| Index | Protein Name | Gene Name Primary | Gene Name Synonym | Uniprot ID | Highest desolvation of bound compounds in the PDB |
| 1 | cGMP-dependent 3',5'-cyclic phosphodiesterase | PDE2A | | O00408 | 98.71 |
| 2 | cGMP-specific 3',5'-cyclic phosphodiesterase | PDE5A | PDE5 | O76074 | 98.11 |
| 3 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | PDE4D | DPDE3 | Q08499 | 94.23 |
| 4 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | PDE4B | DPDE4 | Q07343 | 93.74 |
| 5 | Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B | PDE1B | PDE1B1 PDES1B | Q01064 | 90.63 |
| 6 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | PDE10 | | Q9Y233 | 90.53 |
| 7 | cAMP-specific 3',5'-cyclic phosphodiesterase 4A | PDE4A | DPDE2 | P27815 | 88.89 |
| 8 | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | PDE9A | | O76083 | 87.55 |
| 9 | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | PDE3B | | Q13370 | 86.37 |
| 10 | High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A | PDE7A | | Q13946 | 86.36 |
| 11 | High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A | PDE8A | | O60658 | 79.29 |