| Index | Ligand Name | Structure | PDB code | ligand desolvation |
| 1 | 0cp | Crystal structure of human PDE4b with 5-[3-[(1S,2S,4R)-Bicyclo[2.2.1]hept-2-yloxy]-4-methoxyp henyl]tetrahydro-2(1H)-pyrimidinone reveals ordering of the C-terminal helix residues 502-509. | 3kkt | 93.74 |
| 2 | rol | Catalytic Domain Of Human Phosphodiesterase 4B In Complex With (R,S)-Rolipram | 1xn0 | 92.47 |
| 3 | hbt | Catalytic domain of human phosphodiesterase 4B2B in complex with a tetrahydrobenzothiophene inhibitor | 3hmv | 91.86 |
| 4 | 19t | Selective Inhibition of the Catalytic Domain Of Human Phosphodiesterase 4B With A-33 | 4myq | 91.43 |
| 5 | qpc | Crystal structure of phosphodiesterase 4B in complex with compound 10f | 3wd9 | 91.37 |
| 6 | nvw | Crystal structure of phosphodiesterase 4B in complex with compound 31e | 3w5e | 90.91 |
| 7 | 2o5 | PDE4 catalytic domain | 4nw7 | 90.19 |
| 8 | pil | Catalytic Domain Of Human Phosphodiesterase 4B In Complex With Piclamilast | 1xm4 | 89.89 |
| 9 | rol | Crystal structure of PDE4B2B complexed with Rolipram (R & S) | 1ro6 | 89.41 |
| 10 | rof | Catalytic Domain Of Human Phosphodiesterase 4B In Complex With Roflumilast | 1xmu | 89.15 |
| 11 | cio | Catalytic Domain Of Human Phosphodiesterase 4B In Complex With Cilomilast | 1xlx | 89.04 |
| 12 | rol | Catalytic Domain Of Human Phosphodiesterase 4B In Complex With (R)-Rolipram | 1xmy | 87.97 |
| 13 | z72 | Catalytic Domain of Human Phosphodiesterase 4B in Complex with A Coumarin-Based Inhibitor | 3ly2 | 87.74 |
| 14 | 6qq | Human Phospodiesterase 4B in complex with pyridyloxy-benzoxaborole based inhibitor | 5k6j | 86.66 |
| 15 | via | Catalytic Domain Of Human Phosphodiesterase 4B In Complex With Sildenafil | 1xos | 85.67 |
| 16 | sk4 | Catalytic Domain of Human Phosphodiesterase 4B2B in Complex with a Quinoline Inhibitor | 3frg | 84.81 |
| 17 | 066 | Catalytic domain of human phosphodiesterase 4B2B in complex with a quinoline inhibitor | 3gwt | 84.08 |
| 18 | fil | Catalytic Domain Of Human Phosphodiesterase 4B In Complex With Filaminast | 1xlz | 83.2 |
| 19 | 20a | Crystal structure of PDE4B catalytic domain in complex with a pyrazolopyridine inhibitor | 3d3p | 82.07 |
| 20 | zg2 | Catalytic domain of human phosphodiesterase 4b2b in complex with a 5-heterocycle pyrazolopyridine inhibitor | 3o57 | 78.29 |
| 21 | vdn | Catalytic Domain Of Human Phosphodiesterase 4B In Complex With Vardenafil | 1xot | 76.23 |
| 22 | 6m5 | Crystal structure of human phosphodiesterase 4B catalytic domain with inhibitor NPD-001 | 5laq | 73.98 |