The Ligandable Human Proteome

cAMP-specific 3',5'-cyclic phosphodiesterase 4D

3'5'-cyclic nucleotide phosphodiesterase, catalytic domain

Index	Ligand Name	Structure	PDB code	ligand desolvation
1	pil	Catalytic Domain Of Human Phosphodiesterase 4D In Complex With Piclamilast	1xon	94.23
2	kr4	Crystal Structure of the PDE4D Catalytic Domain and UCR2 Regulatory Helix with T-49	6nji	93.77
3	e31	Crystal Structure of the PDE4D Catalytic Domain and UCR2 Regulatory Helix with BPN5004	6boj	92.79
4	krd	Crystal Structure of the PDE4D Catalytic Domain and UCR2 Regulatory Helix with T-48	6njh	92.77
5	6q2	PDE4D crystal structure in complex with small molecule inhibitor	5k32	92.05
6	rol	Crystal structure of human phosphodiesterase 4d with rolipram	3g4k	91.53
7	d08	Crystal structure of the PDE4D catalytic domain in complex with GEBR-26g	6f8x	90.03
8	r91	Crystal structure of the PDE4D2 catalytic domain in complex with inhibitor (R)-Zl-n-91	5wh5	89.98
9	akj	Crystal structure of PDE4D2 in complex with inhibitor (S_Zl-n-91)	5wh6	89.95
10	15x	Crystal structure of human phosphodiesterase 4D with bound allosteric modulator	3iad	89.44
11	rof	Catalytic Domain Of Human Phosphodiesterase 4D In Complex With Roflumilast	1xoq	88.96
12	3kq	PDE4 complexed with inhibitor	4wcu	88.8
13	rof	Crystal structure of human phosphodiesterase 4d with roflumilast	3g4l	88.67
14	rol	Catalytic Domain Of Human Phosphodiesterase 4D In Complex With Rolipram	1tbb	88.36
15	d0e	Crystal structure of the PDE4D catalytic domain in complex with GEBR-18a	6f8w	87.55
16	cio	Catalytic Domain Of Human Phosphodiesterase 4D In Complex With Cilomilast	1xom	87.01
17	ajx	Crystal structure of PDE4D complexed with a novel inhibitor	6imr	86.81
18	0mo	The structure of the catalytic domain of human PDE4d with 4-(3-Butoxy-4-methoxyphenyl)methyl-2-imidazolidone	3k4s	86.23
19	rol	Three dimensional structures of PDE4D in complex with roliprams and implication on inhibitor selectivity	1q9m	85.88
20	d0b	Crystal structure of the PDE4D catalytic domain in complex with GEBR-18b	6f8v	85.49
21	rol	Crystal structure of PDE4D2 in complex with (R,S)-rolipram	1oyn	84.82
22	3gj	PDE4D complexed with inhibitor	4w1o	83.64
23	ihm	Crystal structure of the catalytic domain of PDE4D2 with (S)-N-(3-{1-[1-(3-Cyclopropylmethoxy-4-difluoromethoxyphenyl)-2-(1-oxypyridin-4-yl)-ethyl]-1H-pyrazl-3-yl}phenyl)acetamide	3v9b	83.43
24	czq	Crystal structure of the PDE4D catalytic domain in complex with GEBR-20b	6f8u	83.39
25	6pt	PDE4 crystal structure in complex with small molecule inhibitor	5k1i	83.26
26	d71	Crystal structure of human phosphodiesterase 4d with d155871	3g4i	82.99
27	e6z	Crystal structure of human phosphodiesterase 4D2 catalytic domain with inhibitor NPD-048	6ftw	82.49
28	cv8	Crystal structure of the PDE4D catalytic domain in complex with GEBR-7b	6f6u	82.35
29	czk	Crystal structure of the PDE4D catalytic domain in complex with GEBR-54	6f8r	81.79
30	czt	Crystal structure of the PDE4D catalytic domain in complex with GEBR-4a	6f8t	80.33
31	dd5	Crystal structure of the PDE4D catalytic domain in complex with GEBR-32a	6fdc	79.27
32	ev1	Crystal structure of human phosphodiesterase 4d (PDE4d) with papaverine.	3iak	78.67
33	ffz	Crystal structure of human phosphodiesterase 4D2 catalytic domain with inhibitor NPD-1335	6hwo	78.64
34	d5n	Crystal structure of the PDE4D catalytic domain in complex with GEBR-32a	6fdc	78.52
35	7dj	CRYSTAL STRUCTURE OF HUMAN PHOSPHODIESTERASE 4D IN COMPLEX WITH A TETRAFLUORANLINE COMPOUND	5tkb	78.37
36	d62	Crystal structure of human phosphodiesterase 4D2 catalytic domain with inhibitor NPD-356	6fe7	78.26
37	ajl	Crystal structure of PDE4D complexed with a novel inhibitor	6imo	78.19
38	m98	Crystal structure of PDE4D in complex with L-869298	2fm0	77.96
39	ak0	Crystal structure of PDE4D complexed with a novel inhibitor	6imt	77.73
40	m99	Crystal structure of PDE4D2 in complex with inhibitor L-869299	2fm5	77.54
41	e8h	Crystal structure of human phosphodiesterase 4D2 catalytic domain with inhibitor NPD-007	6fw3	77.25
42	j25	Crystal structure of the catalytic domain of PDE4D2 complexed with compound 10d	3sl5	77.23
43	d5z	Crystal structure of human phosphodiesterase 4D2 catalytic domain with inhibitor NPD-1086	6feb	76.94
44	ako	Crystal structure of PDE4D complexed with a novel inhibitor	6ind	75.94
45	d5t	Crystal structure of human phosphodiesterase 4D2 catalytic domain with inhibitor NPD-226	6fdi	75.88
46	aku	Crystal structure of PDE4D complexed with a novel inhibitor	6inm	75.62
47	ibm	Structure of PDE4D2-IBMX	1zkn	75.57
48	jn4	Crystal structure of the catalytic domain of PDE4D2 with compound 10D	3sl4	74.98
49	6m5	Crystal structure of human phosphodiesterase 4D2 catalytic domain with inhibitor NPD-001	5lbo	74.8
50	aku	Crystal structure of PDE4D complexed with a novel inhibitor	6ink	74.64
51	jn8	Crystal structure of the catalytic domain of PDE4D2 with compound 12c	3sl6	74.15
52	jn7	Crystal structure of the catalytic domain of PDE4D2 with compound 10o	3sl8	72.45