Hydrophobicities in Binding to the Hydrophobic Wall of Carbonic Anhydrase	3ryx	74.3
75	sab	CARBONIC ANHYDRASE II COMPLEX WITH THE 1OKM INHIBITOR 4-SULFONAMIDE-[1-(4-AMINOBUTANE)]BENZAMIDE	1okm	74.09
76	oy0	Human Carbonic Anhydrase II complexed with 1-(4-(4-(2-(ISOPROPYLSULFONYL)PHENYLAMINO)-1H-PYRROLO[2,3-B]PYRIDIN-6-YLAMINO)-3-METHOXYPHENYL)PIPERIDIN-4-OL	3oy0	73.76
77	e1f	Crystal structure of human carbonic anhydrase isozyme II with 2-Chloro-4-[(pyrimidin-2-ylsulfanyl)acetyl]benzenesulfonamide	4knj	73.7
78	po1	Crystal structure analysis of the human carbonic anhydrase II in complex with a 2-substituted estradiol bis-sulfamate	2gd8	73.37
79	4k9	Carbonic anhydrase inhibitors: Design and synthesis of new heteroaryl-N-carbonylbenzenesulfonamides targeting druggable human carbonic anhydrase isoforms (hCA VII, hCA IX, and hCA XIV)	4z0q	73.25
80	eww	Crystal structure of human carbonic anhydrase isozyme II with 2-chloro-4-{[(4-methyl-6-oxo-1,6-dihydropyrimidin-2-yl)thio]acetyl}benzenesulfonamide	4qsa	73.08
81	mpx	Human CA II inhibition by novel sulfonamide	4ito	73.05
82	vz5	Human Carbonic anhydrase II bound by 2-Ethylestradiol 3-O-sulfamate	3oim	73.02
83	rz8	Fluoroalkyl and Alkyl Chains Have Similar Hydrophobicities in Binding to the Hydrophobic Wall of Carbonic Anhydrase	3rz8	72.8
84	vz5	Human Carbonic anhydrase II mutant A65S, N67Q (CA IX mimic) bound by 2-Ethylestradiol 3-O-sulfamate	3oil	72.71
85	m8s	Benzensulfonamides bearing spyrohydantoin moieties act as potent inhibitors of human carbonic anhydrases II and VII and show neuropathic pain attenuating effects	6oe0	72.7
86	arz	Crystal structure of human cabonic anhydrase II in adduct with an adamantyl analogue of acetazolamide in a novel hydrophobic binding pocket	3mhc	72.63
87	ioe	CARBONIC ANHYDRASE II (F131V) COMPLEXED WITH 4-(AMINOSULFONYL)-N-[(2,4,6-TRIFLUOROPHENYL)METHYL]-BENZAMIDE	1i9p	72.62
88	inq	CARBONIC ANHYDRASE II COMPLEXED WITH AL-6619 2H-THIENO[3,2-E]-1,2-THIAZINE-6-SULFONAMIDE, 2-(3-HYDROXYPHENYL)-3-(4-MORPHOLINYL)-, 1,1-DIOXIDE	1i91	72.56
89	id4	hCA II in complex with novel sulfonamide inhibitors Set D	4dz9	72.47
90	fkq	The crystal structure of human carbonic anhydrase II in complex with 4-(4-phenyl)-4-hydroxy-1-piperidine-1-carbonyl)benzenesulfonamide.	6h33	72.47
91	wwz	Carbonic Anhydrase IX-mimic IN Complex WITH U-F	5jn3	72.39
92	ctf	Crystal structure of the human carbonic anhydrase II in complex with STX 641 at 1.85 angstroms resolution	3bet	72.31
93	tg5	Human Carbonic Anhydrase II complexed with a two-faced guest	5ekm	72.15
94	fke	The crystal structure of human carbonic anhydrase II in complex with 4-(4-phenylpiperidine-1-carbonyl)benzenesulfonamide.	6h2z	72.02
95	0fz	Complex of human carbonic anhydrase II with 4-(6-methoxy-3,4-dihydroisoquinolin-1-yl)benzenesulfonamide	3vbd	71.95
96	6ke	Human carbonic anhydrase II in complex with ligand	5j8z	71.93
97	4wa	Human carbonic anhydrase II with an azobenzene inhibitor (1d)	5byi	71.92
98	bos	Crystal structure of the human carbonic anhydrase II in complex with a hypoxia-activatable sulfonamide.	2hd6	71.92
99	4kd	Carbonic anhydrase inhibitors: Design and synthesis of new heteroaryl-N-carbonylbenzenesulfonamides targeting druggable human carbonic anhydrase isoforms (hCA VII, hCA IX, and hCA XIV)	4z1n	71.86
100	ryz	Fluoroalkyl and Alkyl Chains Have Similar Hydrophobicities in Binding to the Hydrophobic Wall of Carbonic Anhydrase	3ryz	71.8
101	4kc	Carbonic anhydrase inhibitors: Design and synthesis of new heteroaryl-N-carbonylbenzenesulfonamides targeting druggable human carbonic anhydrase isoforms (hCA VII, hCA IX, and hCA XIV)	4z1j	71.77
102	inl	CARBONIC ANHYDRASE II COMPLEXED WITH AL-6629 2H-THIENO[3,2-E]-1,2-THIAZINE-6-SULFONAMIDE, 2-(3-METHOXYPHENYL)-3-(4-MORPHOLINYL)-, 1,1-DIOXIDE	1i8z	71.74
103	j71	Crystal structure of human carbonic anhydrase isozyme II with 4-{[N-(6-methoxy-5-nitropyrimidin-4-yl)amino]methyl}benzenesulfonamide	3mhl	71.68
104	jdr	Crystal structure of human carbonic anhydrase isozyme II with 4-{[N-(6-chloro-5-formyl-2-methylthiopyrimidin-4-yl)amino]methyl}benzenesulfonamide	3m5e	71.64
105	f6b	CARBONIC ANHYDRASE II COMPLEXED WITH 4-(AMINOSULFONYL)-N-[(2,6-DIFLUOROPHENYL)METHYL]-BENZAMIDE	1g53	71.56
106	e65	Crystal structure of human carbonic anhydrase isozyme II with 4-{[(4,6-dimethyl-2-pyrimidinyl)sulfanyl]acetyl}benzenesulfonamide	3sbh	71.25
107	1ez	Structure of human carbonic anhydrase II in complex with an adamantyl sulfonamide inhibitor	4ilx	71.17
108	cqs	Carbonic anhydrase II in complex with nitrogenous base-bearing benezenesulfonamide	6b59	70.83
109	fsb	CARBONIC ANHYDRASE II COMPLEXED WITH 4-(AMINOSULFONYL)-N-[(2-FLUOROPHENYL)METHYL]-BENZAMIDE	1g1d	70.79
110	wza	Structures of human carbonic anhydrase II inhibitor complexes reveal a second binding site for steroidal and non-steroidal inhibitors.	2x7u	70.79
111	mb6	Crystal structure of human carbonic anhydrase II in complex with the 5-(3-(4-chlorophenylsulfonyl)ureido)pyridine-2-sulfonamide inhibitor	4kuv	70.73
112	wwv	Crystal structure of human carbonic anhydrase II in complex with a benzenesulfonamide inhibitor	3n3j	70.7
113	mb2	Crystal structure of human carbonic anhydrase II in complex with the 5-(3-(4-fluorophenylsulfonyl)ureido)pyridine-2-sulfonamide inhibitor	4kuw	70.68
114	mb7	Crystal structure of human carbonic anhydrase II in complex with the 5-(3-tosylureido)pyridine-2-sulfonamide inhibitor	4kv0	70.3
115	fo9	Crystal structure of human carbonic anhydrase II in complex with the inhibitor famotidine	6g3q	70.09
116	j45	Crystal structure of human carbonic anhydrase isozyme II with 4-[N-(6-chloro-5-nitropyrimidin-4-yl)amino]benzenesulfonamide	3m40	70.01
117	e59	Crystal structure of human carbonic anhydrase isozyme II with 4-{[(4-methyl-6-oxo-1,6-dihydro-2-pyrimidinyl)sulfanyl]acetyl}benzenesulfonamide	3s8x	69.92
118	f2b	CARBONIC ANHYDRASE II COMPLEXED WITH 4-(AMINOSULFONYL)-N-[(2,3-DIFLUOROPHENYL)METHYL]-BENZAMIDE	1g52	69.82
119	bfg	Fragment tethered to Carbonic Anhydrase II H64C mutant	3m5t	69.53
120	eg2	SECONDARY INTERACTIONS SIGNIFICANTLY REMOVED FROM THE SULFONAMIDE BINDING POCKET OF CARBONIC ANHYDRASE II INFLUENCE BINDING CONSTANTS	1cnx	69.48
121	4kb	Carbonic anhydrase inhibitors: Design and synthesis of new heteroaryl-N-carbonylbenzenesulfonamides targeting druggable human carbonic anhydrase isoforms (hCA VII, hCA IX, and hCA XIV)	4z1k	69.29
122	ff5	Carbonic Anhydrase CAIX mimic in complex with inhibitor JS13	6gxb	68.78
123	9dh	Carbonic Anhydrase II Inhibitor RA7	5nxp	68.72
124	pof	Crystal structure of human carbonic anhydrase II in complex with STX237	3c7p	68.57
125	wzb	Human Carbonic anhydrase II mutant A65S, N67Q (CA IX mimic) bound by 2-Ethylestradiol 3,17-O,O-bis-sulfamate	3oik	68.46
126	e2i	Crystal structure of human carbonic anhydrase isozyme II with 4-{[(5-butyl-2-pyrimidinyl)sulfanyl]acetyl}benzenesulfonamide	3sap	68.37
127	rz1	Fluoroalkyl and Alkyl Chains Have Similar Hydrophobicities in Binding to the Hydrophobic Wall of Carbonic Anhydrase	3rz1	68.27
128	ffb	CARBONIC ANHYDRASE II COMPLEXED WITH 4-(AMINOSULFONYL)-N-[(2,3,4,5,6-PENTAFLUOROPHENYL)METHYL]-BENZAMIDE	1g54	68.25
129	chd	Structure of cholate bound to human carbonic anhydrase II	4n16	68.2
130	mpx	carbonic anhydrase II in complex with N-4-Methyl-1-piperazinyl-N'-(p-sulfonamide)phenylthiourea as sulfonamide inhibitor	1zh9	68.12
131	8f3	Crystal structure of human carbonic anhydrase II in complex with (S)-4-(6,7-dihydroxy-1-phenyl-3,4-tetrahydroisoquinoline-1H-2-carbonyl)benzenesulfonamide.	5n0e	68.06
132	js7	Crystal structure of human carbonic anhydrase isozyme II with 4-{2-[N-(6-methoxy-5-nitropyrimidin-4-yl)amino]ethyl}benzenesulfonamide	3m3x	67.55
133	rz7	Fluoroalkyl and Alkyl Chains Have Similar Hydrophobicities in Binding to the Hydrophobic Wall of Carbonic Anhydrase	3rz7	67.54
134	pmx	Human carbonic anhydrase II in complex with (+)-Xylariamide A	3p4v	67.53
135	d9h	Crystal structure of human carbonic anhydrase II in complex with a 1,3,5-triazine-substituted benzenesulfonamide inhibitor	3mmf	67.25
136	p9b	Crystal structure of human carbonic anhydrase II in complex with a benzenesulfonamide inhibitor	3n0n	67.24
137	fsb	CARBONIC ANHYDRASE II (F131V) COMPLEXED WITH 4-(AMINOSULFONYL)-N-[(2-FLUOROPHENYL)METHYL]-BENZAMIDE	1g45	67.09
138	stb	CARBONIC ANHYDRASE II COMPLEX WITH THE 1OKN INHIBITOR 4-SULFONAMIDE-[1-(4-N-(5-FLUORESCEIN THIOUREA)BUTANE)]	1okn	66.87
139	2c7	Carbonic anhydrase inhibitors. Interaction of the antitumor sulfamate EMD-486019 with twelve mammalian isoforms: kinetic and X-Ray crystallographic studies	3dd8	66.74
140	r21	Human carbonic anhydrase II in complex with 2-(3-chloro-4-hydroxyphenyl)-N-(4-sulfamoylphenethyl)acetamide	3nb5	66.73
141	cqs	Carbonic anhydrase IX-mimic in complex with nitrogenous base-bearing benezenesulfonamide	6b5a	66.68
142	f6b	CARBONIC ANHYDRASE II (F131V) COMPLEXED WITH 4-(AMINOSULFONYL)-N-[(2,6-DIFLUOROPHENYL)METHYL]-BENZAMIDE	1g48	66.39
143	sbr	Carbonic Anhydrase II Complexed With (R)-N-(3-Indol-1-yl-2-methyl-propyl)-4-sulfamoyl-benzamide	1if7	66.37
144	j75	Crystal structure of human carbonic anhydrase isozyme II with 4-{[N-(6-benzylamino-5-nitropyrimidin-4-yl)amino]methyl}benzenesulfonamide	3mhm	66.33
145	ioa	CARBONIC ANHYDRASE II (F131V) COMPLEXED WITH 4-(AMINOSULFONYL)-N-[(2,5-DIFLUOROPHENYL)METHYL]-BENZAMIDE	1i9n	65.92
146	bsb	CARBONIC ANHYDRASE II (F131V) COMPLEXED WITH 4-(AMINOSULFONYL)-N-PHENYLMETHYLBENZAMIDE	1g4o	65.77
147	3cc	Crystal structure of the complex of hcaii with an indane-sulfonamide inhibitor	2qo8	65.62
148	f2b	CARBONIC ANHYDRASE II (F131V) COMPLEXED WITH 4-(AMINOSULFONYL)-N-[(2,3-DIFLUOROPHENYL)METHYL]-BENZAMIDE	1g46	65.59
149	tg4	Human Carbonic Anhydrase II complexed with a two-faced guest	5ekj	65.57
150	te1	Coumarins are a novel class of suicide carbonic anhydrase inhibitors	3f8e	65.13
151	3bs	Crystal structure of the complex between Carbonic Anhydrase II and a spin-labeled sulfonamide incorporating TEMPO moiety	3eft	64.52
152	9e8	Carbonic Anhydrase II Inhibitor RA11	5ny3	64.32
153	m8v	Benzensulfonamides bearing spyrohydantoin moieties act as potent inhibitors of human carbonic anhydrases II and VII and show neuropathic pain attenuating effects	6oe1	64.23
154	chd	Crystal structure of a highly thermal stabilized variant of Human Carbonic Anhydrase II	4pxx	63.06
155	dwh	The crystal structure of human carbonic anhydrase Ii in complex with a 1,3,5-triazine-substituted benzenesulfonamide inhibitor	3mna	62.99
156	rdt	Crystal structure of human carbonic anhydrase II with 6,7-Dimethoxy-1-methyl-3,4-dihydroisoquinoline-2(1H)-sulfonamide	3po6	62.95
157	d7a	Complex of human carbonic anhydrase II with N-[2-(3,4-dimethoxyphenyl)ethyl]-4-sulfamoylbenzamide	3v7x	62.79
158	sbs	Carbonic Anhydrase II Complexed With (S)-N-(3-Indol-1-yl-2-methyl-propyl)-4-sulfamoyl-benzamide	1if8	61.78
159	wzb	Structures of human carbonic anhydrase II inhibitor complexes reveal a second binding site for steroidal and non-steroidal inhibitors.	2x7t	61.76
160	df5	Carbonic anhydrase inhibitors: Design and synthesis of new heteroaryl-N-carbonylbenzenesulfonamides targeting druggable human carbonic anhydrase isoforms (hCA VII, hCA IX, and hCA XIV)	4z1e	61.73
161	9e2	Carbonic Anhydrase II Inhibitor RA8	5nxv	61.03
162	42g	Carbonic Anhydrase IX-mimic in complex with aryloxy-2-hydroxypropylammine sulfonamide	5wlu	52.7
163	g2y	Carbonic anhydrase IX-mimic in complex with sucralose	6cjv	51.38