The Ligandable Human Proteome

High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A

3'5'-cyclic nucleotide phosphodiesterase, catalytic domain

Index	Ligand Name	Structure	PDB code	ligand desolvation
1	wtc	Human phosphodiesterase 9 in complex with inhibitor	3jsi	87.55
2	49d	Crystal structure of phosphodiesterase 9 in complex with (S)-C33	4y8c	86.94
3	ibm	Crystal structure of PDE9A (E406A) mutant in complex with IBMX	3n3z	86.78
4	49d	Crystal structure of PDE9 in complex with racemic inhibitor C33	4y86	85.54
5	pdb	Crystal structure of PDE9A(Q453E) in complex with inhibitor BAY73-6691	3qi3	84.55
6	pdb	Crystal structure of the PDE9A catalytic domain in complex with (R)-BAY73-6691	3k3e	84.52
7	bye	Crystal structure of the PDE9A catalytic domain in complex with (S)-BAY73-6691	3k3h	83.57
8	ibm	Crystal structure of PDE9 in complex with IBMX	2hd1	80.87
9	9q9	Crystal structure of the PDE9 catalytic domain in complex with inhibitor 2	6a3n	79.66
10	jar	Human PDE9 in complex with selective inhibitor	3jsw	78.58
11	ibm	Crystal structure of PDE9A(Q453E) in complex with IBMX	3qi4	78.45
12	49e	Crystal structure of PDE9 in complex with racemic inhibitor C33	4y86	77.62
13	35o	phosphodiesterase-9A in complex with inhibitor WYQ-C36D	4qge	76.56
14	0wf	Human pde9 in complex with selective compound	4g2j	76.14
15	ibm	Crystal structure of the human Phosphodiesterase 9A catalytic domain complexed with IBMX	2yy2	75.07
16	7rg	Human phosphodiesterase 9 in complex with inhibitors	4e90	74.2
17	ibm	human phosphodiestrase-5'GMP complex (EP), produced by soaking with 20mM cGMP+20 mM MnCl2+20 mM MgCl2 for 2 hours, and flash-cooled to liquid nitrogen temperature when substrate was still abudant.	3dys	74.07
18	0wl	Human PDE9 in complex with selective compound	4g2l	73.69
19	luo	Crystal structure of the PDE9A catalytic domain in complex with inhibitor 28	4gh6	72.22
20	ibm	human phosphodiestrase 9 (inhibited by omitting divalent cation) in complex with cGMP	3dyq	69.95